LOCUS       NM_001964               3137 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens early growth response 1 (EGR1), mRNA.
ACCESSION   NM_001964
VERSION     NM_001964.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Ge,Y., Liu,H., Huang,W., Zhu,H., Zong,D. and He,X.
  TITLE     Immunoinhibitory effects of hypoxia-driven reprogramming of EGR1hi
            and EGR3 positive B cells in the nasopharyngeal carcinoma
            microenvironment
  JOURNAL   Oral Oncol 158, 106999 (2024)
   PUBMED   39197193
  REMARK    GeneRIF: Immunoinhibitory effects of hypoxia-driven reprogramming
            of EGR1[hi] and EGR3 positive B cells in the nasopharyngeal
            carcinoma microenvironment.
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Li,X., Huang,L., Liu,B., Zhang,Z., Zhou,G., Guo,Z., Song,J. and
            Wang,X.
  TITLE     Cyclic negative pressure promotes chondrocyte growth: Association
            of IGF-2 with EGR-1
  JOURNAL   Biomol Biomed 24 (6), 1761-1775 (2024)
   PUBMED   38912889
  REMARK    GeneRIF: Cyclic negative pressure promotes chondrocyte growth:
            Association of IGF-2 with EGR-1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Meng,W., Yu,S., Li,Y., Wang,H., Feng,Y., Sun,W., Liu,Y., Sun,S. and
            Liu,H.
  TITLE     Mutant p53 achieves function by regulating EGR1 to induce
            epithelial mesenchymal transition
  JOURNAL   Tissue Cell 90, 102510 (2024)
   PUBMED   39126833
  REMARK    GeneRIF: Mutant p53 achieves function by regulating EGR1 to induce
            epithelial mesenchymal transition.
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Geng,T., Sun,Q., He,J., Chen,Y., Cheng,W., Shen,J., Liu,B.,
            Zhang,M., Wang,S., Asan,K., Song,M., Gao,Q., Song,Y., Liu,R.,
            Liu,X., Ding,Y., Jing,A., Ye,X., Ren,H., Zeng,K., Zhou,Y.,
            Zhang,B., Ma,S., Liu,W., Liu,S. and Ji,J.
  TITLE     CXXC5 drove inflammation and ovarian cancer proliferation via
            transcriptional activation of ZNF143 and EGR1
  JOURNAL   Cell Signal 119, 111180 (2024)
   PUBMED   38642782
  REMARK    GeneRIF: CXXC5 drove inflammation and ovarian cancer proliferation
            via transcriptional activation of ZNF143 and EGR1.
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Yang,Q., Murata,K., Ikeda,T., Minatoya,K. and Masumoto,H.
  TITLE     miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia
            reperfusion injury in human iPS cell-derived cardiomyocytes
  JOURNAL   Sci Rep 14 (1), 14811 (2024)
   PUBMED   38926457
  REMARK    GeneRIF: miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia
            reperfusion injury in human iPS cell-derived cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Trabandt,A., Gay,R.E., Sukhatme,V.P. and Gay,S.
  TITLE     Expression of collagenase and potential transcriptional factors
            c-fos and egr-1 in periodontal gingival fibroblasts
  JOURNAL   J Oral Pathol Med 21 (5), 232-240 (1992)
   PUBMED   1383501
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Shimizu,N., Ohta,M., Fujiwara,C., Sagara,J., Mochizuki,N., Oda,T.
            and Utiyama,H.
  TITLE     A gene coding for a zinc finger protein is induced during
            12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell
            differentiation
  JOURNAL   J Biochem 111 (2), 272-277 (1992)
   PUBMED   1569051
REFERENCE   8  (bases 1 to 3137)
  AUTHORS   Trabandt,A., Aicher,W.K., Gay,R.E., Sukhatme,V.P., Fassbender,H.G.
            and Gay,S.
  TITLE     Spontaneous expression of immediately-early response genes c-fos
            and egr-1 in collagenase-producing rheumatoid synovial fibroblasts
  JOURNAL   Rheumatol Int 12 (2), 53-59 (1992)
   PUBMED   1411083
REFERENCE   9  (bases 1 to 3137)
  AUTHORS   Morris,J.F., Madden,S.L., Tournay,O.E., Cook,D.M., Sukhatme,V.P.
            and Rauscher,F.J. 3rd.
  TITLE     Characterization of the zinc finger protein encoded by the WT1
            Wilms' tumor locus
  JOURNAL   Oncogene 6 (12), 2339-2348 (1991)
   PUBMED   1662794
REFERENCE   10 (bases 1 to 3137)
  AUTHORS   Heath,R.G.
  TITLE     Brain function and behavior. I. Emotion and sensory phenomena in
            psychotic patients and in experimental animals
  JOURNAL   J Nerv Ment Dis 160 (3), 159-175 (1975)
   PUBMED   1090709
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113403.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_001964.2.
            
            Summary: The protein encoded by this gene belongs to the EGR family
            of C2H2-type zinc-finger proteins. It is a nuclear protein and
            functions as a transcriptional regulator. The products of target
            genes it activates are required for differentitation and
            mitogenesis. Studies suggest this is a cancer suppressor gene.
            [provided by RefSeq, Dec 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M62829.1, X52541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000239938.5/ ENSP00000239938.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               AC113403.4         94965-95554
            591-3137            AC113403.4         96243-98789
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..3137
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /note="early growth response 1"
                     /db_xref="GeneID:1958"
                     /db_xref="HGNC:HGNC:3238"
                     /db_xref="MIM:128990"
     exon            1..590
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1915
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /note="nerve growth factor-induced protein A;
                     transcription factor ETR103; zinc finger protein 225;
                     EGR-1; transcription factor Zif268; zinc finger protein
                     Krox-24; zinc finger gene 225"
                     /codon_start=1
                     /product="early growth response protein 1"
                     /protein_id="NP_001955.1"
                     /db_xref="CCDS:CCDS4206.1"
                     /db_xref="GeneID:1958"
                     /db_xref="HGNC:HGNC:3238"
                     /db_xref="MIM:128990"
                     /translation="MAAAKAEMQLMSPLQISDPFGSFPHSPTMDNYPKLEEMMLLSNG
                     APQFLGAAGAPEGSGSNSSSSSSGGGGGGGGGSNSSSSSSTFNPQADTGEQPYEHLTA
                     ESFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEPLFSLVSG
                     LVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFP
                     EPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTPDQKPFQG
                     LESRTQQPSLTPLSTIKAFATQSGSQDLKALNTSYQSQLIKPSRMRKYPNRPSKTPPH
                     ERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHTG
                     EKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSLSSYPSPVATSY
                     PSPVTTSYPSPATTSYPSPVPTSFSSPGSSTYPSPVHSGFPSPSVATTYSSVPPAFPA
                     QVSSFPSSAVTNSFSASTGLSDMTATFSPRTIEIC"
     exon            591..3137
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3057..3062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /note="hexamer: TATAAA"
     polyA_site      3062
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
     polyA_site      3118
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /note="major polyA site"
     regulatory      3129..3134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /note="hexamer: AATAAA"
     polyA_site      3137
                     /gene="EGR1"
                     /gene_synonym="AT225; G0S30; KROX-24; NGFI-A; TIS8;
                     ZIF-268; ZIF268; ZNF225"
                     /note="major polyA site"
ORIGIN      
        1 gagagatccc agcgcgcaga acttggggag ccgccgccgc catccgccgc cgcagccagc
       61 ttccgccgcc gcaggaccgg cccctgcccc agcctccgca gccgcggcgc gtccacgccc
      121 gcccgcgccc agggcgagtc ggggtcgccg cctgcacgct tctcagtgtt ccccgcgccc
      181 cgcatgtaac ccggccaggc ccccgcaact gtgtcccctg cagctccagc cccgggctgc
      241 acccccccgc cccgacacca gctctccagc ctgctcgtcc aggatggccg cggccaaggc
      301 cgagatgcag ctgatgtccc cgctgcagat ctctgacccg ttcggatcct ttcctcactc
      361 gcccaccatg gacaactacc ctaagctgga ggagatgatg ctgctgagca acggggctcc
      421 ccagttcctc ggcgccgccg gggccccaga gggcagcggc agcaacagca gcagcagcag
      481 cagcgggggc ggtggaggcg gcgggggcgg cagcaacagc agcagcagca gcagcacctt
      541 caaccctcag gcggacacgg gcgagcagcc ctacgagcac ctgaccgcag agtcttttcc
      601 tgacatctct ctgaacaacg agaaggtgct ggtggagacc agttacccca gccaaaccac
      661 tcgactgccc cccatcacct atactggccg cttttccctg gagcctgcac ccaacagtgg
      721 caacaccttg tggcccgagc ccctcttcag cttggtcagt ggcctagtga gcatgaccaa
      781 cccaccggcc tcctcgtcct cagcaccatc tccagcggcc tcctccgcct ccgcctccca
      841 gagcccaccc ctgagctgcg cagtgccatc caacgacagc agtcccattt actcagcggc
      901 acccaccttc cccacgccga acactgacat tttccctgag ccacaaagcc aggccttccc
      961 gggctcggca gggacagcgc tccagtaccc gcctcctgcc taccctgccg ccaagggtgg
     1021 cttccaggtt cccatgatcc ccgactacct gtttccacag cagcaggggg atctgggcct
     1081 gggcacccca gaccagaagc ccttccaggg cctggagagc cgcacccagc agccttcgct
     1141 aacccctctg tctactatta aggcctttgc cactcagtcg ggctcccagg acctgaaggc
     1201 cctcaatacc agctaccagt cccagctcat caaacccagc cgcatgcgca agtaccccaa
     1261 ccggcccagc aagacgcccc cccacgaacg cccttacgct tgcccagtgg agtcctgtga
     1321 tcgccgcttc tcccgctccg acgagctcac ccgccacatc cgcatccaca caggccagaa
     1381 gcccttccag tgccgcatct gcatgcgcaa cttcagccgc agcgaccacc tcaccaccca
     1441 catccgcacc cacacaggcg aaaagccctt cgcctgcgac atctgtggaa gaaagtttgc
     1501 caggagcgat gaacgcaaga ggcataccaa gatccacttg cggcagaagg acaagaaagc
     1561 agacaaaagt gttgtggcct cttcggccac ctcctctctc tcttcctacc cgtccccggt
     1621 tgctacctct tacccgtccc cggttactac ctcttatcca tccccggcca ccacctcata
     1681 cccatcccct gtgcccacct ccttctcctc tcccggctcc tcgacctacc catcccctgt
     1741 gcacagtggc ttcccctccc cgtcggtggc caccacgtac tcctctgttc cccctgcttt
     1801 cccggcccag gtcagcagct tcccttcctc agctgtcacc aactccttca gcgcctccac
     1861 agggctttcg gacatgacag caaccttttc tcccaggaca attgaaattt gctaaaggga
     1921 aaggggaaag aaagggaaaa gggagaaaaa gaaacacaag agacttaaag gacaggagga
     1981 ggagatggcc ataggagagg agggttcctc ttaggtcaga tggaggttct cagagccaag
     2041 tcctccctct ctactggagt ggaaggtcta ttggccaaca atcctttctg cccacttccc
     2101 cttccccaat tactattccc tttgacttca gctgcctgaa acagccatgt ccaagttctt
     2161 cacctctatc caaagaactt gatttgcatg gattttggat aaatcatttc agtatcatct
     2221 ccatcatatg cctgacccct tgctcccttc aatgctagaa aatcgagttg gcaaaatggg
     2281 gtttgggccc ctcagagccc tgccctgcac ccttgtacag tgtctgtgcc atggatttcg
     2341 tttttcttgg ggtactcttg atgtgaagat aatttgcata ttctattgta ttatttggag
     2401 ttaggtcctc acttggggga aaaaaaaaaa agaaaagcca agcaaaccaa tggtgatcct
     2461 ctattttgtg atgatgctgt gacaataagt ttgaaccttt ttttttgaaa cagcagtccc
     2521 agtattctca gagcatgtgt cagagtgttg ttccgttaac ctttttgtaa atactgcttg
     2581 accgtactct cacatgtggc aaaatatggt ttggtttttc tttttttttt tttttgaaag
     2641 tgttttttct tcgtcctttt ggtttaaaaa gtttcacgtc ttggtgcctt ttgtgtgatg
     2701 cgccttgctg atggcttgac atgtgcaatt gtgagggaca tgctcacctc tagccttaag
     2761 gggggcaggg agtgatgatt tgggggaggc tttgggagca aaataaggaa gagggctgag
     2821 ctgagcttcg gttctccaga atgtaagaaa acaaaatcta aaacaaaatc tgaactctca
     2881 aaagtctatt tttttaactg aaaatgtaaa tttataaata tattcaggag ttggaatgtt
     2941 gtagttacct actgagtagg cggcgatttt tgtatgttat gaacatgcag ttcattattt
     3001 tgtggttcta ttttactttg tacttgtgtt tgcttaaaca aagtgactgt ttggcttata
     3061 aacacattga atgcgcttta ttgcccatgg gatatgtggt gtatatcctt ccaaaaaatt
     3121 aaaacgaaaa taaagta
//
