LOCUS       NM_001402               3512 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens eukaryotic translation elongation factor 1 alpha 1
            (EEF1A1), mRNA.
ACCESSION   NM_001402
VERSION     NM_001402.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3512)
  AUTHORS   Wang,Y., Luan,T., Wang,L., Feng,D., Dong,Y., Li,S., Yang,H.,
            Chen,Y., Fei,Y., Lin,L., Pan,J., Zhong,Z. and Zhao,W.
  TITLE     N-Acetylcysteine Inhibits Coxsackievirus B3 Replication by
            Downregulating Eukaryotic Translation Elongation Factor 1 Alpha 1
  JOURNAL   Viruses 16 (9), 1503 (2024)
   PUBMED   39339978
  REMARK    GeneRIF: N-Acetylcysteine Inhibits Coxsackievirus B3 Replication by
            Downregulating Eukaryotic Translation Elongation Factor 1 Alpha 1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3512)
  AUTHORS   Zhao,J., Huo,Q., Zhang,J., Sun,K., Guo,J., Cheng,F., Hu,X. and
            Xu,Q.
  TITLE     UCHL3 promotes hepatocellular carcinoma progression by stabilizing
            EEF1A1 through deubiquitination
  JOURNAL   Biol Direct 19 (1), 53 (2024)
   PUBMED   38965582
  REMARK    GeneRIF: UCHL3 promotes hepatocellular carcinoma progression by
            stabilizing EEF1A1 through deubiquitination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3512)
  AUTHORS   Wilson,R.B., Kozlov,A.M., Hatam Tehrani,H., Twumasi-Ankrah,J.S.,
            Chen,Y.J., Borrelli,M.J., Sawyez,C.G., Maini,S., Shepherd,T.G.,
            Cumming,R.C., Betts,D.H. and Borradaile,N.M.
  TITLE     Elongation factor 1A1 regulates metabolic substrate preference in
            mammalian cells
  JOURNAL   J Biol Chem 300 (3), 105684 (2024)
   PUBMED   38272231
  REMARK    GeneRIF: Elongation factor 1A1 regulates metabolic substrate
            preference in mammalian cells.
REFERENCE   4  (bases 1 to 3512)
  AUTHORS   Minoia,M., Quintana-Cordero,J., Jetzinger,K., Kotan,I.E.,
            Turnbull,K.J., Ciccarelli,M., Masser,A.E., Liebers,D., Gouarin,E.,
            Czech,M., Hauryliuk,V., Bukau,B., Kramer,G. and Andreasson,C.
  TITLE     Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A
            biogenesis
  JOURNAL   Nat Commun 15 (1), 1382 (2024)
   PUBMED   38360885
  REMARK    GeneRIF: Chp1 is a dedicated chaperone at the ribosome that
            safeguards eEF1A biogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3512)
  AUTHORS   Negrutskii,B.S., Porubleva,L.V., Malinowska,A., Novosylna,O.V.,
            Dadlez,M. and Knudsen,C.R.
  TITLE     Understanding functions of eEF1 translation elongation factors
            beyond translation. A proteomic approach
  JOURNAL   Adv Protein Chem Struct Biol 138, 67-99 (2024)
   PUBMED   38220433
  REMARK    GeneRIF: Understanding functions of eEF1 translation elongation
            factors beyond translation. A proteomic approach.
REFERENCE   6  (bases 1 to 3512)
  AUTHORS   Madsen,H.O., Poulsen,K., Dahl,O., Clark,B.F. and Hjorth,J.P.
  TITLE     Retropseudogenes constitute the major part of the human elongation
            factor 1 alpha gene family
  JOURNAL   Nucleic Acids Res 18 (6), 1513-1516 (1990)
   PUBMED   2183196
REFERENCE   7  (bases 1 to 3512)
  AUTHORS   Bec,G., Kerjan,P., Zha,X.D. and Waller,J.P.
  TITLE     Valyl-tRNA synthetase from rabbit liver. I. Purification as a
            heterotypic complex in association with elongation factor 1
  JOURNAL   J Biol Chem 264 (35), 21131-21137 (1989)
   PUBMED   2556394
REFERENCE   8  (bases 1 to 3512)
  AUTHORS   Whiteheart,S.W., Shenbagamurthi,P., Chen,L., Cotter,R.J. and
            Hart,G.W.
  TITLE     Murine elongation factor 1 alpha (EF-1 alpha) is
            posttranslationally modified by novel amide-linked
            ethanolamine-phosphoglycerol moieties. Addition of
            ethanolamine-phosphoglycerol to specific glutamic acid residues on
            EF-1 alpha
  JOURNAL   J Biol Chem 264 (24), 14334-14341 (1989)
   PUBMED   2569467
REFERENCE   9  (bases 1 to 3512)
  AUTHORS   Uetsuki,T., Naito,A., Nagata,S. and Kaziro,Y.
  TITLE     Isolation and characterization of the human chromosomal gene for
            polypeptide chain elongation factor-1 alpha
  JOURNAL   J Biol Chem 264 (10), 5791-5798 (1989)
   PUBMED   2564392
REFERENCE   10 (bases 1 to 3512)
  AUTHORS   Motorin,Yu.A., Wolfson,A.D., Orlovsky,A.F. and Gladilin,K.L.
  TITLE     Mammalian valyl-tRNA synthetase forms a complex with the first
            elongation factor
  JOURNAL   FEBS Lett 238 (2), 262-264 (1988)
   PUBMED   3169261
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Francesco Amaldi. The reference sequence was
            derived from BC066893.1, AJ420488.1 and AL603910.6.
            
            On Nov 28, 2018 this sequence version replaced NM_001402.5.
            
            Summary: This gene encodes an isoform of the alpha subunit of the
            elongation factor-1 complex, which is responsible for the enzymatic
            delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1)
            is expressed in brain, placenta, lung, liver, kidney, and pancreas,
            and the other isoform (alpha 2) is expressed in brain, heart and
            skeletal muscle. This isoform is identified as an autoantigen in
            66% of patients with Felty syndrome. This gene has been found to
            have multiple copies on many chromosomes, some of which, if not
            all, represent different pseudogenes. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.28133.1,
                                           SRR1660807.43653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309268.11/ ENSP00000339053.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1747              BC066893.1         1-1747
            1748-2631           AJ420488.1         1708-2591
            2632-2632           AL603910.6         110144-110144       c
            2633-3512           AJ420488.1         2593-3472
FEATURES             Location/Qualifiers
     source          1..3512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q13"
     gene            1..3512
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /note="eukaryotic translation elongation factor 1 alpha 1"
                     /db_xref="GeneID:1915"
                     /db_xref="HGNC:HGNC:3189"
                     /db_xref="MIM:130590"
     exon            1..33
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     exon            34..207
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1452
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /note="cervical cancer suppressor 3; eukaryotic
                     translation elongation factor 1 alpha 1-like 14; leukocyte
                     receptor cluster (LRC) member 7; CTCL tumor antigen;
                     prostate tumor-inducing protein 1; EF1a-like protein;
                     glucocorticoid receptor AF-1 specific elongation factor;
                     elongation factor 1 alpha subunit; elongation factor Tu;
                     EF-1-alpha-1; eukaryotic elongation factor 1 A-1;
                     leukocyte receptor cluster member 7; epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="elongation factor 1-alpha 1"
                     /protein_id="NP_001393.1"
                     /db_xref="CCDS:CCDS4980.1"
                     /db_xref="GeneID:1915"
                     /db_xref="HGNC:HGNC:3189"
                     /db_xref="MIM:130590"
                     /translation="MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEK
                     EAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNM
                     ITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEP
                     PYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTR
                     KDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGM
                     VVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPP
                     MEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPK
                     FLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGK
                     VTKSAQKAQKAK"
     exon            208..387
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..684
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..835
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1092
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1327
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..3512
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1726..1731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /note="hexamer: ATTAAA"
     polyA_site      1747
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /note="major polyA site"
     regulatory      3494..3499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
                     /note="hexamer: AATGAA"
     polyA_site      3512
                     /gene="EEF1A1"
                     /gene_synonym="CCS-3; CCS3; EE1A1; EEF-1; EEF1A; eEF1A-1;
                     EF-Tu; EF1A; EF1A1; EF1alpha1; GRAF-1EF; LENG7; PTI1"
ORIGIN      
        1 ctttttcgca acgggtttgc cgccagaaca caggtgtcgt gaaaactacc cctaaaagcc
       61 aaaatgggaa aggaaaagac tcatatcaac attgtcgtca ttggacacgt agattcgggc
      121 aagtccacca ctactggcca tctgatctat aaatgcggtg gcatcgacaa aagaaccatt
      181 gaaaaatttg agaaggaggc tgctgagatg ggaaagggct ccttcaagta tgcctgggtc
      241 ttggataaac tgaaagctga gcgtgaacgt ggtatcacca ttgatatctc cttgtggaaa
      301 tttgagacca gcaagtacta tgtgactatc attgatgccc caggacacag agactttatc
      361 aaaaacatga ttacagggac atctcaggct gactgtgctg tcctgattgt tgctgctggt
      421 gttggtgaat ttgaagctgg tatctccaag aatgggcaga cccgagagca tgcccttctg
      481 gcttacacac tgggtgtgaa acaactaatt gtcggtgtta acaaaatgga ttccactgag
      541 ccaccctaca gccagaagag atatgaggaa attgttaagg aagtcagcac ttacattaag
      601 aaaattggct acaaccccga cacagtagca tttgtgccaa tttctggttg gaatggtgac
      661 aacatgctgg agccaagtgc taacatgcct tggttcaagg gatggaaagt cacccgtaag
      721 gatggcaatg ccagtggaac cacgctgctt gaggctctgg actgcatcct accaccaact
      781 cgtccaactg acaagccctt gcgcctgcct ctccaggatg tctacaaaat tggtggtatt
      841 ggtactgttc ctgttggccg agtggagact ggtgttctca aacccggtat ggtggtcacc
      901 tttgctccag tcaacgttac aacggaagta aaatctgtcg aaatgcacca tgaagctttg
      961 agtgaagctc ttcctgggga caatgtgggc ttcaatgtca agaatgtgtc tgtcaaggat
     1021 gttcgtcgtg gcaacgttgc tggtgacagc aaaaatgacc caccaatgga agcagctggc
     1081 ttcactgctc aggtgattat cctgaaccat ccaggccaaa taagcgccgg ctatgcccct
     1141 gtattggatt gccacacggc tcacattgca tgcaagtttg ctgagctgaa ggaaaagatt
     1201 gatcgccgtt ctggtaaaaa gctggaagat ggccctaaat tcttgaagtc tggtgatgct
     1261 gccattgttg atatggttcc tggcaagccc atgtgtgttg agagcttctc agactatcca
     1321 cctttgggtc gctttgctgt tcgtgatatg agacagacag ttgcggtggg tgtcatcaaa
     1381 gcagtggaca agaaggctgc tggagctggc aaggtcacca agtctgccca gaaagctcag
     1441 aaggctaaat gaatattatc cctaatacct gccaccccac tcttaatcag tggtggaaga
     1501 acggtctcag aactgtttgt ttcaattggc catttaagtt tagtagtaaa agactggtta
     1561 atgataacaa tgcatcgtaa aaccttcaga aggaaaggag aatgttttgt ggaccacttt
     1621 ggttttcttt tttgcgtgtg gcagttttaa gttattagtt tttaaaatca gtacttttta
     1681 atggaaacaa cttgaccaaa aatttgtcac agaattttga gacccattaa aaaagttaaa
     1741 tgagaaacct gtgtgttcct ttggtcaaca ccgagacatt taggtgaaag acatctaatt
     1801 ctggttttac gaatctggaa acttcttgaa aatgtaattc ttgagttaac acttctgggt
     1861 ggagaatagg gttgttttcc ccccacataa ttggaagggg aaggaatatc atttaaagct
     1921 atgggagggt tgctttgatt acaacactgg agagaaatgc agcatgttgc tgattgcctg
     1981 tcactaaaac aggccaaaaa ctgagtcctt gtgttgcata gaaagcttca tgttgctaaa
     2041 ccaatgttaa gtgaatcttt ggaaacaaaa tgtttccaaa ttactgggat gtgcatgttg
     2101 aaacgtgggt taaaatgact gggcagtgaa agttgactat ttgccatgac ataagaaata
     2161 agtgtagtgg ctagtgtaca ccctatgagt ggaagggtcc attttgaagt cagtggagta
     2221 agctttatgc cagtttgatg gtttcacaag ttctattgag tgctattcag aataggaaca
     2281 aggttctaat agaaaaagat ggcaatttga agtagctata aaattagact aatctacatt
     2341 gcttttctcc tgcagagtct aatacctttt atgctttgat aattagcagt ttgtctactt
     2401 ggtcactagg aatgaaacta catggtaata ggcttaacag gtgtaatagc ccacttactc
     2461 ctgaatcttt aagcatttgt gcatttgaaa aatgcttttc gcgatcttcc tgctgggatt
     2521 acaggcatga gccactgtgc ctgacctccc atatgtaaaa gtgtctaaag gttttttttt
     2581 ggttataaaa ggaaaatttt tgcttaagtt tgaaggatag gtaaaattaa aggacatgct
     2641 ttctgtttgt gtgatggttt ttaaaaattt tttttaagat ggagttcttg ttgcccaggc
     2701 tagaatgcaa tggcaaaatc tcactgcaat ctcctcctcc tgggttcaag caattctcct
     2761 acttcagcct cccaagtagc tgggattaca ggcatgtgct aatttggtgt ttttaataga
     2821 gatgaggttt ttccatgttg gtcaggctgg tctcaaactc ctgaccttag gtgatcgcct
     2881 cggcctccta aagtgctgga attacaggca tgagccacca tgcctggcca ggacatgtgt
     2941 tcttaaggac atgctaagca ggagttaaag cagcccaaga gataaggcct cttaaagtga
     3001 ctggcaatgt gtattgctca agattcaaag gtacttgaat tggccataga caagtctgta
     3061 atgaagtgtt atcgttttcc ctcatctgag tctgaattag ataaaatgcc ttcccatcag
     3121 ccagtgctct gaggtatcaa gtctaaattg aactagagat ttttgtcctt agtttctttg
     3181 ctatctaatg tttacacaag taaatagtct aagatttgct ggatgacaga aaaaacaggt
     3241 aaggccttta atagatggcc aatagatgcc ctgataatga aagttgacac ctgtaagatt
     3301 taccagtaga gaattcttga catgcaagga agcaagattt aactgaaaaa ttgttcccac
     3361 tggaagcagg aatgagtcag tttacttgca tatactgaga ttgagattaa cttcctgtga
     3421 aacccagtgt cttagacaac tgtggcttga gcaccacctg ctggtattca ttacaaactt
     3481 gctcactaca ataaatgaat tttaagcttt aa
//
