LOCUS       NM_014600               4825 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens EH domain containing 3 (EHD3), mRNA.
ACCESSION   NM_014600
VERSION     NM_014600.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4825)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4825)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4825)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4825)
  AUTHORS   Amessou,M., Ebrahim,A.S., Dilly,A., Joseph,M., Tabolina,M.,
            Chukkapalli,S., Meroueh,L., Syed,J.T., Liddane,A., Lang,S.L.,
            Al-Katib,A. and Kandouz,M.
  TITLE     Spatio-temporal regulation of EGFR signaling by the Eps15 homology
            domain-containing protein 3 (EHD3)
  JOURNAL   Oncotarget 7 (48), 79203-79216 (2016)
   PUBMED   27811356
  REMARK    GeneRIF: Data provide evidence that EHD3 might undergo its tumor
            suppressor functions at least in part through promoting the sorting
            of activated EGFR to the lysosomal degradative compartment and
            spatio-temporal regulation of EGFR signaling via ERK and AKT.
REFERENCE   5  (bases 1 to 4825)
  AUTHORS   Naslavsky,N., Rahajeng,J., Sharma,M., Jovic,M. and Caplan,S.
  TITLE     Interactions between EHD proteins and Rab11-FIP2: a role for EHD3
            in early endosomal transport
  JOURNAL   Mol Biol Cell 17 (1), 163-177 (2006)
   PUBMED   16251358
  REMARK    GeneRIF: presented herein promote a coordinated role for EHD
            proteins and Rab11-FIP2 in mediating endocytic recycling and
            provide evidence for the function of EHD3 in early endosome to
            endocytic recycling compartment transport
REFERENCE   6  (bases 1 to 4825)
  AUTHORS   Naslavsky,N., Boehm,M., Backlund,P.S. Jr. and Caplan,S.
  TITLE     Rabenosyn-5 and EHD1 interact and sequentially regulate protein
            recycling to the plasma membrane
  JOURNAL   Mol Biol Cell 15 (5), 2410-2422 (2004)
   PUBMED   15020713
REFERENCE   7  (bases 1 to 4825)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   8  (bases 1 to 4825)
  AUTHORS   Galperin,E., Benjamin,S., Rapaport,D., Rotem-Yehudar,R.,
            Tolchinsky,S. and Horowitz,M.
  TITLE     EHD3: a protein that resides in recycling tubular and vesicular
            membrane structures and interacts with EHD1
  JOURNAL   Traffic 3 (8), 575-589 (2002)
   PUBMED   12121420
  REMARK    GeneRIF: EHD3: a protein that resides in recycling tubular and
            vesicular membrane structures and interacts with EHD1.
REFERENCE   9  (bases 1 to 4825)
  AUTHORS   Rotem-Yehudar,R., Galperin,E. and Horowitz,M.
  TITLE     Association of insulin-like growth factor 1 receptor with EHD1 and
            SNAP29
  JOURNAL   J Biol Chem 276 (35), 33054-33060 (2001)
   PUBMED   11423532
REFERENCE   10 (bases 1 to 4825)
  AUTHORS   Pohl,U., Smith,J.S., Tachibana,I., Ueki,K., Lee,H.K., Ramaswamy,S.,
            Wu,Q., Mohrenweiser,H.W., Jenkins,R.B. and Louis,D.N.
  TITLE     EHD2, EHD3, and EHD4 encode novel members of a highly conserved
            family of EH domain-containing proteins
  JOURNAL   Genomics 63 (2), 255-262 (2000)
   PUBMED   10673336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK316006.1, DA196836.1, BC033100.1, AF214736.1 and AL121657.4.
            
            On Nov 23, 2018 this sequence version replaced NM_014600.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.27274.1,
                                           SRR1803615.35683.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322054.10/ ENSP00000327116.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AK316006.1         140-287
            149-161             DA196836.1         289-301
            162-411             AK316006.1         288-537
            412-2023            BC033100.1         1-1612
            2024-3768           AF214736.1         1839-3583
            3769-4825           AL121657.4         39783-40839
FEATURES             Location/Qualifiers
     source          1..4825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.1"
     gene            1..4825
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /note="EH domain containing 3"
                     /db_xref="GeneID:30845"
                     /db_xref="HGNC:HGNC:3244"
                     /db_xref="MIM:605891"
     exon            1..697
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             471..2078
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /note="PAST homolog 3"
                     /codon_start=1
                     /product="EH domain-containing protein 3"
                     /protein_id="NP_055415.1"
                     /db_xref="CCDS:CCDS1774.1"
                     /db_xref="GeneID:30845"
                     /db_xref="HGNC:HGNC:3244"
                     /db_xref="MIM:605891"
                     /translation="MFSWLGTDDRRRKDPEVFQTVSEGLKKLYKSKLLPLEEHYRFHE
                     FHSPALEDADFDNKPMVLLVGQYSTGKTTFIRYLLEQDFPGMRIGPEPTTDSFIAVMQ
                     GDMEGIIPGNALVVDPKKPFRKLNAFGNAFLNRFVCAQLPNPVLESISVIDTPGILSG
                     EKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKMRVVL
                     NKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDNRKLFEAEEQ
                     DLFRDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPSVFGKDNKKKELVNN
                     LAEIYGRIEREHQISPGDFPNLKRMQDQLQAQDFSKFQPLKSKLLEVVDDMLAHDIAQ
                     LMVLVRQEESQRPIQMVKGGAFEGTLHGPFGHGYGEGAGEGIDDAEWVVARDKPMYDE
                     IFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDDEFALANHLI
                     KVKLEGHELPNELPAHLLPPSKRKVAE"
     exon            698..874
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..972
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1385
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1550
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..4825
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3744..3749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /note="hexamer: AATACA"
     polyA_site      3768
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /note="major polyA site"
     regulatory      4800..4805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHD3"
                     /gene_synonym="PAST3"
                     /note="hexamer: AATAAA"
     polyA_site      4825
                     /gene="EHD3"
                     /gene_synonym="PAST3"
ORIGIN      
        1 gctgctgcgg atgcagagct gtccgcgggc tgggcagcgt cgccgtctcc cctgagccgc
       61 ctcggtccgg caggagcgga gccgaagcat cccttgctgc acgcagggca gagcaggcga
      121 gggctggggg ccgatcgggg accccggctt gggaccccgg catctggcag tttccttgca
      181 ggttcaactt taattgccaa gatttcaccc ctcctcctca agcccagatt atttatcctc
      241 cctccggcct gggctgctgg atgcagcagc ggctgggctt ggtcccagga gcagggagag
      301 tgcgctcccg gccctcctag ccgcgtgccc gggccatggt gcggctgagc cccgcgcttg
      361 ggtgaggcgg cggcgcggct cggagcccgg cggaccggtc ctacgggaca tcttcccctg
      421 aggaggagtc ttcccctggg gctgcgtgcc gggggcgagc ggcggccgcg atgttcagct
      481 ggctgggtac ggacgaccgc cggaggaagg accccgaggt tttccagacg gtgagtgagg
      541 ggctcaagaa actctacaag agcaagctgc tgcccttgga agagcattac cgcttccacg
      601 agttccactc gcccgccctg gaggatgccg acttcgacaa caagcccatg gttctgctgg
      661 tgggccagta ctccactggg aagaccacct tcatcaggta cctgctggaa caggacttcc
      721 caggcatgag gattgggcct gagcccacca cagactcctt cattgcggtg atgcagggag
      781 acatggaggg gatcatccct gggaacgccc tggtggtgga tcccaagaaa cccttcagga
      841 aactcaacgc ctttggcaac gccttcttga acaggttcgt gtgtgcccag ctacctaacc
      901 ctgtgctgga gagcatcagc gtcatcgaca caccagggat cctctctggg gagaagcaga
      961 ggatcagccg ggggtatgac tttgcagctg tccttgagtg gtttgccgag cgggttgacc
     1021 gcatcattct gctcttcgat gcccacaaac tggacatctc tgatgagttc tcagaagtca
     1081 tcaaagccct caagaaccac gaggacaaga tgcgagtggt gctgaacaaa gctgaccaga
     1141 tcgagacgca gcagctgatg cgggtgtacg gggccctcat gtggtccttg gggaagatcg
     1201 tgaacacccc agaggtgatc cgggtctaca tcggctcctt ctggtcccac cccctcctca
     1261 tccctgacaa ccggaagctc tttgaggctg aggaacagga cctattcagg gacatccaga
     1321 gtctgccccg aaatgctgcc ctgcgcaagc tcaacgacct catcaaaagg gccaggctgg
     1381 ccaaggtcca cgcctacatc atcagctctc tgaagaagga gatgccctcg gtgttcggga
     1441 aggacaacaa gaagaaggag ctggtcaaca acctggccga gatctatggc cggatcgagc
     1501 gggagcacca gatctcacct ggggacttcc ccaatctgaa gaggatgcag gaccagctgc
     1561 aggcccagga ctttagcaag ttccagccgc tgaagagcaa gctgctggag gtagtggacg
     1621 acatgctggc ccatgacatt gcccagctca tggtgctagt gcgccaggag gagtcacagc
     1681 ggcccatcca gatggtgaag ggcggagcgt tcgagggcac cctgcacggc ccctttgggc
     1741 atggctatgg ggagggggct ggagaaggta tcgatgatgc tgagtgggtg gtggccaggg
     1801 acaagcccat gtacgacgag atcttctaca ccctgtcacc ggtggatggc aagatcacag
     1861 gcgctaatgc caagaaggag atggtgcgct ccaagctgcc caacagtgtg ctgggcaaga
     1921 tctggaagct ggccgacatt gacaaggatg gcatgctgga cgacgacgag tttgcactgg
     1981 ccaaccacct catcaaagtc aagctggagg ggcacgagct gcccaacgag ctgcctgccc
     2041 acctcctgcc cccgtccaag aggaaagttg ccgagtgatg gggtgggggg acattcagac
     2101 gggcagtgtt agaggaggag atgggagcgg tgactacaca cacacacaca cacacacaca
     2161 cacacacaaa catgcacaca cacatatgca tatcttgaca ttgctctgta ggtgagagag
     2221 gaccatgacg cccatgtttg cagctgatac ttgtttgggc acacctccaa gttctcggga
     2281 ttagaaggac aagagcactc ccaggcccca gagtctaagc ctaagtctct atcgctcttc
     2341 ccctctcctc ggccactccc cagataccag acctgaggca attcacttgc cagcacagat
     2401 ggccaaccca cctccagatt ccccagtgct tccacacccg ggctctgagc aaatggaaaa
     2461 gacttttcat ttagtagaca attcacttct ttttctgtgc ttcccctatc tgctttggct
     2521 tcctaataag aaatccattc aagagctagg agatctgagg gcaggcgggc agctgcaggg
     2581 aggagaggtg agaaaggaag cgtcttctag agacattggc ccaggagctc tgttctttcc
     2641 taatctaagc ctctgtcttc ttcggcaaac cttgctttga actctgccag tatttcattt
     2701 taaagaatcc cagagcggga gagagaagag aaaaaaattg ataagagtga ggaaattgtc
     2761 ctgtagtcta ttgaaaacca gtcaaggtgg ttttagttca tagattttgt tagatgttct
     2821 ttccacctgg cctatgatgt ttagatgttc atacttgact cacatttacc cagcccctcc
     2881 tgcgtaccag gagctgtgtt aggcacttta tatacattat tctatgtggc cctcactgat
     2941 gccccaggga agtatgcatt agccttccca ttttgcagtt gaggaggctg agtagcctca
     3001 gaagggttta ggcgaccttc tgaaactcac agaagtcacg tgatggagag aggattcaaa
     3061 gccagggcct cagaccctca cacacttgtc tgtgctatga tgtatgcagg atcccagcat
     3121 tgatacccaa tgacaaacta tggagaacaa gcaaagtatg caggccccct gcagcctccc
     3181 aggacaggct ggcaagggag gagggccggc cagcatttgg tggcccatca gtctggccat
     3241 ctgtcacgtc acagaagcaa accgtgcctt ctggctctgc gccccatatt cccagcatca
     3301 tagacatcca acagcaccag caggagagtg ggctagcctg ctggatgctg ttcgtgcctg
     3361 tccctgctct gcctcccacc cagttgcctg aatcatccca gctcagatgc agccactgtc
     3421 tcttgtcaag tgggacctca tactattctc agaaggctaa cttgagaggt ttggggcctt
     3481 gttccccaga gggtccccag ggactctgca gtgtccttgg caaatcccca ctgtactcaa
     3541 tgccctacat tctcttctgt ggtctctccc ctggcttgct tcatggccac tgaaccaatc
     3601 actttgtatg ctatgctcct actgtgatgg aaaacaaaat gagtataact tattttatat
     3661 ccatattcag actatataga gaatattcta tgcatctatg acgtgcttac tactgcagtg
     3721 catttgtcat tagtcttcat gttaatacag tacatttatt ctttggtacc tgcctggcca
     3781 cagagcatca ttcaatggag gctgagggag aagggctggg ttcttacttg gagttcctgg
     3841 tgaaatcttt ggctggaaag ggctcactgg ggccacccaa tggccagcat ccacaaccag
     3901 cttcccagtg ggctggagtt tgtctaggct cagtgaccaa cccaggcaca gctggtggag
     3961 ccaccgctcc ctgctcctct ggagtgaaga tgttccctaa gcccctgggc ttccttctgc
     4021 aaatacacat ttctctttca catgaaatga agggcagaca aaggccaggc aaagaggtct
     4081 cacctgctct ggagaaaacc cttgagtgcc gagtgcaggt tagggaccat ttctcaactc
     4141 cacacctttc ttcaagctga aggagaaatg ggaaggaaat agcagaggta ggtgaagttc
     4201 ctgtcttttt attttatagg aaagggagat gtctgttatc ccctttcttc actgccactg
     4261 gacacacatg ccactttcct gcccttctac atatgctgcc tctcttccct ctctccatct
     4321 tgaagtctcc acccaggaga gacctgtgag gtgtgggaat tccatgtttg cacagctccc
     4381 atctccctgg aaagaggaac tgatgtttga ggggacagat gtgggtcact ttccctggca
     4441 gtgccctcta gccttgctgc cttggctttc tgaccccttc caggcttcag gggcctggga
     4501 gatctcatgc ctcagcccag gaaacattta atagggaaag cagagacatg tcatgtcagc
     4561 cccacagaca agaatttcta gagcacttgt cctgttgttc cttgccccga cattactcag
     4621 tctgggccat ggaatccatc caataaacac agcaacaccc tatgctactg accaagcaaa
     4681 gcttgcccct ggtaccaaag agctaaatca tgaccaaagt gtgacatgaa tgtaactgaa
     4741 atgcgggtta gttgctcaat gtatgcaaag tcccacggac aagagtaaag tctgatacca
     4801 ataaagtgaa tgtattccaa agcta
//
