LOCUS       NM_207307               2139 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens EF-hand calcium binding domain 12 (EFCAB12), mRNA.
ACCESSION   NM_207307
VERSION     NM_207307.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2139)
  AUTHORS   Rolland,T., Tasan,M., Charloteaux,B., Pevzner,S.J., Zhong,Q.,
            Sahni,N., Yi,S., Lemmens,I., Fontanillo,C., Mosca,R., Kamburov,A.,
            Ghiassian,S.D., Yang,X., Ghamsari,L., Balcha,D., Begg,B.E.,
            Braun,P., Brehme,M., Broly,M.P., Carvunis,A.R., Convery-Zupan,D.,
            Corominas,R., Coulombe-Huntington,J., Dann,E., Dreze,M., Dricot,A.,
            Fan,C., Franzosa,E., Gebreab,F., Gutierrez,B.J., Hardy,M.F.,
            Jin,M., Kang,S., Kiros,R., Lin,G.N., Luck,K., MacWilliams,A.,
            Menche,J., Murray,R.R., Palagi,A., Poulin,M.M., Rambout,X.,
            Rasla,J., Reichert,P., Romero,V., Ruyssinck,E., Sahalie,J.M.,
            Scholz,A., Shah,A.A., Sharma,A., Shen,Y., Spirohn,K., Tam,S.,
            Tejeda,A.O., Wanamaker,S.A., Twizere,J.C., Vega,K., Walsh,J.,
            Cusick,M.E., Xia,Y., Barabasi,A.L., Iakoucheva,L.M., Aloy,P., De
            Las Rivas,J., Tavernier,J., Calderwood,M.A., Hill,D.E., Hao,T.,
            Roth,F.P. and Vidal,M.
  TITLE     A proteome-scale map of the human interactome network
  JOURNAL   Cell 159 (5), 1212-1226 (2014)
   PUBMED   25416956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066975.1 and AK127968.1.
            
            On Nov 23, 2018 this sequence version replaced NM_207307.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031104.1, SRR1803616.142890.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000505956.6/ ENSP00000420854.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                BC066975.1         16-84
            70-70               AK127968.1         70-70
            71-2139             BC066975.1         86-2154
FEATURES             Location/Qualifiers
     source          1..2139
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..2139
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /note="EF-hand calcium binding domain 12"
                     /db_xref="GeneID:90288"
                     /db_xref="HGNC:HGNC:28061"
     exon            1..197
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1867
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /note="EF-hand domain-containing protein C3orf25"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 12"
                     /protein_id="NP_997190.1"
                     /db_xref="CCDS:CCDS54638.1"
                     /db_xref="GeneID:90288"
                     /db_xref="HGNC:HGNC:28061"
                     /translation="MDDDYEAYHSLFLSLLGLCPSKTPINENAPVFDPEPVIAHCFKQ
                     FQQKDFRLPQTRRRIIMVPRKEDQTPLNPASQPQAPPKPIPSFKVLEARDIQEQPEDR
                     KTWLSQRSKLRQELESFGDVKRWLENKPSITPSEAKVLHMIHEEQSAQPNASQATTRT
                     TRKKAPRLSRLSRQMVPQLQLPEPPALSVMYSYLHSRKIKILEIFHKVGQGENQRITR
                     EEFIAAVKAVGVPLKNQEVEDIVIYLSSLGKHNTITMDILANTYKQWSMAQQRSSLAT
                     AREHYILAKHRDSLKGPLKKQEVDSAPQLPKVDLLTVPAVDTQMETRPMTLEEMEEVG
                     KRYRERQRQHKLTIPSIQYTEQCHLVRCGNRHFDEHCLPSTIHGDMRELIDSARRHNF
                     LVYLQCWKLCKSYGLPLTEDILMKALLYPGDKIIFQMDKVCPIRQPGGYYSDWKVFSP
                     NLALLRSQGPGKSKRTDKKTPKKSKKMRFKEFEEFTRKLKVKRSSGLQQTHPNSFWPG
                     HLLDKLQLYLPTVATDRSLALFSCVQHQPHVYPATYHPDHWWPLRNKNYMTHAHYDAA
                     KVYYIN"
     exon            198..634
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            635..829
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            830..986
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1183
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1397
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1551
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1608
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..2139
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2109..2114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /note="hexamer: CATAAA"
     polyA_site      2139
                     /gene="EFCAB12"
                     /gene_synonym="C3orf25"
                     /note="major polyA site"
ORIGIN      
        1 aacaggttgc ttctgcagtc tgagctgagc gcctttcgca cgacttggag ttacggttta
       61 tctgataccc cggtacccct acgcaagcaa gcccacatcg acacacattc acacacgccc
      121 ttcagcaccc cctcccagca ccacgaccat ggacgacgac tatgaagcgt accacagtct
      181 gttcttgtcg ctgctcggac tctgcccgtc taagactccc atcaatgaaa atgctcccgt
      241 ctttgatcct gaaccggtca ttgcccactg cttcaagcag ttccagcaga aggacttccg
      301 cctgcctcag acccgccggc gaatcatcat ggtgcctcgc aaggaggatc agacacccct
      361 taatcctgca tcccaacctc aggctccccc aaagcccatc cccagcttca aagttctgga
      421 agctagagat atccaagagc agccagagga caggaagacc tggctgagcc agaggtcgaa
      481 gctgcggcag gagctagagt cctttggtga tgtaaagagg tggctggaga acaagcccag
      541 catcacgcct tcagaggcca aggtcttaca catgatccac gaggagcaga gtgcccagcc
      601 aaatgcctcc caggcaacta ccaggaccac caggaagaaa gcccccaggc tctcccggct
      661 gtcccgccag atggtgcccc agctccagct gcccgagccc cctgccctgt cggtcatgta
      721 ctcctacctg catagccgca agatcaagat cctggagata tttcacaagg tgggccaggg
      781 tgagaaccag agaatcacca gggaggagtt catcgcggct gtaaaggcag tcggagtccc
      841 tctgaagaac caagaggtgg aggatatagt gatctacctc agctctcttg ggaagcacaa
      901 caccatcacc atggatatcc tggccaatac ctacaagcag tggtctatgg ctcagcaaag
      961 gagcagcctg gccactgcaa gggagcatta tatcttggcc aagcacagag attccctgaa
     1021 gggtccgctc aagaagcagg aggtggattc agccccacag cttcccaaag tggacctact
     1081 gacggtgcct gcagtcgaca cgcagatgga gacgcggccc atgaccctgg aggagatgga
     1141 ggaagtgggc aagcggtacc gcgagcggca gcgacagcac aagctcacga tcccctccat
     1201 ccagtacacg gagcaatgtc acctggtgcg ctgtgggaat cggcactttg atgagcactg
     1261 cctcccgtcc accatccacg gggatatgag ggagctcatt gactcggccc gcaggcacaa
     1321 ctttctggtc tacctgcaat gctggaagct ctgtaagtcc tatggcctcc cgctgacaga
     1381 ggacatcctc atgaaagcct tgctgtaccc aggagacaag atcattttcc agatggacaa
     1441 agtgtgcccc atccggcagc cgggaggcta ctactctgac tggaaggtct tttctccgaa
     1501 tctggctctg ctccggtccc agggccctgg caagtctaag aggactgaca agaaaacgcc
     1561 aaagaaaagc aagaaaatgc gctttaagga gtttgaggaa tttaccagga agctgaaggt
     1621 gaagaggtcc agtggtctgc agcaaacaca ccccaattcc ttctggccgg gtcatcttct
     1681 ggataagctg cagctctacc tgcccactgt ggccacagac cggagcctgg cgctcttcag
     1741 ttgtgttcaa caccagcccc atgtctaccc agccacctac caccctgacc actggtggcc
     1801 ccttaggaac aagaactaca tgacccacgc ccattatgat gccgccaagg tgtactacat
     1861 caactagagc tagccaggtg ttgccggacc cagccttcct gggccagggg ccagtgcagc
     1921 cagcggccca gagcccagac acaagaggag tgtcaaagag tcaaactaaa gaaatccttt
     1981 caaagaggga tggaccgggg gccagttccc tctggactca aagtgtccag tgtctcagag
     2041 ggtagatgtg tccaaggaat gacgtgcagt ttttgactat ttccctcccc tgacctctgc
     2101 cctttctaca taaagcaggt tggagttttt ctcatttca
//
