LOCUS       NM_001130053            2090 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens eukaryotic translation elongation factor 1 delta
            (EEF1D), transcript variant 3, mRNA.
ACCESSION   NM_001130053 XM_005250822
VERSION     NM_001130053.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Wang,R., Lv,C., Li,D., Song,Y. and Yan,Z.
  TITLE     EEF1D stabilized by SRSF9 promotes colorectal cancer via enhancing
            the proliferation and metastasis
  JOURNAL   Int J Cancer 155 (8), 1487-1499 (2024)
   PUBMED   38771720
  REMARK    GeneRIF: EEF1D stabilized by SRSF9 promotes colorectal cancer via
            enhancing the proliferation and metastasis.
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Guo,L., Ren,H., Fan,S., Chao,X., Liu,M., Guan,H. and Wang,J.
  TITLE     Autoantibodies against eukaryotic translation elongation factor 1
            delta in two patients with autoimmune cerebellar ataxia
  JOURNAL   Front Immunol 14, 1289175 (2024)
   PUBMED   38332912
  REMARK    GeneRIF: Autoantibodies against eukaryotic translation elongation
            factor 1 delta in two patients with autoimmune cerebellar ataxia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Kaitsuka,T., Tomizawa,K. and Matsushita,M.
  TITLE     Transformation of eEF1Bdelta into heat-shock response transcription
            factor by alternative splicing
  JOURNAL   EMBO Rep 12 (7), 673-681 (2011)
   PUBMED   21597468
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2090)
  AUTHORS   Jung,M., Kondratyev,A.D. and Dritschilo,A.
  TITLE     Elongation factor 1 delta is enhanced following exposure to
            ionizing radiation
  JOURNAL   Cancer Res 54 (10), 2541-2543 (1994)
   PUBMED   8168075
REFERENCE   7  (bases 1 to 2090)
  AUTHORS   Bec,G., Kerjan,P. and Waller,J.P.
  TITLE     Reconstitution in vitro of the valyl-tRNA synthetase-elongation
            factor (EF) 1 beta gamma delta complex. Essential roles of the
            NH2-terminal extension of valyl-tRNA synthetase and of the EF-1
            delta subunit in complex formation
  JOURNAL   J Biol Chem 269 (3), 2086-2092 (1994)
   PUBMED   8294461
REFERENCE   8  (bases 1 to 2090)
  AUTHORS   Sanders,J., Raggiaschi,R., Morales,J. and Moller,W.
  TITLE     The human leucine zipper-containing guanine-nucleotide exchange
            protein elongation factor-1 delta
  JOURNAL   Biochim Biophys Acta 1174 (1), 87-90 (1993)
   PUBMED   8334168
REFERENCE   9  (bases 1 to 2090)
  AUTHORS   Venema,R.C., Peters,H.I. and Traugh,J.A.
  TITLE     Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA
            synthetase by protein kinase C and stimulation of EF-1 activity
  JOURNAL   J Biol Chem 266 (19), 12574-12580 (1991)
   PUBMED   2061327
REFERENCE   10 (bases 1 to 2090)
  AUTHORS   Motorin,Yu.A., Wolfson,A.D., Orlovsky,A.F. and Gladilin,K.L.
  TITLE     Mammalian valyl-tRNA synthetase forms a complex with the first
            elongation factor
  JOURNAL   FEBS Lett 238 (2), 262-264 (1988)
   PUBMED   3169261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067930.7.
            
            On Aug 13, 2020 this sequence version replaced NM_001130053.4.
            
            Summary: This gene encodes a subunit of the elongation factor-1
            complex, which is responsible for the enzymatic delivery of
            aminoacyl tRNAs to the ribosome. This subunit, delta, functions as
            guanine nucleotide exchange factor. It is reported that following
            HIV-1 infection, this subunit interacts with HIV-1 Tat. This
            interaction results in repression of translation of host cell
            proteins and enhanced translation of viral proteins. Several
            alternatively spliced transcript variants encoding multiple
            isoforms have been found for this gene. Related pseudogenes have
            been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by
            RefSeq, Aug 2010].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 both encode the same isoform (1,
            also known as L).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007847.2, AF370363.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618139.4/ ENSP00000484536.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AC067930.7         135513-135580       c
            69-82               AC067930.7         130812-130825       c
            83-1173             AC067930.7         127156-128246       c
            1174-1297           AC067930.7         124894-125017       c
            1298-1369           AC067930.7         124384-124455       c
            1370-1469           AC067930.7         119394-119493       c
            1470-1570           AC067930.7         119219-119319       c
            1571-1792           AC067930.7         118671-118892       c
            1793-1987           AC067930.7         118177-118371       c
            1988-2090           AC067930.7         117893-117995       c
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2090
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /note="eukaryotic translation elongation factor 1 delta"
                     /db_xref="GeneID:1936"
                     /db_xref="HGNC:HGNC:3211"
                     /db_xref="MIM:130592"
     exon            1..68
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            69..82
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..2026
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /note="isoform 1 is encoded by transcript variant 3;
                     elongation factor 1-delta; antigen NY-CO-4; EF-1-delta;
                     eukaryotic translation elongation factor 1 delta (guanine
                     nucleotide exchange protein)"
                     /codon_start=1
                     /product="elongation factor 1-delta isoform 1"
                     /protein_id="NP_001123525.3"
                     /db_xref="CCDS:CCDS6404.1"
                     /db_xref="GeneID:1936"
                     /db_xref="HGNC:HGNC:3211"
                     /db_xref="MIM:130592"
                     /translation="MRSGKASCTLETVWEDKHKYEEAERRFYEHEATQAAASAQQLPA
                     EGPAMNGPGQDDPEDADEAEAPDGGSRRDPRKSQDSRKPLQKKRKRSPKSGLGPADLA
                     LLGLSAERVWLDKSLFDQAESSYRQKLADVAAQAAWPPALAPWGLCTHGNQVACHHVT
                     WGIWVNKSSFDQAERAFVEWSQALLLAPDGSRRQGTPNTGQQVAVPDLAHQPSPPVNG
                     QPPLGSLQALVREVWLEKPRYDAAERGFYEALFDGHPPGKVRLQERAGLAEGARRGRR
                     DRRGRNILGNKRAGLRRADGEAPSALPYCYFLQKDAEAPWLSKPAYDSAECRHHAAEA
                     LRVAWCLEAASLSHRPGPRSGLSVSSLRPNRKMATNFLAHEKIWFDKFKYDDAERRFY
                     EQMNGPVAGASRQENGASVILRDIARARENIQKSLAGSSGPGASSGTSGDHGELVVRI
                     ASLEVENQSLRGVVQELQQAISKLEARLNVLEKSSPGHRATAPQTQHVSPMRQVEPPA
                     KKPATPAEDDEDDDIDLFGSDNEEEDKEAAQLREERLRQYAEKKAKKPALVAKSSILL
                     DVKPWDDETDMAQLEACVRSIQLDGLVWGASKLVPVGYGIRKLQIQCVVEDDKVGTDL
                     LEEEITKFEEHVQSVDIAAFNKI"
     exon            83..1173
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1297
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1369
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1469
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1570
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1792
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1987
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2090
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2072..2077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /note="hexamer: ATTAAA"
     polyA_site      2090
                     /gene="EEF1D"
                     /gene_synonym="EF-1D; EF1D; FP1047"
                     /note="major polyA site"
ORIGIN      
        1 ctccctttca tcagtcttcc cgcgtccgcc gattcctcct ccttggtcgc cgcgtccttg
       61 gctggcgtga ggccaaagca aaatgaggag cgggaaggcc tcctgcaccc tggagaccgt
      121 gtgggaagac aagcacaagt atgaggaggc cgagcggcgc ttctacgaac acgaggccac
      181 acaggcggcc gcctccgccc agcagctgcc agccgagggg ccagccatga atgggcccgg
      241 ccaggacgac cctgaggacg ctgatgaggc ggaagcccct gacggcggca gcaggcgtga
      301 tcccaggaag agccaggaca gcaggaagcc cctgcagaaa aagaggaagc gctcccccaa
      361 gagcgggctc ggccccgcgg acctggccct cctgggcctc tcggccgaac gcgtgtggct
      421 ggacaagtca cttttcgacc aggcagagag ctcctaccgc cagaagctgg cagatgtggc
      481 tgcccaggca gcctggcctc ctgccttggc cccttggggt ctctgcaccc atggaaacca
      541 ggtggcctgc caccacgtga cctgggggat ctgggtcaac aagtcctcct tcgaccaggc
      601 tgagcgggcc ttcgtggagt ggtctcaggc cctgttgctg gcccccgacg gcagccgcag
      661 gcaggggact cccaacacag gccagcaggt ggccgtcccc gacctggccc accagcccag
      721 cccaccggtc aatggccagc ccccgctggg cagcctgcag gcactggttc gggaggtgtg
      781 gctggagaag ccccggtatg atgcagccga gaggggcttc tacgaggccc tgtttgacgg
      841 ccatccccca gggaaggtgc gcctgcaaga gcgagccggc ctggccgagg gtgcccggcg
      901 gggccgcaga gaccggcggg gccgcaacat cttagggaac aagcgggccg ggctgcgacg
      961 ggccgatggg gaggccccct ctgccttgcc ctactgttac ttcctgcaga aggatgcaga
     1021 ggccccctgg ctcagcaagc ctgcctacga cagcgccgag tgccgccacc acgctgccga
     1081 ggccctgcgg gtggcctggt gcctcgaagc tgcctccctg tctcaccgac ccggtcctcg
     1141 gtctggcctg tccgtgtcca gcctgagacc caacagaaaa atggctacaa acttcctagc
     1201 acatgagaag atctggttcg acaagttcaa atatgacgac gcagaaagga gattctacga
     1261 gcagatgaac gggcctgtgg caggtgcctc ccgccaggag aacggcgcca gcgtgatcct
     1321 ccgtgacatt gcgagagcca gagagaacat ccagaaatcc ctggctggaa gctcaggccc
     1381 cggggcctcc agcggcacca gcggagacca cggtgagctc gtcgtccgga ttgccagtct
     1441 ggaagtggag aaccagagtc tgcgtggcgt ggtacaggag ctgcagcagg ccatctccaa
     1501 gctggaggcc cggctgaacg tgctggagaa gagctcgcct ggccaccggg ccacggcccc
     1561 acagacccag cacgtatctc ccatgcgcca agtggagccc ccagccaaga agccagccac
     1621 accagcagag gatgacgagg atgatgacat tgacctgttt ggcagtgaca atgaggagga
     1681 ggacaaggag gcggcacagc tgcgggagga gcggctacgg cagtacgcgg agaagaaggc
     1741 caagaagcct gcactggtgg ccaagtcctc catcctgctg gatgtcaagc cttgggatga
     1801 tgagacggac atggcccagc tggaggcctg tgtgcgctct atccagctgg acgggctggt
     1861 ctggggggct tccaagctgg tgcccgtggg ctacggtatc cggaagctac agattcagtg
     1921 tgtggtggag gacgacaagg tggggacaga cttgctggag gaggagatca ccaagtttga
     1981 ggagcacgtg cagagtgtcg atatcgcagc tttcaacaag atctgaagcc tgagtgtgtg
     2041 tacgtgcgcg cgtgcgtgag gccctgccac gattaaagac tgagaccggc
//
