LOCUS       NM_001958               1773 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens eukaryotic translation elongation factor 1 alpha 2
            (EEF1A2), mRNA.
ACCESSION   NM_001958 XR_017886
VERSION     NM_001958.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Gong,S., Qiao,H., Wang,J.Y., Huang,S.Y., He,S.W., Zhao,Y.,
            Tan,X.R., Ye,M.L., Li,J.Y., Liang,Y.L., Huang,S.W., Chen,J.,
            Zhu,X.H., Liu,N. and Li,Y.Q.
  TITLE     Ac4C modification of lncRNA SIMALR promotes nasopharyngeal
            carcinoma progression through activating eEF1A2 to facilitate
            ITGB4/ITGA6 translation
  JOURNAL   Oncogene 43 (38), 2868-2884 (2024)
   PUBMED   39154122
  REMARK    GeneRIF: Ac4C modification of lncRNA SIMALR promotes nasopharyngeal
            carcinoma progression through activating eEF1A2 to facilitate
            ITGB4/ITGA6 translation.
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Negrutskii,B.S., Porubleva,L.V., Malinowska,A., Novosylna,O.V.,
            Dadlez,M. and Knudsen,C.R.
  TITLE     Understanding functions of eEF1 translation elongation factors
            beyond translation. A proteomic approach
  JOURNAL   Adv Protein Chem Struct Biol 138, 67-99 (2024)
   PUBMED   38220433
  REMARK    GeneRIF: Understanding functions of eEF1 translation elongation
            factors beyond translation. A proteomic approach.
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Kong,R., Wei,W., Man,Q., Chen,L., Jia,Y., Zhang,H., Liu,Z.,
            Cheng,K., Mao,C. and Liu,S.
  TITLE     Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives
            lung metastasis of cancer stem cells from hepatocellular carcinoma
  JOURNAL   Cancer Lett 578, 216442 (2023)
   PUBMED   37852428
  REMARK    GeneRIF: Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex
            drives lung metastasis of cancer stem cells from hepatocellular
            carcinoma.
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   Mohamed,M.S. and Klann,E.
  TITLE     Autism- and epilepsy-associated EEF1A2 mutations lead to
            translational dysfunction and altered actin bundling
  JOURNAL   Proc Natl Acad Sci U S A 120 (38), e2307704120 (2023)
   PUBMED   37695913
  REMARK    GeneRIF: Autism- and epilepsy-associated EEF1A2 mutations lead to
            translational dysfunction and altered actin bundling.
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Li,J., Tang,X. and Zhang,Z.
  TITLE     Eukaryotic Elongation Factor 1Alpha-2 (EEF1A2) Participates in the
            Progression of Gastric Cancer via Interaction with Heat Shock
            Protein B8 (HSPB8)
  JOURNAL   Ann Clin Lab Sci 53 (3), 398-408 (2023)
   PUBMED   37437931
  REMARK    GeneRIF: Eukaryotic Elongation Factor 1Alpha-2 (EEF1A2)
            Participates in the Progression of Gastric Cancer via Interaction
            with Heat Shock Protein B8 (HSPB8).
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Lee,S., Ann,D.K. and Wang,E.
  TITLE     Cloning of human and mouse brain cDNAs coding for S1, the second
            member of the mammalian elongation factor-1 alpha gene family:
            analysis of a possible evolutionary pathway
  JOURNAL   Biochem Biophys Res Commun 203 (3), 1371-1377 (1994)
   PUBMED   7945283
REFERENCE   7  (bases 1 to 1773)
  AUTHORS   Knudsen,S.M., Frydenberg,J., Clark,B.F. and Leffers,H.
  TITLE     Tissue-dependent variation in the expression of elongation factor-1
            alpha isoforms: isolation and characterisation of a cDNA encoding a
            novel variant of human elongation-factor 1 alpha
  JOURNAL   Eur J Biochem 215 (3), 549-554 (1993)
   PUBMED   8354261
REFERENCE   8  (bases 1 to 1773)
  AUTHORS   Wang,E.
  TITLE     Rapid disappearance of statin, a nonproliferating and senescent
            cell-specific protein, upon reentering the process of cell cycling
  JOURNAL   J Cell Biol 101 (5 Pt 1), 1695-1701 (1985)
   PUBMED   3902853
REFERENCE   9  (bases 1 to 1773)
  AUTHORS   Wang,E.
  TITLE     A 57,000-mol-wt protein uniquely present in nonproliferating cells
            and senescent human fibroblasts
  JOURNAL   J Cell Biol 100 (2), 545-551 (1985)
   PUBMED   3968178
REFERENCE   10 (bases 1 to 1773)
  AUTHORS   Beh,K.J.
  TITLE     Immunoglobulin class specificity of non-agglutinating antibody
            produced in cattle following Brucella abortus 45/20 vaccination
  JOURNAL   Aust Vet J 51 (10), 481-483 (1975)
   PUBMED   812466
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121829.30.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_001958.4.
            
            Summary: This gene encodes an isoform of the alpha subunit of the
            elongation factor-1 complex, which is responsible for the enzymatic
            delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2)
            is expressed in brain, heart and skeletal muscle, and the other
            isoform (alpha 1) is expressed in brain, placenta, lung, liver,
            kidney, and pancreas. This gene may be critical in the development
            of ovarian cancer. [provided by RefSeq, Mar 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC110409.1, SRR14038193.515167.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217182.6/ ENSP00000217182.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AL121829.30        28063-28088         c
            27-241              AL121829.30        26625-26839         c
            242-421             AL121829.30        24861-25040         c
            422-718             AL121829.30        23810-24106         c
            719-869             AL121829.30        22142-22292         c
            870-1126            AL121829.30        19484-19740         c
            1127-1361           AL121829.30        17923-18157         c
            1362-1773           AL121829.30        17019-17430         c
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1773
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /note="eukaryotic translation elongation factor 1 alpha 2"
                     /db_xref="GeneID:1917"
                     /db_xref="HGNC:HGNC:3192"
                     /db_xref="MIM:602959"
     exon            1..26
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     exon            27..241
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1489
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /note="statin-S1; eukaryotic elongation factor 1 A-2"
                     /codon_start=1
                     /product="elongation factor 1-alpha 2"
                     /protein_id="NP_001949.1"
                     /db_xref="CCDS:CCDS13522.1"
                     /db_xref="GeneID:1917"
                     /db_xref="HGNC:HGNC:3192"
                     /db_xref="MIM:602959"
                     /translation="MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEK
                     EAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETTKYYITIIDAPGHRDFIKNM
                     ITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEP
                     AYSEKRYDEIVKEVSAYIKKIGYNPATVPFVPISGWHGDNMLEPSPNMPWFKGWKVER
                     KEGNASGVSLLEALDTILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGILRPGM
                     VVTFAPVNITTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDIRRGNVCGDSKSDPP
                     QEAAQFTSQVIILNHPGQISAGYSPVIDCHTAHIACKFAELKEKIDRRSGKKLEDNPK
                     SLKSGDAAIVEMVPGKPMCVESFSQYPPLGRFAVRDMRQTVAVGVIKNVEKKSGGAGK
                     VTKSAQKAQKAGK"
     exon            242..421
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     exon            422..718
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     exon            719..869
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1126
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1361
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1773
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1755..1760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /note="hexamer: AATAAA"
     polyA_site      1773
                     /gene="EEF1A2"
                     /gene_synonym="DEE33; EEF1AL; EF-1-alpha-2; EF1A; EIEE33;
                     HS1; MRD38; STN; STNL"
                     /note="major polyA site"
ORIGIN      
        1 ccctctggct gagacctcgg ctccggaatc actgcagccc ccctcgccct gagccagagc
       61 accccgggtc ccgccagccc ctcacactcc cagcaaaatg ggcaaggaga agacccacat
      121 caacatcgtg gtcatcggcc acgtggactc cggaaagtcc accaccacgg gccacctcat
      181 ctacaaatgc ggaggtattg acaaaaggac cattgagaag ttcgagaagg aggcggctga
      241 gatggggaag ggatccttca agtatgcctg ggtgctggac aagctgaagg cggagcgtga
      301 gcgcggcatc accatcgaca tctccctctg gaagttcgag accaccaagt actacatcac
      361 catcatcgat gcccccggcc accgcgactt catcaagaac atgatcacgg gtacatccca
      421 ggcggactgc gcagtgctga tcgtggcggc gggcgtgggc gagttcgagg cgggcatctc
      481 caagaatggg cagacgcggg agcatgccct gctggcctac acgctgggtg tgaagcagct
      541 catcgtgggc gtgaacaaaa tggactccac agagccggcc tacagcgaga agcgctacga
      601 cgagatcgtc aaggaagtca gcgcctacat caagaagatc ggctacaacc cggccaccgt
      661 gccctttgtg cccatctccg gctggcacgg tgacaacatg ctggagccct cccccaacat
      721 gccgtggttc aagggctgga aggtggagcg taaggagggc aacgcaagcg gcgtgtccct
      781 gctggaggcc ctggacacca tcctgccccc cacgcgcccc acggacaagc ccctgcgcct
      841 gccgctgcag gacgtgtaca agattggcgg cattggcacg gtgcccgtgg gccgggtgga
      901 gaccggcatc ctgcggccgg gcatggtggt gacctttgcg ccagtgaaca tcaccactga
      961 ggtgaagtca gtggagatgc accacgaggc tctgagcgaa gctctgcccg gcgacaacgt
     1021 cggcttcaat gtgaagaacg tgtcggtgaa ggacatccgg cggggcaacg tgtgtgggga
     1081 cagcaagtct gacccgccgc aggaggctgc tcagttcacc tcccaggtca tcatcctgaa
     1141 ccacccgggg cagattagcg ccggctactc cccggtcatc gactgccaca cagcccacat
     1201 cgcctgcaag tttgcggagc tgaaggagaa gattgaccgg cgctctggca agaagctgga
     1261 ggacaacccc aagtccctga agtctggaga cgcggccatc gtggagatgg tgccgggaaa
     1321 gcccatgtgt gtggagagct tctcccagta cccgcctctc ggccgcttcg ccgtgcgcga
     1381 catgaggcag acggtggccg taggcgtcat caagaacgtg gagaagaaga gcggcggcgc
     1441 cggcaaggtc accaagtcgg cgcagaaggc gcagaaggcg ggcaagtgaa gcgcgggcgc
     1501 ccgcggcgcg accctccccg gcggtgccgc gctccgaacc ccgggcccgg gcccccgccc
     1561 cgcccccgcc ccgcgcgccg gtccggcgcc ccgcaccccc gccaggcgca tgtctgcacc
     1621 tccgcttgcc agaggccctc ggtcagcgac tggatgctcg ccatcaaggt ccagtggaag
     1681 ttcttcaaga ggaaaggcgc ccccgcccca ggcttccgcg cccagcgctc gccacgctca
     1741 gtgcccgttt taccaataaa ctgagcgacc cca
//
