LOCUS       NM_001957               3970 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens endothelin receptor type A (EDNRA), transcript variant
            1, mRNA.
ACCESSION   NM_001957
VERSION     NM_001957.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3970)
  AUTHORS   Xu,Z., Zhou,Q., Liu,C., Zhang,H., Bai,N., Xiang,T., Luo,D. and
            Liu,H.
  TITLE     EDNRA affects susceptibility to large artery atherosclerosis stroke
            through potential inflammatory pathway
  JOURNAL   Sci Rep 14 (1), 25173 (2024)
   PUBMED   39448657
  REMARK    GeneRIF: EDNRA affects susceptibility to large artery
            atherosclerosis stroke through potential inflammatory pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3970)
  AUTHORS   Owen,N.E., Williams,T.L., Maguire,J.J., Kuc,R.E., Davenport,E.E.
            and Davenport,A.P.
  TITLE     Microarray analysis demonstrates up-regulation of the endothelin-1
            gene with compensatory down-regulation of the ETA receptor gene in
            human portal vein
  JOURNAL   Biosci Rep 44 (7) (2024)
   PUBMED   38860875
  REMARK    GeneRIF: Microarray analysis demonstrates up-regulation of the
            endothelin-1 gene with compensatory down-regulation of the ETA
            receptor gene in human portal vein.
REFERENCE   3  (bases 1 to 3970)
  AUTHORS   Williams,T.L., Kuc,R.E., Paterson,A.L., Abraham,G.R.,
            Pullinger,A.L., Maguire,J.J., Sinha,S., Greasley,P.J., Ambery,P.
            and Davenport,A.P.
  TITLE     Co-localization of the sodium-glucose co-transporter-2 channel
            (SGLT-2) with endothelin ETA and ETB receptors in human cardiorenal
            tissue
  JOURNAL   Biosci Rep 44 (6) (2024)
   PUBMED   38747277
  REMARK    GeneRIF: Co-localization of the sodium-glucose co-transporter-2
            channel (SGLT-2) with endothelin ETA and ETB receptors in human
            cardiorenal tissue.
REFERENCE   4  (bases 1 to 3970)
  AUTHORS   Miyamoto,Y., Yoshimasa,T., Arai,H., Takaya,K., Ogawa,Y., Itoh,H.
            and Nakao,K.
  TITLE     Alternative RNA splicing of the human endothelin-A receptor
            generates multiple transcripts
  JOURNAL   Biochem J 313 (Pt 3) (Pt 3), 795-801 (1996)
   PUBMED   8611157
REFERENCE   5  (bases 1 to 3970)
  AUTHORS   Yang,H., Tabuchi,H., Furuichi,Y. and Miyamoto,C.
  TITLE     Molecular characterization of the 5'-flanking region of human
            genomic ETA gene
  JOURNAL   Biochem Biophys Res Commun 190 (2), 332-339 (1993)
   PUBMED   8427579
REFERENCE   6  (bases 1 to 3970)
  AUTHORS   Hayzer,D.J., Rose,P.M., Lynch,J.S., Webb,M.L., Kienzle,B.K.,
            Liu,E.C., Bogosian,E.A., Brinson,E. and Runge,M.S.
  TITLE     Cloning and expression of a human endothelin receptor: subtype A
  JOURNAL   Am J Med Sci 304 (4), 231-238 (1992)
   PUBMED   1415318
REFERENCE   7  (bases 1 to 3970)
  AUTHORS   Hosoda,K., Nakao,K., Tamura,N., Arai,H., Ogawa,Y., Suga,S.,
            Nakanishi,S. and Imura,H.
  TITLE     Organization, structure, chromosomal assignment, and expression of
            the gene encoding the human endothelin-A receptor
  JOURNAL   J Biol Chem 267 (26), 18797-18804 (1992)
   PUBMED   1326535
REFERENCE   8  (bases 1 to 3970)
  AUTHORS   Cyr,C., Huebner,K., Druck,T. and Kris,R.
  TITLE     Cloning and chromosomal localization of a human endothelin ETA
            receptor
  JOURNAL   Biochem Biophys Res Commun 181 (1), 184-190 (1991)
   PUBMED   1659806
REFERENCE   9  (bases 1 to 3970)
  AUTHORS   Adachi,M., Yang,Y.Y., Furuichi,Y. and Miyamoto,C.
  TITLE     Cloning and characterization of cDNA encoding human A-type
            endothelin receptor
  JOURNAL   Biochem Biophys Res Commun 180 (3), 1265-1272 (1991)
   PUBMED   1719979
REFERENCE   10 (bases 1 to 3970)
  AUTHORS   Hosoda,K., Nakao,K., Hiroshi-Arai, Suga,S., Ogawa,Y., Mukoyama,M.,
            Shirakami,G., Saito,Y., Nakanishi,S. and Imura,H.
  TITLE     Cloning and expression of human endothelin-1 receptor cDNA
  JOURNAL   FEBS Lett 287 (1-2), 23-26 (1991)
   PUBMED   1652463
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312812.1, AC093908.3 and
            BQ006584.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001957.3.
            
            Summary: This gene encodes the receptor for endothelin-1, a peptide
            that plays a role in potent and long-lasting vasoconstriction. This
            receptor associates with guanine-nucleotide-binding (G) proteins,
            and this coupling activates a phosphatidylinositol-calcium second
            messenger system. Polymorphisms in this gene have been linked to
            migraine headache resistance. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1, also known as ET-AR)
            represents the longest transcript and encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022511.1, D90348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651419.1/ ENSP00000498969.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1634              AK312812.1         1-1634
            1635-3409           AC093908.3         93503-95277
            3410-3970           BQ006584.1         19-579              c
FEATURES             Location/Qualifiers
     source          1..3970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.22-q31.23"
     gene            1..3970
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /note="endothelin receptor type A"
                     /db_xref="GeneID:1909"
                     /db_xref="HGNC:HGNC:3179"
                     /db_xref="MIM:131243"
     exon            1..280
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     exon            281..770
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1634
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; endothelin receptor subtype A;
                     endothelin-1-specific receptor; G protein-coupled
                     receptor"
                     /codon_start=1
                     /product="endothelin-1 receptor isoform a precursor"
                     /protein_id="NP_001948.1"
                     /db_xref="CCDS:CCDS3769.1"
                     /db_xref="GeneID:1909"
                     /db_xref="HGNC:HGNC:3179"
                     /db_xref="MIM:131243"
                     /translation="METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTE
                     LSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLL
                     RIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKL
                     FPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAI
                     PEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYT
                     LMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYN
                     EMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSK
                     SLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN"
     exon            771..898
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1097
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1250
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1384
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1493
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..3970
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3948..3953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /note="hexamer: AATAAA"
     polyA_site      3970
                     /gene="EDNRA"
                     /gene_synonym="ET-A; ETA; ETA-R; ETAR; ETRA; hET-AR; MFDA"
                     /note="major polyA site"
ORIGIN      
        1 agtcatcccg ctggtctgac gattgtggag aggcggtgga gaggcttcat ccatcccacc
       61 cggtcgtcgc cggggattgg ggtcccagcg agacctcccc gggagaagca gtgcccagga
      121 ggttttctga agccggggaa gctgtgcagc cgaagccgcc gccgcgccgg agcccgggac
      181 accggccacc ctccgcgcca cccaccctcg ccggctccgg cttcctctgg cccaggcgcc
      241 gcgcggaccc ggcagctgtc tgcgcacgcc gagctccacg gtgaaaaaaa agtgaaggtg
      301 taaaagcagc acaagtgcaa taagagatat ttcctcaaat ttgcctcaag atggaaaccc
      361 tttgcctcag ggcatccttt tggctggcac tggttggatg tgtaatcagt gataatcctg
      421 agagatacag cacaaatcta agcaatcatg tggatgattt caccactttt cgtggcacag
      481 agctcagctt cctggttacc actcatcaac ccactaattt ggtcctaccc agcaatggct
      541 caatgcacaa ctattgccca cagcagacta aaattacttc agctttcaaa tacattaaca
      601 ctgtgatatc ttgtactatt ttcatcgtgg gaatggtggg gaatgcaact ctgctcagga
      661 tcatttacca gaacaaatgt atgaggaatg gccccaacgc gctgatagcc agtcttgccc
      721 ttggagacct tatctatgtg gtcattgatc tccctatcaa tgtatttaag ctgctggctg
      781 ggcgctggcc ttttgatcac aatgactttg gcgtatttct ttgcaagctg ttcccctttt
      841 tgcagaagtc ctcggtgggg atcaccgtcc tcaacctctg cgctcttagt gttgacaggt
      901 acagagcagt tgcctcctgg agtcgtgttc agggaattgg gattcctttg gtaactgcca
      961 ttgaaattgt ctccatctgg atcctgtcct ttatcctggc cattcctgaa gcgattggct
     1021 tcgtcatggt accctttgaa tataggggtg aacagcataa aacctgtatg ctcaatgcca
     1081 catcaaaatt catggagttc taccaagatg taaaggactg gtggctcttc gggttctatt
     1141 tctgtatgcc cttggtgtgc actgcgatct tctacaccct catgacttgt gagatgttga
     1201 acagaaggaa tggcagcttg agaattgccc tcagtgaaca tcttaagcag cgtcgagaag
     1261 tggcaaaaac agttttctgc ttggttgtaa tttttgctct ttgctggttc cctcttcatt
     1321 taagccgtat attgaagaaa actgtgtata acgagatgga caagaaccga tgtgaattac
     1381 ttagtttctt actgctcatg gattacatcg gtattaactt ggcaaccatg aattcatgta
     1441 taaaccccat agctctgtat tttgtgagca agaaatttaa aaattgtttc cagtcatgcc
     1501 tctgctgctg ctgttaccag tccaaaagtc tgatgacctc ggtccccatg aacggaacaa
     1561 gcatccagtg gaagaaccac gatcaaaaca accacaacac agaccggagc agccataagg
     1621 acagcatgaa ctgaccaccc ttagaagcac tcctcggtac tcccataatc ctctcggaga
     1681 aaaaaatcac aaggcaactg tgagtccggg aatctcttct ctgatccttc ttccttaatt
     1741 cactcccaca cccaagaaga aatgctttcc aaaaccgcaa gggtagactg gtttatccac
     1801 ccacaacatc tacgaatcgt acttctttaa ttgatctaat ttacatattc tgcgtgttgt
     1861 attcagcact aaaaaatggt gggagctggg ggagaatgaa gactgttaaa tgaaaccaga
     1921 aggatattta ctacttttgc atgaaaatag agctttcaag tacatggcta gcttttatgg
     1981 cagttctggt gaatgttcaa tgggaactgg tcaccatgaa actttagaga ttaacgacaa
     2041 gattttctac tttttttaag tgattttttt gtccttcagc caaacacaat atgggctcaa
     2101 gtcactttta tttgaaatgt catttggtgc cagtattttt taactgcata atagcctaac
     2161 atgattattt gaacttattt acacatagtt tgaaaaaaaa aagacaaaaa tagtattcag
     2221 gtgagcaatt agattagtat tttccacgtc actgtttatt tttttaaaac acaaattcta
     2281 aagctacaac aaatactaca ggcccttaaa gcacagtctg atgacacatt tggcagttta
     2341 atagatgtta ctcaaagaat tttttaagaa ctgtatttta ttttttaaat ggtgttttat
     2401 tacaagggac cttgaacatg ttttgtatgt taaattcaaa agtaatgctt caatcagata
     2461 gttctttttc acaagttcaa tctgtttttc atgtaaattt tgtatgaaaa atcaatgtca
     2521 agtaccaaaa tgttaatgta tgtgtcattt aactctgcct gagactttca gtgcactgta
     2581 tatagaagtc taaaacacac ctaagagaaa aagatcgaat ttttcagatg attcagaaat
     2641 tttcattcag gtatttgtaa tagtgacata tatatgtata tacatatcac ctcctattct
     2701 cttaattttt cttaaaatgt taactggcag taagtctttt ttgatcattc ccttttccat
     2761 ataggaaaca taattttgaa gtggccagat gagtttatca tgtcagtgaa aaataattac
     2821 ccacaaatgc caccagaact tacgattctt cacttcttgg ggttttcagt atgaacctaa
     2881 ctccccaccc caacatctcc ctcccacatt gtcaccattt caaagggccc acagtgactt
     2941 ttgctgggca ttttcccaga tgtttacaga ctgtgagtac agcagaaaat cttttactag
     3001 tgtgtgtgtg tatatatata aacaattgta aatttctttt agcccatttt tctagactgt
     3061 ctctgtggaa tatatttgtg tgtgtgatat atgcatgtgt gtgatggtat gtatggattt
     3121 aatctaatct aataattgtg ccccgcagtt gtgccaaagt gcatagtctg agtaaaatct
     3181 aggtgattgt tcatcatgac aacctgcctc agtccatttt aacctgtagc aaccttctgc
     3241 attcataaat cttgtaatca tgttaccatt acaaatggga tataagaggc agcgtgaaag
     3301 cagatgagct gtggactagc aatatagggt tttgtttggt tggttggttt gataaagcag
     3361 tatttggggt catattgttt cctgtgctgg agcaaaagtc attacacttt gaagtattat
     3421 attgttctta tcctcaattc aatgtggtga tgaaattgcc aggttgtctg atatttcttt
     3481 cagacttcgc cagacagatt gctgataata aattaggtaa gataatttgt tgggccatat
     3541 tttaggacag gtaaaataac atcaggttcc agttgcttga attgcaaggc taagaagtac
     3601 tgcccttttg tgtgttagca gtcaaatcta ttattccact ggcgcatcat atgcagtgat
     3661 atatgcctat aatataagcc ataggttcac accattttgt ttagacaatt gtcttttttt
     3721 caagatgctt tgtttctttc atatgaaaaa aatgcatttt ataaattcag aaagtcatag
     3781 atttctgaag gcgtcaacgt gcattttatt tatggactgg taagtaactg tggtttacta
     3841 gcaggaatat ttccaatttc tacctttact acatcttttc aacaagtaac tttgtagaaa
     3901 tgagccagaa gccaaggccc tgagttggca gtggcccata agtgtaaaat aaaagtttac
     3961 agaaaccttg
//
