LOCUS       NM_001171183             704 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens EF-hand calcium binding domain 9 (EFCAB9), mRNA.
ACCESSION   NM_001171183 XM_001715900 XM_941052
VERSION     NM_001171183.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 704)
  AUTHORS   Grabarek,Z.
  TITLE     Structural basis for diversity of the EF-hand calcium-binding
            proteins
  JOURNAL   J Mol Biol 359 (3), 509-525 (2006)
   PUBMED   16678204
  REMARK    Review article
REFERENCE   2  (bases 1 to 704)
  AUTHORS   Bhattacharya,S., Bunick,C.G. and Chazin,W.J.
  TITLE     Target selectivity in EF-hand calcium binding proteins
  JOURNAL   Biochim Biophys Acta 1742 (1-3), 69-79 (2004)
   PUBMED   15590057
  REMARK    Review article
REFERENCE   3  (bases 1 to 704)
  AUTHORS   Maki,M., Kitaura,Y., Satoh,H., Ohkouchi,S. and Shibata,H.
  TITLE     Structures, functions and molecular evolution of the penta-EF-hand
            Ca2+-binding proteins
  JOURNAL   Biochim Biophys Acta 1600 (1-2), 51-60 (2002)
   PUBMED   12445459
  REMARK    Review article
REFERENCE   4  (bases 1 to 704)
  AUTHORS   Lewit-Bentley,A. and Rety,S.
  TITLE     EF-hand calcium-binding proteins
  JOURNAL   Curr Opin Struct Biol 10 (6), 637-643 (2000)
   PUBMED   11114499
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024561.5, CN445899.1 and
            AI024830.1.
            
            On May 17, 2019 this sequence version replaced NM_001171183.1.
            
            Summary: This gene encodes a protein with a C-terminal EF-hand
            calcium-binding domain similar to that found in penta-EF-hand (PEF)
            protein family members. The EF-hand is a helix-loop-helix structure
            with a canonical twelve-residue sequence that coordinates a calcium
            molecule with pentagonal bipyramidal symmetry. [provided by RefSeq,
            Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN445899.1, BU568218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398186.5/ ENSP00000381247.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC024561.5         65540-65577         c
            39-358              CN445899.1         48-367
            359-704             AI024830.1         9-354               c
FEATURES             Location/Qualifiers
     source          1..704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..704
                     /gene="EFCAB9"
                     /note="EF-hand calcium binding domain 9"
                     /db_xref="GeneID:285588"
                     /db_xref="HGNC:HGNC:34530"
                     /db_xref="MIM:618520"
     exon            1..137
                     /gene="EFCAB9"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..595
                     /gene="EFCAB9"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 9"
                     /protein_id="NP_001164654.1"
                     /db_xref="CCDS:CCDS54946.1"
                     /db_xref="GeneID:285588"
                     /db_xref="HGNC:HGNC:34530"
                     /db_xref="MIM:618520"
                     /translation="MRLKQGSFLWYLYLDKIYCLLSVRNVKALAEYFHILDVHGKNTL
                     NDVLFYHFLHHVTDLKKAQINIVFDMLDWNAVGEIDFEKFYMLVCMLLAHQNHLEGQF
                     MYRHSRPVFDLLDLKGDLRIGAKNFEMYRFLFNIQKQELKDLFRDFDITGDNRLNYQE
                     FKLYTIIYTDKLQKRQKTEEKEKGERKRSLYSKCHIK"
     exon            138..286
                     /gene="EFCAB9"
                     /inference="alignment:Splign:2.1.0"
     exon            287..463
                     /gene="EFCAB9"
                     /inference="alignment:Splign:2.1.0"
     exon            464..704
                     /gene="EFCAB9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      680..685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB9"
                     /note="hexamer: AATAAA"
     polyA_site      704
                     /gene="EFCAB9"
                     /note="major polyA site"
ORIGIN      
        1 gatgagactg aagcaaggat cgtttctgtg gtacctctat ctggacaaaa tatactgctt
       61 attatccgtg agaaacgtga aggctttggc agaatatttt catattctgg acgtgcacgg
      121 caagaacacc ttgaatgatg tgctgttcta tcacttcctt catcatgtga ctgacttgaa
      181 aaaggcacag atcaacattg tgtttgacat gctggactgg aacgctgtgg gcgagatcga
      241 ctttgagaag ttctacatgc tggtgtgcat gctgctggcc caccagaacc atttggaagg
      301 acagtttatg tatcgtcatt cccggcctgt ctttgacctg cttgacctga aaggggatct
      361 gagaattggt gcaaaaaact tcgaaatgta cagatttctc ttcaatattc aaaaacagga
      421 actcaaagat ctcttccgtg actttgacat tacaggtgac aatcgtctta attatcagga
      481 atttaagctg tatacaatca tctacactga caaattacag aagaggcaga aaacagagga
      541 gaaagaaaaa ggagagagaa agagaagtct ctactcaaaa tgtcacatca agtagataca
      601 agctgaaaga gtcttggaaa aaaatgggat ctgaaagtac agaacatgaa cattgatgaa
      661 gactgttaac atgtctaaaa ataaattcag agcatcaaag taga
//
