LOCUS       NM_001406               3216 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens ephrin B3 (EFNB3), mRNA.
ACCESSION   NM_001406
VERSION     NM_001406.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3216)
  AUTHORS   Qiao,Z., Liao,M., Xiao,M., Luo,S., Wang,K., Niu,M., Jiang,H.,
            Sun,S., Xu,G., Xu,N., Xu,Q. and Liu,Y.
  TITLE     Ephrin B3 exacerbates colitis and colitis-associated colorectal
            cancer
  JOURNAL   Biochem Pharmacol 220, 116004 (2024)
   PUBMED   38142837
  REMARK    GeneRIF: Ephrin B3 exacerbates colitis and colitis-associated
            colorectal cancer.
REFERENCE   2  (bases 1 to 3216)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3216)
  AUTHORS   Garcia-Diaz,B., Bachelin,C., Coulpier,F., Gerschenfeld,G.,
            Deboux,C., Zujovic,V., Charnay,P., Topilko,P. and Baron-Van
            Evercooren,A.
  TITLE     Blood vessels guide Schwann cell migration in the adult
            demyelinated CNS through Eph/ephrin signaling
  JOURNAL   Acta Neuropathol 138 (3), 457-476 (2019)
   PUBMED   31011859
  REMARK    GeneRIF: Blood vessels guide Schwann cell migration in the adult
            demyelinated CNS through Eph/ephrin signaling.
REFERENCE   4  (bases 1 to 3216)
  AUTHORS   Wu,T., Zhang,B.Q., Raelson,J., Yao,Y.M., Wu,H.D., Xu,Z.X.,
            Marois-Blanchet,F.C., Tahir,M.R., Wang,Y., Bradley,W.E., Luo,H.,
            Wu,J., Sheng,J.Z. and Hu,S.J.
  TITLE     Analysis of the association of EPHB6, EFNB1 and EFNB3 variants with
            hypertension risks in males with hypogonadism
  JOURNAL   Sci Rep 8 (1), 14497 (2018)
   PUBMED   30262919
  REMARK    GeneRIF: Analysis of the association of EPHB6, EFNB1 and EFNB3
            variants with hypertension risks in males with hypogonadism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3216)
  AUTHORS   Prydz,K., Halstensen,T.S., Holen,H.L. and Aasheim,H.C.
  TITLE     Ephrin-B3 binds both cell-associated and secreted proteoglycans
  JOURNAL   Biochem Biophys Res Commun 503 (4), 2212-2217 (2018)
   PUBMED   29953858
  REMARK    GeneRIF: identified secretory and cell associated proteoglycans
            with high ability to bind ephrin-B3 and suggest that ephrin-B3 can
            bind to a protein complex organized by a membrane associated PG.
REFERENCE   6  (bases 1 to 3216)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   7  (bases 1 to 3216)
  AUTHORS   Bergemann,A.D., Zhang,L., Chiang,M.K., Brambilla,R., Klein,R. and
            Flanagan,J.G.
  TITLE     Ephrin-B3, a ligand for the receptor EphB3, expressed at the
            midline of the developing neural tube
  JOURNAL   Oncogene 16 (4), 471-480 (1998)
   PUBMED   9484836
REFERENCE   8  (bases 1 to 3216)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   9  (bases 1 to 3216)
  AUTHORS   Tang,X.X., Pleasure,D.E. and Ikegaki,N.
  TITLE     cDNA cloning, chromosomal localization, and expression pattern of
            EPLG8, a new member of the EPLG gene family encoding ligands of
            EPH-related protein-tyrosine kinase receptors
  JOURNAL   Genomics 41 (1), 17-24 (1997)
   PUBMED   9126477
REFERENCE   10 (bases 1 to 3216)
  AUTHORS   Gale,N.W., Flenniken,A., Compton,D.C., Jenkins,N., Copeland,N.G.,
            Gilbert,D.J., Davis,S., Wilkinson,D.G. and Yancopoulos,G.D.
  TITLE     Elk-L3, a novel transmembrane ligand for the Eph family of receptor
            tyrosine kinases, expressed in embryonic floor plate, roof plate
            and hindbrain segments
  JOURNAL   Oncogene 13 (6), 1343-1352 (1996)
   PUBMED   8808709
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ892951.1, U57001.1, U66406.1
            and BC022499.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001406.3.
            
            Summary:  EFNB3, a member of the ephrin gene family, is important
            in brain development as well as in its maintenance. Moreover, since
            levels of EFNB3 expression were particularly high in several
            forebrain subregions compared to other brain subregions, it may
            play a pivotal role in forebrain function.  The EPH and EPH-related
            receptors comprise the largest subfamily of receptor
            protein-tyrosine kinases and have been implicated in mediating
            developmental events, particularly in the nervous system. EPH
            Receptors typically have a single kinase domain and an
            extracellular region containing a Cys-rich domain and 2 fibronectin
            type III repeats. The ephrin ligands and receptors have been named
            by the Eph Nomenclature Committee (1997). Based on their structures
            and sequence relationships, ephrins are divided into the ephrin-A
            (EFNA) class, which are anchored to the membrane by a
            glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB)
            class, which are transmembrane proteins. The Eph family of
            receptors are similarly divided into 2 groups based on the
            similarity of their extracellular domain sequences and their
            affinities for binding ephrin-A and ephrin-B ligands. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042944.2, U66406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000226091.3/ ENSP00000226091.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BQ892951.1         1-10
            11-1704             U57001.1           11-1704
            1705-3171           U66406.1           1921-3387
            3172-3216           BC022499.1         2611-2655
FEATURES             Location/Qualifiers
     source          1..3216
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..3216
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /note="ephrin B3"
                     /db_xref="GeneID:1949"
                     /db_xref="HGNC:HGNC:3228"
                     /db_xref="MIM:602297"
     exon            1..519
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /inference="alignment:Splign:2.1.0"
     CDS             398..1420
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /note="eph-related receptor tyrosine kinase ligand 8;
                     EPH-related receptor transmembrane ligand ELK-L3"
                     /codon_start=1
                     /product="ephrin-B3 precursor"
                     /protein_id="NP_001397.1"
                     /db_xref="CCDS:CCDS11120.1"
                     /db_xref="GeneID:1949"
                     /db_xref="HGNC:HGNC:3228"
                     /db_xref="MIM:602297"
                     /translation="MGPPHSGPGGVRVGALLLLGVLGLVSGLSLEPVYWNSANKRFQA
                     EGGYVLYPQIGDRLDLLCPRARPPGPHSSPNYEFYKLYLVGGAQGRRCEAPPAPNLLL
                     TCDRPDLDLRFTIKFQEYSPNLWGHEFRSHHDYYIIATSDGTREGLESLQGGVCLTRG
                     MKVLLRVGQSPRGGAVPRKPVSEMPMERDRGAAHSLEPGKENLPGDPTSNATSRGAEG
                     PLPPPSMPAVAGAAGGLALLLLGVAGAGGAMCWRRRRAKPSESRHPGPGSFGRGGSLG
                     LGGGGGMGPREAEPGELGIALRGGGAADPPFCPHYEKVSGDYGHPVYIVQDGPPQSPP
                     NIYYKV"
     exon            520..812
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            813..905
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1010
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..3216
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /note="hexamer: AATAAA"
     polyA_site      3216
                     /gene="EFNB3"
                     /gene_synonym="EFL6; EPLG8; LERK8"
                     /note="major polyA site"
ORIGIN      
        1 ggtttcctcc cttagcccgc tgccctcaat cccagcgagg ctggggctcc ggctcggcgc
       61 ccccttcctc gctccctggt ccggcgcccc atgccgcccc cgcccggtcc ccggctcccc
      121 cagtccccca cttaggcggg ctcacagatc ccggggtgct ggcgcgtggg ccgggggcgc
      181 gtagggcgcc tgcagacggc ccctggaagg gctctggtgg ggctgagcgc tctgccgcgg
      241 gggcgcgggc acagcaggaa gcaggtccgc gtgggcgctg ggggcatcag ctaccggggt
      301 ggtccgggct gaagagccag gcagccaagg cagccacccc ggggggtggg cgactttggg
      361 ggagttggtg ccccgccccc caggccttgg cggggtcatg gggccccccc attctgggcc
      421 ggggggcgtg cgagtcgggg ccctgctgct gctgggggtt ttggggctgg tgtctgggct
      481 cagcctggag cctgtctact ggaactcggc gaataagagg ttccaggcag agggtggtta
      541 tgtgctgtac cctcagatcg gggaccggct agacctgctc tgcccccggg cccggcctcc
      601 tggccctcac tcctctccta attatgagtt ctacaagctg tacctggtag ggggtgctca
      661 gggccggcgc tgtgaggcac cccctgcccc aaacctcctt ctcacttgtg atcgcccaga
      721 cctggatctc cgcttcacca tcaagttcca ggagtatagc cctaatctct ggggccacga
      781 gttccgctcg caccacgatt actacatcat tgccacatcg gatgggaccc gggagggcct
      841 ggagagcctg cagggaggtg tgtgcctaac cagaggcatg aaggtgcttc tccgagtggg
      901 acaaagtccc cgaggagggg ctgtcccccg aaaacctgtg tctgaaatgc ccatggaaag
      961 agaccgaggg gcagcccaca gcctggagcc tgggaaggag aacctgccag gtgaccccac
     1021 cagcaatgca acctcccggg gtgctgaagg ccccctgccc cctcccagca tgcctgcagt
     1081 ggctggggca gcaggggggc tggcgctgct cttgctgggc gtggcagggg ctgggggtgc
     1141 catgtgttgg cggagacggc gggccaagcc ttcggagagt cgccaccctg gtcctggctc
     1201 cttcgggagg ggagggtctc tgggcctggg gggtggaggt gggatgggac ctcgggaggc
     1261 tgagcctggg gagctaggga tagctctgcg gggtggcggg gctgcagatc cccccttctg
     1321 cccccactat gagaaggtga gtggtgacta tgggcatcct gtgtatatcg tgcaggatgg
     1381 gcccccccag agccctccaa acatctacta caaggtatga gggctcctct cacgtggcta
     1441 tcctgaatcc agcccttctt ggggtgctcc tccagtttaa ttcctggttt gagggacacc
     1501 tctaacatct cggccccctg tgccccccca gccccttcac tcctcccggc tgctgtcctc
     1561 gtctccactt ttaggattcc ttaggattcc cactgcccca cttcctgccc tcccgtttgg
     1621 ccatgggtgc ccccctctgt ctcagtgtcc ctggatcctt tttccttggg gaggggcaca
     1681 ggctcagcct cctctctgac catgacccag gcatccttgt ccccctcacc cacccagagc
     1741 taggggcggg aacagcccac cttttggttg gcaccgcctt ctttctgcct ctcactggtt
     1801 ttctcttctc tatctcttat tctttccctc tcttccgtct ctaggtctgt tcttcttccc
     1861 tagcatcctc ctccccacat ctcctttcac cctcttggct tcttatcctg tgcctctccc
     1921 atctcctggg tgggggcatc aaagcatttc tccccttagc tttcagcccc ccttctgacc
     1981 tctcatacca accactcccc tcagtctgcc aaaaatgggg gccttatggg gaaggctctg
     2041 acactccacc ccagctcagg ccatgggcag cagggctcca ttctctggcc tggcccaggc
     2101 ctctacatac ttactccagc catttggggt ggttgggtca tgacagctac catgagaaga
     2161 agtgtcccgt tttgtccagt ggccaatagc aagatatgaa ccggtcggga catgtatgga
     2221 cttggtctga tgctgaatgg gccacttggg accggaagtg acttgctcca gacaagaggt
     2281 gaccaggccc ggacagaaat ggcctgggaa gtagcagaag cagtgcagca ggaactggaa
     2341 gtgccttcat ccaggacagg aagtagcact tctgaaacag gaagtggtct ggctggaact
     2401 ccaagtggct tagtctgggg gatcaggagg tgggaggtgg atggttctta ttctgtggag
     2461 aagaagggcg ggaagaactt cctttcagga ggaagctgga acttactgac tgtaagaggt
     2521 tagaggtgga ccgagaagga cttttcccag tcttcagtgg cacttcccaa gatctccctt
     2581 cccttgtgct ctgtgctgat tttaggacag ctaagatgac tgccatgtgc tgtggcaggc
     2641 ctaatttgtc ttgttctttc ctttccatat cccagtataa tctctgttaa tcaacaggac
     2701 taccccaaga acccatgtgc tctcccgagt aacccagatg gctgtcttgt tcattccatc
     2761 ctacatttct gactcctttc agactcaaca cagttccctt cttagtgacc aaaatggtgg
     2821 cctactggct ggtctagctg acagtggtac ttagcaaagg ccactgtttc catagtgacc
     2881 agctgatacc tcttcctgcc ctctagtgtg caattgggtg ttgcctcagt ttcctcccag
     2941 ctcagtttta ttagatcaaa gctgttgttg ggcaccaggt tggccacctc aatcaccagc
     3001 caagatggtt gctttgtcca ccagaggtca agttcacctc tctggtgctg tagttcccag
     3061 ctccttcctg atttttctaa tcgctccttc tggggaacag gaagttgata ttgccatggt
     3121 ggcggggtat gccgtcacct cagtagtttt actgtaaaag ggaaatttga acaacaaaaa
     3181 ccaaaaaaaa taaaaataaa aaacttcaaa agttga
//
