LOCUS       NM_145231               3136 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens EF-hand calcium binding domain 11 (EFCAB11),
            transcript variant 1, mRNA.
ACCESSION   NM_145231
VERSION     NM_145231.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3136)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3136)
  AUTHORS   Chen,W., Wang,M., Zhang,Z., Tang,H., Zuo,X., Meng,X., Xiong,M.,
            Zhou,F., Liang,B., Dai,F., Fang,J., Gao,J., Zhu,J., Zhu,Y., Wan,H.,
            Wang,M., Chan,S. and Sun,L.
  TITLE     Replication the association of 2q32.2-q32.3 and 14q32.11 with
            hepatocellular carcinoma
  JOURNAL   Gene 561 (1), 63-67 (2015)
   PUBMED   25665738
  REMARK    GeneRIF: This work reported the association of 14q32.11 (EFCAB11)
            with Hepatocellular carcinoma in Chinese Han population and
            revealed the genetic interaction between STAT4 (2q32.2-q32.3) and
            EFCAB11 (14q32.11) in Hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 3136)
  AUTHORS   Volik,S., Raphael,B.J., Huang,G., Stratton,M.R., Bignel,G.,
            Murnane,J., Brebner,J.H., Bajsarowicz,K., Paris,P.L., Tao,Q.,
            Kowbel,D., Lapuk,A., Shagin,D.A., Shagina,I.A., Gray,J.W.,
            Cheng,J.F., de Jong,P.J., Pevzner,P. and Collins,C.
  TITLE     Decoding the fine-scale structure of a breast cancer genome and
            transcriptome
  JOURNAL   Genome Res 16 (3), 394-404 (2006)
   PUBMED   16461635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF593330.1 and AL137230.3.
            
            On Nov 23, 2018 this sequence version replaced NM_145231.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB120927.1, SRR1660803.23013.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316738.12/ ENSP00000326267.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-668               CF593330.1         44-711
            669-3136            AL137230.3         4317-6784
FEATURES             Location/Qualifiers
     source          1..3136
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.11"
     gene            1..3136
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /note="EF-hand calcium binding domain 11"
                     /db_xref="GeneID:90141"
                     /db_xref="HGNC:HGNC:20357"
     exon            1..145
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..562
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /note="isoform 1 is encoded by transcript variant 1;
                     EF-hand domain-containing protein C14orf143; EF-hand
                     calcium-binding domain-containing protein 11"
                     /codon_start=1
                     /product="EF-hand calcium-binding domain-containing
                     protein 11 isoform 1"
                     /protein_id="NP_660274.1"
                     /db_xref="CCDS:CCDS9887.1"
                     /db_xref="GeneID:90141"
                     /db_xref="HGNC:HGNC:20357"
                     /translation="MFFSEARARSRTWEASPSEHRKWVEVFKACDEDHKGYLSREDFK
                     TAVVMLFGYKPSKIEVDSVMSSINPNTSGILLEGFLNIVRKKKEAQRYRNEVRHIFTA
                     FDTYYRGFLTLEDFKKAFRQVAPKLPERTVLEVFREVDRDSDGHVSFRDFEYALNYGQ
                     KEA"
     exon            146..241
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /inference="alignment:Splign:2.1.0"
     exon            242..287
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /inference="alignment:Splign:2.1.0"
     exon            288..389
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /inference="alignment:Splign:2.1.0"
     exon            390..480
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /inference="alignment:Splign:2.1.0"
     exon            481..3136
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /inference="alignment:Splign:2.1.0"
     regulatory      658..663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /note="hexamer: ATTAAA"
     polyA_site      680
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /note="major polyA site"
     regulatory      3112..3117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
                     /note="hexamer: AATAAA"
     polyA_site      3136
                     /gene="EFCAB11"
                     /gene_synonym="C14orf143"
ORIGIN      
        1 aggctgccag ccaggctggg aaagcggtgg tagctggttg ggttgctggg gctcggttgt
       61 tgtagtcgcg atgttcttct ccgaggccag agccaggtcg cggacgtggg aagccagtcc
      121 ctcggaacac aggaagtggg tggaagtatt taaagcatgt gatgaagatc acaaaggata
      181 tctcagcaga gaggacttta aaactgctgt tgtaatgctg tttgggtaca agccctccaa
      241 gatagaagtg gattctgtga tgtcttcaat aaatccaaat acttctggta tattactcga
      301 ggggttttta aatattgtca ggaaaaagaa ggaagctcaa cgatatcgga acgaagtaag
      361 acacatcttc acagcctttg acacctacta tcgtggattt ttaactttgg aagatttcaa
      421 aaaagcattt aggcaggtgg ctcccaaatt accggaaagg actgttcttg aggtattcag
      481 ggaagtagat cgagattcag atggtcacgt cagctttaga gactttgaat atgccctgaa
      541 ctatggacag aaggaagcct aactattgtg aactactttt ggtaactctg gggagatcaa
      601 tagattgtaa tgtcagcaga ctcgactcta ctaatgatgt catgctacag acttgtgatt
      661 aaacatttaa aaatttttaa tttttgtggg tacatagtag gtgcatatgt atacatacac
      721 acacatatat gggttacggg agatattttg gcacaggcat gcaataagta attgactaaa
      781 tttttaatca taatttttgg atgctgatga tagacttgca tctcagaatc ctagagatgg
      841 ttgctgccgg gggtctcctt ctgtgtggcc agcagccctg agtcaggccg ccattgctag
      901 agctggggct agggatggca ctggtggtcc tcctcctcct cactcttctt gccccctacc
      961 ctctccacac tgcaggccac ggtgctctac tcactcactt cattgtcctc accatcccac
     1021 cctgaatctc atcatctcct aatatctgca gaggggcaga cttttcctgc caatggtgcc
     1081 agtttccttc atttgctcaa cattggttga acaaataata gcacctacac atacagaata
     1141 cttactatgt tccaagcaat cagccaggcc ttgggaagca taggcttaag acttctctaa
     1201 gataggctca tgcctacaat cccagcactt tgggaggcca aagcaggagg atcacttgag
     1261 cctaggaatt ggagactagc ctgggcaaca taccgagacc ccatccctac caaaaaatta
     1321 ataataaaaa attatctgga tttagtggtg tgtacctgta gtcccagcta cttgggaggc
     1381 tgaggtggaa ggatcatttg agcccagggg tttgaagctt cagtgagcca tgattgcact
     1441 gtcgcactcc agcctggatg atagagcaag accctgtctc taaaaaaaca ctttcaatta
     1501 aaaaaaaaca tataaagact tctctaagat aatgtccctg agtccaaatc atcactgtaa
     1561 agtggtccca gggcactgtc tgtgcaagac aaagaaatcg gcttgggcta acatgagcaa
     1621 gccctctcgg gctatataca gaggaagaac agggtgatga gggtactggg ggcaagagac
     1681 atgtttgcag aaccctttag gatggtctag gcttgggagt ctcactgtgg agaagcaagc
     1741 cttgagctgc tcagctgccc tctgctccat accccctggt ttctagcagt cacgtcctgc
     1801 acccagacac ttagccatgt gtgttcacgt tccccatgcc ttgcctgtcc tgctgggctc
     1861 cagtaactgc tatactggag caagaacagc aatgctggac actcagcatt tagtgaaggt
     1921 aattccaaaa tactggtatc agtactctta tttataagtg tacggaatgc ataacatgaa
     1981 cattagtcaa agaactttta atataattca ctttttaagt gttaaaattt aaaggtcaag
     2041 taaaattgta aatttgtaat atggaaacat taagcgtcat tatcatacaa attattagca
     2101 gataacctta ataaaaataa acgtttgcgg gttttttttg agacagagtc tcactttgtc
     2161 acctaagctg gagtacagtg cgcgatctcg gctcactgca acttccgcct cctgggatca
     2221 agtgattctc ctgccttagc ctcctgagta tctgggttta caggtgtgta ccgccacacc
     2281 cggctaattt ttagtagaga aggggtttca ccatgttggc caggctggtc ttgaactcct
     2341 gacctcaagt gatccgtctg cctcggcctc ccaaagtgct gggattacag gcgtgagcca
     2401 ccatgcctgg ccaataaaaa taaagtttta aactgtcaaa taagaggagc ctaacaagat
     2461 gtgacaacta aatgtcattt ggtatcctgg atgagatcac ggaataaaaa ataaacattg
     2521 gccggacaca gtgactcagc ctgtaatccc agcacttcgg gaggccgagg cgggtggatc
     2581 acgaggtcgg gagatcgaga ccatcctggc taacacggtg aaaccccgtc tctactaaaa
     2641 atacaaaaaa caaaaaaaga ttagctgggc gtggtggcag gtgcctgtag tcccagctgc
     2701 tcgggaggct gaggcaggag aatagcatga acctgggagg cagagcttgc agtgagctga
     2761 aatggtgcca ctgcactcca gtctgggcaa cagagcgaga ctccctctca aaaaaaaaaa
     2821 aaaaaaaaaa aaaaaagaca ttaagtagaa acaaatcaag catggacttt agctaataat
     2881 aatgtatcac tattggttca ttaattgtaa caaatgtatc ctactcatat ataatgttaa
     2941 tagtagggga aactgggtga ggtatatggg aaccctctac tattttcaca atttttctat
     3001 aaatctaaaa ctattctaaa attaaaaatt catttaaaaa ataaagtctt attcaaaacc
     3061 tgttaaacta aactttatct aaaatgaaga aaacattgaa aatcaagtaa aaataaaatc
     3121 ttatttcaaa tacaaa
//
