LOCUS       NM_022785               4863 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens EF-hand calcium binding domain 6 (EFCAB6), transcript
            variant 1, mRNA.
ACCESSION   NM_022785
VERSION     NM_022785.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4863)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4863)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   3  (bases 1 to 4863)
  AUTHORS   Niki,T., Takahashi-Niki,K., Taira,T., Iguchi-Ariga,S.M. and
            Ariga,H.
  TITLE     DJBP: a novel DJ-1-binding protein, negatively regulates the
            androgen receptor by recruiting histone deacetylase complex, and
            DJ-1 antagonizes this inhibition by abrogation of this complex
  JOURNAL   Mol Cancer Res 1 (4), 247-261 (2003)
   PUBMED   12612053
  REMARK    GeneRIF: androgen receptor is positively regulated by DJ-1, which
            antagonizes the function of negative regulators, including DJBP, a
            novel DJ-1-binding protein
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK058069.1, AK292411.1,
            BC039315.1 and BP325901.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022785.3.
            
            Summary: This gene encodes a protein which directly binds the
            oncogene DJ-1 and androgen receptor to form a ternary complex in
            cells. This binding protein recruits histone-deacetylase complexes
            in order to repress transcription activity of androgen receptor.
            This protein may also play a role in spermatogenesis and
            fertilization. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262726.12/ ENSP00000262726.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1046              AK058069.1         33-1078
            1047-1479           AK292411.1         1019-1451
            1480-3457           BC039315.1         1007-2984
            3458-3722           BP325901.1         30-294
            3723-4863           AK292411.1         3695-4835
FEATURES             Location/Qualifiers
     source          1..4863
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2-q13.31"
     gene            1..4863
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /note="EF-hand calcium binding domain 6"
                     /db_xref="GeneID:64800"
                     /db_xref="HGNC:HGNC:24204"
                     /db_xref="MIM:619664"
     exon            1..138
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..275
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..421
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..4788
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /note="isoform a is encoded by transcript variant 1;
                     EF-hand calcium-binding domain-containing protein 6;
                     DJ-1-binding protein; CAP-binding protein
                     complex-interacting protein 1; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 6 isoform a"
                     /protein_id="NP_073622.2"
                     /db_xref="CCDS:CCDS14049.1"
                     /db_xref="GeneID:64800"
                     /db_xref="HGNC:HGNC:24204"
                     /db_xref="MIM:619664"
                     /translation="MCKMAIIPDWLRSHPHTRKFTHSRPHSSPCRVYSRNGSPNKFRS
                     SSTTAVANPTLSSLDVKRILFQKITDRGDELQKAFQLLDTGQNLTVSKSELRRIITDF
                     LMPLTREQFQDVLAQIPLSTSGTVPYLAFLSRFGGIDLYINGIKRGGGNEMNCCRTLR
                     ELEIQVGEKVFKNIKTVMKAFELIDVNKTGLVRPQELRRVLETFCMKLRDEEYEKFSK
                     HYNIHKDTAVDYNVFLKNLSINNDLNLRYCMGNQEVSLENQQAKNSKKERLLGSASSE
                     DIWRNYSLDEIERNFCLQLSKSYEKVEKALSAGDPCKGGYVSFNYLKIVLDTFVYQIP
                     RRIFIQLMKRFGLKATTKINWKQFLTSFHEPQGLQVSSKGPLTKRNSINSRNESHKEN
                     IITKLFRHTEDHSASLKKALLIINTKPDGPITREEFRYILNCMAVKLSDSEFKELMQM
                     LDPGDTGVVNTSMFIDLIEENCRMRKTSPCTDAKTPFLLAWDSVEEIVHDTITRNLQA
                     FYNMLRSYDLGDTGRIGRNNFKKIMHVFCPFLTNAHFIKLCSKIQDIGSGRILYKKLL
                     ACIGIDGPPTVSPVLVPKDQLLSEHLQKDEQQQPDLSERTKLTEDKTTLTKKMTTEEV
                     IEKFKKCIQQQDPAFKKRFLDFSKEPNGKINVHDFKKVLEDTGMPMDDDQYALLTTKI
                     GFEKEGMSYLDFAAGFEDPPMRGPETTPPQPPTPSKSYVNSHFITAEECLKLFPRRLK
                     ESFRDPYSAFFKTDADRDGIINMHDLHRLLLHLLLNLKDDEFERFLGLLGLRLSVTLN
                     FREFQNLCEKRPWRTDEAPQRLIRPKQKVADSELACEQAHQYLVTKAKNRWSDLSKNF
                     LETDNEGNGILRRRDIKNALYGFDIPLTPREFEKLWARYDTEGKGHITYQEFLQKLGI
                     NYSPAVHRPCAEDYFNFMGHFTKPQQLQEEMKELQQSTEKAVAARDKLMDRHQDISKA
                     FTKTDQSKTNYISICKMQEVLEECGCSLTEGELTHLLNSWGVSRHDNAINYLDFLRAV
                     ENSKSTGAQPKEKEESMPINFATLNPQEAVRKIQEVVESSQLALSTAFSALDKEDTGF
                     VKATEFGQVLKDFCYKLTDNQYHYFLRKLRIHLTPYINWKYFLQNFSCFLEETADEWA
                     EKMPKGPPPTSPKATADRDILARLHKAVTSHYHAITQEFENFDTMKTNTISREEFRAI
                     CNRRVQILTDEQFDRLWNEMPVNAKGRLKYPDFLSRFSSETAATPMATGDSAVAQRGS
                     SVPDVSEGTRSALSLPTQELRPGSKSQSHPCTPASTTVIPGTPPLQNCDPIESRLRKR
                     IQGCWRQLLKECKEKDVARQGDINASDFLALVEKFNLDISKEECQQLIIKYDLKSNGK
                     FAYCDFIQSCVLLLKAKESSLMHRMKIQNAHKMKEAGAETPSFYSALLRIQPKIVHCW
                     RPMRRTFKSYDEAGTGLLSVADFRTVLRQYSINLSEEEFFHILEYYDKTLSSKISYND
                     FLRAFLQ"
     exon            422..633
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..722
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..789
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..926
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1039
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1164
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1313
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1424
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1533
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1701
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1761
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1922
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2096
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2265
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2380
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2514
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2747
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2844
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..2963
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3158
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3159..3314
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3510
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3702
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3703..3930
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3931..4161
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..4330
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4331..4515
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4516..4665
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            4666..4863
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4843..4848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /note="hexamer: AATAAA"
     polyA_site      4863
                     /gene="EFCAB6"
                     /gene_synonym="dJ185D5.1; DJBP; HSCBCIP1"
                     /note="major polyA site"
ORIGIN      
        1 agtcagcgac tgccgtcgtc tctcgggcaa cagcgtccta gagacgccga atgggcagcc
       61 cctctgagac cccgcggctt ggggtccgcg cacgcgggtg ccggcccagc taggcggaga
      121 atcgaggagg ggttcccggg ctcatcgcag aggattggaa gggcctagat tactgcccaa
      181 tgacaaaagt gtgggcttaa tgtcctcact cttcagggag agaatgtgga ctttagcatt
      241 tgaactgaat atttgagatt gaagatttct gaataggatt taatgtgcaa aatggcgatt
      301 ataccagact ggcttaggtc gcatcctcac acacgaaaat ttacacattc aagaccccat
      361 tcttcaccgt gtagagtata ttcaaggaat ggttccccaa ataagttcag atcttcttca
      421 accacagctg ttgcaaatcc aacactgtcc tccttagatg ttaaacggat tttatttcaa
      481 aaaattaccg acagagggga tgagttgcaa aaagcctttc agctgctgga tactggtcag
      541 aacttgactg tgtcaaaaag tgaactgaga agaatcatca cagacttcct gatgccgctc
      601 acacgagaac agtttcagga cgtgttggct cagatccccc ttagcacctc tggtactgta
      661 ccgtaccttg cctttctgtc caggtttggt ggaattgacc tatatataaa tggtataaag
      721 aggggaggtg ggaatgaaat gaattgctgc cgcacattaa gagaacttga aatccaagtg
      781 ggagaaaagg ttttcaaaaa cattaagact gttatgaaag cctttgagct cattgatgtt
      841 aacaagactg gactggttcg accgcaggag ctaagaaggg ttctggagac cttctgtatg
      901 aagttaagag acgaggaata cgaaaagttt tcgaaacact acaacatcca caaggatact
      961 gcagtagatt acaacgtgtt tttgaagaat ctcagcataa ataacgactt gaaccttaga
     1021 tattgtatgg gaaatcaaga ggtctcgttg gagaatcaac aagccaaaaa ttccaaaaag
     1081 gaacgtttgc taggttctgc atcatctgaa gatatctgga gaaactactc cttggatgaa
     1141 attgagagga acttttgtct acaactttcg aagtcttatg aaaaggttga aaaggccctc
     1201 agtgcagggg acccctgtaa aggtggctac gtgtctttta attatctaaa gattgtcctc
     1261 gacacttttg tataccaaat accaagaaga atttttatcc agttaatgaa aagatttgga
     1321 cttaaagcca ccactaaaat caattggaag caatttctaa catcatttca tgagcctcag
     1381 gggttgcaag ttagcagtaa aggtcccctg acaaaaagaa atagcatcaa ctctagaaat
     1441 gaatctcaca aggaaaacat catcacaaag ttatttagac acactgaaga tcactctgcg
     1501 tcactgaaga aagcattact gataatcaac actaaacccg atggaccgat aacaagagaa
     1561 gaatttcgat atattctaaa ttgcatggct gtaaaactaa gcgattcaga attcaaagaa
     1621 ctaatgcaaa tgcttgaccc tggggacact ggagtggtca acaccagcat gtttattgat
     1681 ctgattgaag agaactgtag gatgagaaag acatctccct gtacagatgc taagacacct
     1741 ttcctcctgg cctgggattc agtggaagaa attgttcatg atacaattac taggaaccta
     1801 caagcttttt ataacatgct acgctcatat gaccttggag acacagggcg cattggccga
     1861 aataatttca agaaaatcat gcacgtcttc tgtccatttt taacgaatgc acatttcata
     1921 aaactctgca gtaagattca ggacattggt tcaggaagaa tcctttacaa gaaacttttg
     1981 gcatgcatag gaattgatgg cccacccact gtctctccag ttcttgttcc aaaggatcag
     2041 ctgttaagtg aacatttaca aaaagatgaa cagcagcagc cagatctttc tgagagaacc
     2101 aagctcacgg aggataaaac caccctgacc aagaagatga ccacagaaga agtgattgaa
     2161 aaattcaaaa agtgtataca gcagcaggac ccggcattca aaaaacgatt tcttgacttc
     2221 agcaaggagc ctaatggaaa aattaacgtg catgacttta agaaggtact ggaagacact
     2281 gggatgccca tggacgatga tcagtatgcc ctgctgacca ctaaaatagg cttcgagaag
     2341 gaagggatga gctatcttga ttttgcagca ggatttgaag atcctccaat gagagggccg
     2401 gaaaccactc cgccgcagcc tccaactcct tcaaaaagtt acgtgaacag ccactttatc
     2461 accgcagaag aatgcctgaa gcttttccct aggaggctga aggagtcatt ccgggacccc
     2521 tactctgcct tctttaaaac agatgctgac agggatggca taatcaacat gcatgacctt
     2581 cacagactgc tcctgcatct actgcttaat ctcaaagacg acgagtttga gcgcttcctt
     2641 ggccttcttg gcttgagact tagtgtcact ttaaattttc gggaatttca aaatttgtgt
     2701 gagaagagac catggagaac agatgaagcg cctcaaagac tcattagacc aaaacagaag
     2761 gttgcggatt cagaactagc ttgtgagcag gctcatcagt atcttgttac caaagcaaaa
     2821 aacagatggt cagacttgtc taagaatttt ctagaaaccg ataatgaggg caatggcatt
     2881 cttcgacgcc gggacataaa gaacgcactg tacggttttg atattcccct cacaccaaga
     2941 gagtttgaaa agctttgggc aagatacgac accgagggaa aagggcacat tacttaccag
     3001 gaatttttac agaaattggg tattaactat tcgcctgctg tccatcggcc ctgtgcagag
     3061 gattatttca acttcatggg tcattttaca aagccacagc agctacagga agagatgaag
     3121 gagctgcagc agagcacaga gaaggctgtg gcagccaggg ataagcttat ggaccgccat
     3181 caagatatca gcaaagcatt caccaaaact gatcaatcca aaaccaacta catatccata
     3241 tgcaagatgc aggaagtgct ggaagaatgt ggatgttctc ttaccgaagg ggagctgacc
     3301 catctgctaa acagttgggg agtcagccgg catgataatg ctatcaatta cctcgacttc
     3361 ctgagagcag tggagaacag caagtcaaca ggagctcagc ccaaggaaaa agaagagagc
     3421 atgccaatca attttgcaac gctgaatcca caggaggctg tgaggaagat ccaggaagta
     3481 gttgagtcct cccagctggc tttgtccacg gcattttctg cattggataa agaggataca
     3541 ggatttgtaa aggctacaga attcggacaa gttcttaagg atttctgtta caaactaacg
     3601 gacaatcagt atcattattt tttgaggaaa ctaagaattc atctaacccc ctatataaat
     3661 tggaaatatt ttctccagaa ctttagctgt ttccttgagg agacagctga tgagtgggct
     3721 gagaaaatgc ccaaaggccc gccgcctacc tctcccaagg ccacagccga cagagacatc
     3781 ctggctcgcc tccacaaagc agtgacttcc cattaccatg ccatcaccca ggagtttgag
     3841 aattttgaca ccatgaaaac gaacaccatc tccagagagg agtttagggc catttgtaat
     3901 cgccgcgtcc aaatcctgac ggacgaacag tttgacagac tctggaacga gatgccagtc
     3961 aatgccaagg ggaggctgaa atacccggac ttcctgagca ggttcagttc cgagacagca
     4021 gccacaccaa tggccactgg tgactcggcc gtggcccaga gagggagcag tgtccctgac
     4081 gtctcggaag gcaccagatc tgccctctca ttgcccactc aggagctgag accagggtca
     4141 aagtcgcaga gccacccctg tactccagcg agcaccaccg tgatcccggg cactccaccc
     4201 ttgcagaact gtgatcccat agagagcagg ctccggaaga gaatccaggg ctgctggcgc
     4261 cagctcctga aagaatgcaa ggagaaggac gtggccagac agggggacat caacgcctcc
     4321 gatttcctgg ctcttgtgga gaaattcaac ctggacataa gcaaagagga gtgtcagcag
     4381 ctcattataa aatacgactt aaagagcaac gggaaatttg catactgtga cttcattcag
     4441 agctgtgtcc tcctgctaaa agcaaaggaa agctcactga tgcacaggat gaagatccag
     4501 aatgcacaca agatgaaaga agccggcgcg gagacgccat ctttttactc tgctctgctg
     4561 cgtattcagc ccaaaattgt gcactgctgg aggccaatgc ggcgcacgtt caaaagctat
     4621 gatgaggctg gaacagggct gctaagcgtc gcagatttca ggacggtcct gagacagtac
     4681 agcatcaacc tctctgagga agagttcttc catattctgg agtattacga taagacgctg
     4741 tcttcaaaaa tctcctacaa cgacttcctc cgggcattcc tccagtagac acccctgctg
     4801 tgtgcccagc gggacgacag ccacagggcc tgtttcaagg ctaataaaat cctataattt
     4861 ggg
//
