LOCUS       NM_001404               1446 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation elongation factor 1 gamma
            (EEF1G), mRNA.
ACCESSION   NM_001404 XM_935697 XM_935970 XM_935971 XM_935973 XM_935974
            XM_935976 XM_935977 XM_935978 XM_935979
VERSION     NM_001404.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Sanders,J., Brandsma,M., Janssen,G.M., Dijk,J. and Moller,W.
  TITLE     Immunofluorescence studies of human fibroblasts demonstrate the
            presence of the complex of elongation factor-1 beta gamma delta in
            the endoplasmic reticulum
  JOURNAL   J Cell Sci 109 (Pt 5), 1113-1117 (1996)
   PUBMED   8743958
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Koonin,E.V., Mushegian,A.R., Tatusov,R.L., Altschul,S.F.,
            Bryant,S.H., Bork,P. and Valencia,A.
  TITLE     Eukaryotic translation elongation factor 1 gamma contains a
            glutathione transferase domain--study of a diverse, ancient protein
            superfamily using motif search and structural modeling
  JOURNAL   Protein Sci 3 (11), 2045-2054 (1994)
   PUBMED   7703850
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Sanders,J., Maassen,J.A. and Moller,W.
  TITLE     Elongation factor-1 messenger-RNA levels in cultured cells are high
            compared to tissue and are not drastically affected further by
            oncogenic transformation
  JOURNAL   Nucleic Acids Res 20 (22), 5907-5910 (1992)
   PUBMED   1461723
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Kumabe,T., Sohma,Y. and Yamamoto,T.
  TITLE     Human cDNAs encoding elongation factor 1 gamma and the ribosomal
            protein L19
  JOURNAL   Nucleic Acids Res 20 (10), 2598 (1992)
   PUBMED   1598220
REFERENCE   10 (bases 1 to 1446)
  AUTHORS   Lew,Y., Jones,D.V., Mars,W.M., Evans,D., Byrd,D. and Frazier,M.L.
  TITLE     Expression of elongation factor-1 gamma-related sequence in human
            pancreatic cancer
  JOURNAL   Pancreas 7 (2), 144-152 (1992)
   PUBMED   1372736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BQ947806.1, X63526.1, BC028179.1 and AP001363.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001404.4.
            
            Summary: This gene encodes a subunit of the elongation factor-1
            complex, which is responsible for the enzymatic delivery of
            aminoacyl tRNAs to the ribosome. This subunit contains an
            N-terminal glutathione transferase domain, which may be involved in
            regulating the assembly of multisubunit complexes containing this
            elongation factor and aminoacyl-tRNA synthetases. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.40467.1,
                                           SRR5189667.142373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329251.5/ ENSP00000331901.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BQ947806.1         98-127
            31-1430             X63526.1           1-1400
            1431-1441           BC028179.1         1400-1410
            1442-1446           AP001363.4         55288-55292         c
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1446
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /note="eukaryotic translation elongation factor 1 gamma"
                     /db_xref="GeneID:1937"
                     /db_xref="HGNC:HGNC:3213"
                     /db_xref="MIM:130593"
     exon            1..61
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1363
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /note="EF-1-gamma; eEF-1B gamma; translation elongation
                     factor eEF-1 gamma chain; PRO1608; pancreatic
                     tumor-related protein"
                     /codon_start=1
                     /product="elongation factor 1-gamma"
                     /protein_id="NP_001395.1"
                     /db_xref="CCDS:CCDS44626.1"
                     /db_xref="GeneID:1937"
                     /db_xref="HGNC:HGNC:3213"
                     /db_xref="MIM:130593"
                     /translation="MAAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTN
                     RTPEFLRKFPAGKVPAFEGDDGFCVFESNAIAYYVSNEELRGSTPEAAAQVVQWVSFA
                     DSDIVPPASTWVFPTLGIMHHNKQATENAKEEVRRILGLLDAYLKTRTFLVGERVTLA
                     DITVVCTLLWLYKQVLEPSFRQAFPNTNRWFLTCINQPQFRAVLGEVKLCEKMAQFDA
                     KKFAETQPKKDTPRKEKGSREEKQKPQAERKEEKKAAAPAPEEEMDECEQALAAEPKA
                     KDPFAHLPKSTFVLDEFKRKYSNEDTLSVALPYFWEHFDKDGWSLWYSEYRFPEELTQ
                     TFMSCNLITGMFQRLDKLRKNAFASVILFGTNNSSSISGVWVFRGQELAFPLSPDWQV
                     DYESYTWRKLDPGSEETQTLVREYFSWEGAFQHVGKAFNQGKIFK"
     exon            62..220
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            221..284
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            285..427
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            428..571
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            572..701
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            702..906
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1079
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1204
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1446
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1419..1424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /note="hexamer: ATTAAA"
     polyA_site      1446
                     /gene="EEF1G"
                     /gene_synonym="EF1G; GIG35"
                     /note="major polyA site"
ORIGIN      
        1 actttgcggc agcgccgaga accccacccc ctttctttgc ggaatcacca tggcggctgg
       61 gaccctgtac acgtatcctg aaaactggag ggccttcaag gctctcatcg ctgctcagta
      121 cagcggggct caggtccgcg tgctctccgc accaccccac ttccattttg gccaaaccaa
      181 ccgcacccct gaatttctcc gcaaatttcc tgccggcaag gtcccagcat ttgagggtga
      241 tgatggattc tgtgtgtttg agagcaacgc cattgcctac tatgtgagca atgaggagct
      301 gcggggaagt actccagagg cagcagccca ggtggtgcag tgggtgagct ttgctgattc
      361 cgatatagtg cccccagcca gtacctgggt gttccccacc ttgggcatca tgcaccacaa
      421 caaacaggcc actgagaatg caaaggagga agtgaggcga attctggggc tgctggatgc
      481 ttacttgaag acgaggactt ttctggtggg cgaacgagtg acattggctg acatcacagt
      541 tgtctgcacc ctgttgtggc tctataagca ggttctagag ccttctttcc gccaggcctt
      601 tcccaatacc aaccgctggt tcctcacctg cattaaccag ccccagttcc gggctgtctt
      661 gggcgaagtg aaactgtgtg agaagatggc ccagtttgat gctaaaaagt ttgcagagac
      721 ccaacctaaa aaggacacac cacggaaaga gaagggttca cgggaagaga agcagaagcc
      781 ccaggctgag cggaaggagg agaaaaaggc ggctgcccct gctcctgagg aggagatgga
      841 tgaatgtgag caggcgctgg ctgctgagcc caaggccaag gaccccttcg ctcacctgcc
      901 caagagtacc tttgtgttgg atgaatttaa gcgcaagtac tccaatgagg acacactctc
      961 tgtggcactg ccatatttct gggagcactt tgataaggac ggctggtccc tgtggtactc
     1021 agagtatcgc ttccctgaag aactcactca gaccttcatg agctgcaatc tcatcactgg
     1081 aatgttccag cgactggaca agctgaggaa gaatgccttc gccagtgtca tcctttttgg
     1141 aaccaacaat agcagctcca tttctggagt ctgggtcttc cgaggccagg agcttgcctt
     1201 tccgctgagt ccagattggc aggtggacta cgagtcatac acatggcgga aactggatcc
     1261 tggcagcgag gagacccaga cgctggttcg agagtacttt tcctgggagg gggccttcca
     1321 gcatgtgggc aaagccttca atcagggcaa gatcttcaag tgaacatctc ttgccatcac
     1381 ctagctgcct gcacctgccc ttcagggaga tgggggtcat taaaggaaac tgaacattga
     1441 accctt
//
