LOCUS       NM_001099409            5170 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens EH domain binding protein 1 like 1 (EHBP1L1),
            transcript variant 1, mRNA.
ACCESSION   NM_001099409 XM_170658 XM_941451
VERSION     NM_001099409.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5170)
  AUTHORS   Pan,Y., Shu,G., Fu,L., Huang,K., Zhou,X., Gui,C., Liu,H., Jin,X.,
            Chen,M., Li,P., Cen,J., Feng,Z., Lu,J., Chen,Z., Li,J., Xu,Q.,
            Wang,Y., Liang,H., Wang,Z., Deng,Q., Chen,W., Luo,J., Yang,J.,
            Zhang,J. and Wei,J.
  TITLE     EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through
            Binding and Stabilizing JAK1
  JOURNAL   Adv Sci (Weinh) 10 (11), e2206792 (2023)
   PUBMED   36775874
  REMARK    GeneRIF: EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma
            through Binding and Stabilizing JAK1.
REFERENCE   2  (bases 1 to 5170)
  AUTHORS   Iwano,T., Sobajima,T., Takeda,S., Harada,A. and Yoshimura,S.I.
  TITLE     The Rab GTPase-binding protein EHBP1L1 and its interactors
            CD2AP/CIN85 negatively regulate the length of primary cilia via
            actin remodeling
  JOURNAL   J Biol Chem 299 (3), 102985 (2023)
   PUBMED   36754282
REFERENCE   3  (bases 1 to 5170)
  AUTHORS   Nakajo,A., Yoshimura,S., Togawa,H., Kunii,M., Iwano,T., Izumi,A.,
            Noguchi,Y., Watanabe,A., Goto,A., Sato,T. and Harada,A.
  TITLE     EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed
            transport in polarized epithelial cells
  JOURNAL   J Cell Biol 212 (3), 297-306 (2016)
   PUBMED   26833786
  REMARK    GeneRIF: Data demonstrate that EHBP1L1 links Rab8 and the
            Bin1-dynamin complex, which generates membrane curvature and
            excises the vesicle at the endocytic recycling compartment for
            apical transport.
REFERENCE   4  (bases 1 to 5170)
  AUTHORS   Simino,J., Shi,G., Bis,J.C., Chasman,D.I., Ehret,G.B., Gu,X.,
            Guo,X., Hwang,S.J., Sijbrands,E., Smith,A.V., Verwoert,G.C.,
            Bragg-Gresham,J.L., Cadby,G., Chen,P., Cheng,C.Y., Corre,T., de
            Boer,R.A., Goel,A., Johnson,T., Khor,C.C., Lluis-Ganella,C.,
            Luan,J., Lyytikainen,L.P., Nolte,I.M., Sim,X., Sober,S., van der
            Most,P.J., Verweij,N., Zhao,J.H., Amin,N., Boerwinkle,E.,
            Bouchard,C., Dehghan,A., Eiriksdottir,G., Elosua,R., Franco,O.H.,
            Gieger,C., Harris,T.B., Hercberg,S., Hofman,A., James,A.L.,
            Johnson,A.D., Kahonen,M., Khaw,K.T., Kutalik,Z., Larson,M.G.,
            Launer,L.J., Li,G., Liu,J., Liu,K., Morrison,A.C., Navis,G.,
            Ong,R.T., Papanicolau,G.J., Penninx,B.W., Psaty,B.M., Raffel,L.J.,
            Raitakari,O.T., Rice,K., Rivadeneira,F., Rose,L.M., Sanna,S.,
            Scott,R.A., Siscovick,D.S., Stolk,R.P., Uitterlinden,A.G.,
            Vaidya,D., van der Klauw,M.M., Vasan,R.S., Vithana,E.N., Volker,U.,
            Volzke,H., Watkins,H., Young,T.L., Aung,T., Bochud,M., Farrall,M.,
            Hartman,C.A., Laan,M., Lakatta,E.G., Lehtimaki,T., Loos,R.J.,
            Lucas,G., Meneton,P., Palmer,L.J., Rettig,R., Snieder,H., Tai,E.S.,
            Teo,Y.Y., van der Harst,P., Wareham,N.J., Wijmenga,C., Wong,T.Y.,
            Fornage,M., Gudnason,V., Levy,D., Palmas,W., Ridker,P.M.,
            Rotter,J.I., van Duijn,C.M., Witteman,J.C., Chakravarti,A. and
            Rao,D.C.
  CONSRTM   LifeLines Cohort Study
  TITLE     Gene-age interactions in blood pressure regulation: a large-scale
            investigation with the CHARGE, Global BPgen, and ICBP Consortia
  JOURNAL   Am J Hum Genet 95 (1), 24-38 (2014)
   PUBMED   24954895
REFERENCE   5  (bases 1 to 5170)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5170)
  AUTHORS   Chalasani,N., Guo,X., Loomba,R., Goodarzi,M.O., Haritunians,T.,
            Kwon,S., Cui,J., Taylor,K.D., Wilson,L., Cummings,O.W., Chen,Y.D.
            and Rotter,J.I.
  CONSRTM   Nonalcoholic Steatohepatitis Clinical Research Network
  TITLE     Genome-wide association study identifies variants associated with
            histologic features of nonalcoholic Fatty liver disease
  JOURNAL   Gastroenterology 139 (5), 1567-1576 (2010)
   PUBMED   20708005
REFERENCE   7  (bases 1 to 5170)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 5170)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5170)
  AUTHORS   Chauhan,B.K., Reed,N.A., Zhang,W., Duncan,M.K., Kilimann,M.W. and
            Cvekl,A.
  TITLE     Identification of genes downstream of Pax6 in the mouse lens using
            cDNA microarrays
  JOURNAL   J Biol Chem 277 (13), 11539-11548 (2002)
   PUBMED   11790784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX443367.2, CA397617.1, AL834433.1, AP001362.5, AK024451.1 and
            BU630372.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001099409.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309295.9/ ENSP00000312671.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               BX443367.2         16-220
            206-288             CA397617.1         66-148
            289-646             AL834433.1         1-358
            647-647             AP001362.5         60776-60776
            648-1955            AL834433.1         360-1667
            1956-1956           AP001362.5         62989-62989
            1957-3180           AL834433.1         1669-2892
            3181-4958           AK024451.1         2608-4385
            4959-5170           BU630372.1         18-229              c
FEATURES             Location/Qualifiers
     source          1..5170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..5170
                     /gene="EHBP1L1"
                     /note="EH domain binding protein 1 like 1"
                     /db_xref="GeneID:254102"
                     /db_xref="HGNC:HGNC:30682"
                     /db_xref="MIM:619583"
     exon            1..354
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..4822
                     /gene="EHBP1L1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tangerin; EH domain-binding protein 1-like protein 1"
                     /codon_start=1
                     /product="EH domain-binding protein 1-like protein 1
                     isoform 1"
                     /protein_id="NP_001092879.1"
                     /db_xref="CCDS:CCDS44649.1"
                     /db_xref="GeneID:254102"
                     /db_xref="HGNC:HGNC:30682"
                     /db_xref="MIM:619583"
                     /translation="MTSVWKRLQRVGKRAAKFQFVACYHELVLECTKKWQPDKLVVVW
                     TRRNRRICSKAHSWQPGIQNPYRGTVVWMVPENVDISVTLYRDPHVDQYEAKEWTFII
                     ENESKGQRKVLATAEVDLARHAGPVPVQVPVRLRLKPKSVKVVQAELSLTLSGVLLRE
                     GRATDDDMQSLASLMSVKPSDVGNLDDFAESDEDEAHGPGAPEARARVPQPDPSRELK
                     TLCEEEEEGQGRPQQAVASPSNAEDTSPAPVSAPAPPARTSRGQGSERANEAGGQVGP
                     EAPRPPETSPEMRSSRQPAQDTAPTPAPRLRKGSDALRPPVPQGEDEVPKASGAPPAG
                     LGSARETQAQACPQEGTEAHGARLGPSIEDKGSGDPFGRQRLKAEEMDTEDRPEASGV
                     DTEPRSGGREANTKRSGVRAGEAEESSAVCQVDAEQRSKVRHVDTKGPEATGVMPEAR
                     CRGTPEAPPRGSQGRLGVRTRDEAPSGLSLPPAEPAGHSGQLGDLEGARAAAGQEREG
                     AEVRGGAPGIEGTGLEQGPSVGAISTRPQVSSWQGALLSTAQGAISRGLGGWEAEAGG
                     SGDLETETEVVGLEVLGTQEKEVEGSGFPETRTLEIEILGALEKEAARSRVLESEVAG
                     TAQCEGLETQETEVGVIETPGTETEVLGTQKTEAGGSGVLQTRTTIAETEVLVTQEIS
                     GDLGPLKIEDTIQSEMLGTQETEVEASRVPESEAEGTEAKILGTQEITARDSGVREIE
                     AEIAESDILVAQEIEVGLLGVLGIETGAAEGAILGTQEIASRDSGVPGLEADTTGIQV
                     KEVGGSEVPEIATGTAETEILGTQEIASRSSGVPGLESEVAGAQETEVGGSGISGPEA
                     GMAEARVLMTRKTEIIVPEAEKEEAQTSGVQEAETRVGSALKYEALRAPVTQPRVLGS
                     QEAKAEISGVQGSETQVLRVQEAEAGVWGMSEGKSGAWGAQEAEMKVLESPENKSGTF
                     KAQEAEAGVLGNEKGKEAEGSLTEASLPEAQVASGAGAGAPRASSPEKAEEDRRLPGS
                     QAPPALVSSSQSLLEWCQEVTTGYRGVRITNFTTSWRNGLAFCAILHRFYPDKIDYAS
                     LDPLNIKQNNKQAFDGFAALGVSRLLEPADMVLLSVPDKLIVMTYLCQIRAFCTGQEL
                     QLVQLEGGGGAGTYRVGSAQPSPPDDLDAGGLAQRLRGHGAEGPQEPKEAADRADGAA
                     PGVASRNAVAGRASKDGGAEAPRESRPAEVPAEGLVNGAGAPGGGGVRLRRPSVNGEP
                     GSVPPPRAHGSFSHVRDADLLKKRRSRLRNSSSFSMDDPDAGAMGAAAAEGQAPDPSP
                     APGPPTAADSQQPPGGSSPSEEPPPSPGEEAGLQRFQDTSQYVCAELQALEQEQRQID
                     GRAAEVEMQLRSLMESGANKLQEEVLIQEWFTLVNKKNALIRRQDQLQLLMEEQDLER
                     RFELLSRELRAMLAIEDWQKTSAQQHREQLLLEELVSLVNQRDELVRDLDHKERIALE
                     EDERLERGLEQRRRKLSRQLSRRERCVLS"
     exon            355..412
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            413..508
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..562
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..741
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..884
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..953
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1116
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..3343
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3344..3501
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3502..3550
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..4183
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4184..4253
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4254..4309
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4310..4433
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4434..4533
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4534..4607
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4608..4722
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..5170
                     /gene="EHBP1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5146..5151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHBP1L1"
                     /note="hexamer: AATAAA"
     polyA_site      5170
                     /gene="EHBP1L1"
                     /note="major polyA site"
ORIGIN      
        1 aggaaacggc gcgctcccag ctccgcgctc gccacccgac gcgccccagg cgaccccgca
       61 gactcagcca gaccaccctg cgggccccag cggcggcagc ggagagcgcg gtcccgggtc
      121 ggagcctggg acacctccgc acggacgggg cgggcggcgc ggacaggcca tggggacccg
      181 ggccgggcca gcggtggcgg gccagcggga gccccgggcc tgagaagtgg gcggcggggt
      241 ggcgggggcc atgacctcgg tgtggaagcg cctgcagcgc gtgggcaagc gggcggccaa
      301 gttccagttc gtggcctgtt accacgagct agtgttggag tgcaccaaga aatggcagcc
      361 agataagctg gtggtggtat ggacccgtcg gaaccgacgc atctgctcca aggcccacag
      421 ctggcagccg ggcatccaga acccataccg gggcaccgtg gtgtggatgg tacctgagaa
      481 tgtggacatc tctgtgaccc tctacaggga cccccacgtg gaccagtatg aggccaaaga
      541 gtggacattt attattgaaa atgagtctaa ggggcagcgg aaggtgctgg ccacggccga
      601 ggtggacctg gcccgccatg cagggcccgt gcctgtccaa gtcccagtga ggctgcggct
      661 gaagccaaag tcagtgaagg tggtgcaggc tgagctgagc ctcactcttt ccggggtgct
      721 gctgcgggag ggccgtgcca cggacgatga catgcagagt ctcgcaagcc tcatgagtgt
      781 gaagcctagt gatgtgggca acttggatga ctttgctgag agtgatgaag atgaggctca
      841 tggcccagga gccccggagg cccgggctcg agtcccccag ccagatccct ctcgagagct
      901 gaagacgctt tgtgaggagg aggaggaagg ccaaggacga ccccagcagg cagttgccag
      961 cccttctaat gctgaggata ccagcccagc ccctgtgagt gctcctgcac ccccagccag
     1021 aacctcccga ggccaggggt cagaacgagc taatgaagcg gggggccagg taggccctga
     1081 ggccccaagg cccccggaaa cctcaccaga gatgaggtct tcaaggcagc cagcccagga
     1141 cacggccccc accccagccc ctcggctccg gaaaggctct gatgccctcc ggcccccagt
     1201 cccccagggg gaagatgagg tccccaaagc ctcaggggct cctccagcag gattgggctc
     1261 tgctagggag acccaggccc aggcatgccc tcaggaaggg acagaagccc atggagctag
     1321 gctgggcccg agcattgagg ataaaggttc tggagaccct tttggaaggc agagactcaa
     1381 ggctgaagag atggacactg aggacaggcc agaggccagt ggggtggaca ctgagccaag
     1441 gtcaggaggc agagaggcaa acactaagag gtcaggagtc agagctgggg aggctgaaga
     1501 gagttcagca gtttgtcaag tggatgctga gcagaggtca aaggtgagac atgtggacac
     1561 taagggacca gaggcgacag gggtgatgcc tgaggcaaga tgcaggggga cccctgaggc
     1621 tcctccaagg ggctctcagg ggaggctggg agtcaggacc agggatgagg ctccctcagg
     1681 cctgagcctg cccccagcgg agcctgcagg gcactctggg caacttggtg acctcgaggg
     1741 ggccagggct gctgcaggcc aggagagaga gggtgcagaa gtgaggggtg gagcacctgg
     1801 tattgagggg acaggcctgg agcagggccc ttctgttgga gcaataagca ccaggcccca
     1861 ggtgagcagc tggcaggggg ccctgttatc aactgcccag ggggcaatat ccaggggtct
     1921 gggaggctgg gaggcagaag ctgggggttc aggggacctg gaaacagaga ctgaggtggt
     1981 agggttggag gtgctgggaa cccaggagaa agaagttgag gggtcagggt tcccagagac
     2041 taggacacta gaaattgaga tattgggggc cttggagaaa gaagcagcaa gatcaagggt
     2101 cctggagtca gaggttgctg ggacagcaca gtgtgaggga ctggagaccc aggaaacaga
     2161 ggtgggggtc atagagaccc cagggacaga gactgaggta ttggggaccc agaaaacaga
     2221 agctgggggt tcaggagttt tgcagacaag aactacgata gcagagactg aggtactggt
     2281 gacccaggag atatctgggg atttagggcc actgaagata gaagatacaa tacagtctga
     2341 gatgctgggg acccaggaga cagaggtgga agcttctagg gtaccagagt cagaggctga
     2401 ggggacagaa gctaaaatat tagggaccca ggagataaca gctagggatt caggggtcag
     2461 agagatagaa gcagagatag cagagtctga catattggta gcccaggaga tagaggtggg
     2521 acttttgggg gttctgggaa tagagactgg ggcagcagaa ggtgcgatat tggggaccca
     2581 agagatagca tctagggatt caggggtccc agggttagaa gctgatacaa cagggatcca
     2641 ggtgaaagag gttgggggtt cagaggttcc agagatagcg actgggacag cagaaactga
     2701 gatattgggg acccaagaga tagcatctag gagttcaggg gtcccagggc tagaatctga
     2761 ggtagctggg gcccaggaga cagaggtcgg gggttcaggg atctcagggc ccgaggctgg
     2821 aatggcagag gcccgagtac tgatgacccg taagacagaa attatagttc cagaggctga
     2881 gaaggaagag gctcagactt cgggggtcca ggaagcagag actagagttg ggagtgctct
     2941 caaatatgag gctttaaggg ccccagtcac tcagccaaga gttttaggat cccaggaagc
     3001 aaaagcagag atttcaggag tacaagggtc agagactcaa gttctgagag tccaggaggc
     3061 agaggctggg gtttggggga tgtcagaggg caaatctggg gcttgggggg cccaggaagc
     3121 agagatgaag gttttagagt ctccagagaa caaatctggt acttttaagg cccaggaagc
     3181 ggaggctggg gtcttgggaa atgagaaggg gaaagaagct gagggaagcc tcacagaggc
     3241 cagcctgcct gaagcacagg tggccagtgg ggcaggggct ggggcgccca gggcctcttc
     3301 cccagagaag gctgaagagg acaggaggct gccgggcagc caggcaccac ctgccctggt
     3361 cagctccagc cagtccctgc tggagtggtg ccaggaagtc accactggct accgtggcgt
     3421 ccgcatcacc aacttcacca catcctggcg caacggcttg gccttctgtg ccatcctgca
     3481 ccgattctac ccagacaaga ttgactatgc ctcgctagac ccactcaaca tcaagcagaa
     3541 caacaagcag gccttcgatg gcttcgcggc tctgggcgtg tcgcggctgc tggagcccgc
     3601 ggacatggtg ctactgtcgg tgcccgacaa gctcatcgtc atgacgtacc tgtgccagat
     3661 ccgcgccttc tgcaccgggc aggagctgca gctggtacaa ctggagggcg gcggcggcgc
     3721 cggcacgtac cgcgtgggca gcgcccagcc cagcccgccc gacgacctgg acgccggagg
     3781 cctggcgcag cggctgcgcg gtcacggggc cgaggggccc caggagccca aggaggccgc
     3841 agaccgcgca gacggggcgg ccccgggggt ggcctccagg aacgcggtcg cgggccgcgc
     3901 ctccaaggac ggcggggccg aggccccccg agagtcgcga cccgcggagg tcccggccga
     3961 ggggctggtg aacggggcgg gggcaccggg cggcggcggc gtgaggctgc gacggccctc
     4021 ggtcaacggg gagcccgggt cggtgccccc gccccgcgcg cacggctcct tctcccacgt
     4081 gcgcgacgcg gacctgctca agaagaggcg ctcgcggctg cggaacagca gctcgttctc
     4141 gatggacgat ccggacgcgg gagccatggg agctgcggct gcagaaggcc aggcccctga
     4201 ccccagccct gccccaggcc cacccacagc tgcagactct caacagcccc ctggtgggag
     4261 ttccccctcg gaggaaccac ccccaagccc aggggaggag gctgggctgc aacggttcca
     4321 ggacacaagt cagtacgtgt gtgcagagct gcaggccctg gaacaggagc agaggcagat
     4381 agatgggcgg gcggctgagg tggagatgca gctgaggagc ctcatggagt caggtgccaa
     4441 caagctgcag gaggaggtgc tgatccagga gtggttcacc ctggtcaaca agaagaacgc
     4501 tctcatccgg aggcaggacc agctgcagct gctcatggag gagcaggact tggagcgaag
     4561 gttcgagctg ctgagccgcg agctgcgggc catgctggcc atcgaagact ggcagaaaac
     4621 gtccgctcag cagcaccgag agcagctcct actggaggag ctggtgtcgc tggtgaacca
     4681 gcgcgatgag ctagtccggg acctggacca caaggagcgg atcgccctgg aggaggacga
     4741 gcgcctggag cgcggcctgg aacagcggcg ccgcaagctg agccggcagt tgagccggcg
     4801 ggagcgctgc gtgctgagct gaggccgccg gcccgggtgg cccataactt ctcgcgtccc
     4861 cggcgtccgc cgccgccccg ggcctgcgct gcggacgacc cggccgtccc ggaggccgcg
     4921 cgcgtgtccg ctaggggccg ccggcgccct tccccgtaca gggcagggcg gatccccgac
     4981 cccacgggcg gggcggccgc cgtatttatt tgtcaccgag ggtgtgtgcg cgctcgcggc
     5041 gggtgcgggg tcctccccga cggcacggcc gggccggcgg cctcggggag agggatgcct
     5101 gggcactacc gccccgcgct ggcttgccct cctgttctcc agagcaataa agttggacga
     5161 gactacccca
//
