LOCUS       NM_014971               7486 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens EFR3 homolog B (EFR3B), transcript variant 1, mRNA.
ACCESSION   NM_014971 XM_001717587 XM_039733 XM_940464
VERSION     NM_014971.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7486)
  AUTHORS   Baskin,J.M., Wu,X., Christiano,R., Oh,M.S., Schauder,C.M.,
            Gazzerro,E., Messa,M., Baldassari,S., Assereto,S., Biancheri,R.,
            Zara,F., Minetti,C., Raimondi,A., Simons,M., Walther,T.C.,
            Reinisch,K.M. and De Camilli,P.
  TITLE     The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P
            synthesis at the plasma membrane
  JOURNAL   Nat Cell Biol 18 (1), 132-138 (2016)
   PUBMED   26571211
REFERENCE   2  (bases 1 to 7486)
  AUTHORS   Bojjireddy,N., Guzman-Hernandez,M.L., Reinhard,N.R., Jovic,M. and
            Balla,T.
  TITLE     EFR3s are palmitoylated plasma membrane proteins that control
            responsiveness to G-protein-coupled receptors
  JOURNAL   J Cell Sci 128 (1), 118-128 (2015)
   PUBMED   25380825
  REMARK    GeneRIF: These data suggest that mammalian Efr3s contribute to the
            control of the phosphorylation state and, hence, desensitization of
            AT1a receptors, and could affect responsiveness of
            G-protein-coupled receptors in higher eukaryotes.
REFERENCE   3  (bases 1 to 7486)
  AUTHORS   Graff,M., Ngwa,J.S., Workalemahu,T., Homuth,G., Schipf,S.,
            Teumer,A., Volzke,H., Wallaschofski,H., Abecasis,G.R., Edward,L.,
            Francesco,C., Sanna,S., Scheet,P., Schlessinger,D., Sidore,C.,
            Xiao,X., Wang,Z., Chanock,S.J., Jacobs,K.B., Hayes,R.B., Hu,F., Van
            Dam,R.M., Crout,R.J., Marazita,M.L., Shaffer,J.R., Atwood,L.D.,
            Fox,C.S., Heard-Costa,N.L., White,C., Choh,A.C., Czerwinski,S.A.,
            Demerath,E.W., Dyer,T.D., Towne,B., Amin,N., Oostra,B.A., Van
            Duijn,C.M., Zillikens,M.C., Esko,T., Nelis,M., Nikopensius,T.,
            Metspalu,A., Strachan,D.P., Monda,K., Qi,L., North,K.E.,
            Cupples,L.A., Gordon-Larsen,P. and Berndt,S.I.
  CONSRTM   GIANT Consortium
  TITLE     Genome-wide analysis of BMI in adolescents and young adults reveals
            additional insight into the effects of genetic loci over the life
            course
  JOURNAL   Hum Mol Genet 22 (17), 3597-3607 (2013)
   PUBMED   23669352
REFERENCE   4  (bases 1 to 7486)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
REFERENCE   5  (bases 1 to 7486)
  AUTHORS   Melen,E., Granell,R., Kogevinas,M., Strachan,D., Gonzalez,J.R.,
            Wjst,M., Jarvis,D., Ege,M., Braun-Fahrlander,C., Genuneit,J.,
            Horak,E., Bouzigon,E., Demenais,F., Kauffmann,F., Siroux,V.,
            Michel,S., von Berg,A., Heinzmann,A., Kabesch,M.,
            Probst-Hensch,N.M., Curjuric,I., Imboden,M., Rochat,T.,
            Henderson,J., Sterne,J.A., McArdle,W.L., Hui,J., James,A.L.,
            William Musk,A., Palmer,L.J., Becker,A., Kozyrskyj,A.L.,
            Chan-Young,M., Park,J.E., Leung,A., Daley,D., Freidin,M.B.,
            Deev,I.A., Ogorodova,L.M., Puzyrev,V.P., Celedon,J.C., Brehm,J.M.,
            Cloutier,M.M., Canino,G., Acosta-Perez,E., Soto-Quiros,M.,
            Avila,L., Bergstrom,A., Magnusson,J., Soderhall,C., Kull,I.,
            Scholtens,S., Marike Boezen,H., Koppelman,G.H., Wijga,A.H.,
            Marenholz,I., Esparza-Gordillo,J., Lau,S., Lee,Y.A., Standl,M.,
            Tiesler,C.M., Flexeder,C., Heinrich,J., Myers,R.A., Ober,C.,
            Nicolae,D.L., Farrall,M., Kumar,A., Moffatt,M.F., Cookson,W.O. and
            Lasky-Su,J.
  TITLE     Genome-wide association study of body mass index in 23 000
            individuals with and without asthma
  JOURNAL   Clin Exp Allergy 43 (4), 463-474 (2013)
   PUBMED   23517042
REFERENCE   6  (bases 1 to 7486)
  AUTHORS   Nakatsu,F., Baskin,J.M., Chung,J., Tanner,L.B., Shui,G., Lee,S.Y.,
            Pirruccello,M., Hao,M., Ingolia,N.T., Wenk,M.R. and De Camilli,P.
  TITLE     PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its
            impact on plasma membrane identity
  JOURNAL   J Cell Biol 199 (6), 1003-1016 (2012)
   PUBMED   23229899
REFERENCE   7  (bases 1 to 7486)
  AUTHORS   Bradfield,J.P., Qu,H.Q., Wang,K., Zhang,H., Sleiman,P.M., Kim,C.E.,
            Mentch,F.D., Qiu,H., Glessner,J.T., Thomas,K.A., Frackelton,E.C.,
            Chiavacci,R.M., Imielinski,M., Monos,D.S., Pandey,R., Bakay,M.,
            Grant,S.F., Polychronakos,C. and Hakonarson,H.
  TITLE     A genome-wide meta-analysis of six type 1 diabetes cohorts
            identifies multiple associated loci
  JOURNAL   PLoS Genet 7 (9), e1002293 (2011)
   PUBMED   21980299
REFERENCE   8  (bases 1 to 7486)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 7486)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 7486)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013267.11, DA241650.1, AK095190.1, BC049384.1, AC012457.7 and
            AF131834.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014971.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.2765685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403714.8/ ENSP00000384081.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AC013267.11        91176-91203
            29-398              DA241650.1         1-370
            399-1104            AK095190.1         359-1064
            1105-1751           BC049384.1         621-1267
            1752-2560           AK095190.1         1712-2520
            2561-2657           BC049384.1         2077-2173
            2658-5544           AC012457.7         35029-37915
            5545-7486           AF131834.1         1-1942
FEATURES             Location/Qualifiers
     source          1..7486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..7486
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /note="EFR3 homolog B"
                     /db_xref="GeneID:22979"
                     /db_xref="HGNC:HGNC:29155"
                     /db_xref="MIM:616797"
     exon            1..244
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..2691
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein EFR3 homolog B"
                     /codon_start=1
                     /product="protein EFR3 homolog B isoform 1"
                     /protein_id="NP_055786.1"
                     /db_xref="CCDS:CCDS46231.1"
                     /db_xref="GeneID:22979"
                     /db_xref="HGNC:HGNC:29155"
                     /db_xref="MIM:616797"
                     /translation="MYGVCGCCGALRPRYKRLVDNIFPEDPEDGLVKTNMEKLTFYAL
                     SAPEKLDRIGAYLSERLIRDVGRHRYGYVCIAMEALDQLLMACHCQSINLFVESFLKM
                     VAKLLESEKPNLQILGTNSFVKFANIEEDTPSYHRSYDFFVSRFSEMCHSSHDDLEIK
                     TKIRMSGIKGLQGVVRKTVNDELQANIWDPQHMDKIVPSLLFNLQHVEEAESRSPSPL
                     QAPEKEKESPAELAERCLRELLGRAAFGNIKNAIKPVLIHLDNHSLWEPKVFAIRCFK
                     IIMYSIQPQHSHLVIQQLLGHLDANSRSAATVRAGIVEVLSEAAVIAATGSVGPTVLE
                     MFNTLLRQLRLSIDYALTGSYDGAVSLGTKIIKEHEERMFQEAVIKTVGSFASTLPTY
                     QRSEVILFIMSKVPRPSLHQAVDTGRTGENRNRLTQIMLLKSLLQVSTGFQCNNMMSA
                     LPSNFLDRLLSTALMEDAEIRLFVLEILISFIDRHGNRHKFSTISTLSDISVLKLKVD
                     KCSRQDTVFMKKHSQQLYRHIYLSCKEETNVQKHYEALYGLLALISIELANEEVVVDL
                     IRLVLAVQDVAQVNEENLPVYNRCALYALGAAYLNLISQLTTVPAFCQHIHEVIETRK
                     KEAPYMLPEDVFVERPRLSQNLDGVVIELLFRQSKISEVLGGSGYNSDRLCLPYIPQL
                     TDEDRLSKRRSIGETISLQVEVESRNSPEKEERVPAEEITYETLKKAIVDSVAVEEQE
                     RERRRQVVEKFQKAPFEEIAAHCGARASLLQSKLNQIFEITIRPPPSPSGTITAAYGQ
                     PQNHSIPVYEMKFPDLCVY"
     exon            245..321
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            322..449
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            450..600
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            601..722
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            723..872
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1007
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1086
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1222
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1384
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1496
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1548
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1721
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1797
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1959
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2091
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2159
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2287
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2379
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2428
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2535
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            2536..2585
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     exon            2586..7486
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7464..7469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /note="hexamer: AATAAA"
     polyA_site      7486
                     /gene="EFR3B"
                     /gene_synonym="KIAA0953"
                     /note="major polyA site"
ORIGIN      
        1 agcagtgccc agcaacccga gcggaggcgg ccgctgcagc ccggcgctga atgggctggc
       61 ggcgcccggc tccgtcctgc ccgcggccgg cccccgcgtc tgctccctcc ccgcccgggc
      121 ccctgtcggc cgccgccagt ccccgccccg actgtgaatg aaaggcgggc gccgccgagg
      181 gctggctggg aacgccgcag cgacgccggc ctctcgagag gcgcgcgccc cgccgagatg
      241 tacggtgtgt gtggctgctg tggtgcccta cgccccaggt acaaaaggct ggttgacaac
      301 atcttccctg aggatcccga ggatggtctg gtgaagacca acatggagaa gctgaccttc
      361 tatgccctct cagctccaga aaaacttgat cgtattggcg cctacctctc tgagaggctc
      421 atccgtgacg tgggtcgcca tcgatatggg tacgtgtgca ttgctatgga ggctttggac
      481 cagctgctca tggcctgcca ctgccagagc atcaacctct tcgtggagag cttcctcaag
      541 atggtggcca agctgctgga gtcagagaaa cccaacctgc agatcctcgg caccaactcg
      601 tttgtgaagt ttgccaacat cgaggaggac accccgtcct atcaccggag ctatgacttc
      661 tttgtgtccc gattcagtga aatgtgccac tcgagccatg atgacttaga aatcaagacc
      721 aaaattcgaa tgtcaggcat caaaggcctg caaggggtgg tgaggaagac ggtgaatgat
      781 gaactgcagg ccaatatctg ggacccacag cacatggata agatcgttcc atcactgctt
      841 ttcaatctac agcatgtaga ggaggcagag agccggtctc cctcacccct ccaagcacct
      901 gagaaggaga aagagagccc cgcggagctg gctgagaggt gtcttcggga gctgctgggc
      961 cgggctgcct ttggcaacat caaaaacgcc atcaagcctg ttctcatcca tctggataac
     1021 cattctcttt gggaacccaa ggtgtttgcc atccgttgct ttaaaatcat catgtactca
     1081 attcagccgc agcactcaca cctggtcatc cagcagctcc tgggccacct ggacgccaac
     1141 agccgcagcg ctgcgacggt gcgcgcgggc atcgtggaag tcttgtcgga agccgcggtc
     1201 atcgctgcca ccggctctgt ggggcccaca gtactggaga tgttcaacac gctgctgagg
     1261 cagctgcggc tcagcatcga ctacgcgctg accgggagct acgacggggc ggtcagcctc
     1321 ggcaccaaga tcatcaagga gcacgaggag cgcatgttcc aggaggccgt catcaagacc
     1381 gtgggctcct ttgccagcac gctgcccacc taccagcgct ccgaggtgat cctcttcatc
     1441 atgagcaagg tcccgcggcc atccctgcac caggcggtgg acacaggcag gacgggggag
     1501 aataggaacc gtctgaccca gattatgctg ctaaaatccc tcctgcaggt atccacaggt
     1561 ttccagtgca acaacatgat gtcagccctg cctagcaact tcctggaccg ccttctctcc
     1621 accgccctca tggaggatgc agaaattcga ctctttgttc tagagattct catcagtttc
     1681 attgatcgtc atggcaaccg ccacaagttc tctaccatca gtaccctcag tgacatctct
     1741 gtcctgaagc tgaaagtgga caagtgctct cgacaggaca ccgtcttcat gaagaagcac
     1801 tcccagcagc tctacagaca catctacctg agctgcaagg aggaaacaaa cgtgcagaaa
     1861 cactacgagg cgctctatgg cttgctggcc ctcatcagca tcgagctggc taacgaggag
     1921 gtggtggtgg acctcatccg tctggtgctg gctgttcagg acgtggccca agtcaatgag
     1981 gagaacttgc ctgtctacaa ccgctgtgcc ctctatgctc tgggcgcagc ctacctgaac
     2041 ctcatcagtc agctcacaac agtgcctgcc ttctgccagc acatccatga ggtgatagag
     2101 accaggaaga aagaggctcc atacatgctc cccgaggatg tgtttgtgga gaggcccagg
     2161 ctgtctcaga atcttgatgg ggtggtcatt gagctcctct tccgccagag caagatcagt
     2221 gaagtcctgg gaggcagtgg ctacaactcg gaccggctct gcctgcccta cattcctcag
     2281 ctgacagatg aggatcgttt atccaagagg aggagcattg gagagaccat ctccctgcag
     2341 gtggaggtag aatcgaggaa cagtccggag aaggaggagc gagtgcctgc cgaggagatc
     2401 acctatgaga cactgaagaa agccattgtg gacagcgtag cagtggagga gcaggagcgt
     2461 gagcggcggc ggcaggtggt ggagaagttc cagaaggcac ccttcgagga gattgctgca
     2521 cactgcgggg cccgggcatc gctgctccag agcaaactca atcagatctt tgaaatcacc
     2581 atccggcccc caccaagccc atcaggaacc atcactgcag cctacggtca gccgcagaac
     2641 cactccatcc ccgtctatga aatgaagttt cccgatctgt gtgtatactg aattccaaga
     2701 gcctgagctc ctcaaggaga tggggtctga ggaggggctc acctcacgcc caccccgacc
     2761 acatggagat ctggctgtga tctctgagaa aacatcacct tagatggcag cgcctcccag
     2821 gctaagccaa ggtggagact ctctggtcct tcttggccct cctacctcct cctcgtcttc
     2881 cctgagggag gtctcaccaa tcagcatctc acctgtgccc tctttgtctt ctcttgtgtc
     2941 agccaggggc agagaatcat ggggtgtctc tcaggagaag ccggggggag ggggctgaga
     3001 agctcctact tggtgttttg agtgaagggc atgtcctccc cagaggacgg agctggatgg
     3061 agacttggtt ggtgagagga agctaaggac tctactcccc tggggaagga agctgagatg
     3121 gggatggctc tctcctcccc agcactcccc ctgctccccg cccatgtccc tgctgtgtct
     3181 ctcactctct tgctcatctc ccagttgtct gttcatgttt ctttctacta ttaatgaatg
     3241 ctgagccctt ataacaggag ctggggtgga gacatcacga ggggtcgggg gacagcaaag
     3301 ggcaggaagc aggatgcagg gctggcagga ggtgggcctg tggcatcagc aggcccagcg
     3361 ggcgagtgtg gtccctgcag cagcttccca cctcctttgt tcataaggag cttgtgttgg
     3421 cctcccacag tcctgtctgc tggacgtttt tcagagttgg gttctctctc tttgatgtct
     3481 ttcttctgag ggtcccaagg tgttcctgga gcttctgggt tgaggaaagg cagagcaaga
     3541 taatcttgga ggggaactac agggtcccca agatttgccc acatcacctc ctatggaaaa
     3601 ggctcccagc ctgacctggg ttgtaggaga gtggggaggg tgggatgagt ggtgttttgg
     3661 ggctcaagga tatcagaagc caactttttg gatgttccgt ttgaagaaag aaggatctaa
     3721 cacctaatat tggaatgatt tcttcactct ctggacaaag tctgggacat cagcaccacc
     3781 tggcaacgct tgtggcttgg gaggagccat ggagacccct ttgggttctg ggttcctgtt
     3841 ttcctggtgt gccgtctgtg tctctgtgta atgaggatgt gcagagagga gctaacgcgg
     3901 agccgggcag agccacccag gaggcagttt gttgccttct ttgccaattc cccttcccgg
     3961 cccctcctcc aggtgccttt gtgtctcccg gggtgccact gacagaacct cacctggggc
     4021 tcctcccatg gcagtgccat gtggtccaaa attgcccttt ccttctccgt tagtcacatt
     4081 tcccataact cctccgagcc aacataacct acagtaagat gtgagtgtca gacgttctct
     4141 ccctggagtc tgctttccaa aggaggcagg gtgagtagat ttcttgatcc aaaggaatcc
     4201 gtttttaatt tttttttttt tctagagatg ggggtctcac tatgttgccc aggctggcct
     4261 cgaactcctg agtttaagtg attctcccac ctcagcctcc tgagtagctg agaatccctt
     4321 tttagggtac aatttcaggc agtgtggcat ggagtcagaa gcaggctgtt tctcctcagg
     4381 ggagggcagg cttctcagga cggcctcagc tcatagcccc acgtgtggtg tgcacggatg
     4441 tgcagggaga gcctgattgt taggtggatg tattttccag aatcggggag ggactgaaca
     4501 cgagcatttc ccattaatat gtgcaataaa tgtcttgggg aaggggctat ttgaccctca
     4561 ttcccatagt tttggcactt caaatgaagc tcttccttgt ggtcaccatc tctgctgtgg
     4621 gcacacagct tctttttctt gttttttttt tttttttttt ttttttgaga caccgtctcg
     4681 ctctgtcacc caggctggag tacaatggtg tgacctcaac tcactgtgac ttccgcctcc
     4741 tgggttcaag tgattctcct gcctcagcct cctgagtagc tgggattaca ggcgtgcacc
     4801 accacgcctg gcgaattttg tgtttttagt agacatgagg tttcaccgtg ttggccaggc
     4861 tggtctggaa ctcctgatct caagtgatcc gcccgcctca gcctctcaaa gtgctgggat
     4921 tacaggcgtg agccactgcg cctgcttggc acgtggcttc tgaatggcct gagtgagggc
     4981 agggcccagg catggaggct cctgcacccc caaggctttt tggctgtgct ttatggcctc
     5041 tggcttatac tcaacccaat tttacaagca tgaacttaga cttctcttta gtatttatat
     5101 atttaaaaac caagtttaaa ttaactcaaa cttgacagca actaacctct gaaagaaact
     5161 ttaaagaaaa ttgaaatctt gagccacaaa catgttcttt cctcactagc tcctcccagg
     5221 ttttatcctg cacccagctt ggatgagaga cccactgttt cttgtgccta cttaacatta
     5281 gggttccccg tggcagcttc atcctgagca ctgcctgtga gccctggttc tgggacttgg
     5341 cagtcgcctc cctggagcat ctttccagag ccagcattag aacctgagat ccccagatgt
     5401 ttctgcccct catccccatc ctgtgaatag agagacagaa aaggtgcagg ttcccattct
     5461 gcatagattc tgctgtttcc tctccaccgg tcccaggcag cttttccttt ccatcactgc
     5521 cgcttagcaa aaatgtgctt cttttgaaga actggtcatt ttttttgagt gccctcttct
     5581 cagttttgtt taaacttaca ctcagtagag tgttgggttg tctgctgaca tggagtagaa
     5641 cctggattct ggccaaatag gccagaatcg gaaaggtgaa ggtgagtgtg atagtaggta
     5701 atctcctcac cccagcacag gccctgggag agaggcaaag cagtttgatg ggatctggag
     5761 gggagggagg taccctggcc cttggtctag catcagtgag tcctgccctt ccaagcccct
     5821 ggaggctagt ggcattgcat tgtgcccctt tttgccaccc ttctctgatg tgattttgag
     5881 cgaagaggag tcagtaagcc cattgagacc ggctgctccc aaagcccgag gactctagct
     5941 gtgtggggaa gggctagcat tggtcaggac tctgctgaca gcactgagta ggcaggaatg
     6001 tatttgagat ttggaagtac tgttaatttg gtggagtcag gtgaatggat aagaggcaga
     6061 tcggcagaaa gcatcagtgt ggtcccgagg ctccctctgt tttccttgcc atggagtccc
     6121 cagcgccttg tgcctgtttc catttccctc tctctttgaa aagtagaaat cagtggtttc
     6181 ttgactccta aacagcctcc tcactataga aggagcctga gcaggtcaga agaactagaa
     6241 aagtcctcag atacccccct ctgtccagcc ccctttccca tacacagata tcaatggatg
     6301 agcaggaaaa gaggaggcct ggactcactg aagtacttga agaagcacaa gtgtcataga
     6361 tgtgccgccc tttgccctgg gtgttctaga tcacacagaa cacgtttcag ctggactaag
     6421 aatcagacta gccaggggtt cttctgaaca gctcaggcca gacctctggg ctcctctggg
     6481 ggccctggga catgatgcct tgcagtttcc attccattgt ccccaggcct cctgacctgg
     6541 tgacagagag tgccctgcag aagtgagtct atttttccca attcctcttc atgaccagaa
     6601 aatggcagct ggccggttgg ggtcctgtgg gaaagggcta acctgggctg ttaggtagac
     6661 actaggttta aaggtagaca gggagatggc atcatcaggg caggccaggc ccacttcctg
     6721 tgaccccaga ccttggcagg cgggtcgtgc tgaaaccagg catctccctc acacctgggg
     6781 aaaggtttag ggcaacatgt tgcctcttca tcccattaac cctagaaatc ttctggttag
     6841 agtggcccct taccccaaat ctggcctagg tctgaagact gcaggatagt catgatgggc
     6901 ccatcctaga gcctggctag ctggaagacg cggtatggca gggacaggag ggcggcagga
     6961 agggctttgt ggccctgctg gggccaaagg cagttttctg tgctcccttt agccccagcc
     7021 tggctggcca ggtctcctgt acttcagggg accatggggc cgcccaagcc agtcaccttc
     7081 cccttccaag ctctcccccc atgactgttg atttctggcg cgtggaggca gagttgtgaa
     7141 tccacaaatg ctgtagccca tatctcgtaa tgtgtctgtg tccacttaga gcctcacgac
     7201 ctggctgtgt gtgtgcatgt gtgtgtagta tagtttgtag ttgacaatat gtgtatataa
     7261 tagctggtgt atttatatgt gagtgcagaa ttagtgcccg tggcggtttt ctgtatttta
     7321 aacccattga attggttagt tttattttag ggaagtggga aaggcggagt ggggggaagt
     7381 ataggaagaa ggattcttag caaaatcatt ctctaggact attagtcgcg atctcccagt
     7441 gagccatcac gatgcccttt tcaaataaat gttaatgttg tcacca
//
