LOCUS       NM_012153               5399 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ETS homologous factor (EHF), transcript variant 2,
            mRNA.
ACCESSION   NM_012153 NM_172233
VERSION     NM_012153.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5399)
  AUTHORS   Wang,F., Huang,J., Zeng,S., Pan,Y. and Zhou,H.
  TITLE     ETS homologous factor, controlled by lysine-specific demethylase
            5B, suppresses clear cell renal cell carcinoma by inducing
            Filamin-B
  JOURNAL   Gene 927, 148702 (2024)
   PUBMED   38880187
  REMARK    GeneRIF: ETS homologous factor, controlled by lysine-specific
            demethylase 5B, suppresses clear cell renal cell carcinoma by
            inducing Filamin-B.
REFERENCE   2  (bases 1 to 5399)
  AUTHORS   Nightingale,R., Reehorst,C.M., Vukelic,N., Papadopoulos,N.,
            Liao,Y., Guleria,S., Bell,C., Vaillant,F., Paul,S., Luk,I.Y.,
            Dhillon,A.S., Jenkins,L.J., Morrow,R.J., Jackling,F.C., Chand,A.L.,
            Chisanga,D., Chen,Y., Williams,D.S., Anderson,R.L., Ellis,S.,
            Meikle,P.J., Shi,W., Visvader,J.E., Pal,B. and Mariadason,J.M.
  TITLE     Ehf controls mammary alveolar lineage differentiation and is a
            putative suppressor of breast tumorigenesis
  JOURNAL   Dev Cell 59 (15), 1988-2004 (2024)
   PUBMED   38781975
  REMARK    GeneRIF: Ehf controls mammary alveolar lineage differentiation and
            is a putative suppressor of breast tumorigenesis.
REFERENCE   3  (bases 1 to 5399)
  AUTHORS   Wang,S. and Gao,Y.
  TITLE     Pancreatic cancer cell-derived microRNA-155-5p-containing
            extracellular vesicles promote immune evasion by triggering
            EHF-dependent activation of Akt/NF-kappaB signaling pathway
  JOURNAL   Int Immunopharmacol 100, 107990 (2021)
   PUBMED   34482266
  REMARK    GeneRIF: Pancreatic cancer cell-derived microRNA-155-5p-containing
            extracellular vesicles promote immune evasion by triggering
            EHF-dependent activation of Akt/NF-kappaB signaling pathway.
REFERENCE   4  (bases 1 to 5399)
  AUTHORS   Li,W., Okabe,A., Usui,G., Fukuyo,M., Matsusaka,K., Rahmutulla,B.,
            Mano,Y., Hoshii,T., Funata,S., Hiura,N., Fukayama,M., Tan,P.,
            Ushiku,T. and Kaneda,A.
  TITLE     Activation of EHF via STAT3 phosphorylation by LMP2A in
            Epstein-Barr virus-positive gastric cancer
  JOURNAL   Cancer Sci 112 (8), 3349-3362 (2021)
   PUBMED   34014591
  REMARK    GeneRIF: Activation of EHF via STAT3 phosphorylation by LMP2A in
            Epstein-Barr virus-positive gastric cancer.
REFERENCE   5  (bases 1 to 5399)
  AUTHORS   Zhang,C., Li,J., Guo,Y., Wang,R., Hua,L., Gan,D., Zhu,L., Ma,P.,
            Yang,J., Li,H., Li,S., Song,Y. and Su,H.
  TITLE     Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT
            Cells by Downregulating PSIP1 and NUCKS1
  JOURNAL   Ann Clin Lab Sci 51 (4), 470-486 (2021)
   PUBMED   34452885
  REMARK    GeneRIF: Ese-3 Inhibits the Proliferation, Migration, and Invasion
            of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
REFERENCE   6  (bases 1 to 5399)
  AUTHORS   Jobling,A.I., Fang,Z., Koleski,D. and Tymms,M.J.
  TITLE     Expression of the ETS transcription factor ELF3 in the retinal
            pigment epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 43 (11), 3530-3537 (2002)
   PUBMED   12407165
REFERENCE   7  (bases 1 to 5399)
  AUTHORS   Baron,R.M., Palmer,L.J., Tantisira,K., Gabriel,S., Sonna,L.A.,
            Le,L., Hallock,A., Libermann,T.A., Drazen,J.M., Weiss,S.T. and
            Silverman,E.S.
  TITLE     DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are
            not associated with asthma
  JOURNAL   Am J Respir Crit Care Med 166 (7), 927-932 (2002)
   PUBMED   12359648
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5399)
  AUTHORS   Tugores,A., Le,J., Sorokina,I., Snijders,A.J., Duyao,M.,
            Reddy,P.S., Carlee,L., Ronshaugen,M., Mushegian,A., Watanaskul,T.,
            Chu,S., Buckler,A., Emtage,S. and McCormick,M.K.
  TITLE     The epithelium-specific ETS protein EHF/ESE-3 is a
            context-dependent transcriptional repressor downstream of MAPK
            signaling cascades
  JOURNAL   J Biol Chem 276 (23), 20397-20406 (2001)
   PUBMED   11259407
REFERENCE   9  (bases 1 to 5399)
  AUTHORS   Kas,K., Finger,E., Grall,F., Gu,X., Akbarali,Y., Boltax,J.,
            Weiss,A., Oettgen,P., Kapeller,R. and Libermann,T.A.
  TITLE     ESE-3, a novel member of an epithelium-specific ets transcription
            factor subfamily, demonstrates different target gene specificity
            from ESE-1
  JOURNAL   J Biol Chem 275 (4), 2986-2998 (2000)
   PUBMED   10644770
REFERENCE   10 (bases 1 to 5399)
  AUTHORS   Kleinbaum,L.A., Duggan,C., Ferreira,E., Coffey,G.P., Buttice,G. and
            Burton,F.H.
  TITLE     Human chromosomal localization, tissue/tumor expression, and
            regulatory function of the ets family gene EHF
  JOURNAL   Biochem Biophys Res Commun 264 (1), 119-126 (1999)
   PUBMED   10527851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087783.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_012153.5.
            
            Summary: This gene encodes a protein that belongs to an ETS
            transcription factor subfamily characterized by epithelial-specific
            expression (ESEs). The encoded protein acts as a transcriptional
            repressor and may be involved in epithelial differentiation and
            carcinogenesis. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1. Variants 2 and
            4-10 all encode the same isoform (2).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138512.280423.1,
                                           DRR138512.493930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257831.8/ ENSP00000257831.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC087783.10        90696-90831         c
            137-236             AC087783.10        69197-69296         c
            237-482             AC087783.10        65240-65485         c
            483-545             AC087783.10        62843-62905         c
            546-614             AC087783.10        60314-60382         c
            615-683             AC087783.10        60119-60187         c
            684-746             AC087783.10        54954-55016         c
            747-942             AC087783.10        53196-53391         c
            943-5399            AC087783.10        48636-53092         c
FEATURES             Location/Qualifiers
     source          1..5399
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..5399
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="ETS homologous factor"
                     /db_xref="GeneID:26298"
                     /db_xref="HGNC:HGNC:3246"
                     /db_xref="MIM:605439"
     exon            1..136
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            137..236
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1042
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="isoform 2 is encoded by transcript variant 2; ESE3
                     transcription factor; hEHF; ETS domain-containing
                     transcription factor; epithelium-specific Ets
                     transcription factor 3"
                     /codon_start=1
                     /product="ETS homologous factor isoform 2"
                     /protein_id="NP_036285.2"
                     /db_xref="CCDS:CCDS7894.1"
                     /db_xref="GeneID:26298"
                     /db_xref="HGNC:HGNC:3246"
                     /db_xref="MIM:605439"
                     /translation="MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHE
                     IHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQ
                     LLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDL
                     LDSKTFCRAQISMTTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILL
                     NPDKNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREIL
                     ERVDGRRLVYKFGKNARGWRENEN"
     exon            237..482
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            483..545
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            546..614
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            615..683
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            684..746
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            747..942
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            943..5399
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4573..4578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="hexamer: AATAAA"
     polyA_site      4599
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
     regulatory      5371..5376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="hexamer: AATAAA"
     polyA_site      5399
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="major polyA site"
ORIGIN      
        1 actctgatga gggctcagac ttgataacac ccgtggtgcc ccatccctat aggagctggt
       61 gagattgcag cctgctgcct cccctccaac agccacagct attggatttc ccacccagaa
      121 tctttaggta aatgagatca tgattctgga aggaggtggt gtaatgaatc tcaaccccgg
      181 caacaacctc cttcaccagc cgccagcctg gacagacagc tactccacgt gcaatgtttc
      241 cagtgggttt tttggaggcc agtggcatga aattcatcct cagtactgga ccaagtacca
      301 ggtgtgggag tggctccagc acctcctgga caccaaccag ctggatgcca attgtatccc
      361 tttccaagag ttcgacatca acggcgagca cctctgcagc atgagtttgc aggagttcac
      421 ccgggcggca gggacggcgg ggcagctcct ctacagcaac ttgcagcatc tgaagtggaa
      481 cggccagtgc agtagtgacc tgttccagtc cacacacaat gtcattgtca agactgaaca
      541 aactgagcct tccatcatga acacctggaa agacgagaac tatttatatg acaccaacta
      601 tggtagcaca gtagatttgt tggacagcaa aactttctgc cgggctcaga tctccatgac
      661 aaccaccagt caccttcctg ttgcagagtc acctgatatg aaaaaggagc aagacccccc
      721 tgccaagtgc cacaccaaaa agcacaaccc gagagggact cacttatggg aattcatccg
      781 cgacatcctc ttgaacccag acaagaaccc aggattaata aaatgggaag accgatctga
      841 gggcgtcttc aggttcttga aatcagaggc agtggctcag ctatggggta aaaagaagaa
      901 caacagcagc atgacctatg aaaagctcag ccgagctatg agatattact acaaaagaga
      961 aattctggag cgtgtggatg gacgaagact ggtatataaa tttgggaaga atgcccgagg
     1021 atggagagaa aatgaaaact gaagctgcca atactttgga cacaaaccaa aacacacacc
     1081 aaataatcag aaacaaagaa ctcctggacg taaatatttc aaagactact tttctctgat
     1141 atttatgtac catgagggga acaagaaact acttctaacg ggaagaagaa acactacggt
     1201 cgattaaaaa aattattttg ttacttcgaa gtatgtccta tatggggaaa aaacgtacac
     1261 agttttctgt gaaatatgat gctgtatgtg gttgtgattt tttttcacct ctattgtgaa
     1321 ttctttttca ctgcaagagt aacaggattt gtagccttgt gcttcttgct aagagaaaga
     1381 aaaacaaaat cagagggcat taaatgtttt gtatgtgaca tgatttagaa aaaggtgatg
     1441 catcctcctc acataagcat ccatatggct tcgtcaaggg aggtgaacat tgttgctgag
     1501 ttaaattcca gggtctcaga tggttaggac aaagtggatg gatgccggga agtttaacct
     1561 gagccttagg atccaatgag tggagaatgg ggacttccaa aacccaaggt tggctataat
     1621 ctctgcataa ccacatgact tggaatgctt aaatcagcaa gaagaataat ggtggggtct
     1681 ttatactcat tcaggaatgg tttatctgat gccagggctg tcttcctttc tcccctttgg
     1741 atggttggtg aaatacttta attgccctgt ctgctcactt ctagctattt aagagagaac
     1801 ccagcttggt tcttttttgc tccaagtgct taaaaataag ttggaaaaag gagacggtgg
     1861 tgtggaaatg gctgaagagt ttgctcttgt atccctatag tccaaggttt ctcaatctgc
     1921 acaattgaca tttttggccg gagtgttctt tgtggtgagg gctttcctgt gcattgtaag
     1981 atgttcagca gtatccactc atggtctcta accacttgac accagaaacc ccccagctgt
     2041 gataacgcaa aatgtctcta gacatcacca aatgttccct gggggtggca aatttgccct
     2101 tgattgagaa ccaccagttt agctagtcaa tatgaggatg gtggtttatt ctcagaagaa
     2161 aaagatatgt aaggtctttt agctccttag agtgaagcaa aagcaagact tcaacctcaa
     2221 cctatcttta tgttttaaat gttagggaca ataagttgaa atagctagag gagcttcttt
     2281 tcagaacccc agatgagagc caatgtcaga taaagtaagc atagtaatgt agcaggaact
     2341 acaatagaag acattttcac tggaattaca aagcagaatt aaaattatat tgtagaagga
     2401 aacaccaaga aaagaatttc cagggaaaat cctctttgca ggtattaatt cttataattt
     2461 tttgtctttt ggattatctg tttactgtct catctgaact gatcccaggt gaacggttta
     2521 ttgcctagat ttgtactcag aggaattttt tttgttttgt tttgtctttt aagaaaggaa
     2581 agaaaggatg aaaaaaataa acagaaaact cagctcaggc acaattgtca ccaaggagtt
     2641 aaaagcttct tcttcaatag aggaattgtt ctgggggtcc tggagactta ccattgagcc
     2701 atgcaatctg ggaagcacag gaataagtag acactttgaa aatggatttg aatgttctca
     2761 tcccttttgc agcttttctt tttggctctc tcatgtcctt ggcttgctcc tctattctac
     2821 ctctctttct ccagcaataa tatgcaaatg aagacatgta tccataagaa ggagtgctct
     2881 tcatcaacta atagagcacc taccacagtg tcatacctgg tagaggtgag caattcatat
     2941 tcaaaggttg caaagtgttt gtaatatatt catgaggctg gaagtaagaa gaattaaaaa
     3001 tttgtcctaa ttacaatgag aaccattcta ggtagtgatc ttggagcaca catgaataac
     3061 tttctgaagg tgcaaccaaa tccattttta tttctgcctg gcttggtcac ttctgtaaag
     3121 gtttaactta gtgttgtcaa gtaacagtta ctgaaagagc tgagaaaaag aacaatgaac
     3181 agcaacgatc ttgactgtgc aactcagaca ttcctgcaga aaagacatat gttgctttac
     3241 aagaaggcca aagaactatg gggccttccc agcatttgac tgttcattgc atagaatgaa
     3301 ttaaatatcc agttacttga atgggtataa cgcatgaata tttgtgtgtc tgtgtgtgtg
     3361 tctgagttgt gtgattttat taggggcatc tgccaattct ctcactgtgg ttccttctct
     3421 gactttgcct gttcatcatc taaggaggct agatccttcg ctgacttcac cattcctcaa
     3481 acctgtaagt ttctcacttc ttccaaattg gctttggctc tttctgcaac ctttccattc
     3541 aagagcaatc tttgctaagg agtaagtgaa tgtgaagagt accaactaca acaattctac
     3601 agataattag tggattgtgt tgtttgttga gagtgaaggt ttcttggcat ctggtgcctg
     3661 attaaggctt gagtattaag ttctcagcat atctctctat tgtcttgact tgagtttgct
     3721 gcattttcta tgtgctgttc gtgacttgga gaacttaaag taatcgagct atgccaactt
     3781 ggggtggtaa cagagtactt cccaccacag tgttgaaagg gagagcaaag tcttatggat
     3841 aaaccctcct ttcttttggg gacacatggc tctcacttga gaagctcacc tgtgctgaat
     3901 gtccacatgg tcactaaaca tgttatcctt aaaccccccg tatgcctgag ttgaaagggc
     3961 tctctcttat taggttttca tgggaacatg aggcagcaaa tctattgcta agactttacc
     4021 aggctcaaat catctgaggc tgatagatat ttgacttggt aagacttaag taaggctctg
     4081 gctcccaggg gcataagcaa cagtttcttg aatgtgccat ctgagaaggg agacccaggt
     4141 tgtgagtttt cctttgaaca cattggtctt ttctcaaagt tcctgccttg ctagactgtt
     4201 agctctttga ggacagggac tatgtcttat caatcactat tattttcctg ttacctagca
     4261 tgggacaagt acacaacaca tatttgttca atgaatgaat gaatgtcttc taaaagactc
     4321 ctctgattgg gagaccatat ctataattgg gatgtgaatc atttcttcag tggaataaga
     4381 gcacaacggc acaaccttca aggacatatt atctactatg aacattttac tgtgagactc
     4441 tttattttgc cttctacttg cgctgaaatg aaaccaaaac aggccgttgg gttccacaag
     4501 tcaatatatg ttggatgagg attctgttgc cttattggga actgtgagac ttatctggta
     4561 tgagaagcca gtaataaacc tttgacctgt tttaaccaat gaagattatg aatatgttaa
     4621 tatgatgtaa attgctattt aagtgtaaag cagttctaag ttttagtatt tgggggattg
     4681 gtttttatta tttttttcct ttttgaaaaa tactgaggga tcttttgata aagttagtaa
     4741 tgcatgttag attttagttt tgcaagcatg ttgtttttca aatatatcaa gtatagaaaa
     4801 aggtaaaaca gttaagaagg aaggcaatta tattattctt ctgtagttaa gcaaacactt
     4861 gttgagtgcc tgctatgtgc acggcatggg cccatatgtg tgaggagctt gtctaattat
     4921 gtaggaagca atagatctcg gtagttacgt attgggcaga tacttactgt atgaatgaaa
     4981 gaacatcaca gtaatcacaa tatcagagct gaattatcct cagtgtagct tcttggaatt
     5041 cagtttctgg aactagagat agagcattta ttaaaaaaaa ctcctgttga gactgtgtct
     5101 tatgaacctc tgaaacgtac aagccttcac aagtttaact aaattgggat taatctttct
     5161 gtagttatct gcataattct tgtttttctt tccatctggc tcctgggttg acaatttgtg
     5221 gaaacaactc tattgctact atttaaaaaa aatcagaaat ctttcccttt aagctatgtt
     5281 aaattcaaac tattcctgct attcctgttt tgtcaaagaa ttatattttt caaaatatgt
     5341 ttatttgttt gatgggtccc aggaaacact aataaaaacc acagagacca gcctggaaa
//
