LOCUS       NM_001378046            5355 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens ETS homologous factor (EHF), transcript variant 10,
            mRNA.
ACCESSION   NM_001378046 XM_011519985
VERSION     NM_001378046.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5355)
  AUTHORS   Wang,F., Huang,J., Zeng,S., Pan,Y. and Zhou,H.
  TITLE     ETS homologous factor, controlled by lysine-specific demethylase
            5B, suppresses clear cell renal cell carcinoma by inducing
            Filamin-B
  JOURNAL   Gene 927, 148702 (2024)
   PUBMED   38880187
  REMARK    GeneRIF: ETS homologous factor, controlled by lysine-specific
            demethylase 5B, suppresses clear cell renal cell carcinoma by
            inducing Filamin-B.
REFERENCE   2  (bases 1 to 5355)
  AUTHORS   Nightingale,R., Reehorst,C.M., Vukelic,N., Papadopoulos,N.,
            Liao,Y., Guleria,S., Bell,C., Vaillant,F., Paul,S., Luk,I.Y.,
            Dhillon,A.S., Jenkins,L.J., Morrow,R.J., Jackling,F.C., Chand,A.L.,
            Chisanga,D., Chen,Y., Williams,D.S., Anderson,R.L., Ellis,S.,
            Meikle,P.J., Shi,W., Visvader,J.E., Pal,B. and Mariadason,J.M.
  TITLE     Ehf controls mammary alveolar lineage differentiation and is a
            putative suppressor of breast tumorigenesis
  JOURNAL   Dev Cell 59 (15), 1988-2004 (2024)
   PUBMED   38781975
  REMARK    GeneRIF: Ehf controls mammary alveolar lineage differentiation and
            is a putative suppressor of breast tumorigenesis.
REFERENCE   3  (bases 1 to 5355)
  AUTHORS   Wang,S. and Gao,Y.
  TITLE     Pancreatic cancer cell-derived microRNA-155-5p-containing
            extracellular vesicles promote immune evasion by triggering
            EHF-dependent activation of Akt/NF-kappaB signaling pathway
  JOURNAL   Int Immunopharmacol 100, 107990 (2021)
   PUBMED   34482266
  REMARK    GeneRIF: Pancreatic cancer cell-derived microRNA-155-5p-containing
            extracellular vesicles promote immune evasion by triggering
            EHF-dependent activation of Akt/NF-kappaB signaling pathway.
REFERENCE   4  (bases 1 to 5355)
  AUTHORS   Li,W., Okabe,A., Usui,G., Fukuyo,M., Matsusaka,K., Rahmutulla,B.,
            Mano,Y., Hoshii,T., Funata,S., Hiura,N., Fukayama,M., Tan,P.,
            Ushiku,T. and Kaneda,A.
  TITLE     Activation of EHF via STAT3 phosphorylation by LMP2A in
            Epstein-Barr virus-positive gastric cancer
  JOURNAL   Cancer Sci 112 (8), 3349-3362 (2021)
   PUBMED   34014591
  REMARK    GeneRIF: Activation of EHF via STAT3 phosphorylation by LMP2A in
            Epstein-Barr virus-positive gastric cancer.
REFERENCE   5  (bases 1 to 5355)
  AUTHORS   Zhang,C., Li,J., Guo,Y., Wang,R., Hua,L., Gan,D., Zhu,L., Ma,P.,
            Yang,J., Li,H., Li,S., Song,Y. and Su,H.
  TITLE     Ese-3 Inhibits the Proliferation, Migration, and Invasion of HaCaT
            Cells by Downregulating PSIP1 and NUCKS1
  JOURNAL   Ann Clin Lab Sci 51 (4), 470-486 (2021)
   PUBMED   34452885
  REMARK    GeneRIF: Ese-3 Inhibits the Proliferation, Migration, and Invasion
            of HaCaT Cells by Downregulating PSIP1 and NUCKS1.
REFERENCE   6  (bases 1 to 5355)
  AUTHORS   Jobling,A.I., Fang,Z., Koleski,D. and Tymms,M.J.
  TITLE     Expression of the ETS transcription factor ELF3 in the retinal
            pigment epithelium
  JOURNAL   Invest Ophthalmol Vis Sci 43 (11), 3530-3537 (2002)
   PUBMED   12407165
REFERENCE   7  (bases 1 to 5355)
  AUTHORS   Baron,R.M., Palmer,L.J., Tantisira,K., Gabriel,S., Sonna,L.A.,
            Le,L., Hallock,A., Libermann,T.A., Drazen,J.M., Weiss,S.T. and
            Silverman,E.S.
  TITLE     DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are
            not associated with asthma
  JOURNAL   Am J Respir Crit Care Med 166 (7), 927-932 (2002)
   PUBMED   12359648
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5355)
  AUTHORS   Tugores,A., Le,J., Sorokina,I., Snijders,A.J., Duyao,M.,
            Reddy,P.S., Carlee,L., Ronshaugen,M., Mushegian,A., Watanaskul,T.,
            Chu,S., Buckler,A., Emtage,S. and McCormick,M.K.
  TITLE     The epithelium-specific ETS protein EHF/ESE-3 is a
            context-dependent transcriptional repressor downstream of MAPK
            signaling cascades
  JOURNAL   J Biol Chem 276 (23), 20397-20406 (2001)
   PUBMED   11259407
REFERENCE   9  (bases 1 to 5355)
  AUTHORS   Kas,K., Finger,E., Grall,F., Gu,X., Akbarali,Y., Boltax,J.,
            Weiss,A., Oettgen,P., Kapeller,R. and Libermann,T.A.
  TITLE     ESE-3, a novel member of an epithelium-specific ets transcription
            factor subfamily, demonstrates different target gene specificity
            from ESE-1
  JOURNAL   J Biol Chem 275 (4), 2986-2998 (2000)
   PUBMED   10644770
REFERENCE   10 (bases 1 to 5355)
  AUTHORS   Kleinbaum,L.A., Duggan,C., Ferreira,E., Coffey,G.P., Buttice,G. and
            Burton,F.H.
  TITLE     Human chromosomal localization, tissue/tumor expression, and
            regulatory function of the ets family gene EHF
  JOURNAL   Biochem Biophys Res Commun 264 (1), 119-126 (1999)
   PUBMED   10527851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087783.10.
            
            On Jan 24, 2020 this sequence version replaced XM_011519985.1.
            
            Summary: This gene encodes a protein that belongs to an ETS
            transcription factor subfamily characterized by epithelial-specific
            expression (ESEs). The encoded protein acts as a transcriptional
            repressor and may be involved in epithelial differentiation and
            carcinogenesis. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2011].
            
            Transcript Variant: This variant (10), as well as variants 2 and
            4-9, encodes isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.5179.1,
                                           SRR14243140.4789648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC087783.10        69461-69552         c
            93-192              AC087783.10        69197-69296         c
            193-438             AC087783.10        65240-65485         c
            439-501             AC087783.10        62843-62905         c
            502-570             AC087783.10        60314-60382         c
            571-639             AC087783.10        60119-60187         c
            640-702             AC087783.10        54954-55016         c
            703-898             AC087783.10        53196-53391         c
            899-5355            AC087783.10        48636-53092         c
FEATURES             Location/Qualifiers
     source          1..5355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p13"
     gene            1..5355
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="ETS homologous factor"
                     /db_xref="GeneID:26298"
                     /db_xref="HGNC:HGNC:3246"
                     /db_xref="MIM:605439"
     exon            1..92
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            93..192
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..998
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="isoform 2 is encoded by transcript variant 10; ESE3
                     transcription factor; hEHF; ETS domain-containing
                     transcription factor; epithelium-specific Ets
                     transcription factor 3"
                     /codon_start=1
                     /product="ETS homologous factor isoform 2"
                     /protein_id="NP_001364975.1"
                     /db_xref="CCDS:CCDS7894.1"
                     /db_xref="GeneID:26298"
                     /db_xref="HGNC:HGNC:3246"
                     /db_xref="MIM:605439"
                     /translation="MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHE
                     IHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQ
                     LLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDL
                     LDSKTFCRAQISMTTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILL
                     NPDKNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREIL
                     ERVDGRRLVYKFGKNARGWRENEN"
     exon            193..438
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            439..501
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            502..570
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            571..639
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            640..702
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            703..898
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     exon            899..5355
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4529..4534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="hexamer: AATAAA"
     polyA_site      4555
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
     regulatory      5327..5332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="hexamer: AATAAA"
     polyA_site      5355
                     /gene="EHF"
                     /gene_synonym="ESE3; ESE3B; ESEJ"
                     /note="major polyA site"
ORIGIN      
        1 attcctgatc agagattatt catttatgaa tgggtggctg taaaaacttg cctcatgcat
       61 atgaaaattg aacctggaaa tttttaattg ctatcatgat tctggaagga ggtggtgtaa
      121 tgaatctcaa ccccggcaac aacctccttc accagccgcc agcctggaca gacagctact
      181 ccacgtgcaa tgtttccagt gggttttttg gaggccagtg gcatgaaatt catcctcagt
      241 actggaccaa gtaccaggtg tgggagtggc tccagcacct cctggacacc aaccagctgg
      301 atgccaattg tatccctttc caagagttcg acatcaacgg cgagcacctc tgcagcatga
      361 gtttgcagga gttcacccgg gcggcaggga cggcggggca gctcctctac agcaacttgc
      421 agcatctgaa gtggaacggc cagtgcagta gtgacctgtt ccagtccaca cacaatgtca
      481 ttgtcaagac tgaacaaact gagccttcca tcatgaacac ctggaaagac gagaactatt
      541 tatatgacac caactatggt agcacagtag atttgttgga cagcaaaact ttctgccggg
      601 ctcagatctc catgacaacc accagtcacc ttcctgttgc agagtcacct gatatgaaaa
      661 aggagcaaga cccccctgcc aagtgccaca ccaaaaagca caacccgaga gggactcact
      721 tatgggaatt catccgcgac atcctcttga acccagacaa gaacccagga ttaataaaat
      781 gggaagaccg atctgagggc gtcttcaggt tcttgaaatc agaggcagtg gctcagctat
      841 ggggtaaaaa gaagaacaac agcagcatga cctatgaaaa gctcagccga gctatgagat
      901 attactacaa aagagaaatt ctggagcgtg tggatggacg aagactggta tataaatttg
      961 ggaagaatgc ccgaggatgg agagaaaatg aaaactgaag ctgccaatac tttggacaca
     1021 aaccaaaaca cacaccaaat aatcagaaac aaagaactcc tggacgtaaa tatttcaaag
     1081 actacttttc tctgatattt atgtaccatg aggggaacaa gaaactactt ctaacgggaa
     1141 gaagaaacac tacggtcgat taaaaaaatt attttgttac ttcgaagtat gtcctatatg
     1201 gggaaaaaac gtacacagtt ttctgtgaaa tatgatgctg tatgtggttg tgattttttt
     1261 tcacctctat tgtgaattct ttttcactgc aagagtaaca ggatttgtag ccttgtgctt
     1321 cttgctaaga gaaagaaaaa caaaatcaga gggcattaaa tgttttgtat gtgacatgat
     1381 ttagaaaaag gtgatgcatc ctcctcacat aagcatccat atggcttcgt caagggaggt
     1441 gaacattgtt gctgagttaa attccagggt ctcagatggt taggacaaag tggatggatg
     1501 ccgggaagtt taacctgagc cttaggatcc aatgagtgga gaatggggac ttccaaaacc
     1561 caaggttggc tataatctct gcataaccac atgacttgga atgcttaaat cagcaagaag
     1621 aataatggtg gggtctttat actcattcag gaatggttta tctgatgcca gggctgtctt
     1681 cctttctccc ctttggatgg ttggtgaaat actttaattg ccctgtctgc tcacttctag
     1741 ctatttaaga gagaacccag cttggttctt ttttgctcca agtgcttaaa aataagttgg
     1801 aaaaaggaga cggtggtgtg gaaatggctg aagagtttgc tcttgtatcc ctatagtcca
     1861 aggtttctca atctgcacaa ttgacatttt tggccggagt gttctttgtg gtgagggctt
     1921 tcctgtgcat tgtaagatgt tcagcagtat ccactcatgg tctctaacca cttgacacca
     1981 gaaacccccc agctgtgata acgcaaaatg tctctagaca tcaccaaatg ttccctgggg
     2041 gtggcaaatt tgcccttgat tgagaaccac cagtttagct agtcaatatg aggatggtgg
     2101 tttattctca gaagaaaaag atatgtaagg tcttttagct ccttagagtg aagcaaaagc
     2161 aagacttcaa cctcaaccta tctttatgtt ttaaatgtta gggacaataa gttgaaatag
     2221 ctagaggagc ttcttttcag aaccccagat gagagccaat gtcagataaa gtaagcatag
     2281 taatgtagca ggaactacaa tagaagacat tttcactgga attacaaagc agaattaaaa
     2341 ttatattgta gaaggaaaca ccaagaaaag aatttccagg gaaaatcctc tttgcaggta
     2401 ttaattctta taattttttg tcttttggat tatctgttta ctgtctcatc tgaactgatc
     2461 ccaggtgaac ggtttattgc ctagatttgt actcagagga attttttttg ttttgttttg
     2521 tcttttaaga aaggaaagaa aggatgaaaa aaataaacag aaaactcagc tcaggcacaa
     2581 ttgtcaccaa ggagttaaaa gcttcttctt caatagagga attgttctgg gggtcctgga
     2641 gacttaccat tgagccatgc aatctgggaa gcacaggaat aagtagacac tttgaaaatg
     2701 gatttgaatg ttctcatccc ttttgcagct tttctttttg gctctctcat gtccttggct
     2761 tgctcctcta ttctacctct ctttctccag caataatatg caaatgaaga catgtatcca
     2821 taagaaggag tgctcttcat caactaatag agcacctacc acagtgtcat acctggtaga
     2881 ggtgagcaat tcatattcaa aggttgcaaa gtgtttgtaa tatattcatg aggctggaag
     2941 taagaagaat taaaaatttg tcctaattac aatgagaacc attctaggta gtgatcttgg
     3001 agcacacatg aataactttc tgaaggtgca accaaatcca tttttatttc tgcctggctt
     3061 ggtcacttct gtaaaggttt aacttagtgt tgtcaagtaa cagttactga aagagctgag
     3121 aaaaagaaca atgaacagca acgatcttga ctgtgcaact cagacattcc tgcagaaaag
     3181 acatatgttg ctttacaaga aggccaaaga actatggggc cttcccagca tttgactgtt
     3241 cattgcatag aatgaattaa atatccagtt acttgaatgg gtataacgca tgaatatttg
     3301 tgtgtctgtg tgtgtgtctg agttgtgtga ttttattagg ggcatctgcc aattctctca
     3361 ctgtggttcc ttctctgact ttgcctgttc atcatctaag gaggctagat ccttcgctga
     3421 cttcaccatt cctcaaacct gtaagtttct cacttcttcc aaattggctt tggctctttc
     3481 tgcaaccttt ccattcaaga gcaatctttg ctaaggagta agtgaatgtg aagagtacca
     3541 actacaacaa ttctacagat aattagtgga ttgtgttgtt tgttgagagt gaaggtttct
     3601 tggcatctgg tgcctgatta aggcttgagt attaagttct cagcatatct ctctattgtc
     3661 ttgacttgag tttgctgcat tttctatgtg ctgttcgtga cttggagaac ttaaagtaat
     3721 cgagctatgc caacttgggg tggtaacaga gtacttccca ccacagtgtt gaaagggaga
     3781 gcaaagtctt atggataaac cctcctttct tttggggaca catggctctc acttgagaag
     3841 ctcacctgtg ctgaatgtcc acatggtcac taaacatgtt atccttaaac cccccgtatg
     3901 cctgagttga aagggctctc tcttattagg ttttcatggg aacatgaggc agcaaatcta
     3961 ttgctaagac tttaccaggc tcaaatcatc tgaggctgat agatatttga cttggtaaga
     4021 cttaagtaag gctctggctc ccaggggcat aagcaacagt ttcttgaatg tgccatctga
     4081 gaagggagac ccaggttgtg agttttcctt tgaacacatt ggtcttttct caaagttcct
     4141 gccttgctag actgttagct ctttgaggac agggactatg tcttatcaat cactattatt
     4201 ttcctgttac ctagcatggg acaagtacac aacacatatt tgttcaatga atgaatgaat
     4261 gtcttctaaa agactcctct gattgggaga ccatatctat aattgggatg tgaatcattt
     4321 cttcagtgga ataagagcac aacggcacaa ccttcaagga catattatct actatgaaca
     4381 ttttactgtg agactcttta ttttgccttc tacttgcgct gaaatgaaac caaaacaggc
     4441 cgttgggttc cacaagtcaa tatatgttgg atgaggattc tgttgcctta ttgggaactg
     4501 tgagacttat ctggtatgag aagccagtaa taaacctttg acctgtttta accaatgaag
     4561 attatgaata tgttaatatg atgtaaattg ctatttaagt gtaaagcagt tctaagtttt
     4621 agtatttggg ggattggttt ttattatttt tttccttttt gaaaaatact gagggatctt
     4681 ttgataaagt tagtaatgca tgttagattt tagttttgca agcatgttgt ttttcaaata
     4741 tatcaagtat agaaaaaggt aaaacagtta agaaggaagg caattatatt attcttctgt
     4801 agttaagcaa acacttgttg agtgcctgct atgtgcacgg catgggccca tatgtgtgag
     4861 gagcttgtct aattatgtag gaagcaatag atctcggtag ttacgtattg ggcagatact
     4921 tactgtatga atgaaagaac atcacagtaa tcacaatatc agagctgaat tatcctcagt
     4981 gtagcttctt ggaattcagt ttctggaact agagatagag catttattaa aaaaaactcc
     5041 tgttgagact gtgtcttatg aacctctgaa acgtacaagc cttcacaagt ttaactaaat
     5101 tgggattaat ctttctgtag ttatctgcat aattcttgtt tttctttcca tctggctcct
     5161 gggttgacaa tttgtggaaa caactctatt gctactattt aaaaaaaatc agaaatcttt
     5221 ccctttaagc tatgttaaat tcaaactatt cctgctattc ctgttttgtc aaagaattat
     5281 atttttcaaa atatgtttat ttgtttgatg ggtcccagga aacactaata aaaaccacag
     5341 agaccagcct ggaaa
//
