LOCUS       NM_001122659            4300 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens endothelin receptor type B (EDNRB), transcript variant
            3, mRNA.
ACCESSION   NM_001122659
VERSION     NM_001122659.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4300)
  AUTHORS   Tani,K., Maki-Yonekura,S., Kanno,R., Negami,T., Hamaguchi,T.,
            Hall,M., Mizoguchi,A., Humbel,B.M., Terada,T., Yonekura,K. and
            Doi,T.
  TITLE     Structure of endothelin ETB receptor-Gi complex in a conformation
            stabilized by unique NPxxL motif
  JOURNAL   Commun Biol 7 (1), 1303 (2024)
   PUBMED   39414992
  REMARK    GeneRIF: Structure of endothelin ETB receptor-Gi complex in a
            conformation stabilized by unique NPxxL motif.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4300)
  AUTHORS   Ham,D., Shihoya,W., Nureki,O., Inoue,A. and Chung,K.Y.
  TITLE     Molecular mechanism of the endothelin receptor type B interactions
            with Gs, Gi, and Gq
  JOURNAL   Structure 32 (10), 1632-1639 (2024)
   PUBMED   39043181
  REMARK    GeneRIF: Molecular mechanism of the endothelin receptor type B
            interactions with Gs, Gi, and Gq.
REFERENCE   3  (bases 1 to 4300)
  AUTHORS   Wang,C.H., Tsuji,T., Wu,L.H., Yang,C.Y., Huang,T.L., Sato,M.,
            Shamsi,F. and Tseng,Y.H.
  TITLE     Endothelin 3/EDNRB signaling induces thermogenic differentiation of
            white adipose tissue
  JOURNAL   Nat Commun 15 (1), 7215 (2024)
   PUBMED   39174539
  REMARK    GeneRIF: Endothelin 3/EDNRB signaling induces thermogenic
            differentiation of white adipose tissue.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4300)
  AUTHORS   Medstrand,P., Landry,J.R. and Mager,D.L.
  TITLE     Long terminal repeats are used as alternative promoters for the
            endothelin B receptor and apolipoprotein C-I genes in humans
  JOURNAL   J Biol Chem 276 (3), 1896-1903 (2001)
   PUBMED   11054415
REFERENCE   5  (bases 1 to 4300)
  AUTHORS   Puffenberger,E.G., Hosoda,K., Washington,S.S., Nakao,K., deWit,D.,
            Yanagisawa,M. and Chakravart,A.
  TITLE     A missense mutation of the endothelin-B receptor gene in multigenic
            Hirschsprung's disease
  JOURNAL   Cell 79 (7), 1257-1266 (1994)
   PUBMED   8001158
REFERENCE   6  (bases 1 to 4300)
  AUTHORS   Parisi,M.A.
  TITLE     Hirschsprung Disease Overview - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301612
REFERENCE   7  (bases 1 to 4300)
  AUTHORS   Arai,H., Nakao,K., Hosoda,K., Ogawa,Y., Nakagawa,O., Komatsu,Y. and
            Imura,H.
  TITLE     [Molecular cloning of human endothelin receptors and their
            expression in vascular endothelial cells and smooth muscle cells]
  JOURNAL   Jpn Circ J 56 Suppl 5, 1303-1307 (1992)
   PUBMED   1291713
REFERENCE   8  (bases 1 to 4300)
  AUTHORS   Haendler,B., Hechler,U. and Schleuning,W.D.
  TITLE     Molecular cloning of human endothelin (ET) receptors ETA and ETB
  JOURNAL   J Cardiovasc Pharmacol 20 Suppl 12, S1-S4 (1992)
   PUBMED   1282938
REFERENCE   9  (bases 1 to 4300)
  AUTHORS   Cyr,C., Huebner,K., Druck,T. and Kris,R.
  TITLE     Cloning and chromosomal localization of a human endothelin ETA
            receptor
  JOURNAL   Biochem Biophys Res Commun 181 (1), 184-190 (1991)
   PUBMED   1659806
REFERENCE   10 (bases 1 to 4300)
  AUTHORS   Nakamuta,M., Takayanagi,R., Sakai,Y., Sakamoto,S., Hagiwara,H.,
            Mizuno,T., Saito,Y., Hirose,S., Yamamoto,M. and Nawata,H.
  TITLE     Cloning and sequence analysis of a cDNA encoding human
            non-selective type of endothelin receptor
  JOURNAL   Biochem Biophys Res Commun 177 (1), 34-39 (1991)
   PUBMED   1710450
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139002.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001122659.2.
            
            Summary: The protein encoded by this gene is a G protein-coupled
            receptor which activates a phosphatidylinositol-calcium second
            messenger system. Its ligand, endothelin, consists of a family of
            three potent vasoactive peptides: ET1, ET2, and ET3. Studies
            suggest that the multigenic disorder, Hirschsprung disease type 2,
            is due to mutations in the endothelin receptor type B gene.
            Alternative splicing and the use of alternative promoters results
            in multiple transcript variants. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 and 3 both encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.243839.1,
                                           SRR1660803.99844.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000646607.2/ ENSP00000493527.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-741               AL139002.18        92585-93325         c
            742-854             AL139002.18        77989-78101         c
            855-1059            AL139002.18        77650-77854         c
            1060-1209           AL139002.18        75552-75701         c
            1210-1343           AL139002.18        75015-75148         c
            1344-1452           AL139002.18        74353-74461         c
            1453-4300           AL139002.18        69981-72828         c
FEATURES             Location/Qualifiers
     source          1..4300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q22.3"
     gene            1..4300
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /note="endothelin receptor type B"
                     /db_xref="GeneID:1910"
                     /db_xref="HGNC:HGNC:3180"
                     /db_xref="MIM:131244"
     exon            1..741
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1587
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; endothelin receptor non-selective type;
                     Hirschsprung disease 2; endothelin receptor subtype B1"
                     /codon_start=1
                     /product="endothelin receptor type B isoform 1 precursor"
                     /protein_id="NP_001116131.1"
                     /db_xref="CCDS:CCDS9461.1"
                     /db_xref="GeneID:1910"
                     /db_xref="HGNC:HGNC:3180"
                     /db_xref="MIM:131244"
                     /translation="MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAE
                     IMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKY
                     INTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVY
                     KLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWT
                     AVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWW
                     LFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFAL
                     CWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKR
                     FKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS"
     exon            742..854
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1059
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1209
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1343
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1452
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..4300
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4278..4283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /note="hexamer: ATTAAA"
     polyA_site      4300
                     /gene="EDNRB"
                     /gene_synonym="ABCDS; ET-B; ET-BR; ETB; ETB1; ETBR; ETRB;
                     HSCR; HSCR2; WS4A"
                     /note="major polyA site"
ORIGIN      
        1 aagaaaaaca gctgagaggg catcaggaag gagtttcgac ccgcgctggc gagtcatgag
       61 cgccaagttt cccactggcg cgcaaacttg agttactttt gagcgtggat actggcgaag
      121 aggctgcggg cggtattagc gtttgcagcg acttggctcg ggcagctgac ccaagtgtcc
      181 tgtcttcctt cctctgcttg tctctaggct ctgaaactgc ggagcggcca ccggacgcct
      241 tctggagcag gtagcagcat gcagccgcct ccaagtctgt gcggacgcgc cctggttgcg
      301 ctggttcttg cctgcggcct gtcgcggatc tggggagagg agagaggctt cccgcctgac
      361 agggccactc cgcttttgca aaccgcagag ataatgacgc cacccactaa gaccttatgg
      421 cccaagggtt ccaacgccag tctggcgcgg tcgttggcac ctgcggaggt gcctaaagga
      481 gacaggacgg caggatctcc gccacgcacc atctcccctc ccccgtgcca aggacccatc
      541 gagatcaagg agactttcaa atacatcaac acggttgtgt cctgccttgt gttcgtgctg
      601 gggatcatcg ggaactccac acttctgaga attatctaca agaacaagtg catgcgaaac
      661 ggtcccaata tcttgatcgc cagcttggct ctgggagacc tgctgcacat cgtcattgac
      721 atccctatca atgtctacaa gctgctggca gaggactggc catttggagc tgagatgtgt
      781 aagctggtgc ctttcataca gaaagcctct gtgggaatca ctgtgctgag tctatgtgct
      841 ctgagtattg acagatatcg agctgttgct tcttggagta gaattaaagg aattggggtt
      901 ccaaaatgga cagcagtaga aattgttttg atttgggtgg tctctgtggt tctggctgtc
      961 cctgaagcca taggttttga tataattacg atggactaca aaggaagtta tctgcgaatc
     1021 tgcttgcttc atcccgttca gaagacagct ttcatgcagt tttacaagac agcaaaagat
     1081 tggtggctat tcagtttcta tttctgcttg ccattggcca tcactgcatt tttttataca
     1141 ctaatgacct gtgaaatgtt gagaaagaaa agtggcatgc agattgcttt aaatgatcac
     1201 ctaaagcaga gacgggaagt ggccaaaacc gtcttttgcc tggtccttgt ctttgccctc
     1261 tgctggcttc cccttcacct cagcaggatt ctgaagctca ctctttataa tcagaatgat
     1321 cccaatagat gtgaactttt gagctttctg ttggtattgg actatattgg tatcaacatg
     1381 gcttcactga attcctgcat taacccaatt gctctgtatt tggtgagcaa aagattcaaa
     1441 aactgcttta agtcatgctt atgctgctgg tgccagtcat ttgaagaaaa acagtccttg
     1501 gaggaaaagc agtcgtgctt aaagttcaaa gctaatgatc acggatatga caacttccgt
     1561 tccagtaata aatacagctc atcttgaaag aagaactatt cactgtattt cattttcttt
     1621 atattggacc gaagtcatta aaacaaaatg aaacatttgc caaaacaaaa caaaaaacta
     1681 tgtatttgca cagcacacta ttaaaatatt aagtgtaatt attttaacac tcacagctac
     1741 atatgacatt ttatgagctg tttacggcat ggaaagaaaa tcagtgggaa ttaagaaagc
     1801 ctcgtcgtga aagcacttaa ttttttacag ttagcacttc aacatagctc ttaacaactt
     1861 ccaggatatt cacacaacac ttaggcttaa aaatgagctc actcagaatt tctattcttt
     1921 ctaaaaagag atttattttt aaatcaatgg gactctgata taaaggaaga ataagtcact
     1981 gtaaaacaga acttttaaat gaagcttaaa ttactcaatt taaaatttta aaatccttta
     2041 aaacaacttt tcaattaata ttatcacact attatcagat tgtaattaga tgcaaatgag
     2101 agagcagttt agttgttgca tttttcggac actggaaaca tttaaatgat caggagggag
     2161 taacagaaag agcaaggctg tttttgaaaa tcattacact ttcactagaa gcccaaacct
     2221 cagcattctg caatatgtaa ccaacatgtc acaaacaagc agcatgtaac agactggcac
     2281 atgtgccagc tgaatttaaa atataatact tttaaaaaga aaattattac atcctttaca
     2341 ttcagttaag atcaaacctc acaaagagaa atagaatgtt tgaaaggcta tcccaaaaga
     2401 cttttttgaa tctgtcattc acataccctg tgaagacaat actatctaca attttttcag
     2461 gattattaaa atcttcttct ttcactatcg tagcttaaac tctgtttggt tttgtcatct
     2521 gtaaatactt acctacatac actgcatgta gatgattaaa tgagggcagg ccctgtgctc
     2581 atagctttac gatggagaga tgccagtgac ctcataataa agactgtgaa ctgcctggtg
     2641 cagtgtccac atgacaaagg ggcaggtagc accctctctc acccatgctg tggttaaaat
     2701 ggtttctagc atatgtataa tgctatagtt aaaatactat ttttcaaaat catacagatt
     2761 agtacattta acagctacct gtaaagctta ttactaattt ttgtattatt tttgtaaata
     2821 gccaatagaa aagtttgctt gacatggtgc ttttctttca tctagaggca aaactgcttt
     2881 ttgagaccgt aagaacctct tagctttgtg cgttcctgcc taatttttat atcttctaag
     2941 caaagtgcct taggatagct tgggatgaga tgtgtgtgaa agtatgtaca agagaaaacg
     3001 gaagagagag gaaatgaggt ggggttggag gaaacccatg gggacagatt cccattctta
     3061 gcctaacgtt cgtcattgcc tcgtcacatc aatgcaaaag gtcctgattt tgttccagca
     3121 aaacacagtg caatgttctc agagtgactt tcgaaataaa ttgggcccaa gagctttaac
     3181 tcggtcttaa aatatgccca aatttttact ttgtttttct tttaataggc tgggccacat
     3241 gttggaaata agctagtaat gttgttttct gtcaatattg aatgtgatgg tacagtaaac
     3301 caaaacccaa caatgtggcc agaaagaaag agcaataata attaattcac acaccatatg
     3361 gattctattt ataaatcacc cacaaacttg ttctttaatt tcatcccaat cactttttca
     3421 gaggcctgtt atcatagaag tcattttaga ctctcaattt taaattaatt ttgaatcact
     3481 aatattttca cagtttatta atatatttaa tttctattta aattttagat tatttttatt
     3541 accatgtact gaatttttac atcctgatac cttttccttc tccatgtcag tatcatgttc
     3601 tctaattatc ttgccaaatt ttgaaactac acacaaaaag catacttgca ttatttataa
     3661 taaaattgca ttcagtggct ttttaaaaaa atgtttgatt caaaacttta acatactgat
     3721 aagtaagaaa caattataat ttctttacat actcaaaacc aagatagaaa aaggtgctat
     3781 cgttcaactt caaaacatgt ttcctagtat taaggacttt aatatagcaa cagacaaaat
     3841 tattgttaac atggatgtta cagctcaaaa gatttataaa agattttaac ctattttctc
     3901 ccttattatc cactgctaat gtggatgtat gttcaaacac cttttagtat tgatagctta
     3961 catatggcca aaggaataca gtttatagca aaacatgggt atgctgtagc taactttata
     4021 aaagtgtaat ataacaatgt aaaaaattat atatctggga ggattttttg gttgcctaaa
     4081 gtggctatag ttactgattt tttattatgt aagcaaaacc aataaaaatt taagtttttt
     4141 taacaactac cttatttttc actgtacaga cactaattca ttaaatacta attgattgtt
     4201 taaaagaaat ataaatgtga caagtggaca ttatttatgt taaatataca attatcaagc
     4261 aagtatgaag ttattcaatt aaaatgccac atttctggtc
//
