LOCUS       NM_016215               1759 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens EGF like domain multiple 7 (EGFL7), transcript variant
            1, mRNA.
ACCESSION   NM_016215
VERSION     NM_016215.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1759)
  AUTHORS   de Oliveira,C., Martins,S.F.F., Goncalves,P.G., Limone,G.A.,
            Longatto-Filho,A., Reis,R.M. and Bidinotto,L.T.
  TITLE     Low EGFL7 expression is associated with high lymph node spread and
            invasion of lymphatic vessels in colorectal cancer
  JOURNAL   Sci Rep 13 (1), 19783 (2023)
   PUBMED   37957249
  REMARK    GeneRIF: Low EGFL7 expression is associated with high lymph node
            spread and invasion of lymphatic vessels in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1759)
  AUTHORS   Goda,C., Kolovich,S., Rudich,A., Karunasiri,M., Kulkarni,R.,
            Rajgolikar,G., Neidemire-Colley,L., Singh,S., Sircar,A.,
            Ranganathan,P., Garzon,R., Sehgal,L. and Dorrance,A.M.
  TITLE     Epidermal growth factor-like 7 is a novel therapeutic target in
            mantle cell lymphoma
  JOURNAL   Exp Hematol 123, 28-33 (2023)
   PUBMED   37209901
  REMARK    GeneRIF: Epidermal growth factor-like 7 is a novel therapeutic
            target in mantle cell lymphoma.
REFERENCE   3  (bases 1 to 1759)
  AUTHORS   Wang,Y., Chen,P., Zhao,M., Cao,H., Zhao,Y., Ji,M., Hou,P. and
            Chen,M.
  TITLE     EGFL7 drives the evolution of resistance to EGFR inhibitors in lung
            cancer by activating NOTCH signaling
  JOURNAL   Cell Death Dis 13 (10), 910 (2022)
   PUBMED   36309484
  REMARK    GeneRIF: EGFL7 drives the evolution of resistance to EGFR
            inhibitors in lung cancer by activating NOTCH signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1759)
  AUTHORS   Sznurkowski,J.J., Zawrocki,A., Krawczynska,N., Bienkowski,M.,
            Wasag,B. and Biernat,W.
  TITLE     Impact of Activation of EGFL7 within Microenvironment of High Grade
            Ovarian Serous Carcinoma on Infiltration of CD4+ and CD8+
            Lymphocytes
  JOURNAL   Medicina (Kaunas) 58 (5), 588 (2022)
   PUBMED   35630004
  REMARK    GeneRIF: Impact of Activation of EGFL7 within Microenvironment of
            High Grade Ovarian Serous Carcinoma on Infiltration of CD4+ and
            CD8+ Lymphocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1759)
  AUTHORS   Pinte,S., Delfortrie,S., Havet,C., Villain,G., Mattot,V. and
            Soncin,F.
  TITLE     EGF repeats of epidermal growth factor-like domain 7 promote
            endothelial cell activation and tumor escape from the immune system
  JOURNAL   Oncol Rep 47 (1) (2022)
   PUBMED   34738625
  REMARK    GeneRIF: EGF repeats of epidermal growth factorlike domain 7
            promote endothelial cell activation and tumor escape from the
            immune system.
REFERENCE   6  (bases 1 to 1759)
  AUTHORS   Musiyenko,A., Bitko,V. and Barik,S.
  TITLE     Ectopic expression of miR-126*, an intronic product of the vascular
            endothelial EGF-like 7 gene, regulates prostein translation and
            invasiveness of prostate cancer LNCaP cells
  JOURNAL   J Mol Med (Berl) 86 (3), 313-322 (2008)
   PUBMED   18193184
  REMARK    GeneRIF: Intronic miRNAs from tissue-specific transcripts, or their
            natural absence, make cardinal contributions to cellular gene
            expression and phenotype.
REFERENCE   7  (bases 1 to 1759)
  AUTHORS   Xu,D., Perez,R.E., Ekekezie,I.I., Navarro,A. and Truog,W.E.
  TITLE     Epidermal growth factor-like domain 7 protects endothelial cells
            from hyperoxia-induced cell death
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 294 (1), L17-L23 (2008)
   PUBMED   17934064
  REMARK    GeneRIF: Human EGFL7 may protect endothelial cell from
            hyperoxia-induced apoptosis by inhibition of mitochondria-dependent
            apoptosis pathway.
REFERENCE   8  (bases 1 to 1759)
  AUTHORS   Parker,L.H., Schmidt,M., Jin,S.W., Gray,A.M., Beis,D., Pham,T.,
            Frantz,G., Palmieri,S., Hillan,K., Stainier,D.Y., De Sauvage,F.J.
            and Ye,W.
  TITLE     The endothelial-cell-derived secreted factor Egfl7 regulates
            vascular tube formation
  JOURNAL   Nature 428 (6984), 754-758 (2004)
   PUBMED   15085134
REFERENCE   9  (bases 1 to 1759)
  AUTHORS   Soncin,F., Mattot,V., Lionneton,F., Spruyt,N., Lepretre,F.,
            Begue,A. and Stehelin,D.
  TITLE     VE-statin, an endothelial repressor of smooth muscle cell migration
  JOURNAL   EMBO J 22 (21), 5700-5711 (2003)
   PUBMED   14592969
  REMARK    GeneRIF: is the first identified inhibitor of mural cell migration
            specifically produced by endothelial cells.
REFERENCE   10 (bases 1 to 1759)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590226.23, BI770335.1,
            AY358902.1 and AL512735.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016215.4.
            
            Summary: This gene encodes a secreted endothelial cell protein that
            contains two epidermal growth factor-like domains. The encoded
            protein may play a role in regulating vasculogenesis. This protein
            may be involved in the growth and proliferation of tumor cells.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358902.1, DRR138524.674975.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308874.12/ ENSP00000307843.7
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL590226.23        88968-88978
            12-58               BI770335.1         1-47
            59-1001             AY358902.1         1-943
            1002-1002           AL590226.23        96268-96268
            1003-1378           AY358902.1         945-1320
            1379-1625           AL590226.23        98350-98596
            1626-1759           AL512735.1         1396-1529
FEATURES             Location/Qualifiers
     source          1..1759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1759
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /note="EGF like domain multiple 7"
                     /db_xref="GeneID:51162"
                     /db_xref="HGNC:HGNC:20594"
                     /db_xref="MIM:608582"
     exon            1..193
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..409
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            410..503
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..625
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     CDS             546..1367
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /note="epidermal growth factor-like protein 7; EGF-like
                     protein 7; NOTCH4-like protein; vascular endothelial
                     statin; multiple EGF-like domains protein 7; multiple
                     epidermal growth factor-like domains protein 7"
                     /codon_start=1
                     /product="epidermal growth factor-like protein 7
                     precursor"
                     /protein_id="NP_057299.1"
                     /db_xref="CCDS:CCDS7002.1"
                     /db_xref="GeneID:51162"
                     /db_xref="HGNC:HGNC:20594"
                     /db_xref="MIM:608582"
                     /translation="MRGSQEVLLMWLLVLAVGGTEHAYRPGRRVCAVRAHGDPVSESF
                     VQRVYQPFLTTCDGHRACSTYRTIYRTAYRRSPGLAPARPRYACCPGWKRTSGLPGAC
                     GAAICQPPCRNGGSCVQPGRCRCPAGWRGDTCQSDVDECSARRGGCPQRCVNTAGSYW
                     CQCWEGHSLSADGTLCVPKGGPPRVAPNPTGVDSAMKEEVQRLQSRVDLLEEKLQLVL
                     APLHSLASQALEHGLPDPGSLLVHSFQQLGRIDSLSEQISFLEEQLGSCSCKKDS"
     exon            626..742
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..858
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..954
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1116
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1181
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1344
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1759
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1742..1747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /note="hexamer: AATAAA"
     polyA_site      1759
                     /gene="EGFL7"
                     /gene_synonym="NEU1; VE-STATIN; ZNEU1"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctccc tgcaccaagc tggccctgca cggctgcaag ggaggctcct gtggacaggc
       61 caggcaggtg ggcctcagga ggtgcctcca ggcggccagt gggcctgagg ccccagcaag
      121 ggctagggtc catctccagt cccaggacac agcagcggcc accatggcca cgcctgggct
      181 ccagcagcat cagagcagcc cctgtggttg gcagcaaagt tcagcttggc tgggcccgct
      241 gtgaggggct tcgcgctacg ccctgcggtg tcccgagggc tgaggtctcc tcatcttctc
      301 cctagcagtg gatgagcaac ccaacggggg cccggggagg ggaactggcc ccgagggaga
      361 ggaaccccaa agccacatct gtagccagga tgagcagtgt gaatccaggc agcccccagg
      421 accggggagg cacaggtggc ccccaccacc cggaggagca gctcctgccc ctgtccgggg
      481 gatgactgat tctcctccgc caggccaccc agaggagaag gccaccccgc ctggaggcac
      541 aggccatgag gggctctcag gaggtgctgc tgatgtggct tctggtgttg gcagtgggcg
      601 gcacagagca cgcctaccgg cccggccgta gggtgtgtgc tgtccgggct cacggggacc
      661 ctgtctccga gtcgttcgtg cagcgtgtgt accagccctt cctcaccacc tgcgacgggc
      721 accgggcctg cagcacctac cgaaccatct ataggaccgc ctaccgccgc agccctgggc
      781 tggcccctgc caggcctcgc tacgcgtgct gccccggctg gaagaggacc agcgggcttc
      841 ctggggcctg tggagcagca atatgccagc cgccatgccg gaacggaggg agctgtgtcc
      901 agcctggccg ctgccgctgc cctgcaggat ggcggggtga cacttgccag tcagatgtgg
      961 atgaatgcag tgctaggagg ggcggctgtc cccagcgctg cgtcaacacc gccggcagtt
     1021 actggtgcca gtgttgggag gggcacagcc tgtctgcaga cggtacactc tgtgtgccca
     1081 agggagggcc ccccagggtg gcccccaacc cgacaggagt ggacagtgca atgaaggaag
     1141 aagtgcagag gctgcagtcc agggtggacc tgctggagga gaagctgcag ctggtgctgg
     1201 ccccactgca cagcctggcc tcgcaggcac tggagcatgg gctcccggac cccggcagcc
     1261 tcctggtgca ctccttccag cagctcggcc gcatcgactc cctgagcgag cagatttcct
     1321 tcctggagga gcagctgggg tcctgctcct gcaagaaaga ctcgtgactg cccagcgccc
     1381 caggctggac tgagcccctc acgccgccct gcagccccca tgcccctgcc caacatgctg
     1441 ggggtccaga aaccacctcg gggtgactga gcggaaggcc aggcagggcc ttcctcctct
     1501 tcctcctccc cttcctcggg aggctcccca gaccctggca tgggatgggc tgggatcttc
     1561 tctgtgaatc cacccctggc tacccccacc ctggctaccc caacggcatc ccaaggccag
     1621 gtgggccctc agctgaggga aggtacgagc tccctgctgg agcctgggac ccatggcaca
     1681 ggccaggcag cccggaggct gggtggggcc tcagtggggg ctgctgcctg acccccagca
     1741 caataaaaat gaaacgtga
//
