LOCUS       NM_014774               5817 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens EF-hand calcium binding domain 14 (EFCAB14), mRNA.
ACCESSION   NM_014774 XM_375726
VERSION     NM_014774.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5817)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5817)
  AUTHORS   Lange,C.M., Kutalik,Z., Morikawa,K., Bibert,S., Cerny,A.,
            Dollenmaier,G., Dufour,J.F., Gerlach,T.J., Heim,M.H.,
            Malinverni,R., Mullhaupt,B., Negro,F., Moradpour,D. and Bochud,P.Y.
  CONSRTM   Swiss Hepatitis C Cohort Study Group
  TITLE     Serum ferritin levels are associated with a distinct phenotype of
            chronic hepatitis C poorly responding to pegylated interferon-alpha
            and ribavirin therapy
  JOURNAL   Hepatology 55 (4), 1038-1047 (2012)
   PUBMED   22095909
REFERENCE   3  (bases 1 to 5817)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: occurrence of an unusual TG 3' splice site in intron 1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL593856.8, AB007963.1, BC002525.2 and AA974135.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014774.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.72372.1,
                                           SRR1803612.143894.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371933.8/ ENSP00000361001.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AL593856.8         72760-72809         c
            51-217              AB007963.1         1-167
            218-905             AL593856.8         71905-72592         c
            906-2760            BC002525.2         1-1855
            2761-5662           AL593856.8         29009-31910         c
            5663-5817           AA974135.1         28-182              c
FEATURES             Location/Qualifiers
     source          1..5817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..5817
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /note="EF-hand calcium binding domain 14"
                     /db_xref="GeneID:9813"
                     /db_xref="HGNC:HGNC:29051"
                     /db_xref="MIM:619559"
     exon            1..1212
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     CDS             1028..2515
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 14"
                     /protein_id="NP_055589.1"
                     /db_xref="CCDS:CCDS30706.1"
                     /db_xref="GeneID:9813"
                     /db_xref="HGNC:HGNC:29051"
                     /db_xref="MIM:619559"
                     /translation="MKKRKELNALIGLAGDSRRKKPKKGPSSHRLLRTEPPDSDSESS
                     SEEEEEFGVVGNRSRFAKGDYLRCCKICYPLCGFVILAACVVACVGLVWMQVALKEDL
                     DALKEKFRTMESNQKSSFQEIPKLNEELLSKQKQLEKIESGEMGLNKVWINITEMNKQ
                     ISLLTSAVNHLKANVKSAADLISLPTTVEGLQKSVASIGNTLNSVHLAVEALQKTVDE
                     HKKTMELLQSDMNQHFLKETPGSNQIIPSPSATSELDNKTHSENLKQDILYLHNSLEE
                     VNSALVGYQRQNDLKLEGMNETVSNLTQRVNLIESDVVAMSKVEKKANLSFSMMGDRS
                     ATLKRQSLDQVTNRTDTVKIQSIKKEDSSNSQVSKLREKLQLISALTNKPESNRPPET
                     ADEEQVESFTSKPSALPKFSQFLGDPVEKAAQLRPISLPGVSSTEDLQDLFRKTGQDV
                     DGKLTYQEIWTSLGSAMPEPESLRAFDSDGDGRYSFLELRVALGI"
     exon            1213..1361
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1507
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1606
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..1717
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1822
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2014
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2101
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2213
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2339
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..5817
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4384..4389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /note="hexamer: AATAAA"
     polyA_site      4408
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /note="major polyA site"
     regulatory      5791..5796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /note="hexamer: AATAAA"
     polyA_site      5817
                     /gene="EFCAB14"
                     /gene_synonym="KIAA0494"
                     /note="major polyA site"
ORIGIN      
        1 gaagtgatct ggggctggag cgatggcccg gggctggagc tcgcggccgc cgccgccgca
       61 gccgccgcca ccaacgccaa caacaacgtg tcgggagcag ccgcggccga agccggagca
      121 ggggccggag tcgcggctgg agtggggcct gcgcgtgtga gtggccgaga gttgcccgtg
      181 ccggagacct caaactccgg gcgggagcgc tttcggtcgg ccgagccgcc gtcgcccgcg
      241 gcaccgtgtc cccaaggccc agacagcggg gcgggggtct atcaggcgcg ggactggctt
      301 ctctcaggcc gacccttcta gccgggctcc ggatcttcct cggcctcggg cccccttcac
      361 gttcaggacg gaggccggag aacggtgatc atcacacacc ccagccggct tcctggccag
      421 ggcattttct ctgcggccaa gcagtgttgg gattgtagct gctgggagcc ccctcctgcc
      481 gccacctctc ctgcaaggaa gggactgacg cgttcccact ttcttactct gcacctcccc
      541 actctcttcc cattcaagaa cgagtttctc ttccctctcc attggaaatc ttgctccgga
      601 ggtccgaaac acgtatttta agcgtgccct tcctcacctc ctggagcacc cttagaagta
      661 ttgcctactt atccgggctg agaatccttc atttttgacc tggctttttt ttcgcccttt
      721 gggagataaa ggtccctctc caccctctac taacactctg cacccaaggc cttatccttt
      781 ggggtcacca gctccttggc catttctatg tgatttcccc cacccatctg agttccagtt
      841 tcctctgggc tccaatctcc agtccctggc ggatctggtc agtcccaccc ctaggtggga
      901 gtgaccaggg ggctctggcc caggattccc aaccctggaa ggcagctcca aggcaggaag
      961 agaattgggc atcgggtacg aacctggcag ctcaggagtc ggggctccac tcaccccaca
     1021 caaaaagatg aaaaagcgca aagagctcaa tgcattgatt ggtttggctg gggacagccg
     1081 gagaaagaag cccaagaaag gcccaagcag tcaccgcctg cttcgcactg agcctcccga
     1141 ctcagactct gagtccagct ccgaagagga agaggaattc ggtgtggttg gaaatcgctc
     1201 tcgctttgcc aagggagact atttacgatg ctgcaagatc tgttatccgc tctgtggttt
     1261 tgtcatcctt gctgcctgtg ttgtggcctg tgttggcttg gtgtggatgc aggttgctct
     1321 caaggaggat ctggatgccc tcaaggaaaa atttcgaaca atggaatcta atcagaaaag
     1381 ctcattccaa gaaatcccca aacttaatga agaactactc agcaagcaaa aacaacttga
     1441 gaagattgaa tctggagaga tgggtttgaa caaagtctgg ataaacatca cagaaatgaa
     1501 taagcagatt tctctgttga cttctgcagt gaaccacctc aaagccaatg ttaagtcagc
     1561 tgcagacttg attagcctgc ctaccactgt agagggactt cagaagagtg tagcttccat
     1621 tggcaatact ttaaacagcg tccatcttgc tgtggaagca ctacagaaaa ctgtggatga
     1681 acacaagaaa acgatggaat tactgcagag tgatatgaat cagcacttct tgaaggagac
     1741 tcctggaagc aaccagatca ttccgtcacc ttcagccaca tcagaacttg acaataaaac
     1801 ccacagtgag aatttgaaac aggatatcct gtaccttcac aactctttag aggaggtaaa
     1861 cagtgcccta gtggggtacc agagacagaa tgatcttaaa ctcgagggaa tgaacgagac
     1921 agtcagtaat cttacccaga gagtcaacct gatagaaagc gatgtggttg ctatgagcaa
     1981 ggtagaaaag aaagcaaacc tgtccttcag catgatgggt gatagatctg ccactctgaa
     2041 aagacagtct ttggatcaag tcaccaacag aacagataca gtaaaaatcc aaagcataaa
     2101 gaaagaagat agttcaaatt ctcaggtatc caagctaaga gagaaactcc agctgatcag
     2161 tgctcttaca aacaaacctg agagcaacag gcctccagag accgccgatg aagagcaagt
     2221 agagagtttc acatcaaagc catcagcatt gccaaaattt tcacagtttc ttggagaccc
     2281 agttgagaaa gctgcccaac taagacctat ctccctacca ggagtttcta gcactgaaga
     2341 tcttcaggat ttattccgca agactggcca ggacgtggat gggaagctga cctaccagga
     2401 aatctggacc tccctaggtt ctgctatgcc agaaccagag agcttgagag catttgattc
     2461 cgatggagat ggaagatact cattcctgga gctaagggta gctttaggta tctagcttca
     2521 tcaggcatat tttagaaatg gactgcctaa tatctattta cctaacaaca aaacaaccct
     2581 tacttaccca tcagtcctct agtcctccaa actactgtag cagatacttt gccacctttt
     2641 aacttgtttg aagaagctat ataaaagtta tttttttaaa gaagaagacc attttactta
     2701 tgatgttcag aaatctatga tttcctacaa ccagtaagat cttacatttt aaaattgcca
     2761 gaaaaaaaat taaagccctc tttttttctc tttccttttt ttgaggggag gagaccttat
     2821 cttttaaagc tgggaaatgt atatagagag agaataagcc acttttatat ttcacttaaa
     2881 tttgccttaa attagctgca ctttatagag actcagaaaa tgtcttttct ttaaaagata
     2941 ggccttttct gtttgtaaat atttaaatga aagaaagcat tgtgcatatt gtgtggaaag
     3001 taggaagaat ggttttgaac aggatatgaa caaatgactt attaaaaatt gctgatctgg
     3061 tgtaggtggc agctgaaact acatccatgt ctccataagg tatccctcaa aggcccaggc
     3121 gctgccaggg ggtttgtcct ggtagctgga ggaaccgatt tcagggagta gacactggag
     3181 acaatactga ctccaggcat ggctcatgga agtaggattc tggttctttg ttcctattcc
     3241 ctcagctaat cccaacctgg gaatcagaga agtcttgggg atttttctca tttttagtac
     3301 tatttcaggg tttatgagca taaaaagtta tccattgggg agctccattt tccctgctga
     3361 gtgagctaga ttgccttccc cacccaccca cttaagtctg tcttaaagcc gtagctggct
     3421 cccaccacca gtaccatctc catttgaatg gcagggctaa attcccccag ccattatctc
     3481 acactgacca cccagagctt tagaagagag ctgtgcttct aattttgacc cagaaaacca
     3541 taccccttga gattttacct agaggctaac caagagccta atatgtttct ctgggggatg
     3601 actaaagcca aaaaggctgt gagatgaaac atgtgaaata atattcagtt tccttaccat
     3661 taccagctca gaagtagcta gaggctttct acccaaagga tgccaaagta tagcagggca
     3721 ggcctggagc tagggccttc acatggtggt agcaagtttt tcaaatctaa tacaatcaag
     3781 tacaatactt cctttaaatg cttctgtgga cctggcatga aagatcccta gattgaaagg
     3841 aataatacct ccatgtctcc tgtatgttga gtctagaatt gctgtgttgt tcttagaagc
     3901 agtctttggg caacaacttg aaaggggaaa aaaaaactac aaaaacttaa ctttggtata
     3961 ggccaagtca gggagaaagt agagaaagct gtcatgccac agacttcttt agtggagatc
     4021 atttcctttt taactttgtt caggttgccc ttcaccatgg atacagtccg gtacccttaa
     4081 acatttaagg gctgtttttt ttttctttac atgatgttca gcttggtatt aaccaaactt
     4141 aaattttttt tccagaagta ttaaaattta gttaaagcaa gatgaagtct tttcccatga
     4201 atgtgtcccc ttatctcatt atagcttatg ctcagtttca ctttcttgga aaggttaaaa
     4261 caaattagcc tggcacttta ggtaacttga aaataactct cacccttctg actgccttcc
     4321 atccactctc accccacacc tttttttaat atatatacac ccttacagat tttctaacaa
     4381 ccaaataaaa ttctagcaat aaattgaatt atactgctat atttgtatat actgtaccat
     4441 aaatagtatg tctgtacctg gaaggtattt ttttgagaac tgatttatat gaaatatact
     4501 tgagggtaat gtagcttgtc ctttttagtt tcaaattctt attcataggc agatactttg
     4561 aagacacctt aactctttgt tgtgtgtatt ttcccttgca tcagataact atacatggag
     4621 aaatccattt tgttttttgg tttatcttct gttcttccta ccttgtgctt gtctgactag
     4681 tatcacccct gagccagtat acagtaccat cctctccccc taccaagttt ggcagaggtg
     4741 tttatactgc attctcagat ctatgaatat ttttgtcatc ctgcctgaga aagtacatct
     4801 tccaggcaaa agtagggtat cttgaactcc tttcttctga gttgagcaga ctcactggct
     4861 taagcatccc ataagcctat tatttagtgt gaatttggga cttttatttg tatgttgtct
     4921 taacttacta agcctgtgac ttgtatttag ctgtagtcaa gcctcaccag ccatatctca
     4981 tctctgagag gaagactgga tagtgagttt ggttttggtt ttggttttaa acccttttac
     5041 cttttcagtc tggcagctcc tactgctgct ttcctaagtt actcaaagca ctgcttcttg
     5101 gtccttgttt tcttttgcct tgtactatct tgtataatgt ttactaaaag agcctcccca
     5161 taaatcagag aggcaaaaag gtagcatata aaaagaagaa ccaaaagaag agaaaacctg
     5221 acttctagat gactgtggtg tcatctaaaa ggcagaggtg cctgaccctc aggaatgtgt
     5281 atgatgcaac agagctgaag aatgggttcc cttcacctac tgctggccat tgtcccttct
     5341 gttggagatt cctttcttta tggttgctgt tcataacccc ttcaacaccc ccccttgctg
     5401 gtcctgccgg tcacagttga ggattttggc tgtgatgggc tcatactcat aatggcctgt
     5461 tgagttgttt ttagtgacag gttttgtttg ctgcacacct cattggcttg cttaccaaca
     5521 ccagctagaa gtggtccctc tttcatatcc aaaccagaac acatttgggt attcctgaga
     5581 ctttatagag cgtgtattgt ttgttatacg aacctaacct accttgttgt tttctcatat
     5641 taagaaattt aaatctactt tgttttagtg aagctatttt ggtaatgtat aagcaatttt
     5701 ggttctgttt agggagaatt cagggtttcc atgacttgat ttgagctttg catatttcaa
     5761 ataagtaaca cagccatttt aatttagcta aataaaaaaa tttctttttt ctctcaa
//
