LOCUS       NM_001405               2424 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens ephrin A2 (EFNA2), mRNA.
ACCESSION   NM_001405 XR_109551 XR_111809 XR_115223
VERSION     NM_001405.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2424)
  AUTHORS   Lakshman Kumar,P., Wilson,A.C., Rocco,A., Cho,M.H., Wan,E.,
            Hobbs,B.D., Washko,G.R., Ortega,V.E., Christenson,S.A., Li,X.,
            Wells,J.M., Bhatt,S.P., DeMeo,D.L., Lutz,S.M., Rossiter,H.,
            Casaburi,R., Rennard,S.I., Lomas,D.A., Labaki,W.W., Tal-Singer,R.,
            Bowler,R.P., Hersh,C.P., Tiwari,H.K., Dransfield,M.,
            Thalacker-Mercer,A., Meyers,D.A., Silverman,E.K. and McDonald,M.N.
  CONSRTM   COPDGene, ECLIPSE and SPIROMICS investigators
  TITLE     Genetic variation in genes regulating skeletal muscle regeneration
            and tissue remodelling associated with weight loss in chronic
            obstructive pulmonary disease
  JOURNAL   J Cachexia Sarcopenia Muscle 12 (6), 1803-1817 (2021)
   PUBMED   34523824
  REMARK    GeneRIF: Genetic variation in genes regulating skeletal muscle
            regeneration and tissue remodelling associated with weight loss in
            chronic obstructive pulmonary disease.
            Erratum:[J Cachexia Sarcopenia Muscle. 2024 Apr;15(2):765. doi:
            10.1002/jcsm.13442.. PMID: 38327146]
REFERENCE   2  (bases 1 to 2424)
  AUTHORS   Zhao,Y., Cai,C., Zhang,M., Shi,L., Wang,J., Zhang,H., Ma,P. and
            Li,S.
  TITLE     Ephrin-A2 promotes prostate cancer metastasis by enhancing
            angiogenesis and promoting EMT
  JOURNAL   J Cancer Res Clin Oncol 147 (7), 2013-2023 (2021)
   PUBMED   33772606
  REMARK    GeneRIF: Ephrin-A2 promotes prostate cancer metastasis by enhancing
            angiogenesis and promoting EMT.
REFERENCE   3  (bases 1 to 2424)
  AUTHORS   Li,S., Wu,Z., Chen,Y., Kang,Z., Wang,H., He,P., Zhang,X., Hu,T.,
            Zhang,Q., Cai,Y., Xu,X. and Guan,M.
  TITLE     Diagnostic and prognostic value of tissue and circulating levels of
            Ephrin-A2 in prostate cancer
  JOURNAL   Tumour Biol 37 (4), 5365-5374 (2016)
   PUBMED   26561474
  REMARK    GeneRIF: Ephrin-A2 expression was correlated with Ki-67 expression
            in PCa patients, both at the gene scale and protein level. Our data
            indicate that Ephrin-A2 is a potential diagnostic and prognostic
            biomarker and a promising molecular therapeutic target to attenuate
            prostate cancer progression
REFERENCE   4  (bases 1 to 2424)
  AUTHORS   Bandyopadhyay,C., Valiya-Veettil,M., Dutta,D., Chakraborty,S. and
            Chandran,B.
  TITLE     CIB1 synergizes with EphrinA2 to regulate Kaposi's
            sarcoma-associated herpesvirus macropinocytic entry in human
            microvascular dermal endothelial cells
  JOURNAL   PLoS Pathog 10 (2), e1003941 (2014)
   PUBMED   24550731
  REMARK    GeneRIF: these studies suggested that Kaposi's sarcoma-associated
            herpesvirus utilizes CIB1 as one of the key molecule(s) to
            coordinate and sustain the EphA2 mediated signaling involved in its
            entry
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2424)
  AUTHORS   Strimpakos,A., Pentheroudakis,G., Kotoula,V., De Roock,W.,
            Kouvatseas,G., Papakostas,P., Makatsoris,T., Papamichael,D.,
            Andreadou,A., Sgouros,J., Zizi-Sermpetzoglou,A., Kominea,A.,
            Televantou,D., Razis,E., Galani,E., Pectasides,D., Tejpar,S.,
            Syrigos,K. and Fountzilas,G.
  TITLE     The prognostic role of ephrin A2 and endothelial growth factor
            receptor pathway mediators in patients with advanced colorectal
            cancer treated with cetuximab
  JOURNAL   Clin Colorectal Cancer 12 (4), 267-274 (2013)
   PUBMED   24050852
  REMARK    GeneRIF: High EphA2 receptor expression in colorectal cancer was
            associated with a worse outcome in patients treated with
            cetuximab-based therapy
REFERENCE   6  (bases 1 to 2424)
  AUTHORS   Ciossek,T., Monschau,B., Kremoser,C., Loschinger,J., Lang,S.,
            Muller,B.K., Bonhoeffer,F. and Drescher,U.
  TITLE     Eph receptor-ligand interactions are necessary for guidance of
            retinal ganglion cell axons in vitro
  JOURNAL   Eur J Neurosci 10 (5), 1574-1580 (1998)
   PUBMED   9751130
REFERENCE   7  (bases 1 to 2424)
  AUTHORS   Zhou,R.
  TITLE     The Eph family receptors and ligands
  JOURNAL   Pharmacol Ther 77 (3), 151-181 (1998)
   PUBMED   9576626
  REMARK    Review article
REFERENCE   8  (bases 1 to 2424)
  AUTHORS   Cerretti,D.P. and Nelson,N.
  TITLE     Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3),
            mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6):
            conservation of intron/exon structure
  JOURNAL   Genomics 47 (1), 131-135 (1998)
   PUBMED   9465306
REFERENCE   9  (bases 1 to 2424)
  AUTHORS   Flanagan,J.G. and Vanderhaeghen,P.
  TITLE     The ephrins and Eph receptors in neural development
  JOURNAL   Annu Rev Neurosci 21, 309-345 (1998)
   PUBMED   9530499
  REMARK    Review article
REFERENCE   10 (bases 1 to 2424)
  AUTHORS   Gale,N.W., Holland,S.J., Valenzuela,D.M., Flenniken,A., Pan,L.,
            Ryan,T.E., Henkemeyer,M., Strebhardt,K., Hirai,H., Wilkinson,D.G.,
            Pawson,T., Davis,S. and Yancopoulos,G.D.
  TITLE     Eph receptors and ligands comprise two major specificity subclasses
            and are reciprocally compartmentalized during embryogenesis
  JOURNAL   Neuron 17 (1), 9-19 (1996)
   PUBMED   8755474
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004258.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001405.3.
            
            Summary: This gene encodes a member of the ephrin family. The
            protein is composed of a signal sequence, a receptor-binding
            region, a spacer region, and a hydrophobic region. The EPH and
            EPH-related receptors comprise the largest subfamily of receptor
            protein-tyrosine kinases and have been implicated in mediating
            developmental events, particularly in the nervous system. Based on
            their structures and sequence relationships, ephrins are divided
            into the ephrin-A (EFNA) class, which are anchored to the membrane
            by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB)
            class, which are transmembrane proteins. Posttranslational
            modifications determine whether this protein localizes to the
            nucleus or the cytoplasm. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ007292.1, ERR3218367.690954.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215368.4/ ENSP00000215368.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-436               AC004258.1         20112-20547
            437-750             AC004258.1         29784-30097
            751-816             AC004258.1         32790-32855
            817-2424            AC004258.1         34063-35670
FEATURES             Location/Qualifiers
     source          1..2424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2424
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /note="ephrin A2"
                     /db_xref="GeneID:1943"
                     /db_xref="HGNC:HGNC:3222"
                     /db_xref="MIM:602756"
     exon            1..436
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..938
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /note="eph-related receptor tyrosine kinase ligand 6; HEK7
                     ligand"
                     /codon_start=1
                     /product="ephrin-A2 precursor"
                     /protein_id="NP_001396.2"
                     /db_xref="CCDS:CCDS12061.1"
                     /db_xref="GeneID:1943"
                     /db_xref="HGNC:HGNC:3222"
                     /db_xref="MIM:602756"
                     /translation="MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRS
                     NPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASC
                     DHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVD
                     RPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS"
     exon            437..750
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /inference="alignment:Splign:2.1.0"
     exon            751..816
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /inference="alignment:Splign:2.1.0"
     exon            817..2424
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /note="hexamer: AATAAA"
     polyA_site      2424
                     /gene="EFNA2"
                     /gene_synonym="ELF-1; EPLG6; HEK7-L; LERK-6; LERK6"
                     /note="major polyA site"
ORIGIN      
        1 ggagcccggg cccctccccg gcgggtgcgg cggcggcggc ccgcgctccg acagtccgcg
       61 cggccgggtc ctgcgcccgg ggcgaccccg gcgccccgcc ccgccgccgc ctgacttctc
      121 ggcgcccgag gtcgcgcgcg cggaggcggg ggcggcccgg gatctccaag cgccgccgcg
      181 ccctcctccc gcccgccctc cgcccgcccg ctcggcggcg gcggcggcgg cggaggaggc
      241 ggagaaggct ggcaggcggc ggccgggaga gcgagcgcgg cggccggacc ggggccatgg
      301 cgcccgcgca gcgcccgctg ctcccgctgc tgctcctgct gttaccgctg ccgccgccgc
      361 ccttcgcgcg cgccgaggac gccgcccgcg ccaactcgga ccgctacgcc gtctactgga
      421 accgcagcaa ccccaggttc cacgcaggcg cgggggacga cggcgggggc tacacggtgg
      481 aggtgagcat caatgactac ctggacatct actgcccgca ctatggggcg ccgctgccgc
      541 cggccgagcg catggagcac tacgtgctgt acatggtcaa cggcgagggc cacgcctcct
      601 gcgaccaccg ccagcgcggc ttcaagcgct gggagtgcaa ccggcccgcg gcgcccgggg
      661 ggccgctcaa gttctcggag aagttccagc tcttcacgcc cttctccctg ggcttcgagt
      721 tccggcccgg ccacgagtat tactacatct ctgccacgcc tcccaatgct gtggaccggc
      781 cctgcctgcg actgaaggtg tacgtgcggc cgaccaacga gaccctgtac gaggctcctg
      841 agcccatctt caccagcaat aactcgtgta gcagcccggg cggctgccgc ctcttcctca
      901 gcaccatccc cgtgctctgg accctcctgg gttcctagtc ccagccccgc aggacgccga
      961 ccctgcctgg acggccccgc ctggaccgcc tgacctcggc cctccggacc cggctgcggc
     1021 ccccgcctcc gagaccaaat agagacgctg cttctccctc gcctggtgcc gcccccgccg
     1081 ggcaggggcc atccacccgc cccaggacca gccctcaggg aggggaaacg gccgagagcc
     1141 cccccccgga ggcccgaggg gccggggtgt ggatgcggac cgtggccagg ccatctcctc
     1201 tggggcgtcg gagaacccgg gaacctcttg gcgatttttt tttttttttt tttttttttt
     1261 ttttttttta gtgtattttt cgtggttgga tcaaaaagac ttgagttttt aatttaattt
     1321 attccctgcc gttgtagcgg ggcggggtcc ctgtgccctg gcctggggga ggggaacgcg
     1381 gaacatgggg tcgggaacac agccgctccc ctctgctctg caccccactc gtgggggaac
     1441 acagccgctc ccctctgctc tgcaccccac tcgtggggga acacagccgc tcccctctgc
     1501 tctgcacccc actcgtgggg gaacacagcc gctcccctct gctctgcacc ccactcgtgg
     1561 gggaacacag ctgcagccca ccgcggaccc ccctggtgct ccaggttggg tgagtctgag
     1621 ccggaagggg tacgtggtgg gcgcccctca ttgtggctgg ggagacctca taccccatcg
     1681 cccacccccg tcctcctggt catttcctcc cagacactgt tttgccccag cgcccttcgg
     1741 aatcacagtc ccgccgtgtc ttagaaactg ctttggccga tgcaaacagc cccctacccg
     1801 tccccctcgc ctcacacggt ccctctccga ggccgagaag accttctgtt cctgtaaata
     1861 cagccagcaa gtgcaaactg tgattttatt ttccacgtat tcctgaggac ggactggacc
     1921 gtctatgttt tttcagccct tcataggggg tcttttattt tggtgggggg gtggggtgga
     1981 cttttagagt agaagctgca cttggcaata agctcgtgtc gtctgtcaga gcccctctct
     2041 caactctgtg acctgataat gtttctaaga aaaagaaaaa aaggacaaaa gggagggaac
     2101 cactaccaaa aaaaaaaaaa gaaactcctc cccgaagaca ctttaatgaa ggaaacaaca
     2161 catttatacg gatttcatat ttctacccgc ctttcctgac tctgtgtttt atatatatta
     2221 tatataaata tatattgtgt acggccgccg gccggcggct cgaggcacgc ccggtggtgg
     2281 ggggtgggca gagggctttt gtagggggtc ggcggggcgg gccgcgttgc caggcctgga
     2341 gctggcgacc gggcctccct cttcccgtca caatcaactt tggattctgt atttttttat
     2401 aataaaatga gcataaacct caaa
//
