LOCUS       NM_152403               4720 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens EGF like, fibronectin type III and laminin G domains
            (EGFLAM), transcript variant 1, mRNA.
ACCESSION   NM_152403
VERSION     NM_152403.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4720)
  AUTHORS   Li,K., Zhu,Q., Du,S., Zhao,Q., Ba,D., Zeng,X., Peng,Q., Cai,J.,
            Zhao,Y., Jin,H. and Qi,L.
  TITLE     EGFLAM exhibits oncogenic activity and shows promise as a
            prognostic biomarker and therapeutic target in glioblastoma
  JOURNAL   Int Immunopharmacol 138, 112625 (2024)
   PUBMED   38996666
  REMARK    GeneRIF: EGFLAM exhibits oncogenic activity and shows promise as a
            prognostic biomarker and therapeutic target in glioblastoma.
REFERENCE   2  (bases 1 to 4720)
  AUTHORS   Patil,D.N., Pantalone,S., Cao,Y., Laboute,T., Novick,S.J.,
            Singh,S., Savino,S., Faravelli,S., Magnani,F., Griffin,P.R.,
            Singh,A.K., Forneris,F. and Martemyanov,K.A.
  TITLE     Structure of the photoreceptor synaptic assembly of the
            extracellular matrix protein pikachurin with the orphan receptor
            GPR179
  JOURNAL   Sci Signal 16 (795), eadd9539 (2023)
   PUBMED   37490546
  REMARK    GeneRIF: Structure of the photoreceptor synaptic assembly of the
            extracellular matrix protein pikachurin with the orphan receptor
            GPR179.
REFERENCE   3  (bases 1 to 4720)
  AUTHORS   Chen,J., Zhang,J., Hong,L. and Zhou,Y.
  TITLE     EGFLAM correlates with cell proliferation, migration, invasion and
            poor prognosis in glioblastoma
  JOURNAL   Cancer Biomark 24 (3), 343-350 (2019)
   PUBMED   30829611
  REMARK    GeneRIF: this is the first report to describe that EGFLAM promoted
            the proliferation, migration and invasion of GBM cells via the
            activation of PI3K/AKT pathway, and predicted poor prognosis in GBM
            patients.
REFERENCE   4  (bases 1 to 4720)
  AUTHORS   Orlandi,C., Omori,Y., Wang,Y., Cao,Y., Ueno,A., Roux,M.J.,
            Condomitti,G., de Wit,J., Kanagawa,M., Furukawa,T. and
            Martemyanov,K.A.
  TITLE     Transsynaptic Binding of Orphan Receptor GPR179 to
            Dystroglycan-Pikachurin Complex Is Essential for the Synaptic
            Organization of Photoreceptors
  JOURNAL   Cell Rep 25 (1), 130-145 (2018)
   PUBMED   30282023
REFERENCE   5  (bases 1 to 4720)
  AUTHORS   Yamada,Y., Sakuma,J., Takeuchi,I., Yasukochi,Y., Kato,K., Oguri,M.,
            Fujimaki,T., Horibe,H., Muramatsu,M., Sawabe,M., Fujiwara,Y.,
            Taniguchi,Y., Obuchi,S., Kawai,H., Shinkai,S., Mori,S., Arai,T. and
            Tanaka,M.
  TITLE     Identification of EGFLAM, SPATC1L and RNASE13 as novel
            susceptibility loci for aortic aneurysm in Japanese individuals by
            exome-wide association studies
  JOURNAL   Int J Mol Med 39 (5), 1091-1100 (2017)
   PUBMED   28339009
  REMARK    GeneRIF: rs1465567 of EGFLAM and rs113710653 of SPATC1L may be
            susceptibility loci for true aortic aneurysm and rs143881017 of
            RNASE13 may be such a locus for dissecting aortic aneurysm in
            Japanese individuals.
REFERENCE   6  (bases 1 to 4720)
  AUTHORS   Adkins,D.E., Clark,S.L., Aberg,K., Hettema,J.M., Bukszar,J.,
            McClay,J.L., Souza,R.P. and van den Oord,E.J.
  TITLE     Genome-wide pharmacogenomic study of citalopram-induced side
            effects in STAR*D
  JOURNAL   Transl Psychiatry 2 (7), e129 (2012)
   PUBMED   22760553
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4720)
  AUTHORS   Hu,H., Li,J., Zhang,Z. and Yu,M.
  TITLE     Pikachurin interaction with dystroglycan is diminished by defective
            O-mannosyl glycosylation in congenital muscular dystrophy models
            and rescued by LARGE overexpression
  JOURNAL   Neurosci Lett 489 (1), 10-15 (2011)
   PUBMED   21129441
REFERENCE   8  (bases 1 to 4720)
  AUTHORS   Gu,X.H., Lu,Y., Ma,D., Liu,X.S. and Guo,S.W.
  TITLE     [Model of aberrant DNA methylation patterns and its applications in
            epithelial ovarian cancer.]
  JOURNAL   Zhonghua Fu Chan Ke Za Zhi 44 (10), 754-759 (2009)
   PUBMED   20078962
REFERENCE   9  (bases 1 to 4720)
  AUTHORS   Sato,S., Omori,Y., Katoh,K., Kondo,M., Kanagawa,M., Miyata,K.,
            Funabiki,K., Koyasu,T., Kajimura,N., Miyoshi,T., Sawai,H.,
            Kobayashi,K., Tani,A., Toda,T., Usukura,J., Tano,Y., Fujikado,T.
            and Furukawa,T.
  TITLE     Pikachurin, a dystroglycan ligand, is essential for photoreceptor
            ribbon synapse formation
  JOURNAL   Nat Neurosci 11 (8), 923-931 (2008)
   PUBMED   18641643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010338.7, AC091839.2 and AC010457.7.
            
            On Nov 23, 2018 this sequence version replaced NM_152403.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063822.1, AK291602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322350.10/ ENSP00000313084.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC010338.7         93850-94142
            294-403             AC091839.2         113955-114064       c
            404-487             AC091839.2         112803-112886       c
            488-605             AC091839.2         100966-101083       c
            606-741             AC091839.2         99253-99388         c
            742-908             AC091839.2         81122-81288         c
            909-1024            AC091839.2         45343-45458         c
            1025-1343           AC091839.2         44438-44756         c
            1344-1444           AC091839.2         43679-43779         c
            1445-1545           AC091839.2         42480-42580         c
            1546-1690           AC091839.2         38936-39080         c
            1691-1880           AC091839.2         33329-33518         c
            1881-2006           AC091839.2         26492-26617         c
            2007-2250           AC091839.2         24332-24575         c
            2251-2362           AC091839.2         20296-20407         c
            2363-2479           AC091839.2         16331-16447         c
            2480-2660           AC091839.2         13129-13309         c
            2661-2739           AC091839.2         3205-3283           c
            2740-2883           AC091839.2         126-269             c
            2884-2967           AC010457.7         28019-28102
            2968-3071           AC010457.7         32616-32719
            3072-4720           AC010457.7         33540-35188
FEATURES             Location/Qualifiers
     source          1..4720
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2-p13.1"
     gene            1..4720
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /note="EGF like, fibronectin type III and laminin G
                     domains"
                     /db_xref="GeneID:133584"
                     /db_xref="HGNC:HGNC:26810"
                     /db_xref="MIM:617683"
     exon            1..293
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..3226
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; pikachurin; agrin-like protein; EGF-like,
                     fibronectin type-III and laminin G-like domain-containing
                     protein"
                     /codon_start=1
                     /product="pikachurin isoform 1 precursor"
                     /protein_id="NP_689616.2"
                     /db_xref="CCDS:CCDS3924.1"
                     /db_xref="GeneID:133584"
                     /db_xref="HGNC:HGNC:26810"
                     /db_xref="MIM:617683"
                     /translation="MDLIRGVLLRLLLLASSLGPGAVSLRAAIRKPGKVGPPLDIKLG
                     ALNCTAFSIQWKMPRHPGSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIG
                     DLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLPPAAPQQPHVIVVSDSEVAL
                     SWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMVIKGLDPDTNYQFAVRA
                     MNSHGPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGEDDEGFEDDLDLDISFEE
                     VKPLPATKGGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTTVAPQPIPIQRKGKN
                     GVAIMSRLFDMPCDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFF
                     GHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFR
                     FNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRT
                     PLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGECSS
                     GICDEASCIHGGTCTAIKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW
                     PLEPQHYLSFMEFEITFRPDSGDGVLLYSYDTGSKDFLSINLAGGHVEFRFDCGSGTG
                     VLRSEDPLTLGNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVP
                     NYDDVKKNSGVLKPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVRAPCAHGGS
                     CRPRKEGYDCDCPLGFEGLHCQKAIIEAIEIPQFIGRSYLTYDNPDILKRVSGSRSNV
                     FMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFND
                     GRWHRVKAVRDGQSGKITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQY
                     MRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK"
     exon            294..403
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            404..487
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            488..605
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            606..741
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            742..908
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1024
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1343
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1444
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1545
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1690
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1880
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2006
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2250
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2362
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2479
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2660
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2739
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2883
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2884..2967
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3071
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     exon            3072..4720
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3767..3772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /note="hexamer: AATAAA"
     polyA_site      3789
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /note="major polyA site"
     regulatory      4155..4160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /note="hexamer: ATTAAA"
     polyA_site      4178
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
     regulatory      4236..4241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /note="hexamer: AATAAA"
     polyA_site      4257
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
     regulatory      4702..4707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
                     /note="hexamer: AATAAA"
     polyA_site      4720
                     /gene="EGFLAM"
                     /gene_synonym="AGRINL; AGRNL; PIKA"
ORIGIN      
        1 actcgcgcac gccgacctcc cggctgcagt cctacctctt ggaactaccc gtgtttccgg
       61 gcccagccct cgcagccccc cacctcctcg ccccggcccg gggatccgtt ggggccgcgt
      121 cccccacgcg cccccggaga cgccctttcc gtgtgcgccc gggacttggt gaaactttgc
      181 aggcgccggc tgcgaaatgg atttaatccg aggcgtcttg ctccggctcc tgctcctggc
      241 ttccagcctc ggacccggcg cggtgtcgct ccgagcggcc atccgaaaac caggcaaggt
      301 agggcctcct cttgacatca agctgggcgc attgaactgt acggctttca gcatccagtg
      361 gaaaatgcca aggcatcctg gaagtcccat ccttgggtac actgtctttt actctgaggt
      421 tggcgcagat aaatccctgc aggagcagtt gcacagcgtg cctctcagcc gggacatccc
      481 gaccacggag gaagtgattg gagatttgaa accaggcact gaatatcgtg tgagcatagc
      541 agcttacagc caggctggca aagggcggct gagctctcct cggcatgtca ccactttgtc
      601 ccaagattcc tgcctgcctc ctgcagctcc ccagcagcca catgtcattg tggtttcgga
      661 ttctgaggtg gccctgtctt ggaaacctgg agcgagtgaa ggaagcgccc ctattcagta
      721 ctattctgtg gaattcatca ggccagattt cgacaagaag tggacctcaa tccatgagcg
      781 gatccagatg gactccatgg ttatcaaggg cctcgatcca gataccaact accagtttgc
      841 cgtgagggca atgaattccc atggccccag cccccgcagc tggcccagtg acatcatccg
      901 gaccctctgc cctgaggagg cgggaagtgg ccgctatgga ccccgttata tcaccgacat
      961 gggagctggt gaggatgatg aaggatttga agacgactta gatttggata tttcctttga
     1021 ggaggttaaa ccacttcctg ctaccaaagg agggaataag aaatttttgg tggaaagcaa
     1081 gaagatgtct atatctaacc caaagaccat ttctaggctc atccccccta cctcagcatc
     1141 tctccctgtg accacggtgg ctccccagcc cattcccata cagagaaagg ggaagaatgg
     1201 tgtggccata atgtcaaggc tctttgacat gccttgtgat gaaactctct gctctgctga
     1261 cagcttctgt gtcaatgact acacctgggg gggctcgcga tgccagtgca ccctgggcaa
     1321 aggtggtgag agctgctcag aagatattgt tatccagtat cctcagttct ttggccactc
     1381 ctatgtaacg tttgaacctc tgaagaattc ttatcaggca tttcaaatta ctcttgaatt
     1441 tagggcggag gcagaggatg gcttactgct ctactgtggg gagaacgaac acgggagggg
     1501 ggatttcatg tccctggcta tcatccgacg ctccctgcag ttcaggttta attgtggaac
     1561 tggggttgcc atcatcgtaa gtgagaccaa aatcaaacta gggggttggc acacggttat
     1621 gctctacaga gatgggctga acgggctgct gcagctgaac aatggcaccc cagtgacagg
     1681 ccagtctcag ggccaataca gtaaaattac tttccggaca cctctctatc ttggtggcgc
     1741 tcccagcgct tactggttgg ttagagcaac agggacaaac cgaggctttc aaggctgtgt
     1801 gcagtcgctc gctgtgaatg ggaggagaat tgacatgagg ccctggcccc tgggaaaagc
     1861 actcagtggg gctgatgtgg gggaatgcag cagtggaatc tgtgatgagg cctcgtgcat
     1921 ccatggtggc acctgcacag caatcaaagc cgactcctac atttgcctct gtccccttgg
     1981 gtttaaaggt cgacactgtg aagatgcttt caccttgacc attcctcagt tcagagagtc
     2041 tctgagatct tacgctgcaa ctccctggcc actggagccc cagcattacc tttccttcat
     2101 ggaatttgag atcacatttc ggccagactc aggagatggt gtcctcctgt acagctatga
     2161 cacaggcagc aaagacttcc tgtccatcaa cttggcaggg ggccacgtgg agttccgctt
     2221 tgactgtggc tctgggaccg gtgtcctcag gagtgaagat cccctcaccc tgggcaactg
     2281 gcacgagctt cgtgtatctc gcacagcaaa gaatggaatc ttacaggtgg ataagcagaa
     2341 gatagtggag ggaatggcag agggaggctt cacacagatt aagtgcaaca cagacatttt
     2401 cattggcgga gtccccaatt atgatgatgt gaagaagaac tcgggtgtcc tgaagccttt
     2461 cagcgggagc atccagaaga tcatcctgaa tgaccgaacc atccatgtga agcatgactt
     2521 cacctccgga gtgaatgtgg agaatgcggc ccacccctgt gtgagagccc cttgtgccca
     2581 tgggggcagc tgccggccca ggaaggaggg ctatgactgt gactgcccct tgggctttga
     2641 ggggcttcac tgccagaaag cgatcataga agccattgag atcccgcagt ttatcggccg
     2701 cagttacctg acgtatgaca acccagatat cttgaagagg gtgtcaggat caagatcaaa
     2761 tgtgttcatg aggtttaaaa caactgccaa ggatggcctt ttgctgtgga ggggagacag
     2821 ccccatgaga cccaacagcg acttcatttc cttgggcctt cgggatggag ccctcgtgtt
     2881 cagctataac ctgggcagtg gtgtggcatc catcatggtg aatggctcct tcaacgatgg
     2941 tcggtggcac cgagttaagg ccgttaggga tggccagtca ggaaagataa ccgtggatga
     3001 ctatggagcc agaacaggca aatccccagg catgatgcgg cagcttaaca tcaatggagc
     3061 tctgtatgtg ggtggaatga aggaaattgc tctgcacact aacaggcaat atatgagagg
     3121 gctcgtgggc tgtatctctc acttcaccct gtccaccgat taccacattt ccctcgtgga
     3181 agatgccgtg gatgggaaaa acatcaacac ttgtggagcc aagtaacacc agctggcctt
     3241 gtccaaggga cagagccttc tattctgaga atcccagggg ccctcagacc ctgcctgatg
     3301 ctatatgcag aggcccaggg accaggtgtg tttcctctca ccaagaagaa agtacacact
     3361 gatgagaaac tgagaaccaa gacaggcatc cctgggtggc ctttcctgct gacactccac
     3421 gagctgaccc agcagaattc tctgtgtagg aagcatcgga ctttgtccat tgaatatgta
     3481 gcggctgcca gagatcacac atcaatgcaa attccagagc ctgtctgcta tagctcagtg
     3541 actgtgttgt gattcatagt acattaaaaa gagagagaga gagaaagaat cccacagggc
     3601 actattaaaa tacttctctc cttccctgac tcatgacact cttcctgaca gcagaatgac
     3661 tgtgtgacct tgaacttcac atttcccaca ttggcccttg gattgttcgg attaacccct
     3721 tccactcctc actggctggt tcactgtgtt ctgactagtc cataaaaata aagatggaag
     3781 gagatcaaac acagaatcat aatcataatg cggccccctt ccccagagct tacctcgaat
     3841 gtgaaatccc tacttcttat aatgcagagt taaggagctg agcccccatg attttgtagc
     3901 tgtacttttg tatgtgtata tttttatagc tgcagattgt ccacacagta tacttttgga
     3961 agtttgggtg gatgactctg aattcttgca cacctttcct aaaaatttct cccaagagag
     4021 acttgtttgg gccttttgtg gtgtcagtgg aatggatagg taacttgggt gggcaacttg
     4081 gggagctgac cattctcttt tggtaaatgt tgacggctca agaggatgaa tatgaagctt
     4141 tccaagataa gcagattaaa aggaacatgt gttaccgagg taggtcactg tcatttttgt
     4201 tttaagagtt ggggggagta tctatagtaa acttgaataa aggggacaaa gctagaactt
     4261 attcattcat tcattcactt atggagttgt tactgatttt gcggaggtca ggttcatacc
     4321 aatggacact aatacaatca gtgttcccaa ggctgtgcag gggtgggggg acatgctgtc
     4381 aggatggtct gagcatctgg gtgagaacca gagaaacagg acttcttcct tctgtaccat
     4441 gagctgtgtc cctttactat gcaagcacat gaccccagag acagctggtt cactggcaga
     4501 tccccatgat ggacttacta agggaaaggt gagatgaaca ctgcccccaa ggagggggtg
     4561 aaatatgatc taacttatgc aagagcctat aattagtccc agtctcgact ctacatttgt
     4621 ttgtgcagca ttcattcagc aaagactttt ggggtttgtg caaggcacag ttttaagcac
     4681 ataatgtaat tctaaaagat gaataaacta gagaggttca
//
