LOCUS       NM_004952               1817 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens ephrin A3 (EFNA3), mRNA.
ACCESSION   NM_004952
VERSION     NM_004952.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Yiminniyaze,R., Zhang,X., Zhu,N., Wang,J., Li,C., Wumaier,G.,
            Zhou,D., Li,J., Xia,J., Zhang,Y., Dong,L., Zhang,Y. and Li,S.
  TITLE     EphrinA3 is a key regulator of malignant behaviors and a potential
            prognostic factor in lung adenocarcinoma
  JOURNAL   Cancer Med 12 (2), 1630-1642 (2023)
   PUBMED   35770949
  REMARK    GeneRIF: EphrinA3 is a key regulator of malignant behaviors and a
            potential prognostic factor in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Ye,B., Liang,X., Zhao,Y., Cai,X., Wang,Z., Lin,S., Wang,W.,
            Shan,P., Huang,W. and Huang,Z.
  TITLE     Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid
            metabolism imbalance in ox-LDL-stimulated macrophage via
            miR-765/EFNA3 axis
  JOURNAL   Chem Biol Interact 368, 110195 (2022)
   PUBMED   36191606
  REMARK    GeneRIF: Hsa_circ_0007478 aggravates NLRP3 inflammasome activation
            and lipid metabolism imbalance in ox-LDL-stimulated macrophage via
            miR-765/EFNA3 axis.
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Zhuang,Y., Cheng,M., Li,M., Cui,J., Huang,J., Zhang,C., Si,J.,
            Lin,K. and Yu,H.
  TITLE     Small extracellular vesicles derived from hypoxic mesenchymal stem
            cells promote vascularized bone regeneration through the
            miR-210-3p/EFNA3/PI3K pathway
  JOURNAL   Acta Biomater 150, 413-426 (2022)
   PUBMED   35850484
  REMARK    GeneRIF: Small extracellular vesicles derived from hypoxic
            mesenchymal stem cells promote vascularized bone regeneration
            through the miR-210-3p/EFNA3/PI3K pathway.
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Husain,A., Chiu,Y.T., Sze,K.M., Ho,D.W., Tsui,Y.M., Suarez,E.M.S.,
            Zhang,V.X., Chan,L.K., Lee,E., Lee,J.M., Cheung,T.T., Wong,C.C.,
            Chung,C.Y. and Ng,I.O.
  TITLE     Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to
            enhance cancer stemness in hypoxic hepatocellular carcinoma
  JOURNAL   J Hepatol 77 (2), 383-396 (2022)
   PUBMED   35227773
  REMARK    GeneRIF: Ephrin-A3/EphA2 axis regulates cellular metabolic
            plasticity to enhance cancer stemness in hypoxic hepatocellular
            carcinoma.
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Jiang,B., Yang,K., Tang,C., Chen,R. and Wang,C.
  TITLE     LncRNA LINC01270 aggravates the progression of gastric cancer
            through modulation of miR-326/EFNA3 axis
  JOURNAL   Bioengineered 13 (4), 8994-9005 (2022)
   PUBMED   35345980
  REMARK    GeneRIF: LncRNA LINC01270 aggravates the progression of gastric
            cancer through modulation of miR-326/EFNA3 axis.
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   7  (bases 1 to 1817)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   8  (bases 1 to 1817)
  AUTHORS   Cerretti,D.P., Lyman,S.D., Kozlosky,C.J., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Valentine,V., Kirstein,M.N.,
            Shapiro,D.N. and Morris,S.W.
  TITLE     The genes encoding the eph-related receptor tyrosine kinase ligands
            LERK-1 (EPLG1, Epl1), LERK-3 (EPLG3, Epl3), and LERK-4 (EPLG4,
            Epl4) are clustered on human chromosome 1 and mouse chromosome 3
  JOURNAL   Genomics 33 (2), 277-282 (1996)
   PUBMED   8660976
REFERENCE   9  (bases 1 to 1817)
  AUTHORS   Kozlosky,C.J., Maraskovsky,E., McGrew,J.T., VandenBos,T., Teepe,M.,
            Lyman,S.D., Srinivasan,S., Fletcher,F.A., Gayle,R.B. 3rd,
            Cerretti,D.P. et al.
  TITLE     Ligands for the receptor tyrosine kinases hek and elk: isolation of
            cDNAs encoding a family of proteins
  JOURNAL   Oncogene 10 (2), 299-306 (1995)
   PUBMED   7838529
REFERENCE   10 (bases 1 to 1817)
  AUTHORS   Davis,S., Gale,N.W., Aldrich,T.H., Maisonpierre,P.C., Lhotak,V.,
            Pawson,T., Goldfarb,M. and Yancopoulos,G.D.
  TITLE     Ligands for EPH-related receptor tyrosine kinases that require
            membrane attachment or clustering for activity
  JOURNAL   Science 266 (5186), 816-819 (1994)
   PUBMED   7973638
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL691442.32.
            
            On Nov 22, 2018 this sequence version replaced NM_004952.4.
            
            Summary: This gene encodes a member of the ephrin (EPH) family. The
            ephrins and EPH-related receptors comprise the largest subfamily of
            receptor protein-tyrosine kinases and have been implicated in
            mediating developmental events, especially in the nervous system
            and in erythropoiesis. Based on their structures and sequence
            relationships, ephrins are divided into the ephrin-A (EFNA) class,
            which are anchored to the membrane by a
            glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB)
            class, which are transmembrane proteins. This gene encodes an EFNA
            class ephrin. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.438053.1,
                                           SRR3476690.820847.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368408.4/ ENSP00000357393.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AL691442.32        27109-27341
            234-547             AL691442.32        33363-33676
            548-613             AL691442.32        34149-34214
            614-691             AL691442.32        34400-34477
            692-1817            AL691442.32        34685-35810
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1817
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /note="ephrin A3"
                     /db_xref="GeneID:1944"
                     /db_xref="HGNC:HGNC:3223"
                     /db_xref="MIM:601381"
     exon            1..233
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..822
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /note="ligand of eph-related kinase 3; eph-related
                     receptor tyrosine kinase ligand 3; EFL-2; LERK-3; EHK1
                     ligand"
                     /codon_start=1
                     /product="ephrin-A3 precursor"
                     /protein_id="NP_004943.1"
                     /db_xref="CCDS:CCDS1090.1"
                     /db_xref="GeneID:1944"
                     /db_xref="HGNC:HGNC:3223"
                     /db_xref="MIM:601381"
                     /translation="MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHL
                     RREGYTVQVNVNDYLDIYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNAS
                     QGFKRWECNRPHAPHSPIKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLR
                     MKVFVCCASTSHSGEKPVPTLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPK
                     REHLPLAVGIAFFLMTFLAS"
     exon            234..547
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /inference="alignment:Splign:2.1.0"
     exon            548..613
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /inference="alignment:Splign:2.1.0"
     exon            614..691
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1817
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1796..1801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /note="hexamer: AATAAA"
     polyA_site      1817
                     /gene="EFNA3"
                     /gene_synonym="EFL2; Ehk1-L; EPLG3; LERK3"
                     /note="major polyA site"
ORIGIN      
        1 ggcctaaggc tgggggccga cggcggcggc agcagggagc tgggaagcgg agaagccggg
       61 agcgcggggc tcagtcgggg ggcggcggcg gcggcggctc cggggatggc ggcggctccg
      121 ctgctgctgc tgctgctgct cgtgcccgtg ccgctgctgc cgctgctggc ccaagggccc
      181 ggaggggcgc tgggaaaccg gcatgcggtg tactggaaca gctccaacca gcacctgcgg
      241 cgagagggct acaccgtgca ggtgaacgtg aacgactatc tggatattta ctgcccgcac
      301 tacaacagct cgggggtggg ccccggggcg ggaccggggc ccggaggcgg ggcagagcag
      361 tacgtgctgt acatggtgag ccgcaacggc taccgcacct gcaacgccag ccagggcttc
      421 aagcgctggg agtgcaaccg gccgcacgcc ccgcacagcc ccatcaagtt ctcggagaag
      481 ttccagcgct acagcgcctt ctctctgggc tacgagttcc acgccggcca cgagtactac
      541 tacatctcca cgcccactca caacctgcac tggaagtgtc tgaggatgaa ggtgttcgtc
      601 tgctgcgcct ccacatcgca ctccggggag aagccggtcc ccactctccc ccagttcacc
      661 atgggcccca atgtgaagat caacgtgctg gaagactttg agggagagaa ccctcaggtg
      721 cccaagcttg agaagagcat cagcgggacc agccccaaac gggaacacct gcccctggcc
      781 gtgggcatcg ccttcttcct catgacgttc ttggcctcct agctctgccc cctcccctgg
      841 ggggggagag atggggcggg gcttggaagg agcagggagc ctttggcctc tccaagggaa
      901 gcctagtggg cctagacccc tcctcccatg gctagaagtg gggcctgcac catacatctg
      961 tgtccgcccc ctctacccct tccccccacg tagggcactg tagtggacca agcacgggga
     1021 cagccatggg tcccgggcgg ccttgtggct ctggtaatgt ttggtaccaa acttgggggc
     1081 caaaaagggc agtgctcagg actccctggc ccctggtacc tttccctgac tcctggtgcc
     1141 ctctcccttt gtccccccag agagacatat gcccccagag agagcaaatc gaagcgtggg
     1201 aggcaccccc attgctctcc tccaggggca gaacatgggg aggggactag atgggcaagg
     1261 ggcagcactg cctgctgctt ccttcccctg tttacagcaa taagcacgtc ctcctccccc
     1321 actcccactt ccaggattgt ggtttggatt gaaaccaagt ttacaagtag acacccctgg
     1381 gggggcgggc agtggacaag gatggcaagg ggtgggcatt ggggtgccag gcaggcatgt
     1441 acagactcta tatctctata tataatgtac agacagacag agtcccttcc ctctttaacc
     1501 ccctgacctt tcttgacttc cccttcagct tcagacccct tccccaccag gctaggcccc
     1561 ccacacctgg gggaccccct ggcccctctt ttgtcttctg tgaagacagg acctatgcaa
     1621 cgcacagaca cttttggaga ccgtaaaaca acaacgcccc ctcccttcca gccctgagcc
     1681 gggaaccatc tcccaggacc ttgccctgct caccctatgt ggtcccacct atcctcctgg
     1741 gcctttttca agtgctttgg ctgtgacttt catactctgc tcttagtcta aaaaaaataa
     1801 actggagata aaaataa
//
