LOCUS       NM_001202438            4483 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens erythroid differentiation regulatory factor 1 (EDRF1),
            transcript variant 1, mRNA.
ACCESSION   NM_001202438
VERSION     NM_001202438.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4483)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4483)
  AUTHORS   Wang,D., Li,Y. and Shen,B.
  TITLE     A novel erythroid differentiation related gene EDRF1 upregulating
            globin gene expression in HEL cells
  JOURNAL   Chin Med J (Engl) 115 (11), 1701-1705 (2002)
   PUBMED   12609092
  REMARK    GeneRIF: EDRF1 regulated alpha- and gamma-globin gene synthesis by
            modulating DNA-binding activity of GATA-1 transcription factor.
REFERENCE   3  (bases 1 to 4483)
  AUTHORS   Wang,D., Ma,S., Wang,S. and Shen,B.
  TITLE     Antisense EDRF1 gene inhibited GATA-1 transcription factor
            DNA-binding activity in K562 cells
  JOURNAL   Sci China C Life Sci 45 (3), 289-297 (2002)
   PUBMED   18759052
REFERENCE   4  (bases 1 to 4483)
  AUTHORS   Wang,D., Li,Y. and Shen,B.
  TITLE     Initial function analysis of a novel erythroid differentiation
            related gene EDRF1
  JOURNAL   Sci China C Life Sci 44 (5), 489-496 (2001)
   PUBMED   18726394
REFERENCE   5  (bases 1 to 4483)
  AUTHORS   Wang,X., Wang,D., Chen,X., Hu,M., Wang,J., Li,Y., Guo,N. and
            Shen,B.
  TITLE     cDNA cloning and function analysis of two novel erythroid
            differentiation related genes
  JOURNAL   Sci China C Life Sci 44 (1), 99-105 (2001)
   PUBMED   18763094
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC026172.1, BC107479.1 and
            AL050102.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001202438.1.
            
            Summary: This gene may play a role in erythroid cell
            differentiation. The encoded protein inhibits DNA binding of the
            erythroid transcription factor GATA-1 and may regulate the
            expression of alpha-globin and gamma-globin. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Feb
            2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.189997.1,
                                           SRR1660805.125095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000356792.9/ ENSP00000349244.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-819               BC026172.1         196-1014
            820-3995            BC107479.1         953-4128
            3996-4483           AL050102.1         1666-2153
FEATURES             Location/Qualifiers
     source          1..4483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..4483
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /note="erythroid differentiation regulatory factor 1"
                     /db_xref="GeneID:26098"
                     /db_xref="HGNC:HGNC:24640"
                     /db_xref="MIM:620463"
     exon            1..207
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..3816
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /note="isoform 1 is encoded by transcript variant 1;
                     erythroid differentiation-related factor 1"
                     /codon_start=1
                     /product="erythroid differentiation-related factor 1
                     isoform 1"
                     /protein_id="NP_001189367.1"
                     /db_xref="CCDS:CCDS55733.1"
                     /db_xref="GeneID:26098"
                     /db_xref="HGNC:HGNC:24640"
                     /db_xref="MIM:620463"
                     /translation="MGDAKEAGAEGPPAGAAARGGLSLLSQGESEESSAQGSALFLGG
                     NEVKSRAVVKYSSAPPRTAFARLEEKTDLKLPPANWLRESAKLGPAGTTILGNSKKSK
                     PFSSFGMAYDFIDSVGNDVDVVSDSENIKKLLKIPYSKSHVSMAVHRIGRTLLLDELD
                     IQELFMRSSQTGDWTWLKEFYQRLIDQKWQRKKKSKEHWYQKAILSKFLYYSINGDGA
                     AQPVSSTAEQQESSSSDQTNDSEGASWPAPFEMPSSVSEDPSASSQGSEPLEPSYIVG
                     HVASAPKEQNLITLFNDGEHSQGLKNDFVRNILWTFEDIHMLVGSNMPIFGGGRYPAV
                     SLRLRDNNKPINVLTGIDYWLDNLICNVPELVMCFHVNGIVQKYEMIKTEEIPNLENS
                     NFSTKVIKDIAQNILSFLKSNCTKEGHTYWLFKASGSDIVKLYDLTTLCEETEDKYQN
                     PFTMPVAILLYKVACNMMMKKNQNKKHYGTIRTLLLNCLKLLDKSRHPQIIASANYML
                     SELFQLDEPKKEENSESPLNENSDESYSEEEEEMPDSDENGSYSTSSDPSDDSKAVAI
                     IKSVGELSVPEKYKSIHQIRPSCAFPVCHDTEERCRLVLSYVLEGLKSVDSSIKKESD
                     LPAADPSTPIPLKYEDESSRGGPEGLEKQMALFLDKMGSLQKGNYSSQSGMIPGSWQH
                     KMKLQLILKSSKAYYVLSDAAMSLQKYGRALRYIKLALQSHDTYCCLCTNMLSEVLLF
                     LSQYLTLCGDIQLMLAQNANNRAAHLEEFHYQTKEDQEILHSLHRESSCQGFAWATDL
                     STDLESQLSVSCKCYEAANEILQFSDLKSQNPEHYVQVLKRMGNIRNEIGVFYMNQAA
                     ALQSERLVSKSVSAAEQQLWKKSFSCFEKGIHNFESIEDATNAALLLCNTGRLMRICA
                     QAHCGAGDELKREFSPEEGLYYNKAIDYYLKALRSLGTRDIHPAVWDSVNWELSTTYF
                     TMATLQQDYAPLSRKAQEQIEKEVSEAMMKSLKYCDVDSVSARQPLCQYRAATIHHRL
                     ASMYHSCLRNQVGDEHLRKQHRVLADLHYSKAAKLFQLLKDAPCELLRVQLERVAFAE
                     FQMTSQNSNVGKLKTLSGALDIMVRTEHAFQLIQKELIEEFGQPKSGDAAAAADASPS
                     LNREEVMKLLSIFESRLSFLLLQSIKLLSSTKKKTSNNIEDDTILKTNKHIYSQLLRA
                     TANKTATLLERINVIVHLLGQLAAGSAASSNAVQ"
     exon            208..416
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            417..483
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            484..609
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            610..734
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            735..891
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            892..993
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1115
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1227
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1375
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1484
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1596
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1857
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1929
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2080
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2269
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2470
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2689
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2913
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3072
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3222
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            3223..3376
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3492
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3644
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     exon            3645..4483
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /note="hexamer: AATAAA"
     polyA_site      4483
                     /gene="EDRF1"
                     /gene_synonym="C10orf137"
                     /note="major polyA site"
ORIGIN      
        1 ggtccgcgga gcgtctctgg cgcttaccct gctttgggcc tgcgttgctg ctgctgctcc
       61 tccgctcccc cgtcgtatcg cctgccctgg atcgaagtga tgggggatgc caaggaggcc
      121 ggagccgagg gtccgccggc cggggccgcc gctcgaggag ggctcagcct cctgtcccag
      181 ggagaatccg aggaatcttc tgcacaggga tcagctttat ttcttggagg caatgaagtg
      241 aagagccgag ctgtggtgaa atactcttct gcccctcctc gaacagcatt tgcacgcctt
      301 gaagagaaaa cagacttgaa actcccacct gccaactggt tacgagagag tgccaaacta
      361 gggccagcag gaactaccat tcttggcaac agcaagaaaa gcaagccatt ttcaagcttt
      421 ggcatggcat atgactttat tgattcagtg ggaaatgatg tggatgttgt ctctgactct
      481 gaaaacataa aaaaactcct gaaaattccc tacagcaagt cgcacgtgag catggcagta
      541 caccgcatag gaaggactct cttactagat gagctagata ttcaagaact ctttatgaga
      601 tcgtctcaga ctggtgactg gacatggttg aaagagtttt atcaaagact cattgatcag
      661 aagtggcaga ggaagaaaaa gagcaaagag cactggtatc aaaaggcaat tctttccaag
      721 tttttatatt acagtatcaa tggtgatgga gccgctcagc ctgtctcatc caccgcagaa
      781 cagcaggaat cgtccagttc agatcagaca aatgattcgg aaggggcttc atggcctgct
      841 cccttcgaaa tgccttcttc agtttctgaa gatcccagtg cttccagtca gggaagtgag
      901 cctcttgaac cctcatacat agtggggcat gtggcctcag cccccaaaga acaaaacctg
      961 attactttat tcaatgacgg ggagcacagt cagggtctta aaaatgattt tgttcggaat
     1021 attctatgga catttgaaga tatccatatg ttggtcggct ccaacatgcc catatttgga
     1081 ggaggcagat acccagcagt cagcttacgt ctcagggata acaacaaacc aattaatgtg
     1141 ctaactggaa ttgactattg gttggacaac ttgatatgca atgtgccaga gcttgtgatg
     1201 tgttttcatg taaatggaat tgtacagaaa tatgaaatga taaagacaga agaaattccc
     1261 aatttggaaa attctaattt ttctactaaa gtcataaaag acattgcaca gaatatttta
     1321 tcatttttga aatctaattg taccaaagaa ggacatacct attggctctt taaagcaagt
     1381 ggcagcgata tagtgaagct ctatgacctc actactcttt gtgaagaaac tgaagacaaa
     1441 taccaaaatc cattcacaat gccggtagcc attctcttgt acaaggttgc ttgcaacatg
     1501 atgatgaaga agaatcaaaa taagaaacac tatggaacta ttagaacatt gcttcttaat
     1561 tgtctgaaat tactggacaa aagtaggcat cctcaaatta ttgcttccgc caattacatg
     1621 ctttcagaac tttttcaatt ggatgaacct aaaaaggaag aaaattcaga atctccttta
     1681 aatgagaatt ctgatgaaag ttatagtgaa gaggaggaag agatgcccga cagtgatgaa
     1741 aatggatcct atagcaccag ctctgatcca tcagatgata gcaaagcagt agctataatc
     1801 aagtctgttg gagaactatc agtaccagaa aaatacaaat ctattcatca aatcagaccc
     1861 agttgtgcat ttccagtttg ccatgacaca gaagagcgct gtagacttgt gcttagctat
     1921 gttctagagg gtttaaaatc tgtcgatagc agcatcaaaa aagaaagcga ccttccagca
     1981 gctgacccca gcactccaat cccgttaaaa tatgaagatg aatcctcaag agggggtccc
     2041 gaggggctag agaagcagat ggccttgttt ttggacaaaa tgggctccct tcagaagggc
     2101 aattattcca gtcaatctgg aatgatccct ggctcttggc aacataaaat gaaacttcag
     2161 ctgattctca agtcatcaaa ggcctattat gttttgtccg atgctgccat gagtcttcag
     2221 aaatacggaa gagcattacg atacattaaa ttagctttgc aaagccatga tacttattgc
     2281 tgcctctgca ccaatatgct ttccgaagtg ctgttgtttc tctctcaata tttgacactt
     2341 tgtggtgata tccaactaat gctggcccag aatgcaaata atagagcagc acaccttgaa
     2401 gagtttcatt accaaacaaa agaagaccag gagatcctgc atagccttca cagagagtcc
     2461 agttgccaag gatttgcatg ggcaactgat ttgtctacag acttagaaag tcaactctct
     2521 gttagttgta aatgttatga ggctgctaat gaaatcttgc agtttagtga cttgaaaagc
     2581 caaaatccag aacactatgt acaagtatta aagagaatgg gtaacattag aaatgaaatt
     2641 ggtgtgtttt acatgaatca ggctgctgca ttacagagtg agagactagt gagcaaatct
     2701 gtgtctgctg ccgagcaaca gttgtggaaa aaaagctttt cttgttttga aaagggaatt
     2761 cacaactttg aatcaattga ggatgccacc aatgccgccc ttttattatg taacacggga
     2821 aggctcatgc ggatttgtgc gcaggcccac tgtggtgcag gggatgaact gaaacgtgaa
     2881 ttttcaccag aagaaggctt gtattataat aaggctattg attactattt gaaagcgcta
     2941 aggtcattgg gaacacgaga catacaccca gctgtttggg attcagtgaa ctgggaattg
     3001 tccactactt actttactat ggcaactcta cagcaagatt atgctccgtt atctagaaaa
     3061 gctcaggagc agattgagaa agaagtcagt gaggccatga tgaagtccct aaaatactgc
     3121 gatgtggatt cagtgtctgc tcgacagccc ctttgtcagt atcgagctgc aaccatccat
     3181 cacaggctgg cctccatgta ccacagctgt ctgaggaatc aggttggtga tgaacacctt
     3241 aggaaacaac accgggtgct ggcagatctt cattacagca aggccgcaaa gctgtttcag
     3301 ctgctgaaag atgctccctg cgaactgctt agagtacagc tagagagagt agcatttgct
     3361 gaatttcaga tgaccagtca gaatagcaat gttggaaagt tgaaaacact atctggggct
     3421 cttgatataa tggtgagaac tgagcacgca ttccagctta tccagaagga gcttatagaa
     3481 gaatttggcc agcctaagag tggtgacgcc gctgcagctg ctgatgcttc tcctagtctc
     3541 aatcgagaag aagtgatgaa actcctcagt atatttgagt ctcggttgtc atttcttctc
     3601 cttcagtcca ttaaactgct atcttcaact aaaaagaaaa caagcaataa catcgaagat
     3661 gacacaattc tcaaaaccaa caagcacatt tactcccagc ttttgagagc aactgcaaat
     3721 aaaaccgcga ctcttctgga aagaatcaac gttatcgtcc acctgctggg ccagcttgcc
     3781 gccggcagtg cagcgagcag caatgccgtt cagtgactgc acagagccgt gtcccagaca
     3841 cgctgtcagt gccttcaaca cggagccggt ttgttcattc ggtgctttgt ttcattaaat
     3901 aatagggaaa tatccattta aaacaggtat atcagtggaa acacagagtt attttaagtg
     3961 acagacaaat tacggttgag ttctgtggct tcttcacttg aagtgctaac atcagaatca
     4021 aacttaaagc ttccactatt tatgtctttg agaagtatgt agtacctcgg tattaacaga
     4081 cctgctgtga tgcagttaca ctttcacgta tttttgaagt atgtcaagct acacgggtct
     4141 aagatatgat tattttggat aaaatgttac tttggtcaag agaactttta tccagatgac
     4201 attacaggtt caagtgggtt aaggagacct cctgtacatc tacagtgttt ccttttaaat
     4261 tgtccagaaa aaaggtgtgt tcttcataag cttcagtgca ggatttttca aagacgagct
     4321 gttgtgcaat ttgctgtatt taatgcatgt tctgaaagga ttcacttttg actttatatg
     4381 acagttgatc aagaacaggt actacccctt tttttcattt caaacttgaa actgtgaata
     4441 aggtaagaaa actattttga ataaataaac tatttattta aaa
//
