LOCUS       NM_001035254            4617 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens estrogen-induced osteoclastogenesis regulator 1
            (EEIG1), transcript variant 1, mRNA.
ACCESSION   NM_001035254
VERSION     NM_001035254.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4617)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4617)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4617)
  AUTHORS   Nongpiur,M.E., Cheng,C.Y., Duvesh,R., Vijayan,S., Baskaran,M.,
            Khor,C.C., Allen,J., Kavitha,S., Venkatesh,R., Goh,D., Husain,R.,
            Boey,P.Y., Quek,D., Ho,C.L., Wong,T.T., Perera,S., Wong,T.Y.,
            Krishnadas,S.R., Sundaresan,P., Aung,T. and Vithana,E.N.
  TITLE     Evaluation of Primary Angle-Closure Glaucoma Susceptibility Loci in
            Patients with Early Stages of Angle-Closure Disease
  JOURNAL   Ophthalmology 125 (5), 664-670 (2018)
   PUBMED   29310965
  REMARK    GeneRIF: In this study, 2 of 8 (primary angle-closure glaucoma)
            PACG-associated loci were associated significantly with PACS
            status, the earliest stage in the angle-closure glaucoma disease
            course. The association of these PACG loci with PACS status
            suggests that these loci may confer susceptibility to a narrow
            angle configuration.
REFERENCE   4  (bases 1 to 4617)
  AUTHORS   Choi,H.K., Kang,H.R., Jung,E., Kim,T.E., Lin,J.J. and Lee,S.Y.
  TITLE     Early estrogen-induced gene 1, a novel RANK signaling component, is
            essential for osteoclastogenesis
  JOURNAL   Cell Res 23 (4), 524-536 (2013)
   PUBMED   23478294
  REMARK    GeneRIF: EEIG1 is a novel RANK signaling component controlling
            RANK-mediated osteoclast formation.
REFERENCE   5  (bases 1 to 4617)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   6  (bases 1 to 4617)
  AUTHORS   Wang,D.Y., Fulthorpe,R., Liss,S.N. and Edwards,E.A.
  TITLE     Identification of estrogen-responsive genes by complementary
            deoxyribonucleic acid microarray and characterization of a novel
            early estrogen-induced gene: EEIG1
  JOURNAL   Mol Endocrinol 18 (2), 402-411 (2004)
   PUBMED   14605097
  REMARK    GeneRIF: A novel estrogen-responsive gene was identified and named
            EEIG1 for early estrogen-induced gene 1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157935.28, AK058004.1, CN482844.1, BC047949.1 and BI008660.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001035254.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.145466.1,
                                           SRR1803613.76497.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373095.6/ ENSP00000362187.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               AL157935.28        153867-154322       c
            457-773             AK058004.1         1-317
            774-1433            CN482844.1         1-660
            1434-1865           BC047949.1         460-891
            1866-2096           BI008660.1         1-231               c
            2097-4617           AL157935.28        113915-116435       c
FEATURES             Location/Qualifiers
     source          1..4617
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..4617
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /note="estrogen-induced osteoclastogenesis regulator 1"
                     /db_xref="GeneID:399665"
                     /db_xref="HGNC:HGNC:31419"
                     /db_xref="MIM:610891"
     exon            1..998
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             853..2007
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /note="isoform a is encoded by transcript variant 1; early
                     estrogen-induced gene 1 protein; protein FAM102A; sym-3
                     homolog A; family with sequence similarity 102 member A"
                     /codon_start=1
                     /product="early estrogen-induced gene 1 protein isoform a"
                     /protein_id="NP_001030331.1"
                     /db_xref="CCDS:CCDS35150.1"
                     /db_xref="GeneID:399665"
                     /db_xref="HGNC:HGNC:31419"
                     /db_xref="MIM:610891"
                     /translation="MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFV
                     SLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCVFRVSVRKELKGGKAYSKLGF
                     ADLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAK
                     SISIPGQDSSLQLTCKGGGTSSGGSSTNSLTGSRPPKARPTILSSGLPEEPDQNLSSP
                     EEVFHSGHSRNSSYASQQSKISGYSTEHSRSSSLSDLTHRRNTSTSSSASGGLGMTVE
                     GPEGSEREHRPPEKPPRPPRPLHLSDRSFRRKKDSVESHPTWVDDTRIDADAIVEKIV
                     QSQDFTDGSNTEDSNLRLFVSRDGSATLSGIQLATRVSSGVYEPVVIESH"
     exon            999..1119
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1149
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1266
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1313
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1468
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1573
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1769
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1891
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1961
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..4617
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4300..4305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /note="hexamer: AATAAA"
     polyA_site      4318
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /note="major polyA site"
     regulatory      4594..4599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
                     /note="hexamer: ATTAAA"
     polyA_site      4617
                     /gene="EEIG1"
                     /gene_synonym="bA203J24.7; C9orf132; FAM102A; SYM-3A"
ORIGIN      
        1 attctccaag cggcgcctcg cagcatcggg ctctggctgc agcgtcgggg ccgcaggggg
       61 cggcgctgct gctcgaaggg tgccgggcga ggcgggcgcc accggccggg ccgaagggcg
      121 cctcagctcc gccggggccc gcggcgcggg tcccaggatc gaggaggagg cggcgcctcc
      181 gctgcccggg gccggcccgg tgcctgccct gaggaggccc gaggccggac gttcccggcc
      241 cgcagcgacc ccgacgcgcc tcctggagag gcccccgagc tcctggcagc cccctggggg
      301 tgccccacct tccccggctt cacctgcgct ggccgcccgg cacccaggtg cgggggcgtg
      361 agcggcgagg gcacctcccc cggccgccag cggggcgggg gcggggccgc cctccgccct
      421 cagccttacc ggccagccag cccgcccgcc gccctcagtc tcaccggtcc gcccggccgc
      481 gcggcgtgag ctccccggac atcgcgtctc gggatgctgc aagccagcgc ggccgctcgc
      541 gcgcagcccc gcacctccgc ccctgcctct gcctcctggg ccatgccctg ctgtttacat
      601 gccggtgagg tccccggccg ctccgaaccc ctccgagccc cggctccccg agggtgaagc
      661 ccgccggccc gcgaactgga ctggtggatc tctcagacct ggggccccgg actccgatct
      721 ccgccgtctc cgccaccatc agggcgggat ccggctctgg tgttttgagg agggggtgtg
      781 gtgtagggaa aggaatcccg tccctctcca ccttttttcg ccttcggggc ttcagactca
      841 gggaactcgc tcatggcttt cttgatgaag aagaagaaat tcaaattcca aactactttc
      901 accctggagg agctgactgc ggttcccttc gtgaacgggg tcctcttctg caaggtccgg
      961 ctgctggatg gaggggattt tgtcagcttg tcgtcaaggg aggaggtaca ggagaactgt
     1021 gtgcggtggc gaaagaggtt caccttcgtg tgtaagatga gtgctaaccc ggccaccggc
     1081 ctgctggacc cctgtgtctt ccgtgtgtct gtgcgcaagg agctgaaagg cgggaaggct
     1141 tattccaagc tgggcttcgc tgacttgaac ctggccgagt ttgcgggctc gggctccacg
     1201 gtgcgctgct gcctgctcga gggatatgac acgaagaaca ctcgccagga caactccatc
     1261 cttaaggtca ccattggtat gttcctgctc tctggagatc cctgcttcaa gacgccacca
     1321 tcgactgcca agtccatctc catcccaggc caggattcct ccctgcagct gacgtgtaag
     1381 ggtggtggga ccagcagtgg gggcagcagc accaactccc tgactgggtc ccggcccccc
     1441 aaggctcggc ccactattct cagctcaggg ctgccagagg aacccgacca gaacctgtcc
     1501 agccctgagg aggtgttcca ctctggccac tcccgcaact ccagctatgc cagccagcag
     1561 tccaagatct ccggctacag cacagagcac tcgcgctcct ccagcctctc agacctgacg
     1621 caccgccgca acacgtccac cagcagcagc gcctctgggg gccttggcat gaccgtggag
     1681 ggccctgagg gcagtgagcg ggagcaccgg cccccggaga agccgccgcg gccaccccgg
     1741 cccctgcatc tgtccgatcg ctctttcagg cggaagaagg actcggtgga gagccacccg
     1801 acctgggtgg acgacacgcg gatcgatgcg gatgccatcg tggagaagat cgtgcagagc
     1861 caggatttca cagatggcag caacaccgag gacagcaacc tccggctgtt cgtgagccgc
     1921 gatggctctg ccacgctgag cggcatccag cttgccacca gggtctcttc tggggtctac
     1981 gagccagttg tgattgaaag ccattgagga gcaggtgtcc gggctggaga agagtcctgc
     2041 tttctctgga gtccagacct gtatcattcc atgaggaact ttccccttca gatcacctct
     2101 gcgccacatc tcatccatgc ctcctccatg cactccagtc cacactcccc gtagcatcat
     2161 tccattgccc ctcccatcca tgctgggacc ctcctggccc accaaggccc aggcaccact
     2221 gtgaatattc tcctctgaac cactagaggg caggccaggc aggccaggcg ggcccgtgca
     2281 gcttgtgggc aagaaggagc tggcaaggac cggcgctgct ggagactgac ccagccctct
     2341 ggctgaggac atgcagcggc tcctaaatgt agagatgcct gtggctgagg gggcctctct
     2401 acctgtgtcc ccactcactc caggagcact ggctttggtc acgtcttagc agcagggcct
     2461 tgctccgttg ttcccttgcc ctggtggtgg gggggccaga ccacctccgg aatcctgcca
     2521 cctgtgactg tctgactgct tagtgcttca gctgtccctt ccttgtgtcc tgggggacct
     2581 gctggcggcc tcttcctggg agccatgacc tcagacccca cccacactcc agatcgagac
     2641 ccctgcctcc ccccggcaaa tgtcctcccg ctgccttgca gcctgcactt tgcacatgct
     2701 cacccccagc acagtcccac tggcccctca cctccccttc cctgagctcc ttcccaagga
     2761 ctcctggtca ctgcctgctg tgcagtcaga ggcccagggt ccagcagccc ggcgggaacg
     2821 ggtgctgcct cttcctccag ttagctccag ctcaggtctg agacccgtgc tgagaaaggt
     2881 ctgagcaccg accgtgccct ctgcccaggg ctgggtcctg agcagctggt tttcctgcag
     2941 gaaggttgga gcaagcaaag tccttctctg ccctcagggt cagctgccca gactggggcg
     3001 gatgccagag aggcaggtgg gctgtggctg gactggtccg gagctggctt ccttaccaga
     3061 aaagcctcag ccttcctctg gaagcatccc ccgttctggg caagggggaa gggctccttt
     3121 aaggggtgtg ctttcccagt ggggagcagt ctggccctgc cccctactaa agcctctgct
     3181 ctcagcactt tcccccaagt ccttgtaact tgcttgaagg tgggttctgg ctgccagcca
     3241 gtccctggac aaactctcct gcccctttta aatttcactc attttgtata aacccagcag
     3301 gctggtgttt acttagccct gtagcttttt tcattttttc tttccgtctt tcttcttgag
     3361 ttcacggttc aatattgcct cctcgccctg gtgaggggag gtgctgcttt tctgccccac
     3421 ctgccggctg gttccagcag cgctggggcc cagctggggg gccgggatgg gggcttctct
     3481 ctctgggagg ggtgcaggtg ccctccccag gctgggaggg ttccttccct agctccccat
     3541 ctgcccccgc tggtgagagt tgggcttctt ggtcttggaa ctccctggca ttgggaacag
     3601 agcatttcca gcatttgttg ttgttttact cacctaaccc ttagaaaatg aatgttagaa
     3661 ggtgcctgcc gaggcgggac agagtgttcg ctcgcgctgg agaaggctct gctcagccct
     3721 gagagtccct tcctgcccca ccgatactgg cactttaaaa aggaagctga ccgcacagtg
     3781 tccagacgaa ttggccccca gaagatgggg agttctgtcc tgcccttctg tgtctgcgtg
     3841 acctcaccca gcctaggagg gaggtgcatt cagggtagat ttgcctctca ttcaaagttc
     3901 tggggctttg ggtggaaaac agccagcttt ggcgctgttg gggagactcc tccagaccag
     3961 gaaccccaga aggagacaga gcctgccaca tcctcccacg ccaggccctg ggccagggtg
     4021 attggactga gaatttggcc acaaccaaat tgatgctggc tggaaccaga ggccagaaag
     4081 cctggccttg tccccatgtg ggagccctgt cctcagccct cttgtcccct tgagctcagt
     4141 gaattcccac caggtgccca cagctcctgg acttcaaatt ctatatattg agagagttgg
     4201 agagtatatc agagatattt ttggaaagga gttggtctat gcaatgtcag tttggaatct
     4261 tcttgaaagt ttaatgtttt tattaggaga tttaaagaaa ataaaggtct acaatatctt
     4321 taggtttttt ttttttcctg tttaccgcac aaactgacca catggcatgt ctatcaggat
     4381 ggagggtgtc catgttctcc tctgtcttta gggaggtgat aaggagatgg gcggaggggt
     4441 gtttttttct ttgactcccc tcctttctaa cagaatgttg ccaccactgc ttgagtgggc
     4501 tgtgtttgtt cctctgtccc agcttctgtt gtagaaaata acattgttag gggaactcag
     4561 gctagtgtca gcgtcttggt ttggggagaa aaaattaaat gtttcggttt ttgtttc
//
