LOCUS       NM_001955               2035 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens endothelin 1 (EDN1), transcript variant 1, mRNA.
ACCESSION   NM_001955
VERSION     NM_001955.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Edgerton-Fulton,M., Abdul,Y., Jamil,S. and Ergul,A.
  TITLE     Endothelin-1 (ET-1) contributes to senescence and phenotypic
            changes in brain pericytes in diabetes-mimicking conditions
  JOURNAL   Clin Sci (Lond) 138 (16), 1009-1022 (2024)
   PUBMED   39106080
  REMARK    GeneRIF: Endothelin-1 (ET-1) contributes to senescence and
            phenotypic changes in brain pericytes in diabetes-mimicking
            conditions.
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Wang,Z., Wu,Z., Hu,Z., Zheng,H. and Chen,Z.
  TITLE     ET1 acts as a potential plasma biomarker and therapeutic target in
            deep venous thrombosis rat model
  JOURNAL   J Thromb Thrombolysis 57 (6), 1067-1075 (2024)
   PUBMED   38824487
  REMARK    GeneRIF: ET1 acts as a potential plasma biomarker and therapeutic
            target in deep venous thrombosis rat model.
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Owen,N.E., Williams,T.L., Maguire,J.J., Kuc,R.E., Davenport,E.E.
            and Davenport,A.P.
  TITLE     Microarray analysis demonstrates up-regulation of the endothelin-1
            gene with compensatory down-regulation of the ETA receptor gene in
            human portal vein
  JOURNAL   Biosci Rep 44 (7) (2024)
   PUBMED   38860875
  REMARK    GeneRIF: Microarray analysis demonstrates up-regulation of the
            endothelin-1 gene with compensatory down-regulation of the ETA
            receptor gene in human portal vein.
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Tocci,P., Roman,C., Sestito,R., Caprara,V., Sacconi,A.,
            Molineris,I., Tonon,G., Blandino,G. and Bagnato,A.
  TITLE     The endothelin-1-driven tumor-stroma feed-forward loops in
            high-grade serous ovarian cancer
  JOURNAL   Clin Sci (Lond) 138 (14), 851-862 (2024)
   PUBMED   38884602
  REMARK    GeneRIF: The endothelin-1-driven tumor-stroma feed-forward loops in
            high-grade serous ovarian cancer.
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Saito,Y., Nodai,T., Munemasa,T., Mukaibo,T., Kondo,Y., Masaki,C.
            and Hosokawa,R.
  TITLE     Diagnostic potential of endothelin-1 in peri-implant diseases: a
            cross-sectional study
  JOURNAL   Int J Implant Dent 10 (1), 32 (2024)
   PUBMED   38874661
  REMARK    GeneRIF: Diagnostic potential of endothelin-1 in peri-implant
            diseases: a cross-sectional study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   Rosano,L., Spinella,F. and Bagnato,A.
  TITLE     Endothelin 1 in cancer: biological implications and therapeutic
            opportunities
  JOURNAL   Nat Rev Cancer 13 (9), 637-651 (2013)
   PUBMED   23884378
  REMARK    Review article
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Imokawa,G., Yada,Y. and Miyagishi,M.
  TITLE     Endothelins secreted from human keratinocytes are intrinsic
            mitogens for human melanocytes
  JOURNAL   J Biol Chem 267 (34), 24675-24680 (1992)
   PUBMED   1280264
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Donlan,M.L., Brown,F.K. and Jeffs,P.W.
  TITLE     Solution conformation of human big endothelin-1
  JOURNAL   J Biomol NMR 2 (5), 407-420 (1992)
   PUBMED   1422154
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Wolff,M., Day,J., Greenwood,A., Larson,S. and McPherson,A.
  TITLE     Crystallization and preliminary X-ray analysis of human endothelin
  JOURNAL   Acta Crystallogr B 48 (Pt 2), 239-240 (1992)
   PUBMED   1515112
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Sakamoto,A., Yanagisawa,M., Sakurai,T., Takuwa,Y., Yanagisawa,H.
            and Masaki,T.
  TITLE     Cloning and functional expression of human cDNA for the ETB
            endothelin receptor
  JOURNAL   Biochem Biophys Res Commun 178 (2), 656-663 (1991)
   PUBMED   1713452
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from S56805.1, Z98050.1, BQ009676.1,
            AL548191.3 and AW044634.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001955.4.
            
            Summary: This gene encodes a preproprotein that is proteolytically
            processed to generate a secreted peptide that belongs to the
            endothelin/sarafotoxin family. This peptide is a potent
            vasoconstrictor and its cognate receptors are therapeutic targets
            in the treatment of pulmonary arterial hypertension. Aberrant
            expression of this gene may promote tumorigenesis. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Oct 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.336746.1,
                                           SRR3476690.1151519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379375.6/ ENSP00000368683.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                S56805.1           66-131
            67-138              S56805.1           135-206
            139-139             Z98050.1           154385-154385
            140-586             S56805.1           207-653
            587-587             Z98050.1           157911-157911
            588-913             S56805.1           655-980
            914-1382            BQ009676.1         16-484              c
            1383-2000           AL548191.3         1-618               c
            2001-2035           AW044634.1         13-47               c
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.1"
     gene            1..2035
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /note="endothelin 1"
                     /db_xref="GeneID:1906"
                     /db_xref="HGNC:HGNC:3176"
                     /db_xref="MIM:131240"
     exon            1..333
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..908
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; preproendothelin-1"
                     /codon_start=1
                     /product="endothelin-1 isoform 1 preproprotein"
                     /protein_id="NP_001946.3"
                     /db_xref="CCDS:CCDS4522.1"
                     /db_xref="GeneID:1906"
                     /db_xref="HGNC:HGNC:3176"
                     /db_xref="MIM:131240"
                     /translation="MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPP
                     WRLRRSKRCSCSSLMDKECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKA
                     TDRENRCQCASQKDKKCWNFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQL
                     VRGRKIRRSSEEHLRQTRSETMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW"
     exon            334..502
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /inference="alignment:Splign:2.1.0"
     exon            503..658
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /inference="alignment:Splign:2.1.0"
     exon            659..802
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /inference="alignment:Splign:2.1.0"
     exon            803..2035
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /note="hexamer: AATAAA"
     polyA_site      2035
                     /gene="EDN1"
                     /gene_synonym="ARCND3; ET1; HDLCQ7; PPET1; QME"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgcct ctgcatctgc gccaggcgaa cgggtcctgc gcctcctgca gtcccagctc
       61 tccaccgccg cgtgcgcctg cagacgctcc gctcgctgcc ttctctcctg gcaggcgctg
      121 ccttttctcc ccgttaaaag ggcacttggg ctgaaggatc gctttgagat ctgaggaacc
      181 cgcagcgctt tgagggacct gaagctgttt ttcttcgttt tcctttgggt tcagtttgaa
      241 cgggaggttt ttgatccctt tttttcagaa tggattattt gctcatgatt ttctctctgc
      301 tgtttgtggc ttgccaagga gctccagaaa cagcagtctt aggcgctgag ctcagcgcgg
      361 tgggtgagaa cggcggggag aaacccactc ccagtccacc ctggcggctc cgccggtcca
      421 agcgctgctc ctgctcgtcc ctgatggata aagagtgtgt ctacttctgc cacctggaca
      481 tcatttgggt caacactccc gagcacgttg ttccgtatgg acttggaagc cctaggtcca
      541 agagagcctt ggagaattta cttcccacaa aggcaacaga ccgtgaaaat agatgccaat
      601 gtgctagcca aaaagacaag aagtgctgga atttttgcca agcaggaaaa gaactcaggg
      661 ctgaagacat tatggagaaa gactggaata atcataagaa aggaaaagac tgttccaagc
      721 ttgggaaaaa gtgtatttat cagcagttag tgagaggaag aaaaatcaga agaagttcag
      781 aggaacacct aagacaaacc aggtcggaga ccatgagaaa cagcgtcaaa tcatcttttc
      841 atgatcccaa gctgaaaggc aagccctcca gagagcgtta tgtgacccac aaccgagcac
      901 attggtgaca gaccttcggg gcctgtctga agccatagcc tccacggaga gccctgtggc
      961 cgactctgca ctctccaccc tggctgggat cagagcagga gcatcctctg ctggttcctg
     1021 actggcaaag gaccagcgtc ctcgttcaaa acattccaag aaaggttaag gagttccccc
     1081 aaccatcttc actggcttcc atcagtggta actgctttgg tctcttcttt catctgggga
     1141 tgacaatgga cctctcagca gaaacacaca gtcacattcg aattcgggtg gcatcctccg
     1201 gagagagaga gaggaaggag attccacaca ggggtggagt ttctgacgaa ggtcctaagg
     1261 gagtgtttgt gtctgactca ggcgcctggc acatttcagg gagaaactcc aaagtccaca
     1321 caaagatttt ctaaggaatg cacaaattga aaacacactc aaaagacaaa catgcaagta
     1381 aagaaaaaaa aaagaaagac ttttgtttaa atttgtaaaa tgcaaaactg aatgaaactg
     1441 ttactaccat aaatcaggat atgtttcatg aatatgagtc tacctcacct atattgcact
     1501 ctggcagaag tatttcccac atttaattat tgcctcccca aactcttccc acccctgctg
     1561 ccccttcctc catcccccat actaaatcct agcctcgtag aagtctggtc taatgtgtca
     1621 gcagtagata taatattttc atggtaatct actagctctg atccataaga aaaaaaagat
     1681 cattaaatca ggagattccc tgtccttgat ttttggagac acaatggtat agggttgttt
     1741 atgaaatata ttgaaaagta agtgtttgtt acgctttaaa gcagtaaaat tattttcctt
     1801 tatataaccg gctaatgaaa gaggttggat tgaattttga tgtacttatt tttttataga
     1861 tatttatatt caaacaattt attccttata tttaccatgt taaatatctg tttgggcagg
     1921 ccatattggt ctatgtattt ttaaaatatg tatttctaaa tgaaattgag aacatgcttt
     1981 gttttgcctg tcaaggtaat gactttagaa aataaatatt tttttcctta ctgta
//
