LOCUS       NM_004430               4514 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens early growth response 3 (EGR3), transcript variant 1,
            mRNA.
ACCESSION   NM_004430 XM_939234
VERSION     NM_004430.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4514)
  AUTHORS   Ge,Y., Liu,H., Huang,W., Zhu,H., Zong,D. and He,X.
  TITLE     Immunoinhibitory effects of hypoxia-driven reprogramming of EGR1hi
            and EGR3 positive B cells in the nasopharyngeal carcinoma
            microenvironment
  JOURNAL   Oral Oncol 158, 106999 (2024)
   PUBMED   39197193
  REMARK    GeneRIF: Immunoinhibitory effects of hypoxia-driven reprogramming
            of EGR1[hi] and EGR3 positive B cells in the nasopharyngeal
            carcinoma microenvironment.
REFERENCE   2  (bases 1 to 4514)
  AUTHORS   Abudukeyimu,Z., Luo,J., Liu,F., Ma,Y., Li,J., Wang,J. and Li,X.
  TITLE     Early growth response factor 3 may regulate coronary
            atherosclerosis through the NF-kappaB signaling pathway and VEGF
            expression
  JOURNAL   Am J Med Sci 368 (5), 476-484 (2024)
   PUBMED   38992750
  REMARK    GeneRIF: Early growth response factor 3 may regulate coronary
            atherosclerosis through the NF-kappaB signaling pathway and VEGF
            expression.
REFERENCE   3  (bases 1 to 4514)
  AUTHORS   Chen,C.H., Chen,Y., Li,Y.N., Zhang,H., Huang,X., Li,Y.Y., Li,Z.Y.,
            Han,J.X., Wu,X.Y., Liu,H.J. and Sun,T.
  TITLE     EGR3 Inhibits Tumor Progression by Inducing Schwann Cell-Like
            Differentiation
  JOURNAL   Adv Sci (Weinh) 11 (34), e2400066 (2024)
   PUBMED   38973154
  REMARK    GeneRIF: EGR3 Inhibits Tumor Progression by Inducing Schwann
            Cell-Like Differentiation.
REFERENCE   4  (bases 1 to 4514)
  AUTHORS   da Silva,A.R., Gunawan,F., Boezio,G.L.M., Faure,E., Theron,A.,
            Avierinos,J.F., Lim,S., Jha,S.G., Ramadass,R., Guenther,S.,
            Looso,M., Zaffran,S., Juan,T. and Stainier,D.Y.R.
  TITLE     egr3 is a mechanosensitive transcription factor gene required for
            cardiac valve morphogenesis
  JOURNAL   Sci Adv 10 (20), eadl0633 (2024)
   PUBMED   38748804
  REMARK    GeneRIF: egr3 is a mechanosensitive transcription factor gene
            required for cardiac valve morphogenesis.
REFERENCE   5  (bases 1 to 4514)
  AUTHORS   Peng,L., Sun,X., Yi,X., Wang,Z. and Chen,K.
  TITLE     EGR3 reduces podocyte inflammatory damage in obesity related
            glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 49 (3), 349-358 (2024)
   PUBMED   38970508
  REMARK    GeneRIF: EGR3 reduces podocyte inflammatory damage in obesity
            related glomerulopathy by inhibiting the PRMT1/p-STAT3 pathway.
REFERENCE   6  (bases 1 to 4514)
  AUTHORS   Yang,Y., Dong,B., Mittelstadt,P.R., Xiao,H. and Ashwell,J.D.
  TITLE     HIV Tat binds Egr proteins and enhances Egr-dependent
            transactivation of the Fas ligand promoter
  JOURNAL   J Biol Chem 277 (22), 19482-19487 (2002)
   PUBMED   11909874
  REMARK    GeneRIF: HIV Tat binds Egr proteins and enhances Egr-dependent
            transactivation of the Fas ligand promoter
REFERENCE   7  (bases 1 to 4514)
  AUTHORS   Tourtellotte,W.G. and Milbrandt,J.
  TITLE     Sensory ataxia and muscle spindle agenesis in mice lacking the
            transcription factor Egr3
  JOURNAL   Nat Genet 20 (1), 87-91 (1998)
   PUBMED   9731539
REFERENCE   8  (bases 1 to 4514)
  AUTHORS   Morris,M.E., Viswanathan,N., Kuhlman,S., Davis,F.C. and Weitz,C.J.
  TITLE     A screen for genes induced in the suprachiasmatic nucleus by light
  JOURNAL   Science 279 (5356), 1544-1547 (1998)
   PUBMED   9488654
REFERENCE   9  (bases 1 to 4514)
  AUTHORS   Mages,H.W., Stamminger,T., Rilke,O., Bravo,R. and Kroczek,R.A.
  TITLE     Expression of PILOT, a putative transcription factor, requires two
            signals and is cyclosporin A sensitive in T cells
  JOURNAL   Int Immunol 5 (1), 63-70 (1993)
   PUBMED   8443122
REFERENCE   10 (bases 1 to 4514)
  AUTHORS   Patwardhan,S., Gashler,A., Siegel,M.G., Chang,L.C., Joseph,L.J.,
            Shows,T.B., Le Beau,M.M. and Sukhatme,V.P.
  TITLE     EGR3, a novel member of the Egr family of genes encoding
            immediate-early transcription factors
  JOURNAL   Oncogene 6 (6), 917-928 (1991)
   PUBMED   1906159
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105046.10, S40832.1, X63741.1
            and N66802.1.
            
            On Nov 24, 2018 this sequence version replaced NM_004430.2.
            
            Summary: This gene encodes a transcriptional regulator that belongs
            to the EGR family of C2H2-type zinc-finger proteins. It is an
            immediate-early growth response gene which is induced by mitogenic
            stimulation. The protein encoded by this gene participates in the
            transcriptional regulation of genes in controling biological
            rhythm. It may also play a role in a wide variety of processes
            including muscle development, lymphocyte development, endothelial
            cell growth and migration, and neuronal development. Alternative
            splicing results in multiple transcript variants encoding distinct
            isoforms.[provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S40832.1, X63741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317216.3/ ENSP00000318057.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC105046.10        32473-32650
            179-183             S40832.1           1-5
            184-2633            X63741.1           1-2450
            2634-2657           S40832.1           2455-2478
            2658-2862           X63741.1           2475-2679
            2863-3700           S40832.1           2684-3521
            3701-4448           X63741.1           3517-4264
            4449-4512           N66802.1           9-72                c
            4513-4514           AC105046.10        38293-38294
FEATURES             Location/Qualifiers
     source          1..4514
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..4514
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
                     /note="early growth response 3"
                     /db_xref="GeneID:1960"
                     /db_xref="HGNC:HGNC:3240"
                     /db_xref="MIM:602419"
     exon            1..690
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
                     /inference="alignment:Splign:2.1.0"
     CDS             537..1700
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein pilot; early growth response protein 3"
                     /codon_start=1
                     /product="early growth response protein 3 isoform 1"
                     /protein_id="NP_004421.2"
                     /db_xref="CCDS:CCDS6033.1"
                     /db_xref="GeneID:1960"
                     /db_xref="HGNC:HGNC:3240"
                     /db_xref="MIM:602419"
                     /translation="MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVV
                     HYNQMATENVMDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNI
                     ISLMSAGILGVPPASGALSTQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSF
                     HDPQGNPGLAYSPQDYQSAKPALDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPI
                     RVNPPPITPLETIKAFKDKQIHPGFGSLPQPPLTLKPIRPRKYPNRPSKTPLHERPHA
                     CPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHLTTHIRTHTGEKPFA
                     CEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAPPVSLAPVVTTCA"
     exon            691..4514
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4424..4429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
                     /note="hexamer: AATATA"
     polyA_site      4448
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
                     /note="major polyA site"
     regulatory      4491..4496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
                     /note="hexamer: CATAAA"
     polyA_site      4514
                     /gene="EGR3"
                     /gene_synonym="EGR-3; PILOT"
ORIGIN      
        1 gggagctttt gggcagcagt gagcttgcta ggaagcggcg gggctggtgg tggtggtagc
       61 agcggcggca gcggcggcag aggcggcggc ggcggcggcg gcggcggcgg cggtggcggt
      121 ggcggtggcg gtggcagatc ggggggcggg ggggcggcgg gcgcgtgtct gtttgtgaga
      181 tcaatactga ggccgcgtcc gacccccttg agccgagatc cccccccagc ccagccccca
      241 ccccaccccc cgcacacgcc ccaccccccc cacgacccag cctcataccg caccagctga
      301 ggcacccaag aggattaccc cctggggccc tctcccgccc cccaaaaaag agaagatccc
      361 ctctcctggc ccatcccttc ccttcttccc tcccccctcc ccccgaactt tccctctcgc
      421 atgcttttcc cctgcaccac ggatcgcctc tcggatgccg cttgcctgga agctgcgtta
      481 ggagcgagcg gcggcggtgg cggcggtggc ggcggcggcg gcagctcggg agtgctatga
      541 ccggcaaact cgccgagaag ctgccggtga ccatgagcag tttgctaaac caactgcctg
      601 acaatctgta ccccgaggag atccccagcg cgctcaacct cttctccggc agcagcgact
      661 cggtagtcca ttacaatcag atggctacag agaatgtaat ggacatcggt ctgaccaacg
      721 agaagcccaa cccggaactc tcttactccg gctccttcca gccagccccc ggcaacaaga
      781 ccgtgaccta cttgggaaag ttcgccttcg actccccttc caactggtgc caggacaaca
      841 tcattagcct catgagcgcc ggcatcttgg gggtgccccc ggcttcaggg gcgctcagca
      901 cgcagacgtc cacggccagc atggtgcagc caccgcaggg tgacgtggag gccatgtatc
      961 ccgcgctacc cccctactcc aactgcggcg acctctactc agagcccgtg tctttccacg
     1021 acccccaggg caatcccggg ctcgcctatt ccccccagga ttaccaatcg gccaagccgg
     1081 cgttggacag caatctcttc cccatgattc ctgactacaa cctctaccac caccccaacg
     1141 acatgggctc cattccggag cacaagccct tccagggcat ggaccccatc cgggtcaacc
     1201 cgccccctat tacccctctg gagaccatca aggcattcaa agacaagcag atccacccgg
     1261 gctttggcag cctgccccag ccgccgctca ccctcaagcc catccggccc cgcaagtacc
     1321 ccaaccggcc tagcaagaca ccgctccacg aacggcccca cgcgtgcccg gccgagggct
     1381 gcgaccgccg tttcagccgt tcggacgagc tgacccggca cctgcgcatc cacacgggcc
     1441 acaagccctt ccagtgccgg atctgcatgc ggagcttcag ccgcagcgac cacctcacca
     1501 ctcacatccg cactcatacg ggcgagaagc cctttgcctg cgagttctgc gggcgcaagt
     1561 ttgcgcgcag cgacgagcgc aagcgccacg ccaagatcca cctcaagcaa aaggagaaga
     1621 aggcggagaa gggcggtgca ccctctgcat cctcggcgcc ccccgtgtcg ctggcccccg
     1681 tggtcaccac ctgcgcctga ggatcgggcc cccagatccc cacttttccc ctccagtgcc
     1741 tcccggctgc tagcctgaaa gcagcgggaa agccagccac ggaggcgtag gggccgcgcc
     1801 ctggcctctc catggacgtg cggccccttg cttccccttc gatgcccccg gttcccaacc
     1861 tttcacgccg gccagcggtc aggggccagg gctggaggcg ccttcccctc gcggtccccc
     1921 acttagccaa ggcgtggggg cggaaaggtg gcgtctagcc cgctttgttc agttcggatc
     1981 gccttgatcc aggggccgcc gggccgcgcc aaggacctgc aagggactga aggcggagcc
     2041 catccaaccc tcgcccgacc caaacacctc attgtttccc ccacgtctcc ctctataccc
     2101 cctcgaagac tcgagagggg gagggggtaa ggagcgcacc aaagcgcaga gcttgctgcc
     2161 cgccgcacgc acgcgcgcct gcgtgcgggg atgcgcgcga gtgtgtgcgt gctcgcgtgt
     2221 gtgtgtatgt gtgtgtgtga gtgtgtgtgt gtgcgcgcgc gcaagcgtgt gtgtttaaga
     2281 ctcttgagct gaactgggct gtgtttaccc caaactcttc cccacctcgg gtccccaagc
     2341 cgctgggaga tgtcccatgc tgggggtccg cacgtggctg gaggaggtgg tcttccatcc
     2401 gctctgaaat catgtttctt agagaaatgc ctcggatgcc gccgacgcgg tgctgctgcc
     2461 gccgcttcgg gtttggcccc tcagaacccc tccttttctg agcgcttccc tcttaggcct
     2521 cagggcagtt tgatctgtgg ggagaaagag cagccatcgc tgagcctgcc ttttaaaata
     2581 tatgtgtatt tccttagccc cactctaaga aatctatgtt cctgagtttg ccccctgccc
     2641 tcccactcct tccccttctc ccctctaaac cttctcccat ctctttcaaa atcttttccc
     2701 agaaaggcag gcttcaacca gccactccag ctttgtgtct tctctcaatt acatagcaat
     2761 ttctccttcc caccatcatg gggaagctgg ctctgctttt gccctttgtc atcaccaaca
     2821 caacagatag aatttaaata taagtatatg gtgtgcgtgt gtatgtatgt gtatgtatat
     2881 gcatgcatgt gtataaagat gcacatgcgt acatatacat aacatacaca caatatgtat
     2941 tcctagcaaa ataaaatctc taaggtactt ggttatccag tgcagtgcac cggaataaag
     3001 agaatttgta ggcgtataca gctttaaatg atttattttt tatgaaaatg ttaactgatg
     3061 agattatatc tacatacgtg tgttatgtgt gtggatatag atgcacacat atctgtacat
     3121 atacatgtga gtgtacatat atacacatat acacatctat gtatggatat gtgtgtatac
     3181 acatatacac atctctgtcc aaaatttcct caaagatatg gggatttttt catgaatcca
     3241 tgtggatgaa tgaggtgtct cctttccata cccagtctca ccttctcccc accctacctc
     3301 acctcttctc aggcacccct cttccccagc tgtcctgcca gcccttctcg tacagggtgg
     3361 ctcctttgaa gtggagtaat agggaaggtt gctctctgcc acagcttgca gcatggtctt
     3421 gactgaatgt actgttcctg ttagcgttac ttctcctgtg gtcagtaagt tgcccagaga
     3481 gaaggaacaa aggtctggag tttacagaat gtctgttttt aaagtcactt tatgcgtttt
     3541 ccactttttt cttttttaag aaaaagaagt accatttttg ttttgttttg ttttgatttt
     3601 tggtggtgga taaataatac taaaaggact ctagtggaaa ggggggatat cgaagagcag
     3661 ggggttgtga atttccaggt acttggactt tttgtagaag gagagagaag aagatgaagt
     3721 ttgccaggag ggcccatatt ttttcagctg aagggtaaaa tctttctttg cagagacagt
     3781 attttgctga atacttttta taatgtgatg attattaaaa aagcaaaaat tttggtcact
     3841 tccaagctag aaggaggaat cagataccct ttaatatttt ttcctcgctc cttctggtat
     3901 atgcatgtca ctgcatgata attgagtttt cctttgtttt aataaaactg ttctcagaca
     3961 ttaagctaaa ctaagagaaa aataactttg ttgccaaaag gttgtgctat ccagattttt
     4021 tatatgtctg catgtttaaa aaaaaaaagc aacaaaagaa aatgcactct aacttatgtg
     4081 aactgagaga aaaaaatcag gttttaaaca ggaaaaccta tggggaatga tattttttga
     4141 aagacttttg tataaagttg agtacttaga aaaaagacaa accagatgta atatattttg
     4201 tggatgtttt tatttcttgg atttatagta ccttatacta aggttaaaaa aatatgcttg
     4261 atattgtgaa aaggtgaaat tcttcaccaa catttcattt gctcctttgt catattgtaa
     4321 tgccaatata atatagttaa tgaaaacagc atttttaaaa accgaaatat tgaaatggtg
     4381 taatgttgta ccatttgcac tgtgagcaaa tgctaataca gtaaatatat tgtgtttgct
     4441 gacaatcagc cggcctataa atctccttat tttatttctt gtttttatag cataaagctt
     4501 tagtttggcc tgtt
//
