LOCUS       NM_001178131            6262 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens epidermal growth factor (EGF), transcript variant 3,
            mRNA.
ACCESSION   NM_001178131
VERSION     NM_001178131.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6262)
  AUTHORS   Chatterjee,P., Ghosh,D., Chowdhury,S.R. and Roy,S.S.
  TITLE     ETS1 drives EGF-induced glycolytic shift and metastasis of
            epithelial ovarian cancer cells
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (8), 119805 (2024)
   PUBMED   39159682
  REMARK    GeneRIF: ETS1 drives EGF-induced glycolytic shift and metastasis of
            epithelial ovarian cancer cells.
REFERENCE   2  (bases 1 to 6262)
  AUTHORS   Hu,S., Yuan,Y., Yan,R., Xie,H., Cai,R. and Xu,J.
  TITLE     NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 708, 149798 (2024)
   PUBMED   38518721
  REMARK    GeneRIF: NRF2 regulates EGF stability through OTUD4 in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 6262)
  AUTHORS   Czerczak-Kwiatkowska,K., Kaminska,M., Fraczyk,J., Majsterek,I. and
            Kolesinska,B.
  TITLE     Searching for EGF Fragments Recreating the Outer Sphere of the
            Growth Factor Involved in Receptor Interactions
  JOURNAL   Int J Mol Sci 25 (3), 1470 (2024)
   PUBMED   38338748
  REMARK    GeneRIF: Searching for EGF Fragments Recreating the Outer Sphere of
            the Growth Factor Involved in Receptor Interactions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6262)
  AUTHORS   Hommel,U., Harvey,T.S., Driscoll,P.C. and Campbell,I.D.
  TITLE     Human epidermal growth factor. High resolution solution structure
            and comparison with human transforming growth factor alpha
  JOURNAL   J Mol Biol 227 (1), 271-282 (1992)
   PUBMED   1522591
REFERENCE   5  (bases 1 to 6262)
  AUTHORS   Hernandez-Sotomayor,S.M. and Carpenter,G.
  TITLE     Epidermal growth factor receptor: elements of intracellular
            communication
  JOURNAL   J Membr Biol 128 (2), 81-89 (1992)
   PUBMED   1501243
  REMARK    Review article
REFERENCE   6  (bases 1 to 6262)
  AUTHORS   Bell,G.I., Fong,N.M., Stempien,M.M., Wormsted,M.A., Caput,D.,
            Ku,L.L., Urdea,M.S., Rall,L.B. and Sanchez-Pescador,R.
  TITLE     Human epidermal growth factor precursor: cDNA sequence, expression
            in vitro and gene organization
  JOURNAL   Nucleic Acids Res 14 (21), 8427-8446 (1986)
   PUBMED   3491360
REFERENCE   7  (bases 1 to 6262)
  AUTHORS   Morton,C.C., Byers,M.G., Nakai,H., Bell,G.I. and Shows,T.B.
  TITLE     Human genes for insulin-like growth factors I and II and epidermal
            growth factor are located on 12q22----q24.1, 11p15, and
            4q25----q27, respectively
  JOURNAL   Cytogenet Cell Genet 41 (4), 245-249 (1986)
   PUBMED   3486749
REFERENCE   8  (bases 1 to 6262)
  AUTHORS   Brissenden,J.E., Ullrich,A. and Francke,U.
  TITLE     Human chromosomal mapping of genes for insulin-like growth factors
            I and II and epidermal growth factor
  JOURNAL   Nature 310 (5980), 781-784 (1984)
   PUBMED   6382023
REFERENCE   9  (bases 1 to 6262)
  AUTHORS   Smith,J., Cook,E., Fotheringham,I., Pheby,S., Derbyshire,R.,
            Eaton,M.A., Doel,M., Lilley,D.M., Pardon,J.F., Patel,T., Lewis,H.
            and Bell,L.D.
  TITLE     Chemical synthesis and cloning of a gene for human beta-urogastrone
  JOURNAL   Nucleic Acids Res 10 (15), 4467-4482 (1982)
   PUBMED   6290982
REFERENCE   10 (bases 1 to 6262)
  AUTHORS   Gregory,H. and Preston,B.M.
  TITLE     The primary structure of human urogastrone
  JOURNAL   Int J Pept Protein Res 9 (2), 107-118 (1977)
   PUBMED   300079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005509.1, AK299306.1,
            AC004050.1 and CA437074.1.
            
            On May 31, 2019 this sequence version replaced NM_001178131.2.
            
            Summary: This gene encodes a member of the epidermal growth factor
            superfamily. The encoded preproprotein is proteolytically processed
            to generate the 53-amino acid epidermal growth factor peptide. This
            protein acts a potent mitogenic factor that plays an important role
            in the growth, proliferation and differentiation of numerous cell
            types. This protein acts by binding with high affinity to the cell
            surface receptor, epidermal growth factor receptor. Defects in this
            gene are the cause of hypomagnesemia type 4. Dysregulation of this
            gene has been associated with the growth and progression of certain
            cancers. Alternative splicing results in multiple transcript
            variants, at least one of which encodes a preproprotein that is
            proteolytically processed. [provided by RefSeq, Jan 2016].
            
            Transcript Variant: This variant (3) lacks an in-frame exon in the
            coding region, compared to variant 1. The encoded isoform (3) is
            shorter than isoform 1. This isoform (3) may undergo proteolytic
            processing similar to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK299306.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC005509.1         64439-64439
            2-71                AK299306.1         3-72
            72-72               AC005509.1         64510-64510
            73-1356             AK299306.1         74-1357
            1357-1357           AC005509.1         96795-96795
            1358-2450           AK299306.1         1359-2451
            2451-2451           AC005509.1         131598-131598
            2452-3085           AK299306.1         2453-3086
            3086-3086           AC004050.1         122045-122045       c
            3087-4490           AK299306.1         3088-4491
            4491-4864           AC004050.1         102948-103321       c
            4865-5458           CA437074.1         18-611              c
            5459-6262           AC004050.1         101550-102353       c
FEATURES             Location/Qualifiers
     source          1..6262
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..6262
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /note="epidermal growth factor"
                     /db_xref="GeneID:1950"
                     /db_xref="HGNC:HGNC:3229"
                     /db_xref="MIM:131530"
     exon            1..580
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..3951
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; beta-urogastrone; pro-epidermal growth factor"
                     /codon_start=1
                     /product="pro-epidermal growth factor isoform 3 precursor"
                     /protein_id="NP_001171602.1"
                     /db_xref="CCDS:CCDS54795.1"
                     /db_xref="GeneID:1950"
                     /db_xref="HGNC:HGNC:3229"
                     /db_xref="MIM:131530"
                     /translation="MLLTLIILLPVVSKFSFVSLSAPQHWSCPEGTLAGNGNSTCVGP
                     APFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVF
                     LNGSRQERVCNIEKNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILLSALKYP
                     ANVAVDPVERFIFWSSEVAGSLYRADLDGVGVKALLETSEKITAVSLDVLDKRLFWIQ
                     YNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHT
                     GKDMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPDVNECAFWNHGCTLGCKNTPG
                     SYYCTCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGK
                     TCSGCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQPFLLFANSQD
                     IRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDGSQRERLI
                     EEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRGIAVHPM
                     AKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAKQSVI
                     EMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGS
                     MLKPSSLVVVHPLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLA
                     LDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEIMVSDQDDCAPVGC
                     SMYARCISEGEDATCQCLKGFAGDGKLCSDIDECEMGVPVCPPASSKCINTEGGYVCR
                     CSEGYQGDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTP
                     PPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQY
                     RDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYE
                     ESSRDVRSRRPADTEDGMSSCPQPWFVVIKEHQDLKNGGQPVAGEDGQAADGSMQPTS
                     WRQEPQLCGMGTEQGCWIPVSSDKGSCPQVMERSFHMPSYGTQTLEGGVEKPHSLLSA
                     NPLWQQRALDPPHQMELTQ"
     exon            581..780
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            781..962
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1190
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1393
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1516
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1639
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1765
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1902
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2051
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            2052..2156
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2380
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2548
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2698
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..2818
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            2819..2935
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3061
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3184
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3332
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            3333..3500
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            3501..3618
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3697
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..6262
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4740..4745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /note="hexamer: AATAAA"
     polyA_site      4762
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /note="major polyA site"
     regulatory      5439..5444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /note="hexamer: AATAAA"
     polyA_site      5458
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
     regulatory      6241..6246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
                     /note="hexamer: AATAAA"
     polyA_site      6262
                     /gene="EGF"
                     /gene_synonym="HOMG4; URG"
ORIGIN      
        1 caaaaagaga aactgttggg agaggaatcg tatctccata tttcttcttt cagccccaat
       61 ccaagggttg tagctggaac tttccatcag ttcttccttt ctttttcctc tctaagcctt
      121 tgccttgctc tgtcacagtg aagtcagcca gagcagggct gttaaactct gtgaaatttg
      181 tcataagggt gtcaggtatt tcttactggc ttccaaagaa acatagataa agaaatcttt
      241 cctgtggctt cccttggcag gctgcattca gaaggtctct cagttgaaga aagagcttgg
      301 aggacaacag cacaacagga gagtaaaaga tgccccaggg ctgaggcctc cgctcaggca
      361 gccgcatctg gggtcaatca tactcacctt gcccgggcca tgctccagca aaatcaagct
      421 gttttctttt gaaagttcaa actcatcaag attatgctgc tcactcttat cattctgttg
      481 ccagtagttt caaaatttag ttttgttagt ctctcagcac cgcagcactg gagctgtcct
      541 gaaggtactc tcgcaggaaa tgggaattct acttgtgtgg gtcctgcacc cttcttaatt
      601 ttctcccatg gaaatagtat ctttaggatt gacacagaag gaaccaatta tgagcaattg
      661 gtggtggatg ctggtgtctc agtgatcatg gattttcatt ataatgagaa aagaatctat
      721 tgggtggatt tagaaagaca acttttgcaa agagtttttc tgaatgggtc aaggcaagag
      781 agagtatgta atatagagaa aaatgtttct ggaatggcaa taaattggat aaatgaagaa
      841 gttatttggt caaatcaaca ggaaggaatc attacagtaa cagatatgaa aggaaataat
      901 tcccacattc ttttaagtgc tttaaaatat cctgcaaatg tagcagttga tccagtagaa
      961 aggtttatat tttggtcttc agaggtggct ggaagccttt atagagcaga tctcgatggt
     1021 gtgggagtga aggctctgtt ggagacatca gagaaaataa cagctgtgtc attggatgtg
     1081 cttgataagc ggctgttttg gattcagtac aacagagaag gaagcaattc tcttatttgc
     1141 tcctgtgatt atgatggagg ttctgtccac attagtaaac atccaacaca gcataatttg
     1201 tttgcaatgt ccctttttgg tgaccgtatc ttctattcaa catggaaaat gaagacaatt
     1261 tggatagcca acaaacacac tggaaaggac atggttagaa ttaacctcca ttcatcattt
     1321 gtaccacttg gtgaactgaa agtagtgcat ccacttgcac aacccaaggc agaagatgac
     1381 acttgggagc ctgatgttaa tgaatgtgct ttttggaatc atggctgtac tcttgggtgt
     1441 aaaaacaccc ctggatccta ttactgcacg tgccctgtag gatttgttct gcttcctgat
     1501 gggaaacgat gtcatcaact tgtttcctgt ccacgcaatg tgtctgaatg cagccatgac
     1561 tgtgttctga catcagaagg tcccttatgt ttctgtcctg aaggctcagt gcttgagaga
     1621 gatgggaaaa catgtagcgg ttgttcctca cccgataatg gtggatgtag ccagctctgc
     1681 gttcctctta gcccagtatc ctgggaatgt gattgctttc ctgggtatga cctacaactg
     1741 gatgaaaaaa gctgtgcagc ttcaggacca caaccatttt tgctgtttgc caattctcaa
     1801 gatattcgac acatgcattt tgatggaaca gactatggaa ctctgctcag ccagcagatg
     1861 ggaatggttt atgccctaga tcatgaccct gtggaaaata agatatactt tgcccataca
     1921 gccctgaagt ggatagagag agctaatatg gatggttccc agcgagaaag gcttattgag
     1981 gaaggagtag atgtgccaga aggtcttgct gtggactgga ttggccgtag attctattgg
     2041 acagacagag ggaaatctct gattggaagg agtgatttaa atgggaaacg ttccaaaata
     2101 atcactaagg agaacatctc tcaaccacga ggaattgctg ttcatccaat ggccaagaga
     2161 ttattctgga ctgatacagg gattaatcca cgaattgaaa gttcttccct ccaaggcctt
     2221 ggccgtctgg ttatagccag ctctgatcta atctggccca gtggaataac gattgacttc
     2281 ttaactgaca agttgtactg gtgcgatgcc aagcagtctg tgattgaaat ggccaatctg
     2341 gatggttcaa aacgccgaag acttacccag aatgatgtag gtcacccatt tgctgtagca
     2401 gtgtttgagg attatgtgtg gttctcagat tgggctatgc catcagtaat gagagtaaac
     2461 aagaggactg gcaaagatag agtacgtctc caaggcagca tgctgaagcc ctcatcactg
     2521 gttgtggttc atccattggc aaaaccagga gcagatccct gcttatatca aaacggaggc
     2581 tgtgaacata tttgcaaaaa gaggcttgga actgcttggt gttcgtgtcg tgaaggtttt
     2641 atgaaagcct cagatgggaa aacgtgtctg gctctggatg gtcatcagct gttggcaggt
     2701 ggtgaagttg atctaaagaa ccaagtaaca ccattggaca tcttgtccaa gactagagtg
     2761 tcagaagata acattacaga atctcaacac atgctagtgg ctgaaatcat ggtgtcagat
     2821 caagatgact gtgctcctgt gggatgcagc atgtatgctc ggtgtatttc agagggagag
     2881 gatgccacat gtcagtgttt gaaaggattt gctggggatg gaaaactatg ttctgatata
     2941 gatgaatgtg agatgggtgt cccagtgtgc ccccctgcct cctccaagtg catcaacacc
     3001 gaaggtggtt atgtctgccg gtgctcagaa ggctaccaag gagatgggat tcactgtctt
     3061 gatattgatg agtgccaact gggggagcac agctgtggag agaatgccag ctgcacaaat
     3121 acagagggag gctatacctg catgtgtgct ggacgcctgt ctgaaccagg actgatttgc
     3181 cctgactcta ctccaccccc tcacctcagg gaagatgacc accactattc cgtaagaaat
     3241 agtgactctg aatgtcccct gtcccacgat gggtactgcc tccatgatgg tgtgtgcatg
     3301 tatattgaag cattggacaa gtatgcatgc aactgtgttg ttggctacat cggggagcga
     3361 tgtcagtacc gagacctgaa gtggtgggaa ctgcgccacg ctggccacgg gcagcagcag
     3421 aaggtcatcg tggtggctgt ctgcgtggtg gtgcttgtca tgctgctcct cctgagcctg
     3481 tggggggccc actactacag gactcagaag ctgctatcga aaaacccaaa gaatccttat
     3541 gaggagtcga gcagagatgt gaggagtcgc aggcctgctg acactgagga tgggatgtcc
     3601 tcttgccctc aaccttggtt tgtggttata aaagaacacc aagacctcaa gaatgggggt
     3661 caaccagtgg ctggtgagga tggccaggca gcagatgggt caatgcaacc aacttcatgg
     3721 aggcaggagc cccagttatg tggaatgggc acagagcaag gctgctggat tccagtatcc
     3781 agtgataagg gctcctgtcc ccaggtaatg gagcgaagct ttcatatgcc ctcctatggg
     3841 acacagaccc ttgaaggggg tgtcgagaag ccccattctc tcctatcagc taacccatta
     3901 tggcaacaaa gggccctgga cccaccacac caaatggagc tgactcagtg aaaactggaa
     3961 ttaaaaggaa agtcaagaag aatgaactat gtcgatgcac agtatctttt ctttcaaaag
     4021 tagagcaaaa ctataggttt tggttccaca atctctacga ctaatcacct actcaatgcc
     4081 tggagacaga tacgtagttg tgcttttgtt tgctctttta agcagtctca ctgcagtctt
     4141 atttccaagt aagagtactg ggagaatcac taggtaactt attagaaacc caaattggga
     4201 caacagtgct ttgtaaattg tgttgtcttc agcagtcaat acaaatagat ttttgttttt
     4261 gttgttcctg cagccccaga agaaattagg ggttaaagca gacagtcaca ctggtttggt
     4321 cagttacaaa gtaatttctt tgatctggac agaacattta tatcagtttc atgaaatgat
     4381 tggaatatta caataccgtt aagatacagt gtaggcattt aactcctcat tggcgtggtc
     4441 catgctgatg attttgcaaa atgagttgtg atgaatcaat gaaaaatgta atttagaaac
     4501 tgatttcttc agaattagat ggcttatttt ttaaaatatt tgaatgaaaa cattttattt
     4561 ttaaaatatt acacaggagg cttcggagtt tcttagtcat tactgtcctt ttcccctaca
     4621 gaattttccc tcttggtgtg attgcacaga atttgtatgt attttcagtt acaagattgt
     4681 aagtaaattg cctgatttgt tttcattata gacaacgatg aatttcttct aattatttaa
     4741 ataaaatcac caaaaacata aacattttat tgtatgcctg attaagtagt taattatagt
     4801 ctaaggcagt actagagttg aaccaaaatg atttgtcaag cttgctgatg tttctgtttt
     4861 tcgttttttt tttttttccg gagagaggat aggatctcac tctgttatcc aggctggagt
     4921 gtgcaatggc acaatcatag ctcagtgcag cctcaaactc ctgggctcaa gcaatcctcc
     4981 tgcctcagcc tcccgagtaa ctaggaccac aggcacaggc caccatgcct ggctaaggtt
     5041 tttattttta ttttttgtag acatggggat cacacaatgt tgcccaggct ggtcttgaac
     5101 tcctggcctc aagcaaggtc gtgctggtaa ttttgcaaaa tgaattgtga ttgactttca
     5161 gcctcccaac gtattagatt ataggcatta gccatggtgc ccagccttgt aacttttaaa
     5221 aaaatttttt aatctacaac tctgtagatt aaaatttcac atggtgttct aattaaatat
     5281 ttttcttgca gccaagatat tgttactaca gataacacaa cctgatatgg taactttaaa
     5341 ttttgggggc tttgaatcat tcagtttatg cattaactag tccctttgtt tatctttcat
     5401 ttctcaaccc cttgtacttt ggtgatacca gacatcagaa taaaaagaaa ttgaagtacc
     5461 tgttttcaaa tggatacttt ataggaattt tggtaaagat ttggtgatgg gaggatgact
     5521 tgaggtttgt ggatattagt taattattca gtatgatacc tcacccagct aatttagatt
     5581 tttctatatt cggttttgct ttcattgaca atatcctgga ggatcagaag acttgtctat
     5641 ttctgctgag tcactggcct cagaaaaata ataaccataa tttcccccaa ggttttcttt
     5701 acctaagtgt gaatattttt tcttcctcca aaagctcact tttgggttta gattaaattt
     5761 ttgtatttta gcaccttttt cttttagggg ttcaatgatg acaaaagaaa tgacatgaga
     5821 acacggctac ccataacata ccattatctt tgtaccagaa aaatccttgt ttccttctta
     5881 atgactctgg taccttagaa actgggaccc tgctaagtcc ttgactaggc tatctaccag
     5941 ctcctggtcg gattaaagaa aaaacacact ttgtgttttt taatcaccaa ggcaccctgc
     6001 agagatatct tcttcttgca acttcacatc tttatcagta atgtcctctt tcctttaaaa
     6061 attcaagttt taagaacagc attttcatgt aaaaacttga tttgtgtttt ttccagactg
     6121 aatacttttc ctccctaact ctcatcgtct cattgcgcgc aacgcctgat tgagcttctg
     6181 tttgactaaa tatcacctac tatgtaaaaa atgagcatat tggcctcttt tctagcatct
     6241 aataaaggct taatacactg ta
//
