LOCUS       NM_015137               5433 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens EFR3 homolog A (EFR3A), transcript variant 1, mRNA.
ACCESSION   NM_015137 XM_035825
VERSION     NM_015137.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5433)
  AUTHORS   Jiang,P. and Xia,B.
  TITLE     Circular RNA EFR3A promotes nasopharyngeal carcinoma progression
            through modulating the miR-654-3p/EFR3A axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (12), 111-117 (2023)
   PUBMED   38063110
  REMARK    GeneRIF: Circular RNA EFR3A promotes nasopharyngeal carcinoma
            progression through modulating the miR-654-3p/EFR3A axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5433)
  AUTHORS   Trybus,M., Hryniewicz-Jankowska,A., Wojtowicz,K., Trombik,T.,
            Czogalla,A. and Sikorski,A.F.
  TITLE     EFR3A: a new raft domain organizing protein?
  JOURNAL   Cell Mol Biol Lett 28 (1), 86 (2023)
   PUBMED   37880612
  REMARK    GeneRIF: EFR3A: a new raft domain organizing protein?
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5433)
  AUTHORS   Adhikari,H., Kattan,W.E., Kumar,S., Zhou,P., Hancock,J.F. and
            Counter,C.M.
  TITLE     Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for
            potent tumorigenic activity
  JOURNAL   Nat Commun 12 (1), 5248 (2021)
   PUBMED   34504076
  REMARK    GeneRIF: Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling
            axis for potent tumorigenic activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5433)
  AUTHORS   Baskin,J.M., Wu,X., Christiano,R., Oh,M.S., Schauder,C.M.,
            Gazzerro,E., Messa,M., Baldassari,S., Assereto,S., Biancheri,R.,
            Zara,F., Minetti,C., Raimondi,A., Simons,M., Walther,T.C.,
            Reinisch,K.M. and De Camilli,P.
  TITLE     The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P
            synthesis at the plasma membrane
  JOURNAL   Nat Cell Biol 18 (1), 132-138 (2016)
   PUBMED   26571211
REFERENCE   5  (bases 1 to 5433)
  AUTHORS   Bojjireddy,N., Guzman-Hernandez,M.L., Reinhard,N.R., Jovic,M. and
            Balla,T.
  TITLE     EFR3s are palmitoylated plasma membrane proteins that control
            responsiveness to G-protein-coupled receptors
  JOURNAL   J Cell Sci 128 (1), 118-128 (2015)
   PUBMED   25380825
  REMARK    GeneRIF: These data suggest that mammalian Efr3s contribute to the
            control of the phosphorylation state and, hence, desensitization of
            AT1a receptors, and could affect responsiveness of
            G-protein-coupled receptors in higher eukaryotes.
REFERENCE   6  (bases 1 to 5433)
  AUTHORS   Gupta,A.R., Pirruccello,M., Cheng,F., Kang,H.J., Fernandez,T.V.,
            Baskin,J.M., Choi,M., Liu,L., Ercan-Sencicek,A.G., Murdoch,J.D.,
            Klei,L., Neale,B.M., Franjic,D., Daly,M.J., Lifton,R.P., De
            Camilli,P., Zhao,H., Sestan,N. and State,M.W.
  TITLE     Rare deleterious mutations of the gene EFR3A in autism spectrum
            disorders
  JOURNAL   Mol Autism 5, 31 (2014)
   PUBMED   24860643
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5433)
  AUTHORS   Martinelli-Boneschi,F., Giacalone,G., Magnani,G., Biella,G.,
            Coppi,E., Santangelo,R., Brambilla,P., Esposito,F., Lupoli,S.,
            Clerici,F., Benussi,L., Ghidoni,R., Galimberti,D., Squitti,R.,
            Confaloni,A., Bruno,G., Pichler,S., Mayhaus,M., Riemenschneider,M.,
            Mariani,C., Comi,G., Scarpini,E., Binetti,G., Forloni,G.,
            Franceschi,M. and Albani,D.
  TITLE     Pharmacogenomics in Alzheimer's disease: a genome-wide association
            study of response to cholinesterase inhibitors
  JOURNAL   Neurobiol Aging 34 (6), 1711 (2013)
   PUBMED   23374588
REFERENCE   8  (bases 1 to 5433)
  AUTHORS   Nakatsu,F., Baskin,J.M., Chung,J., Tanner,L.B., Shui,G., Lee,S.Y.,
            Pirruccello,M., Hao,M., Ingolia,N.T., Wenk,M.R. and De Camilli,P.
  TITLE     PtdIns4P synthesis by PI4KIIIalpha at the plasma membrane and its
            impact on plasma membrane identity
  JOURNAL   J Cell Biol 199 (6), 1003-1016 (2012)
   PUBMED   23229899
REFERENCE   9  (bases 1 to 5433)
  AUTHORS   Munemoto,Y., Houtani,T., Kase,M., Sakuma,S., Baba,K., Yamashita,T.
            and Sugimoto,T.
  TITLE     Mouse homolog of KIAA0143 protein: hearing deficit induces specific
            changes of expression in auditory brainstem neurons
  JOURNAL   Brain Res Mol Brain Res 128 (2), 131-140 (2004)
   PUBMED   15363888
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY095205.1, BC071611.1,
            BC152442.1, CX165980.1, BQ424552.1, CA775398.1 and BU632041.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015137.5.
            
            Summary: The protein encoded by this gene is part of a complex that
            plays a role in maintaining an active pool of phosphatidylinositol
            4-kinase (PI4K) at the plasma membrane. This protein is thought to
            be a peripheral membrane protein that associates with the plasma
            membrane through palmitoylation. Studies indicate that this gene
            product plays a role in controlling G protein-coupled receptor
            (GPCR) activity by affecting receptor phosphorylation. Whole exome
            sequencing studies have implicated mutations in this gene with
            autism spectrum disorders. [provided by RefSeq, Apr 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.168880.1,
                                           SRR1660805.65763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254624.10/ ENSP00000254624.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               HY095205.1         2-120
            120-1312            BC071611.1         102-1294
            1313-2706           BC152442.1         1286-2679
            2707-2937           CX165980.1         574-804
            2938-3138           BC152442.1         2911-3111
            3139-3139           BQ424552.1         643-643
            3140-4381           BC152442.1         3113-4354
            4382-4810           CA775398.1         257-685
            4811-5318           BC152442.1         4784-5291
            5319-5433           BU632041.1         14-128              c
FEATURES             Location/Qualifiers
     source          1..5433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.22"
     gene            1..5433
                     /gene="EFR3A"
                     /note="EFR3 homolog A"
                     /db_xref="GeneID:23167"
                     /db_xref="HGNC:HGNC:28970"
                     /db_xref="MIM:611798"
     exon            1..230
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..2686
                     /gene="EFR3A"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="protein EFR3 homolog A isoform 1"
                     /protein_id="NP_055952.2"
                     /db_xref="CCDS:CCDS34942.2"
                     /db_xref="GeneID:23167"
                     /db_xref="HGNC:HGNC:28970"
                     /db_xref="MIM:611798"
                     /translation="MPTRVCCCCSALRPRYKRLVDNIFPEDPKDGLVKTDMEKLTFYA
                     VSAPEKLDRIGSYLAERLSRDVVRHRSGYVLIAMEALDQLLMACHSQSIKPFVESFLH
                     MVAKLLESGEPKLQVLGTNSFVKFANIEEDTPSYHRRYDFFVSRFSAMCHSCHSDPEI
                     RTEIRIAGIRGIQGVVRKTVNDELRATIWEPQHMDKIVPSLLFNMQKIEEVDSRIGPP
                     SSPSATDKEENPAVLAENCFRELLGRATFGNMNNAVRPVFAHLDHHKLWDPNEFAVHC
                     FKIIMYSIQAQYSHHVIQEILGHLDARKKDAPRVRAGIIQVLLEAVAIAAKGSIGPTV
                     LEVFNTLLKHLRLSVEFEANDLQGGSVGSVNLNTSSKDNDEKIVQNAIIQTIGFFGSN
                     LPDYQRSEIMMFIMGKVPVFGTSTHTLDISQLGDLGTRRIQIMLLRSLLMVTSGYKAK
                     TIVTALPGSFLDPLLSPSLMEDYELRQLVLEVMHNLMDRHDNRAKLRGIRIIPDVADL
                     KIKREKICRQDTSFMKKNGQQLYRHIYLGCKEEDNVQKNYELLYTSLALITIELANEE
                     VVIDLIRLAIALQDSAIINEDNLPMFHRCGIMALVAAYLNFVSQMIAVPAFCQHVSKV
                     IEIRTMEAPYFLPEHIFRDKCMLPKSLEKHEKDLYFLTNKIAESLGGSGYSVERLSVP
                     YVPQVTDEDRLSRRKSIVDTVSIQVDILSNNVPSDDVVSNTEEITFEALKKAIDTSGM
                     EEQEKEKRRLVIEKFQKAPFEEIAAQCESKANLLHDRLAQILELTIRPPPSPSGTLTI
                     TSGHAQYQSVPVYEMKFPDLCVY"
     exon            231..307
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            308..435
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            436..586
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            587..708
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            709..858
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            859..996
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1075
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1211
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1379
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1494
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1546
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1719
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1795
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1957
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2089
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2157
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2285
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2286..2377
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2426
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2530
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2580
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     exon            2581..5433
                     /gene="EFR3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5291..5296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFR3A"
                     /note="hexamer: AATAAA"
     polyA_site      5318
                     /gene="EFR3A"
                     /note="major polyA site"
     regulatory      5344..5349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFR3A"
                     /note="hexamer: AATAAA"
     polyA_site      5365
                     /gene="EFR3A"
     regulatory      5400..5405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFR3A"
                     /note="hexamer: ATTAAA"
     polyA_site      5433
                     /gene="EFR3A"
ORIGIN      
        1 gtccgtcgcg ccgcccggcg aggagtgggc tggcggcggt agctgtcgcc cgcttggttg
       61 cgtgaccgcg gggtccgcgt ccgctccctc cacccttcgc ccttcgccct tcgcctcgtt
      121 ccggcctccg cggcccagca acggccgtca tggtgccgtc ggcgctccct gcgcggcccc
      181 gctgagcctc ggtgcggcgg cgagcgcggt cgagatcgcc atgcctaccc gagtatgctg
      241 ctgctgttcc gctttgcgtc ctcgctacaa acgcctggtg gacaacatat tccctgaaga
      301 tccaaaagat ggccttgtga aaactgatat ggagaaattg acattttatg cagtatctgc
      361 tccagagaaa ctggatcgaa ttggttctta cctggcagaa aggttgagca gggatgttgt
      421 cagacatcgt tctgggtatg ttttgattgc tatggaggca ctggaccaac ttctcatggc
      481 ttgccattct caaagcatta agccatttgt agaaagcttt cttcatatgg tggcaaagct
      541 gctggaatcg ggggaaccaa agcttcaagt tcttggaaca aattcttttg tcaaatttgc
      601 aaatattgaa gaagacacac catcctatca cagacgttat gacttttttg tgtctcgatt
      661 cagtgccatg tgccattcct gtcatagtga tccagaaata cgaacagaga tacgaattgc
      721 tggaattaga ggtattcaag gtgtggttcg caaaacagtc aacgatgaac ttcgggccac
      781 catttgggaa cctcagcata tggataagat tgttccatcc ctcctgttta acatgcaaaa
      841 gatagaagaa gttgacagtc gcataggccc tccttcttct ccttctgcaa ctgacaaaga
      901 agagaatcct gctgtgctgg ctgaaaactg tttcagagaa ctgctgggtc gagcaacttt
      961 tgggaatatg aataatgctg ttagaccagt ttttgcgcat ttagatcatc acaaactgtg
     1021 ggatcccaat gaatttgcag ttcactgctt taaaattata atgtattcca ttcaggctca
     1081 gtattctcac catgtgatcc aggagattct aggacacctt gatgctcgta aaaaagatgc
     1141 tccccgggtt cgagcaggta ttattcaggt tctgttagag gctgttgcca ttgctgctaa
     1201 aggttccata ggtccgacag tgctggaagt cttcaatacc cttttgaaac atctgcgtct
     1261 cagcgttgaa ttcgaagcaa atgatttaca ggggggatct gtaggcagtg tcaacttaaa
     1321 tacaagttcc aaagacaatg atgagaagat tgtgcagaat gctatcatcc aaacaatagg
     1381 attttttgga agtaacctac cagattatca gaggtcagaa atcatgatgt tcattatggg
     1441 gaaagtacct gtctttggaa catctaccca tactttggat atcagtcaac taggggattt
     1501 gggaaccagg agaattcaga taatgttgct gagatctttg cttatggtga cctctggata
     1561 taaagcgaag acgattgtta ctgcactgcc agggtctttc ctggatcctt tgttatcacc
     1621 atctctcatg gaggactacg aactgagaca gttggtcttg gaagtaatgc ataatctcat
     1681 ggatcgtcat gacaataggg caaagcttcg agggatcaga ataataccgg atgtagctga
     1741 cctaaagata aaaagagaaa aaatttgcag acaagacaca agtttcatga aaaagaatgg
     1801 gcaacagctg tatcggcaca tatatttggg ttgtaaagag gaagacaacg ttcagaaaaa
     1861 ctatgaacta ctttatactt ctcttgctct tataactatt gaactggcta atgaagaagt
     1921 agttattgat ctcattcgac tggccattgc tttacaggac agtgcaatta tcaatgagga
     1981 taatttgcca atgttccatc gttgtggaat catggcactg gttgcagcat acctcaactt
     2041 tgtaagtcag atgatagctg tccctgcatt ttgccagcat gttagcaagg ttattgaaat
     2101 tcgaactatg gaagcccctt attttctacc agagcatatc ttcagagata agtgcatgct
     2161 tccaaaatct ttagagaagc atgaaaaaga tttgtacttt ctgaccaaca agattgcaga
     2221 gtcgctaggt ggaagtggat atagtgttga gagattgtca gttccgtatg taccacaagt
     2281 aacagatgaa gatcgacttt ctagaagaaa aagcattgtg gacaccgtat ccattcaggt
     2341 ggatatttta tccaacaatg ttccttctga tgatgtggtt agtaacactg aagaaatcac
     2401 ttttgaagca ttgaagaaag caattgatac cagtggaatg gaagaacagg aaaaggaaaa
     2461 gaggcgtctt gtgatagaga aatttcagaa agcacctttt gaagaaatag cagcacagtg
     2521 tgaatccaaa gcaaatttgc ttcatgatag acttgcccaa atattggaac tcaccatacg
     2581 tcctcctccc agtccatcag gaacactgac cattacttct gggcatgccc aataccaatc
     2641 tgtcccagtc tatgagatga agtttccaga tctgtgtgtg tactgatcgg cgcatgaaga
     2701 cctcaggata tgatttgtaa agcctaaaaa ttaaggccaa gctgagcttt cagggtttac
     2761 ttaatgtgta ttaacatact tcttgaaaat aatgatggaa catatcttta accaaatgtt
     2821 tggcatacca tattagaagt tttggagcta tatataattt cgagtacttt caaagataga
     2881 tttatgccat gttaatttgc tttgaggttc ctgttgcctt tttaagttga acatgttttg
     2941 gtttcacttt attccactgt taagtagtat gttttaaact tttcacaaat gtaatgtttt
     3001 ttaaaaagta agccttcaga ggattgaaac tgtataaatt gtttatctct taaacatcta
     3061 cacagccgct tagatgtaga atttttgttg ttgttttctg caaaggcaga tacatttaaa
     3121 tatattccta gtcctgggac tgcaaaactg ttcggtggct ttttgtcccc atgctttaga
     3181 taagctggga taggcacctt gctattcagt tactataata atatgtgata ggcattcctc
     3241 atcttcttca caataatagg acatctgttg aatagcattc ctcgaatata accctaaaaa
     3301 cgccatactt taaattgtct ggttcttgta atattgtgtt tcctgccaag agtttgacca
     3361 ttctgcttga gaagtgtaga gcttactctt ggagtaccaa actgtgcaat atttttacat
     3421 cataagatgt attagtttac aggctgtgct ttgaaattat agtagtattt tgctgtggct
     3481 ccattaatta aatgagatat atatttagtg cagaaaaaag acatttaaaa cagctattag
     3541 ttcacctgtg aagagtctgt acattttgat ttctattaag agcacattta tttacatttg
     3601 tatattattt taaatcctca tagtcaaaaa attctccaga tggactttta atttgtaaga
     3661 tttgaactgt gacttgtata catctgttta gaatcaatta tatttgaaaa gctgcctgtg
     3721 ttttaacagt caagtgtgct aaagtttgtc aatttaagct gcttttgatt tcagctacca
     3781 agatcacagg tgcactctac acataacact gacagaccca taacattaca tacatcttag
     3841 tgaattctat cacatggtaa aatgaacagc tttctttgta actcataaaa ttctcttagg
     3901 acatttttat aaagtcacct gtttatagtt ctatcttttc agattccatt tctttttaca
     3961 taaaacagca tacatatcaa aaactgtagc ctagaataca gtttaatttt tggcttttgt
     4021 ttttgtttaa aaaattgcag tgaagaatgg gatgtttgtg tttatggcta tttgggcacc
     4081 tttagtagaa acagacaaaa gtaaggaaac gataatagga caagcatact tgaaaatttc
     4141 tgaatactta aacaaaagcg caacatcttg aaaaccagtc tagtcattga aacctatgaa
     4201 atgacactga aagatcctgg gctgcttctt aaataagtag atcagcaaga cttgtttcag
     4261 agtgacagtg gagtcgttac cgctggagga ctaaagggcc ctgtggcagc tgtcactgga
     4321 actttgcctc ttgatcagga aaaatgcttc accagtccgt aaagccaagt tgtatttttt
     4381 taattgccct tttttccttc tgtattttta aagaaggatg ttaatttttg actatatatt
     4441 ttaaaaaaat ctaagcaggg ggacatgcaa aaacaatcat catccacttg gatgtcattt
     4501 tatagattaa cactgtgtgc ttttgtatgg aaaaaatata tataatttaa tagtataaaa
     4561 aataaaatat atattcattt gcacttacgt gaaacacaaa ctttgctcta caaaatttcg
     4621 tgtttcttag tgattttaaa atgcatgtat tgcatgtaaa ggaaaaccat tacaattaat
     4681 gtttatcaca cctttatctt ggtctttgtt gatttgggtt ttgttggggt ttttgttact
     4741 gtttttaaat tacagtaggc ttctatatat cctggatttc tgaactggtc ttgttgacaa
     4801 ggattcccaa gaaatggatc ttttcactgg ctgactctcc catatctgca agagattctg
     4861 caggaactgg gtgtgcacac ggtgttgtag ccagttcagg tactgaatat ttaggatttg
     4921 gtgaagttca ctgtattgct atatttttgt agataaataa aactcaataa attgttaatc
     4981 attctctttt tgctgtatag aattgcttat atcactcttt ctttcatgac attggttaac
     5041 atttaaatgt tcctcctgta cttgtgttgt ctgtgaccgc ttatagagtt ttattgttat
     5101 tggtgtttac ctgaatacct atgcgtacac acacacatat ttccttaata cttctgaact
     5161 cattatcttt tagaataata atactactac actttaccag caattaactt ctccctaccc
     5221 aaaatgtttt tcttcctgtc tgaaaatgga actaatttgt cttattcgtg cttatatctg
     5281 tattaaatgc aataaagtta gtttttgaaa tgtaaaaatt cactgtgcaa ttcatatgtc
     5341 agcaataaaa catagattat ttgtatataa gttcattttt atagctattg ttacatttaa
     5401 ttaaatttat tcaatatttg cttaaattaa aaa
//
