LOCUS       NM_001143967            4197 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens EF-hand calcium binding domain 8 (EFCAB8), mRNA.
ACCESSION   NM_001143967 XM_001720320 XM_371397 XM_936526
VERSION     NM_001143967.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4197)
  AUTHORS   Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M,
            Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow
            KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE,
            Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C,
            Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee
            CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A,
            Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA,
            Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths
            MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S,
            Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K,
            Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A,
            Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM,
            Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray
            AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver
            K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ,
            Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE,
            Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C,
            Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L,
            Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis
            JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA,
            Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S and
            Rogers J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035071.17, AL390298.13 and AL139826.15.
            
            On Dec 17, 2020 this sequence version replaced NM_001143967.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400522.9/ ENSP00000383366.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AL035071.17        118829-118899
            72-84               AL390298.13        101-113
            85-136              AL390298.13        4890-4941
            137-302             AL390298.13        8689-8854
            303-421             AL390298.13        17033-17151
            422-525             AL390298.13        19811-19914
            526-661             AL390298.13        26612-26747
            662-767             AL390298.13        30408-30513
            768-852             AL390298.13        33320-33404
            853-977             AL390298.13        34281-34405
            978-1051            AL390298.13        37561-37634
            1052-1182           AL390298.13        39600-39730
            1183-1250           AL390298.13        47669-47736
            1251-1402           AL390298.13        47950-48101
            1403-1540           AL139826.15        274-411
            1541-1651           AL139826.15        1820-1930
            1652-1879           AL139826.15        3479-3706
            1880-1950           AL139826.15        4793-4863
            1951-2155           AL139826.15        9300-9504
            2156-2368           AL139826.15        10361-10573
            2369-2506           AL139826.15        12077-12214
            2507-2725           AL139826.15        22397-22615
            2726-2884           AL139826.15        23177-23335
            2885-3053           AL139826.15        35635-35803
            3054-3183           AL139826.15        50420-50549
            3184-3388           AL139826.15        51777-51981
            3389-3487           AL139826.15        52062-52160
            3488-4197           AL139826.15        53135-53844
FEATURES             Location/Qualifiers
     source          1..4197
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..4197
                     /gene="EFCAB8"
                     /note="EF-hand calcium binding domain 8"
                     /db_xref="GeneID:388795"
                     /db_xref="HGNC:HGNC:34532"
     exon            1..84
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            85..136
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3961
                     /gene="EFCAB8"
                     /note="EF-hand domain-containing protein ENSP00000383366"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 8"
                     /protein_id="NP_001137439.1"
                     /db_xref="GeneID:388795"
                     /db_xref="HGNC:HGNC:34532"
                     /translation="MSSEDLAEIPQLQKLSIPHGFQNKEAASSPTPSITLSQVPDLQP
                     GSQLFTEIHLAKIEKMFEEDINSTGALGMDAFIKAMKKVLSSVSDEMLKELFLKVDSD
                     CEGFVTWQKYVDYMMREFQGKEDMRKSQYRLHFYLPMTVVPLNHGCEVVKVVFLIHRF
                     KKIGCFLTVTKDGILQFWSESFSLMSSFRLNQTQQLYNQPMWVIDMVCLHNMNLVAVA
                     STRQKIDFFDISDHKCVRAFTFVDLDSCALVMDYWSDYHRGVFCYGDAKGNVIVFTSE
                     NMTSGLFNPRILPRASKWDHWIKVSLQKLLNEKSALHRSYRLKALHPNWCEQVKFIPQ
                     MNVVVSCSAIEKSSLVLTILPAKASKKPRLSVLRLRKGILCFDYCPDRNFLVTGGYDA
                     FIRLWNPFVSKRPVWLMKGHQTSVTHILVDSRNNSILISVSKDKNIRVWDMLDYICLQ
                     SFCGKFFALGNCPITSAYFFEKDNTLICSTYSIGILKGYLEAQGLIKARKRTTHCSPL
                     CAVLYSKIFKQVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCLL
                     TGLRDGTMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWSKRITHFLFHKTK
                     PVLLCYHWQTYHTEDILSMAKYRNQFLGTSSYSGDILFWNTGTLKPIFNFNASRSPSP
                     LQPKRVQDVNNCLAESHRPSRPYVEREKWTYKTSRKLSSLSPESVANTNLRRSLVSAP
                     PVMRCPRDKEPDRPVPQQKPSSASGTSRQSSKIHSKQSIYKEDETRKGEWQKNMLVQS
                     SASVEKIIFLQTRPRLPHTAALLSSCMDGYIYAWSLHENGGLLGKFPVDLDNGDVVVG
                     AMATDKNDWILITGDCKGYIKIWDIKDYCALIDKQPFQSSGAKVVSEAHNKFRLLIPQ
                     QLGTNFPHYIPLEDKEVVAGHTISLVPPTLLMTWKGHLNSVADILYVDNFQLVISAGQ
                     DRDVKAWKLSGDAIGTFGLSVWKRLQDACDGPRENRASLEEDGDSTGTTQKVLHLELQ
                     EQRDLAEALIYQRREQAALMALLHGKADKEADTWAKLQKMALMSPWAGERPLEDIEDS
                     WNKWESRDKQVSKVLGAAYKPKERLQNTRFLSTRVPYGWMKHQISPQVYQSLHFSDLM
                     PTQQPDFLTSRGPDQQDQHIRLVAHHVQKDLVPSREQAVLDTTDSTPAAASSPSSLLS
                     VTASASRLLDSSLPTFLTPQFSFLLRPQSASTAHSTPSVPSPVSKSTLQGSVTPKHIV
                     SSFERPPRPLKATFMSSVKGSSHVRF"
     exon            137..302
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            303..421
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            422..525
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            526..661
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            662..767
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            768..852
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            853..977
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1051
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1182
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1250
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1402
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1540
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1651
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1879
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1950
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2155
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2368
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2506
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2725
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2884
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..3053
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3183
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3388
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            3389..3487
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..4197
                     /gene="EFCAB8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4158..4163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB8"
                     /note="hexamer: AATAAA"
     polyA_site      4197
                     /gene="EFCAB8"
                     /note="major polyA site"
ORIGIN      
        1 tttgttgaga tgggagttgg aaagtgttag cactttgcca gactttgcca gcaagattaa
       61 ctgaggagat caaattgagt cagggtcaag gctaatgtct tctgaagact tagcagagat
      121 ccctcaactc caaaagctgt ccatcccaca tggcttccag aacaaggagg ctgctagctc
      181 cccaacacca tccatcaccc ttagccaggt gcctgacctc cagcctgggt cccagctgtt
      241 tactgagata cacctggcca agatagagaa aatgtttgag gaggacatca actcgactgg
      301 agccctgggc atggacgcct tcatcaaggc catgaagaag gttctgagca gtgtgtcgga
      361 cgagatgcta aaggagctgt ttttgaaggt ggactcggac tgtgaaggct ttgtcacctg
      421 gcaaaagtat gtggattaca tgatgcgtga gttccaggga aaagaggaca tgcgaaagag
      481 ccagtaccgc ctgcacttct accttcccat gacggtcgtc cccctgaacc atggctgtga
      541 ggtggtgaag gtggtgtttt taatccaccg gttcaagaag atcgggtgtt tcctgactgt
      601 caccaaagac gggatcctgc agttctggtc tgagtccttc tcgctgatga gctcctttag
      661 gcttaaccag acccagcagc tctacaacca gccgatgtgg gtcattgaca tggtatgtct
      721 gcacaatatg aacctcgttg cagttgcgtc taccaggcaa aagatagatt tctttgatat
      781 tagtgaccac aaatgtgtcc gggccttcac ctttgttgat ctggacagct gtgctctggt
      841 catggactac tggtctgact atcacagagg tgtgttctgc tatggagacg ccaaaggcaa
      901 cgtcattgtc ttcacctccg aaaacatgac cagtgggctg ttcaaccccc gtatcctccc
      961 cagggcctcc aagtgggatc actggatcaa agtttccttg cagaaactct taaatgagaa
     1021 gtctgctttg catagaagct accggctgaa ggctctccat cccaactggt gtgagcaggt
     1081 caagttcatc ccccagatga atgtggtagt ctcctgttca gccatcgaga agtcctctct
     1141 ggtgctgaca atattgccag ccaaagcctc taagaaaccc aggttgtcag tgctgcgttt
     1201 aaggaaaggg attctttgct ttgattactg cccagacagg aacttcctgg tgactggtgg
     1261 ctacgatgcc ttcatccgcc tgtggaaccc ctttgtctca aagaggcccg tgtggctgat
     1321 gaagggacac cagacctcag tgacgcacat ccttgtggat agcaggaaca acagcatcct
     1381 catcagtgtc tccaaggaca agaatattcg cgtgtgggac atgctggact acatatgcct
     1441 ccagtccttc tgtgggaagt tttttgctct gggaaactgc cccatcacca gtgcctactt
     1501 cttcgagaag gacaataccc tcatctgcag cacctactca atcgggatcc taaaagggta
     1561 cttagaggcc caggggctta tcaaagcaag gaagaggacc actcattgct cacccctgtg
     1621 tgctgtcctc tacagcaaga tctttaagca ggtggtgagt ggctgcctgc gcggcacagt
     1681 gagtgtgtgg gaggtcgtga cgggcaggaa gacgatggag tttgctgtgt ctgggggcca
     1741 gcacgtggag atgaccgcca tggccctgga tgagtcagag cggtgcctgc tcacaggttt
     1801 gcgggatggc acaatgaaga tgtggaacta caacattggc aaatgcctgt tgacctttcc
     1861 cagtccggaa cagctggaga ttagtgggat tatccatatg aacaaagtgt tctatgtgac
     1921 aggatggagt aagagaatca ctcatttcct gttccacaag accaagccag tgctcttgtg
     1981 ctaccactgg cagacctacc acacggagga catcctgagc atggccaagt accggaacca
     2041 gttccttggg acctcctcct acagtgggga catcctcttc tggaacaccg gcacactcaa
     2101 gcccatcttc aacttcaatg cctctaggag cccctcgccc ttgcagccca agagggtgca
     2161 agatgtgaac aactgcctgg ctgagagcca caggcccagc agaccctatg tggagcggga
     2221 gaagtggaca tacaagacct ccaggaagct ctccagtctc agccccgagt ctgtggccaa
     2281 taccaacctg aggcggagcc tggtgtcggc tcccccagtg atgcggtgcc cgagagacaa
     2341 ggagccagac aggcctgtgc cccagcagaa accttccagt gcttctggca catccaggca
     2401 gtcaagcaag atccacagca aacagtccat ttacaaagag gatgaaacga gaaaaggaga
     2461 atggcagaag aatatgttgg ttcaatccag tgcctcggtg gagaagataa tcttcctgca
     2521 gaccaggcct cgcctgccgc acacggctgc cctgctgagc agctgcatgg acggctacat
     2581 ctacgcctgg tccctccatg agaatggagg cctgctgggg aagttccctg tggacctaga
     2641 caatggggat gttgtcgtgg gtgccatggc cactgataaa aatgactgga tcctcatcac
     2701 gggggattgt aaaggataca tcaagatctg ggacatcaag gattactgcg cattgattga
     2761 taaacagcca ttccaatcca gtggggccaa ggttgtctct gaagcacaca acaagttccg
     2821 gttgttaatt cctcagcaac ttgggaccaa cttcccacac tacattccct tggaggataa
     2881 agaggttgtg gctggccata ccatttccct ggttcccccc acgctcctga tgacctggaa
     2941 aggccatttg aatagtgtgg cagacatcct gtatgtggac aacttccagc tggttatcag
     3001 cgctggccag gaccgggacg tcaaggcttg gaaactctcc ggtgatgcca ttggaacgtt
     3061 tggcctgagt gtgtggaaaa gactacagga tgcctgtgat ggtcctcgtg aaaacagagc
     3121 aagcttagag gaagatggtg actccactgg caccacccag aaggtcttac atctggagct
     3181 gcaggagcag cgggatctgg ctgaggccct gatataccag cggcgagagc aggcggcgct
     3241 gatggctctc ctgcatggga aggcagataa ggaggcagac acttgggcca agctgcagaa
     3301 gatggccctg atgtccccgt gggccggaga gcgccccctg gaagacattg aggacagctg
     3361 gaacaagtgg gagtccaggg acaagcaggt gagcaaagtc ttgggagcgg cgtataagcc
     3421 caaggaacgc ttgcagaata ccaggttcct gtccaccagg gtgccatatg gctggatgaa
     3481 gcatcagatc tcgcctcagg tctaccaaag cctgcacttc agtgatctga tgccgactca
     3541 gcagcctgac ttcctgacca gcaggggccc agaccagcaa gaccagcaca tccgcctggt
     3601 ggcccaccat gtccagaagg acctggtgcc cagcagggag caggctgtgc tggataccac
     3661 ggacagcacg cctgcggccg cctcctcccc atcttccttg ttatctgtca ctgcctcagc
     3721 ctccaggctg ctggactcca gcttgcccac cttcctgacg ccccagttct ccttcttgct
     3781 gcggccccag tcagcctcca cagcccattc caccccctcg gtcccatccc cggtgtccaa
     3841 gtccaccctg caggggtcag tgacccccaa gcacattgtc tcctccttcg agcggccccc
     3901 aaggcctctg aaggccacct tcatgtcctc tgtgaagggg agctcccatg tcaggttctg
     3961 aggtgctccg ctgtcttctc tagtcctcca gcagggcaac caggcccatg gcggtcctgc
     4021 atgttctcgg cttattccct accagaccca gaggatgtgg ctcttccccc ggccacccca
     4081 ctgggcctct ctggggaagt tcacctgtct cctaatcttg tcttctctct ggccccgcac
     4141 agagccctgg ggcagaaaat aaatgttctc agctgtgggc atccacaggt gatgagg
//
