LOCUS       NM_001354216            5417 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens EH domain binding protein 1 (EHBP1), transcript
            variant 9, mRNA.
ACCESSION   NM_001354216 XM_017003646
VERSION     NM_001354216.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5417)
  AUTHORS   Rai,A., Bleimling,N., Vetter,I.R. and Goody,R.S.
  TITLE     The mechanism of activation of the actin binding protein EHBP1 by
            Rab8 family members
  JOURNAL   Nat Commun 11 (1), 4187 (2020)
   PUBMED   32826901
  REMARK    GeneRIF: The mechanism of activation of the actin binding protein
            EHBP1 by Rab8 family members.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5417)
  AUTHORS   Beikzadeh,B., Angaji,S.A. and Abolhasani,M.
  TITLE     Association study between common variations in some candidate genes
            and prostate adenocarcinoma predisposition through multi-stage
            approach in Iranian population
  JOURNAL   BMC Med Genet 21 (1), 81 (2020)
   PUBMED   32295536
  REMARK    GeneRIF: The purpose of this study was to evaluate the association
            of rs16901979, rs4242382 and rs1447295 on 8q24 locus, rs2735839
            (KLK3 gene) and rs721048 (EHBP1 gene) with prostate adenocarcinoma
            through multi-stage approach to identify the polymorphisms
            associated with prostate cancer and use them as screening factors
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5417)
  AUTHORS   Li,Z., Schulze,R.J., Weller,S.G., Krueger,E.W., Schott,M.B.,
            Zhang,X., Casey,C.A., Liu,J., Stockli,J., James,D.E. and
            McNiven,M.A.
  TITLE     A novel Rab10-EHBP1-EHD2 complex essential for the autophagic
            engulfment of lipid droplets
  JOURNAL   Sci Adv 2 (12), e1601470 (2016)
   PUBMED   28028537
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5417)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   5  (bases 1 to 5417)
  AUTHORS   Xu,J., Kibel,A.S., Hu,J.J., Turner,A.R., Pruett,K., Zheng,S.L.,
            Sun,J., Isaacs,S.D., Wiley,K.E., Kim,S.T., Hsu,F.C., Wu,W.,
            Torti,F.M., Walsh,P.C., Chang,B.L. and Isaacs,W.B.
  TITLE     Prostate cancer risk associated loci in African Americans
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (7), 2145-2149 (2009)
   PUBMED   19549807
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5417)
  AUTHORS   Wiklund,F.E., Adami,H.O., Zheng,S.L., Stattin,P., Isaacs,W.B.,
            Gronberg,H. and Xu,J.
  TITLE     Established prostate cancer susceptibility variants are not
            associated with disease outcome
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1659-1662 (2009)
   PUBMED   19423541
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5417)
  AUTHORS   Waters,K.M., Le Marchand,L., Kolonel,L.N., Monroe,K.R., Stram,D.O.,
            Henderson,B.E. and Haiman,C.A.
  TITLE     Generalizability of associations from prostate cancer genome-wide
            association studies in multiple populations
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (4), 1285-1289 (2009)
   PUBMED   19318432
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5417)
  AUTHORS   Gudmundsson,J., Sulem,P., Rafnar,T., Bergthorsson,J.T.,
            Manolescu,A., Gudbjartsson,D., Agnarsson,B.A., Sigurdsson,A.,
            Benediktsdottir,K.R., Blondal,T., Jakobsdottir,M., Stacey,S.N.,
            Kostic,J., Kristinsson,K.T., Birgisdottir,B., Ghosh,S.,
            Magnusdottir,D.N., Thorlacius,S., Thorleifsson,G., Zheng,S.L.,
            Sun,J., Chang,B.L., Elmore,J.B., Breyer,J.P., McReynolds,K.M.,
            Bradley,K.M., Yaspan,B.L., Wiklund,F., Stattin,P., Lindstrom,S.,
            Adami,H.O., McDonnell,S.K., Schaid,D.J., Cunningham,J.M., Wang,L.,
            Cerhan,J.R., St Sauver,J.L., Isaacs,S.D., Wiley,K.E., Partin,A.W.,
            Walsh,P.C., Polo,S., Ruiz-Echarri,M., Navarrete,S., Fuertes,F.,
            Saez,B., Godino,J., Weijerman,P.C., Swinkels,D.W., Aben,K.K.,
            Witjes,J.A., Suarez,B.K., Helfand,B.T., Frigge,M.L.,
            Kristjansson,K., Ober,C., Jonsson,E., Einarsson,G.V., Xu,J.,
            Gronberg,H., Smith,J.R., Thibodeau,S.N., Isaacs,W.B.,
            Catalona,W.J., Mayordomo,J.I., Kiemeney,L.A., Barkardottir,R.B.,
            Gulcher,J.R., Thorsteinsdottir,U., Kong,A. and Stefansson,K.
  TITLE     Common sequence variants on 2p15 and Xp11.22 confer susceptibility
            to prostate cancer
  JOURNAL   Nat Genet 40 (3), 281-283 (2008)
   PUBMED   18264098
REFERENCE   9  (bases 1 to 5417)
  AUTHORS   Guilherme,A., Soriano,N.A., Furcinitti,P.S. and Czech,M.P.
  TITLE     Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated
            GLUT4 recycling in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 279 (38), 40062-40075 (2004)
   PUBMED   15247266
REFERENCE   10 (bases 1 to 5417)
  AUTHORS   Guilherme,A., Soriano,N.A., Bose,S., Holik,J., Bose,A.,
            Pomerleau,D.P., Furcinitti,P., Leszyk,J., Corvera,S. and Czech,M.P.
  TITLE     EHD2 and the novel EH domain binding protein EHBP1 couple
            endocytosis to the actin cytoskeleton
  JOURNAL   J Biol Chem 279 (11), 10593-10605 (2004)
   PUBMED   14676205
  REMARK    GeneRIF: EHBP1 is an EH domain binding protein that, along with
            EHD2, has a role in coupling endocytosis to the actin cytoskeleton
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA312518.1, AY331186.2,
            DA403235.1, BP361773.1, AY531390.1, BQ215191.1 and BC067215.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001354216.1.
            
            Summary: This gene encodes an Eps15 homology domain binding
            protein. The encoded protein may play a role in endocytic
            trafficking. A single nucleotide polymorphism in this gene is
            associated with an aggressive form of prostate cancer. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.255291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               DA312518.1         1-538
            539-1071            AY331186.2         152-684
            1072-1420           DA403235.1         197-545
            1421-1680           BP361773.1         323-582
            1681-3256           AY531390.1         839-2414
            3257-3420           BQ215191.1         1-164
            3421-4430           AY531390.1         2582-3591
            4431-5417           BC067215.1         3820-4806
FEATURES             Location/Qualifiers
     source          1..5417
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..5417
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="EH domain binding protein 1"
                     /db_xref="GeneID:23301"
                     /db_xref="HGNC:HGNC:29144"
                     /db_xref="MIM:609922"
     exon            1..442
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            443..841
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             738..4430
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="isoform 4 is encoded by transcript variant 9; NPF
                     calponin-like protein; testis tissue sperm-binding protein
                     Li 50e"
                     /codon_start=1
                     /product="EH domain-binding protein 1 isoform 4"
                     /protein_id="NP_001341145.1"
                     /db_xref="GeneID:23301"
                     /db_xref="HGNC:HGNC:29144"
                     /db_xref="MIM:609922"
                     /translation="MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVW
                     TRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVI
                     ENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLR
                     EGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLN
                     ALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAA
                     ELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKD
                     SPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELE
                     TERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLL
                     VWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAY
                     DGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTY
                     KVGNYETDTNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGES
                     ESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQV
                     LLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLENS
                     RSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNH
                     ADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQ
                     DEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTN
                     EEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAV
                     TESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMK
                     RQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQID
                     TRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLER
                     RYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEE
                     EDEHLERTLEQNKGKMAKKEEKCVLQ"
     exon            842..899
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            900..995
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1049
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1231
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1371
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1476
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1599
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1840
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..2027
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2206
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2255
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..3158
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3302
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3303..3447
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3555
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3680
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3819
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3926
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..4050
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4051..4150
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4224
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4225..4339
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..5417
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5389..5394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="hexamer: AATAAA"
     polyA_site      5417
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="major polyA site"
ORIGIN      
        1 atttccctcc ggttggcagc gaaggagccc aagtggcctg gagccgggac attgccctct
       61 ctctgcctgg agatttccct ccactcctcg ttccccatcc atttcctccc tccgactgaa
      121 aaatagcatt cctcctggct ccctaatttg ttccaagcac atattgtcgg acttgaggct
      181 attaattatc gactgaaaaa caaagtttat taaaaaatac tccacttctc cctctttctg
      241 gcggtggaca ttaaacagca tccctagact ttcccgctct gctcgccctt cagtgatgct
      301 aacaggggga ggtagggccc cgagttaccg tctctctgga ttgttgttgg tgctgactac
      361 ctgatgtgtc gctccacgtc ttcggtgtga attgtaattt cttccttggt gtcttgcatc
      421 cttgatgtta ctggcttttg agccctccag aatacccatc atatagcccc tgaggtggca
      481 tggtgatgtc tccatgaggg aaccccttcc cactcatcct gtcacgtata tcatagtgtt
      541 cttgactggg ccattcatct aagatgggat ttaccctgtg aaacagggag aagacttatg
      601 gaccccaagc atcatttcga gttgtagttg agtttttaaa agacatacat gcaaagttcc
      661 tttgctttgg accctctgca ttattaaagc tgctgtattg ctaacccaga actgctccag
      721 tgtcttgact gatcatcatg gcttcagttt ggaagagact gcagcgtgtg ggaaaacatg
      781 catccaagtt ccagtttgtg gcctcctacc aggagctcat ggttgagtgt acgaagaaat
      841 ggcaaccaga taaactggtg gtagtttgga ccagaagaag ccgaaggaag tcttctaagg
      901 cacatagctg gcaacctgga ataaaaaatc cctatcgtgg tgttgttgtg tggcctgttc
      961 ctgaaaacat tgaaatcact gtaacacttt ttaaggatcc tcatgcggaa gaatttgaag
     1021 acaaagagtg gacatttgtc atagaaaatg aatccccttc tggtcgaagg aaagctcttg
     1081 ctactagcag catcaatatg aaacagtatg caagccctat gccaactcag actgatgtca
     1141 agttaaaatt caagccatta tctaaaaaag ttgtatctgc cgctcttcag ttttcattat
     1201 cttgcatttt tctgagggaa ggaaaagcca cagatgaaga catgcaaagt ttggctagtt
     1261 tgatgagtat gaagcaggct gacattggca atttagatga cttcgaagaa gataatgaag
     1321 atgatgatga gaacagagtg aaccaagaag aaaaggcagc taaaattaca gaaattgtaa
     1381 accagttgaa tgctctgagc agcttagatg aagatcaaga tgactgcata aagcaagcaa
     1441 atatgcgttc agctaaatca gccagttcct ctgaagagct tatcaacaaa cttaactttt
     1501 tggatgaagc agaaaaggac ttggccaccg tgaattcaaa tccatttgat gatcctgatg
     1561 ctgcagaatt aaatccattt ggagatcctg actcagaaga acctatcact gaaacagctt
     1621 cacctagaaa aacagaagac tctttttata ataacagcta taatcccttt aaagaggtgc
     1681 agactccaca gtatttgaac ccattcgatg agccagaagc atttgtgacc ataaaggatt
     1741 ctcctcccca gtctacaaaa agaaaaaata taagacctgt ggatatgagc aagtacctct
     1801 atgctgatag ttctaaaact gaagaagaag aattggatga atcaaatcct ttttatgaac
     1861 ctaaatcaac tcctcctcca aataatttgg taaatcctgt tcaagaacta gaaactgaaa
     1921 ggcgagtgaa aagaaaggcc ccggctccac cagtcctctc accaaaaaca ggagtattaa
     1981 atgaaaacac agtttctgca ggaaaagatc tctctacttc tcctaagcca agccctatac
     2041 caagtcctgt tttggggcga aagccaaatg ctagtcagtc tttgcttgta tggtgtaaag
     2101 aagttacaaa gaactaccga ggagtaaaaa tcaccaattt tactacatcg tggagaaatg
     2161 gtttatcttt ttgtgcaata ttacaccact ttagaccaga tttaattgac tacaagtctc
     2221 tgaatcctca agatattaaa gagaacaaca aaaaggcata cgatggattt gccagcatag
     2281 gaatttcccg attattggaa ccttctgata tggtattatt agcaattcct gataaactga
     2341 ctgttatgac ttatctctat caaataaggg cacatttcag tggccaagaa ctaaatgtcg
     2401 ttcagataga ggaaaacagc agtaaaagca catataaagt tggaaactat gaaacagata
     2461 caaacagttc tgttgatcaa gaaaaattct atgcagagct tagtgatctg aagcgggagc
     2521 ctgaactaca acagcctatc agcggagcag tagacttctt atcacaggat gactctgtat
     2581 ttgtaaatga tagcggggtt ggagagtcag aaagtgagca tcaaactcct gatgatcacc
     2641 ttagtccaag cacagcctcc ccttactgtc gcaggactaa aagtgacaca gaaccccaga
     2701 agtctcagca gagctctgga aggacttcag gatctgatga ccctggaata tgttccaata
     2761 cagattcaac ccaagcacag gttttgttag gcaaaaagag actattgaaa gctgagactt
     2821 tagaattgag tgacttatat gttagtgata agaagaagga tatgtctcca ccctttattt
     2881 gtgaggagac agatgaacaa aagcttcaaa ctctagacat cggtagtaac ttggagaaag
     2941 aaaaattaga gaattccaga tccttagaat gcagatcaga tccagaatct cctatcaaaa
     3001 aaacaagttt atctcctact tctaaacttg gatactcata tagtagagat ctagaccttg
     3061 ctaagaaaaa acatgcttcc ctgaggcaga cggagtctga tccagatgct gatagaacca
     3121 ctttaaatca tgcagatcat tcatcaaaaa tagtccagca tcgattgtta tctagacaag
     3181 aagaacttaa ggaaagagca agagttctgc ttgagcaagc aagaagagat gcagccttaa
     3241 aggcggggaa taagcacaat accaacacag ccaccccatt ctgcaacagg cagctaagtg
     3301 atcaagatga agagcgacgt cggcagctga gagagagagc tcgtcagcta atagcagaag
     3361 ctcgatctgg agtgaagatg tcagaacttc ccagctatgg tgaaatggct gcagaaaagt
     3421 tgaaagaaag gtcaaaggca tctggagatg aaaatgataa tattgagata gatactaacg
     3481 aggagatccc tgaaggcttt gttgtaggag gtggagatga acttactaac ttagaaaatg
     3541 accttgatac tcccgaacaa aacagtaagt tggtggactt gaagctgaag aagctcctag
     3601 aagttcagcc acaggtggca aattcaccct ccagtgctgc ccagaaagct gtaactgaga
     3661 gctcagagca ggacatgaaa agtggcacag aagatctccg gactgaacga ttacaaaaaa
     3721 caacagaacg ttttagaaat cctgttgtgt tcagcaaaga ttctacagtc agaaaaactc
     3781 aacttcagtc tttcagccaa tatattgaga atagaccaga gatgaaaagg cagagatcaa
     3841 tacaggaaga tacaaagaaa ggaaatgagg agaaggcagc gataactgaa actcagagga
     3901 agccatcaga agatgaagtg cttaataaag ggttcaaaga caccagtcag tatgtagtag
     3961 gagaattggc agcactagag aatgagcaaa agcaaattga cacccgtgcc gcgctggtgg
     4021 agaagcgcct tcgctatctc atggacacag gaaggaacac agaagaagaa gaagctatga
     4081 tgcaggaatg gtttatgtta gttaataaga aaaatgcctt aataaggaga atgaatcagc
     4141 tctctcttct ggaaaaagaa catgatttag aacgacggta tgagctgctg aaccgggaat
     4201 tgagggcaat gctagccatt gaagactggc agaagaccga ggcccagaag cgacgcgaac
     4261 agcttctgct agatgagctg gtggccctgg tgaacaagcg cgatgcgctc gtcagggacc
     4321 tggacgcgca ggagaagcag gccgaagaag aagatgagca tttggagcga actctggagc
     4381 aaaacaaagg caagatggcc aagaaagagg agaaatgtgt tcttcagtag ccatcagatc
     4441 agaaagaatc tctcccaaca ttttagagtc ttgcttccca aaccagaaaa agtcagactc
     4501 attgttgatt taaaactttt aacattttgt ttggctggat tgtactactt tacctctact
     4561 ttaccaccac cacccttttc ctccctcctt tccaaataat atacagaact ccaaaatagc
     4621 ttcatttaag gatttttttg tgagttaaca atttccttga aatcctgtga aatagatttg
     4681 cacagacacc ttgtgagtga ttggtattgg aggtgttcaa gaaactgttc gaaaaagaac
     4741 aaaaacactt ccctcgttat tttctctcat tttttgatga gaggaaaatt tgaaacatta
     4801 ttcttgttgt tgttggtaat agcataatga cagtgggagg ggtacaaggg gataagaaaa
     4861 atgtcatgat ttttttccgg tcctgccaca tgtaacactt actctgttac ctaaatttta
     4921 tagttagatc atatccaatc tacttattaa actgtgttct atttaccagt ggagtttttc
     4981 tgcagtggtt gcgtttcact gtaaggataa tggagttcct ctcctctgct ttcctcagag
     5041 gatggtcctt taacatagcc agaaacaagc cctgtggttt gaaggtgagc tgtgaggatg
     5101 ggactaattg atatgcacca gtttacaaag acagtcttat catccgagaa tacaccatct
     5161 ttttctctgg ataattattt cttacatcat gcttgattcc tacattttgt tgggtctcaa
     5221 cattggctca cgaatgctgt taatatttat tctgtattga taaaaagtct gtcttgccac
     5281 tacaagtaaa tcccccattt aatattttct tctttagcat agcactgtca ttttttgtga
     5341 aaatggttat gtttatttat tacaatactg agtcatatat aaattttcaa taaaagcaga
     5401 aactttctta ccttaaa
//
