LOCUS       NM_001142616            5105 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens EH domain binding protein 1 (EHBP1), transcript
            variant 4, mRNA.
ACCESSION   NM_001142616
VERSION     NM_001142616.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5105)
  AUTHORS   Rai,A., Bleimling,N., Vetter,I.R. and Goody,R.S.
  TITLE     The mechanism of activation of the actin binding protein EHBP1 by
            Rab8 family members
  JOURNAL   Nat Commun 11 (1), 4187 (2020)
   PUBMED   32826901
  REMARK    GeneRIF: The mechanism of activation of the actin binding protein
            EHBP1 by Rab8 family members.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5105)
  AUTHORS   Beikzadeh,B., Angaji,S.A. and Abolhasani,M.
  TITLE     Association study between common variations in some candidate genes
            and prostate adenocarcinoma predisposition through multi-stage
            approach in Iranian population
  JOURNAL   BMC Med Genet 21 (1), 81 (2020)
   PUBMED   32295536
  REMARK    GeneRIF: The purpose of this study was to evaluate the association
            of rs16901979, rs4242382 and rs1447295 on 8q24 locus, rs2735839
            (KLK3 gene) and rs721048 (EHBP1 gene) with prostate adenocarcinoma
            through multi-stage approach to identify the polymorphisms
            associated with prostate cancer and use them as screening factors
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5105)
  AUTHORS   Li,Z., Schulze,R.J., Weller,S.G., Krueger,E.W., Schott,M.B.,
            Zhang,X., Casey,C.A., Liu,J., Stockli,J., James,D.E. and
            McNiven,M.A.
  TITLE     A novel Rab10-EHBP1-EHD2 complex essential for the autophagic
            engulfment of lipid droplets
  JOURNAL   Sci Adv 2 (12), e1601470 (2016)
   PUBMED   28028537
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5105)
  AUTHORS   Willer,C.J., Schmidt,E.M., Sengupta,S., Peloso,G.M., Gustafsson,S.,
            Kanoni,S., Ganna,A., Chen,J., Buchkovich,M.L., Mora,S.,
            Beckmann,J.S., Bragg-Gresham,J.L., Chang,H.Y., Demirkan,A., Den
            Hertog,H.M., Do,R., Donnelly,L.A., Ehret,G.B., Esko,T.,
            Feitosa,M.F., Ferreira,T., Fischer,K., Fontanillas,P., Fraser,R.M.,
            Freitag,D.F., Gurdasani,D., Heikkila,K., Hypponen,E., Isaacs,A.,
            Jackson,A.U., Johansson,A., Johnson,T., Kaakinen,M., Kettunen,J.,
            Kleber,M.E., Li,X., Luan,J., Lyytikainen,L.P., Magnusson,P.K.E.,
            Mangino,M., Mihailov,E., Montasser,M.E., Muller-Nurasyid,M.,
            Nolte,I.M., O'Connell,J.R., Palmer,C.D., Perola,M., Petersen,A.K.,
            Sanna,S., Saxena,R., Service,S.K., Shah,S., Shungin,D., Sidore,C.,
            Song,C., Strawbridge,R.J., Surakka,I., Tanaka,T., Teslovich,T.M.,
            Thorleifsson,G., Van den Herik,E.G., Voight,B.F., Volcik,K.A.,
            Waite,L.L., Wong,A., Wu,Y., Zhang,W., Absher,D., Asiki,G.,
            Barroso,I., Been,L.F., Bolton,J.L., Bonnycastle,L.L., Brambilla,P.,
            Burnett,M.S., Cesana,G., Dimitriou,M., Doney,A.S.F., Doring,A.,
            Elliott,P., Epstein,S.E., Ingi Eyjolfsson,G., Gigante,B.,
            Goodarzi,M.O., Grallert,H., Gravito,M.L., Groves,C.J., Hallmans,G.,
            Hartikainen,A.L., Hayward,C., Hernandez,D., Hicks,A.A., Holm,H.,
            Hung,Y.J., Illig,T., Jones,M.R., Kaleebu,P., Kastelein,J.J.P.,
            Khaw,K.T., Kim,E., Klopp,N., Komulainen,P., Kumari,M.,
            Langenberg,C., Lehtimaki,T., Lin,S.Y., Lindstrom,J., Loos,R.J.F.,
            Mach,F., McArdle,W.L., Meisinger,C., Mitchell,B.D., Muller,G.,
            Nagaraja,R., Narisu,N., Nieminen,T.V.M., Nsubuga,R.N., Olafsson,I.,
            Ong,K.K., Palotie,A., Papamarkou,T., Pomilla,C., Pouta,A.,
            Rader,D.J., Reilly,M.P., Ridker,P.M., Rivadeneira,F., Rudan,I.,
            Ruokonen,A., Samani,N., Scharnagl,H., Seeley,J., Silander,K.,
            Stancakova,A., Stirrups,K., Swift,A.J., Tiret,L.,
            Uitterlinden,A.G., van Pelt,L.J., Vedantam,S., Wainwright,N.,
            Wijmenga,C., Wild,S.H., Willemsen,G., Wilsgaard,T., Wilson,J.F.,
            Young,E.H., Zhao,J.H., Adair,L.S., Arveiler,D., Assimes,T.L.,
            Bandinelli,S., Bennett,F., Bochud,M., Boehm,B.O., Boomsma,D.I.,
            Borecki,I.B., Bornstein,S.R., Bovet,P., Burnier,M., Campbell,H.,
            Chakravarti,A., Chambers,J.C., Chen,Y.I., Collins,F.S.,
            Cooper,R.S., Danesh,J., Dedoussis,G., de Faire,U., Feranil,A.B.,
            Ferrieres,J., Ferrucci,L., Freimer,N.B., Gieger,C., Groop,L.C.,
            Gudnason,V., Gyllensten,U., Hamsten,A., Harris,T.B., Hingorani,A.,
            Hirschhorn,J.N., Hofman,A., Hovingh,G.K., Hsiung,C.A.,
            Humphries,S.E., Hunt,S.C., Hveem,K., Iribarren,C., Jarvelin,M.R.,
            Jula,A., Kahonen,M., Kaprio,J., Kesaniemi,A., Kivimaki,M.,
            Kooner,J.S., Koudstaal,P.J., Krauss,R.M., Kuh,D., Kuusisto,J.,
            Kyvik,K.O., Laakso,M., Lakka,T.A., Lind,L., Lindgren,C.M.,
            Martin,N.G., Marz,W., McCarthy,M.I., McKenzie,C.A., Meneton,P.,
            Metspalu,A., Moilanen,L., Morris,A.D., Munroe,P.B., Njolstad,I.,
            Pedersen,N.L., Power,C., Pramstaller,P.P., Price,J.F., Psaty,B.M.,
            Quertermous,T., Rauramaa,R., Saleheen,D., Salomaa,V.,
            Sanghera,D.K., Saramies,J., Schwarz,P.E.H., Sheu,W.H.,
            Shuldiner,A.R., Siegbahn,A., Spector,T.D., Stefansson,K.,
            Strachan,D.P., Tayo,B.O., Tremoli,E., Tuomilehto,J., Uusitupa,M.,
            van Duijn,C.M., Vollenweider,P., Wallentin,L., Wareham,N.J.,
            Whitfield,J.B., Wolffenbuttel,B.H.R., Ordovas,J.M., Boerwinkle,E.,
            Palmer,C.N.A., Thorsteinsdottir,U., Chasman,D.I., Rotter,J.I.,
            Franks,P.W., Ripatti,S., Cupples,L.A., Sandhu,M.S., Rich,S.S.,
            Boehnke,M., Deloukas,P., Kathiresan,S., Mohlke,K.L., Ingelsson,E.
            and Abecasis,G.R.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   5  (bases 1 to 5105)
  AUTHORS   Xu,J., Kibel,A.S., Hu,J.J., Turner,A.R., Pruett,K., Zheng,S.L.,
            Sun,J., Isaacs,S.D., Wiley,K.E., Kim,S.T., Hsu,F.C., Wu,W.,
            Torti,F.M., Walsh,P.C., Chang,B.L. and Isaacs,W.B.
  TITLE     Prostate cancer risk associated loci in African Americans
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (7), 2145-2149 (2009)
   PUBMED   19549807
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5105)
  AUTHORS   Wiklund,F.E., Adami,H.O., Zheng,S.L., Stattin,P., Isaacs,W.B.,
            Gronberg,H. and Xu,J.
  TITLE     Established prostate cancer susceptibility variants are not
            associated with disease outcome
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1659-1662 (2009)
   PUBMED   19423541
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5105)
  AUTHORS   Waters,K.M., Le Marchand,L., Kolonel,L.N., Monroe,K.R., Stram,D.O.,
            Henderson,B.E. and Haiman,C.A.
  TITLE     Generalizability of associations from prostate cancer genome-wide
            association studies in multiple populations
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (4), 1285-1289 (2009)
   PUBMED   19318432
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5105)
  AUTHORS   Gudmundsson,J., Sulem,P., Rafnar,T., Bergthorsson,J.T.,
            Manolescu,A., Gudbjartsson,D., Agnarsson,B.A., Sigurdsson,A.,
            Benediktsdottir,K.R., Blondal,T., Jakobsdottir,M., Stacey,S.N.,
            Kostic,J., Kristinsson,K.T., Birgisdottir,B., Ghosh,S.,
            Magnusdottir,D.N., Thorlacius,S., Thorleifsson,G., Zheng,S.L.,
            Sun,J., Chang,B.L., Elmore,J.B., Breyer,J.P., McReynolds,K.M.,
            Bradley,K.M., Yaspan,B.L., Wiklund,F., Stattin,P., Lindstrom,S.,
            Adami,H.O., McDonnell,S.K., Schaid,D.J., Cunningham,J.M., Wang,L.,
            Cerhan,J.R., St Sauver,J.L., Isaacs,S.D., Wiley,K.E., Partin,A.W.,
            Walsh,P.C., Polo,S., Ruiz-Echarri,M., Navarrete,S., Fuertes,F.,
            Saez,B., Godino,J., Weijerman,P.C., Swinkels,D.W., Aben,K.K.,
            Witjes,J.A., Suarez,B.K., Helfand,B.T., Frigge,M.L.,
            Kristjansson,K., Ober,C., Jonsson,E., Einarsson,G.V., Xu,J.,
            Gronberg,H., Smith,J.R., Thibodeau,S.N., Isaacs,W.B.,
            Catalona,W.J., Mayordomo,J.I., Kiemeney,L.A., Barkardottir,R.B.,
            Gulcher,J.R., Thorsteinsdottir,U., Kong,A. and Stefansson,K.
  TITLE     Common sequence variants on 2p15 and Xp11.22 confer susceptibility
            to prostate cancer
  JOURNAL   Nat Genet 40 (3), 281-283 (2008)
   PUBMED   18264098
REFERENCE   9  (bases 1 to 5105)
  AUTHORS   Guilherme,A., Soriano,N.A., Furcinitti,P.S. and Czech,M.P.
  TITLE     Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated
            GLUT4 recycling in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 279 (38), 40062-40075 (2004)
   PUBMED   15247266
REFERENCE   10 (bases 1 to 5105)
  AUTHORS   Guilherme,A., Soriano,N.A., Bose,S., Holik,J., Bose,A.,
            Pomerleau,D.P., Furcinitti,P., Leszyk,J., Corvera,S. and Czech,M.P.
  TITLE     EHD2 and the novel EH domain binding protein EHBP1 couple
            endocytosis to the actin cytoskeleton
  JOURNAL   J Biol Chem 279 (11), 10593-10605 (2004)
   PUBMED   14676205
  REMARK    GeneRIF: EHBP1 is an EH domain binding protein that, along with
            EHD2, has a role in coupling endocytosis to the actin cytoskeleton
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092567.4, HY174910.1,
            CA394214.1 and BC067215.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001142616.2.
            
            Summary: This gene encodes an Eps15 homology domain binding
            protein. The encoded protein may play a role in endocytic
            trafficking. A single nucleotide polymorphism in this gene is
            associated with an aggressive form of prostate cancer. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Feb 2010].
            
            Transcript Variant: This variant (4) lacks two in-frame exons in
            the coding region, compared to variant 1. This variant encodes a
            shorter isoform (3) than isoform 1. Variants 3, 4 and 11 encode the
            same isoform (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067215.1, SRR1803613.263758.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431489.6/ ENSP00000403783.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC092567.4         21823-21831
            10-153              HY174910.1         3-146
            154-299             CA394214.1         1-146
            300-5105            BC067215.1         1-4806
FEATURES             Location/Qualifiers
     source          1..5105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..5105
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="EH domain binding protein 1"
                     /db_xref="GeneID:23301"
                     /db_xref="HGNC:HGNC:29144"
                     /db_xref="MIM:609922"
     exon            1..340
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            341..739
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             636..4118
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="isoform 3 is encoded by transcript variant 4; NPF
                     calponin-like protein; testis tissue sperm-binding protein
                     Li 50e"
                     /codon_start=1
                     /product="EH domain-binding protein 1 isoform 3"
                     /protein_id="NP_001136088.1"
                     /db_xref="CCDS:CCDS46300.1"
                     /db_xref="GeneID:23301"
                     /db_xref="HGNC:HGNC:29144"
                     /db_xref="MIM:609922"
                     /translation="MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVW
                     TRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVI
                     ENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLR
                     EGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITELINKLN
                     FLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPF
                     KEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDES
                     NPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLST
                     SPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHF
                     RPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQI
                     RAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPELQQPI
                     SGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQS
                     SGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEE
                     TDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLA
                     KKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAA
                     LKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEM
                     AAEKLKERSKASGEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGT
                     EDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKG
                     NEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRY
                     LMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAM
                     LAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQN
                     KGKMAKKEEKCVLQ"
     exon            740..797
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            798..893
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            894..947
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1129
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1269
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1392
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1633
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1820
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..1999
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2048
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2951
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3095
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3096..3243
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3368
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3507
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3508..3614
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3738
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3739..3838
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3912
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4027
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     exon            4028..5105
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5077..5082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="hexamer: AATAAA"
     polyA_site      5105
                     /gene="EHBP1"
                     /gene_synonym="HPC12; NACSIN"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgagag gtgcggcggg ggaggtaatg atgatggtgg cggaggagaa aggcggggga
       61 gggggtgctg ggcgctgagc ggtggctctg gcagggcttg gtagggtggg ggacggtcgc
      121 ggggcgatct gtcagggagg gggtgggcgt gaggggcgcc gtccgcctga ggggctgcag
      181 atcccggcta ccgcgagcgc cgtggctggc ttggctgttc catgtggctc cggcggggat
      241 ggaggactcg gtggcggcgg cggctgctgc tgcggcggcg acggaggagc ggctatgaga
      301 agggaacggg gccagactca gcccgacagc gggattagag ccctccagaa tacccatcat
      361 atagcccctg aggtggcatg gtgatgtctc catgagggaa ccccttccca ctcatcctgt
      421 cacgtatatc atagtgttct tgactgggcc attcatctaa gatgggattt accctgtgaa
      481 acagggagaa gacttatgga ccccaagcat catttcgagt tgtagttgag tttttaaaag
      541 acatacatgc aaagttcctt tgctttggac cctctgcatt attaaagctg ctgtattgct
      601 aacccagaac tgctccagtg tcttgactga tcatcatggc ttcagtttgg aagagactgc
      661 agcgtgtggg aaaacatgca tccaagttcc agtttgtggc ctcctaccag gagctcatgg
      721 ttgagtgtac gaagaaatgg caaccagata aactggtggt agtttggacc agaagaagcc
      781 gaaggaagtc ttctaaggca catagctggc aacctggaat aaaaaatccc tatcgtggtg
      841 ttgttgtgtg gcctgttcct gaaaacattg aaatcactgt aacacttttt aaggatcctc
      901 atgcggaaga atttgaagac aaagagtgga catttgtcat agaaaatgaa tccccttctg
      961 gtcgaaggaa agctcttgct actagcagca tcaatatgaa acagtatgca agccctatgc
     1021 caactcagac tgatgtcaag ttaaaattca agccattatc taaaaaagtt gtatctgccg
     1081 ctcttcagtt ttcattatct tgcatttttc tgagggaagg aaaagccaca gatgaagaca
     1141 tgcaaagttt ggctagtttg atgagtatga agcaggctga cattggcaat ttagatgact
     1201 tcgaagaaga taatgaagat gatgatgaga acagagtgaa ccaagaagaa aaggcagcta
     1261 aaattacaga gcttatcaac aaacttaact ttttggatga agcagaaaag gacttggcca
     1321 ccgtgaattc aaatccattt gatgatcctg atgctgcaga attaaatcca tttggagatc
     1381 ctgactcaga agaacctatc actgaaacag cttcacctag aaaaacagaa gactcttttt
     1441 ataataacag ctataatccc tttaaagagg tgcagactcc acagtatttg aacccattcg
     1501 atgagccaga agcatttgtg accataaagg attctcctcc ccagtctaca aaaagaaaaa
     1561 atataagacc tgtggatatg agcaagtacc tctatgctga tagttctaaa actgaagaag
     1621 aagaattgga tgaatcaaat cctttttatg aacctaaatc aactcctcct ccaaataatt
     1681 tggtaaatcc tgttcaagaa ctagaaactg aaaggcgagt gaaaagaaag gccccggctc
     1741 caccagtcct ctcaccaaaa acaggagtat taaatgaaaa cacagtttct gcaggaaaag
     1801 atctctctac ttctcctaag ccaagcccta taccaagtcc tgttttgggg cgaaagccaa
     1861 atgctagtca gtctttgctt gtatggtgta aagaagttac aaagaactac cgaggagtaa
     1921 aaatcaccaa ttttactaca tcgtggagaa atggtttatc tttttgtgca atattacacc
     1981 actttagacc agatttaatt gactacaagt ctctgaatcc tcaagatatt aaagagaaca
     2041 acaaaaaggc atacgatgga tttgccagca taggaatttc ccgattattg gaaccttctg
     2101 atatggtatt attagcaatt cctgataaac tgactgttat gacttatctc tatcaaataa
     2161 gggcacattt cagtggccaa gaactaaatg tcgttcagat agaggaaaac agcagtaaaa
     2221 gcacatataa agttggaaac tatgaaacag atacaaacag ttctgttgat caagaaaaat
     2281 tctatgcaga gcttagtgat ctgaagcggg agcctgaact acaacagcct atcagcggag
     2341 cagtagactt cttatcacag gatgactctg tatttgtaaa tgatagcggg gttggagagt
     2401 cagaaagtga gcatcaaact cctgatgatc accttagtcc aagcacagcc tccccttact
     2461 gtcgcaggac taaaagtgac acagaacccc agaagtctca gcagagctct ggaaggactt
     2521 caggatctga tgaccctgga atatgttcca atacagattc aacccaagca caggttttgt
     2581 taggcaaaaa gagactattg aaagctgaga ctttagaatt gagtgactta tatgttagtg
     2641 ataagaagaa ggatatgtct ccacccttta tttgtgagga gacagatgaa caaaagcttc
     2701 aaactctaga catcggtagt aacttggaga aagaaaaatt agagaattcc agatccttag
     2761 aatgcagatc agatccagaa tctcctatca aaaaaacaag tttatctcct acttctaaac
     2821 ttggatactc atatagtaga gatctagacc ttgctaagaa aaaacatgct tccctgaggc
     2881 agacggagtc tgatccagat gctgatagaa ccactttaaa tcatgcagat cattcatcaa
     2941 aaatagtcca gcatcgattg ttatctagac aagaagaact taaggaaaga gcaagagttc
     3001 tgcttgagca agcaagaaga gatgcagcct taaaggcggg gaataagcac aataccaaca
     3061 cagccacccc attctgcaac aggcagctaa gtgatcagca agatgaagag cgacgtcggc
     3121 agctgagaga gagagctcgt cagctaatag cagaagctcg atctggagtg aagatgtcag
     3181 aacttcccag ctatggtgaa atggctgcag aaaagttgaa agaaaggtca aaggcatctg
     3241 gagaacaaaa cagtaagttg gtggacttga agctgaagaa gctcctagaa gttcagccac
     3301 aggtggcaaa ttcaccctcc agtgctgccc agaaagctgt aactgagagc tcagagcagg
     3361 acatgaaaag tggcacagaa gatctccgga ctgaacgatt acaaaaaaca acagaacgtt
     3421 ttagaaatcc tgttgtgttc agcaaagatt ctacagtcag aaaaactcaa cttcagtctt
     3481 tcagccaata tattgagaat agaccagaga tgaaaaggca gagatcaata caggaagata
     3541 caaagaaagg aaatgaggag aaggcagcga taactgaaac tcagaggaag ccatcagaag
     3601 atgaagtgct taataaaggg ttcaaagaca ccagtcagta tgtagtagga gaattggcag
     3661 cactagagaa tgagcaaaag caaattgaca cccgtgccgc gctggtggag aagcgccttc
     3721 gctatctcat ggacacagga aggaacacag aagaagaaga agctatgatg caggaatggt
     3781 ttatgttagt taataagaaa aatgccttaa taaggagaat gaatcagctc tctcttctgg
     3841 aaaaagaaca tgatttagaa cgacggtatg agctgctgaa ccgggaattg agggcaatgc
     3901 tagccattga agactggcag aagaccgagg cccagaagcg acgcgaacag cttctgctag
     3961 atgagctggt ggccctggtg aacaagcgcg atgcgctcgt cagggacctg gacgcgcagg
     4021 agaagcaggc cgaagaagaa gatgagcatt tggagcgaac tctggagcaa aacaaaggca
     4081 agatggccaa gaaagaggag aaatgtgttc ttcagtagcc atcagatcag aaagaatctc
     4141 tcccaacatt ttagagtctt gcttcccaaa ccagaaaaag tcagactcat tgttgattta
     4201 aaacttttaa cattttgttt ggctggattg tactacttta cctctacttt accaccacca
     4261 cccttttcct ccctcctttc caaataatat acagaactcc aaaatagctt catttaagga
     4321 tttttttgtg agttaacaat ttccttgaaa tcctgtgaaa tagatttgca cagacacctt
     4381 gtgagtgatt ggtattggag gtgttcaaga aactgttcga aaaagaacaa aaacacttcc
     4441 ctcgttattt tctctcattt tttgatgaga ggaaaatttg aaacattatt cttgttgttg
     4501 ttggtaatag cataatgaca gtgggagggg tacaagggga taagaaaaat gtcatgattt
     4561 ttttccggtc ctgccacatg taacacttac tctgttacct aaattttata gttagatcat
     4621 atccaatcta cttattaaac tgtgttctat ttaccagtgg agtttttctg cagtggttgc
     4681 gtttcactgt aaggataatg gagttcctct cctctgcttt cctcagagga tggtccttta
     4741 acatagccag aaacaagccc tgtggtttga aggtgagctg tgaggatggg actaattgat
     4801 atgcaccagt ttacaaagac agtcttatca tccgagaata caccatcttt ttctctggat
     4861 aattatttct tacatcatgc ttgattccta cattttgttg ggtctcaaca ttggctcacg
     4921 aatgctgtta atatttattc tgtattgata aaaagtctgt cttgccacta caagtaaatc
     4981 ccccatttaa tattttcttc tttagcatag cactgtcatt ttttgtgaaa atggttatgt
     5041 ttatttatta caatactgag tcatatataa attttcaata aaagcagaaa ctttcttacc
     5101 ttaaa
//
