LOCUS       NM_004428               1552 bp    mRNA    linear   PRI 28-JUL-2024
DEFINITION  Homo sapiens ephrin A1 (EFNA1), transcript variant 1, mRNA.
ACCESSION   NM_004428
VERSION     NM_004428.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1552)
  AUTHORS   Wu,X., Tao,W., Wang,Y., Wu,Q., Ye,C., Song,X., Guo,X. and Liu,J.
  TITLE     Increased Serum EphrinA1 Is Associated with Parenchymal Hematoma
            after Ischemic Stroke
  JOURNAL   Cerebrovasc Dis 52 (6), 651-657 (2023)
   PUBMED   37105137
  REMARK    GeneRIF: Increased Serum EphrinA1 Is Associated with Parenchymal
            Hematoma after Ischemic Stroke.
REFERENCE   2  (bases 1 to 1552)
  AUTHORS   Salem,E., Keshvari,A., Mahdavinezhad,A., Soltanian,A.R.,
            Saidijam,M. and Afshar,S.
  TITLE     Role of EFNA1 SNP (rs12904) in Tumorigenesis and Metastasis of
            Colorectal Cancer: A Bioinformatic Analysis and HRM SNP Genotyping
            Verification
  JOURNAL   Asian Pac J Cancer Prev 23 (10), 3523-3531 (2022)
   PUBMED   36308379
  REMARK    GeneRIF: Role of EFNA1 SNP (rs12904) in Tumorigenesis and
            Metastasis of Colorectal Cancer: A Bioinformatic Analysis and HRM
            SNP Genotyping Verification.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1552)
  AUTHORS   Shen,X., Li,M., Lei,Y., Lu,S., Wang,S., Liu,Z., Wang,C., Zhao,Y.,
            Wang,A., Bi,C. and Zhu,G.
  TITLE     An integrated analysis of single-cell and bulk transcriptomics
            reveals EFNA1 as a novel prognostic biomarker for cervical cancer
  JOURNAL   Hum Cell 35 (2), 705-720 (2022)
   PUBMED   35072898
  REMARK    GeneRIF: An integrated analysis of single-cell and bulk
            transcriptomics reveals EFNA1 as a novel prognostic biomarker for
            cervical cancer.
REFERENCE   4  (bases 1 to 1552)
  AUTHORS   Asadian,F., Ghadyani,M., Antikchi,M.H., Dastgheib,S.A.,
            Neamatzadeh,H., Sheikhpour,E., Khajehnoori,S. and Tabei,S.S.
  TITLE     Association of Epidermal Growth Factor 61A>G, Survivin -31G>C, and
            EFNA1 -1732G>A Polymorphisms with Susceptibility to Colorectal
            Cancer
  JOURNAL   J Gastrointest Cancer 53 (1), 78-83 (2022)
   PUBMED   33180239
  REMARK    GeneRIF: Association of Epidermal Growth Factor 61A>G, Survivin
            -31G>C, and EFNA1 -1732G>A Polymorphisms with Susceptibility to
            Colorectal Cancer.
REFERENCE   5  (bases 1 to 1552)
  AUTHORS   Hao,Y.P., Wang,W.Y., Qiao,Q. and Li,G.
  TITLE     EFNA1 is a potential key gene that correlates with immune
            infiltration in low-grade glioma
  JOURNAL   Medicine (Baltimore) 100 (22), e26188 (2021)
   PUBMED   34087884
  REMARK    GeneRIF: EFNA1 is a potential key gene that correlates with immune
            infiltration in low-grade glioma.
REFERENCE   6  (bases 1 to 1552)
  AUTHORS   Mahadevan,D., Thanki,N., Singh,J., McPhie,P., Zangrilli,D.,
            Wang,L.M., Guerrero,C., LeVine,H. 3rd, Humblet,C., Saldanha,J. et
            al.
  TITLE     Structural studies on the PH domains of Db1, Sos1, IRS-1, and beta
            ARK1 and their differential binding to G beta gamma subunits
  JOURNAL   Biochemistry 34 (28), 9111-9117 (1995)
   PUBMED   7619809
REFERENCE   7  (bases 1 to 1552)
  AUTHORS   Kozlosky,C.J., Maraskovsky,E., McGrew,J.T., VandenBos,T., Teepe,M.,
            Lyman,S.D., Srinivasan,S., Fletcher,F.A., Gayle,R.B. 3rd,
            Cerretti,D.P. et al.
  TITLE     Ligands for the receptor tyrosine kinases hek and elk: isolation of
            cDNAs encoding a family of proteins
  JOURNAL   Oncogene 10 (2), 299-306 (1995)
   PUBMED   7838529
REFERENCE   8  (bases 1 to 1552)
  AUTHORS   Davis,S., Gale,N.W., Aldrich,T.H., Maisonpierre,P.C., Lhotak,V.,
            Pawson,T., Goldfarb,M. and Yancopoulos,G.D.
  TITLE     Ligands for EPH-related receptor tyrosine kinases that require
            membrane attachment or clustering for activity
  JOURNAL   Science 266 (5186), 816-819 (1994)
   PUBMED   7973638
REFERENCE   9  (bases 1 to 1552)
  AUTHORS   Beckmann,M.P., Cerretti,D.P., Baum,P., Vanden Bos,T., James,L.,
            Farrah,T., Kozlosky,C., Hollingsworth,T., Shilling,H.,
            Maraskovsky,E. et al.
  TITLE     Molecular characterization of a family of ligands for eph-related
            tyrosine kinase receptors
  JOURNAL   EMBO J 13 (16), 3757-3762 (1994)
   PUBMED   8070404
REFERENCE   10 (bases 1 to 1552)
  AUTHORS   Holzman,L.B., Marks,R.M. and Dixit,V.M.
  TITLE     A novel immediate-early response gene of endothelium is induced by
            cytokines and encodes a secreted protein
  JOURNAL   Mol Cell Biol 10 (11), 5830-5838 (1990)
   PUBMED   2233719
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057845.1, M57730.1,
            AL833641.1 and AW274944.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004428.2.
            
            Summary: This gene encodes a member of the ephrin (EPH) family. The
            ephrins and EPH-related receptors comprise the largest subfamily of
            receptor protein-tyrosine kinases and have been implicated in
            mediating developmental events, especially in the nervous system
            and in erythropoiesis. Based on their structures and sequence
            relationships, ephrins are divided into the ephrin-A (EFNA) class,
            which are anchored to the membrane by a
            glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB)
            class, which are transmembrane proteins. This gene encodes an EFNA
            class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and
            EPHA7 receptors. Two transcript variants that encode different
            isoforms were identified through sequence analysis. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095432.1, AK057845.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368407.8/ ENSP00000357392.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AK057845.1         417-445
            30-577              M57730.1           1-548
            578-945             AL833641.1         513-880
            946-1491            M57730.1           917-1462
            1492-1552           AW274944.1         36-96               c
FEATURES             Location/Qualifiers
     source          1..1552
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1552
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /note="ephrin A1"
                     /db_xref="GeneID:1942"
                     /db_xref="HGNC:HGNC:3221"
                     /db_xref="MIM:191164"
     exon            1..194
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..720
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; tumor necrosis factor, alpha-induced protein 4;
                     immediate early response protein B61; eph-related receptor
                     tyrosine kinase ligand 1; ligand of eph-related kinase 1;
                     TNF alpha-induced protein 4; epididymis secretory sperm
                     binding protein; gastric cancer metastasis associated long
                     noncoding RNA"
                     /codon_start=1
                     /product="ephrin-A1 isoform a precursor"
                     /protein_id="NP_004419.2"
                     /db_xref="CCDS:CCDS1091.1"
                     /db_xref="GeneID:1942"
                     /db_xref="HGNC:HGNC:3221"
                     /db_xref="MIM:191164"
                     /translation="MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLN
                     DYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPE
                     KLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDN
                     PQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP"
     exon            195..490
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            491..556
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            557..607
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            608..1552
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1487..1492
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /note="hexamer: AATAAA"
     polyA_site      1510
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /note="major polyA site"
     regulatory      1532..1537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
                     /note="hexamer: ATTAAA"
     polyA_site      1552
                     /gene="EFNA1"
                     /gene_synonym="B61; ECKLG; EFL1; EPLG1; GMAN; LERK-1;
                     LERK1; TNFAIP4"
ORIGIN      
        1 agatctgtga gcccagcgct gactgcgccg cggagaaagc cagtgggaac ccagacccat
       61 aggagacccg cgtccccgct cggcctggcc aggccccgcg ctatggagtt cctctgggcc
      121 cctctcttgg gtctgtgctg cagtctggcc gctgctgatc gccacaccgt cttctggaac
      181 agttcaaatc ccaagttccg gaatgaggac tacaccatac atgtgcagct gaatgactac
      241 gtggacatca tctgtccgca ctatgaagat cactctgtgg cagacgctgc catggagcag
      301 tacatactgt acctggtgga gcatgaggag taccagctgt gccagcccca gtccaaggac
      361 caagtccgct ggcagtgcaa ccggcccagt gccaagcatg gcccggagaa gctgtctgag
      421 aagttccagc gcttcacacc tttcaccctg ggcaaggagt tcaaagaagg acacagctac
      481 tactacatct ccaaacccat ccaccagcat gaagaccgct gcttgaggtt gaaggtgact
      541 gtcagtggca aaatcactca cagtcctcag gcccatgaca atccacagga gaagagactt
      601 gcagcagatg acccagaggt gcgggttcta catagcatcg gtcacagtgc tgccccacgc
      661 ctcttcccac ttgcctggac tgtgctgctc cttccacttc tgctgctgca aaccccgtga
      721 aggtgtatgc cacacctggc cttaaagagg gacaggctga agagagggac aggcactcca
      781 aacctgtctt ggggccactt tcagagcccc cagccctggg aaccactccc accacaggca
      841 taagctatca cctagcagcc tcaaaacggg tcagtattaa ggttttcaac cggaaggagg
      901 ccaaccagcc cgacagtgcc atccccacct tcacctcgga gggatggaga aagaagtgga
      961 gacagtcctt tcccaccatt cctgccttta agccaaagaa acaagctgtg caggcatggt
     1021 cccttaaggc acagtgggag ctgagctgga aggggccacg tggatgggca aagcttgtca
     1081 aagatgcccc ctccaggaga gagccaggat gcccagatga actgactgaa ggaaaagcaa
     1141 gaaacagttt cttgcttgga agccaggtac aggagaggca gcatgcttgg gctgacccag
     1201 catctcccag caagacctca tctgtggagc tgccacagag aagtttgtag ccaggtactg
     1261 cattctctcc catcctgggg cagcactccc cagagctgtg ccagcagggg ggctgtgcca
     1321 acctgttctt agagtgtagc tgtaagggca gtgcccatgt gtacattctg cctagagtgt
     1381 agcctaaagg gcagggccca cgtgtatagt atctgtatat aagttgctgt gtgtctgtcc
     1441 tgatttctac aactggagtt tttttataca atgttctttg tctcaaaata aagcaatgtg
     1501 ttttttcgga catgcttttc tgccactcca tattaaaaca tatgaccatt ga
//
