LOCUS       NM_003792                662 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens endothelial differentiation related factor 1 (EDF1),
            transcript variant alpha, mRNA.
ACCESSION   NM_003792
VERSION     NM_003792.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 662)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 662)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 662)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 662)
  AUTHORS   Sinha,N.K., Ordureau,A., Best,K., Saba,J.A., Zinshteyn,B.,
            Sundaramoorthy,E., Fulzele,A., Garshott,D.M., Denk,T., Thoms,M.,
            Paulo,J.A., Harper,J.W., Bennett,E.J., Beckmann,R. and Green,R.
  TITLE     EDF1 coordinates cellular responses to ribosome collisions
  JOURNAL   Elife 9, e58828 (2020)
   PUBMED   32744497
  REMARK    GeneRIF: EDF1 coordinates cellular responses to ribosome
            collisions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 662)
  AUTHORS   Nassa,G., Giurato,G., Salvati,A., Gigantino,V., Pecoraro,G.,
            Lamberti,J., Rizzo,F., Nyman,T.A., Tarallo,R. and Weisz,A.
  TITLE     The RNA-mediated estrogen receptor alpha interactome of
            hormone-dependent human breast cancer cell nuclei
  JOURNAL   Sci Data 6 (1), 173 (2019)
   PUBMED   31527615
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 662)
  AUTHORS   Kabe,Y., Goto,M., Shima,D., Imai,T., Wada,T., Morohashi,Ki.,
            Shirakawa,M., Hirose,S. and Handa,H.
  TITLE     The role of human MBF1 as a transcriptional coactivator
  JOURNAL   J Biol Chem 274 (48), 34196-34202 (1999)
   PUBMED   10567391
REFERENCE   7  (bases 1 to 662)
  AUTHORS   Ozaki,J., Takemaru,K.I., Ikegami,T., Mishima,M., Ueda,H.,
            Hirose,S., Kabe,Y., Handa,H. and Shirakawa,M.
  TITLE     Identification of the core domain and the secondary structure of
            the transcriptional coactivator MBF1
  JOURNAL   Genes Cells 4 (7), 415-424 (1999)
   PUBMED   10469174
REFERENCE   8  (bases 1 to 662)
  AUTHORS   Dragoni,I., Mariotti,M., Consalez,G.G., Soria,M.R. and Maier,J.A.
  TITLE     EDF-1, a novel gene product down-regulated in human endothelial
            cell differentiation
  JOURNAL   J Biol Chem 273 (47), 31119-31124 (1998)
   PUBMED   9813014
REFERENCE   9  (bases 1 to 662)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   10 (bases 1 to 662)
  AUTHORS   Li,F.Q., Ueda,H. and Hirose,S.
  TITLE     Mediators of activation of fushi tarazu gene transcription by
            BmFTZ-F1
  JOURNAL   Mol Cell Biol 14 (5), 3013-3021 (1994)
   PUBMED   8164657
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY029111.1 and BC015500.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003792.3.
            
            Summary: This gene encodes a protein that may regulate endothelial
            cell differentiation, lipid metabolism, and hormone-induced
            cardiomyocyte hypertrophy. The encoded protein has also been found
            to act as a transcriptional coactivator by interconnecting the
            general transcription factor TATA element-binding protein (TBP) and
            gene-specific activators. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (alpha) encodes the longest
            isoform (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.234522.1,
                                           SRR5189655.171420.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000224073.6/ ENSP00000224073.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                HY029111.1         29-50
            23-662              BC015500.1         1-640
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..662
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /note="endothelial differentiation related factor 1"
                     /db_xref="GeneID:8721"
                     /db_xref="HGNC:HGNC:3164"
                     /db_xref="MIM:605107"
     exon            1..128
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..497
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; multiprotein bridging factor 1"
                     /codon_start=1
                     /product="endothelial differentiation-related factor 1
                     isoform alpha"
                     /protein_id="NP_003783.1"
                     /db_xref="CCDS:CCDS7011.1"
                     /db_xref="GeneID:8721"
                     /db_xref="HGNC:HGNC:3164"
                     /db_xref="MIM:605107"
                     /translation="MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKW
                     AAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEK
                     PQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPRAK"
     exon            129..180
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..341
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..435
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..662
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      644..649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /note="hexamer: AACAAA"
     polyA_site      662
                     /gene="EDF1"
                     /gene_synonym="CFAP280; EDF-1; MBF1"
                     /note="major polyA site"
ORIGIN      
        1 ctctagcagc tgccgctgag ccgccggacg gacgctcgtc ttcgcccgcc atggccgaga
       61 gcgactggga cacggtgacg gtgctgcgca agaagggccc tacggccgcc caggccaaat
      121 ccaagcaggc tatcttagcg gcacagagac gaggagaaga tgtggagact tccaagaaat
      181 gggctgctgg ccagaacaaa caacattcta ttaccaagaa cacggccaag ctggaccggg
      241 agacagagga gctgcaccat gacagggtga ccctggaggt gggcaaggtg atccagcaag
      301 gtcggcagag caaggggctt acgcagaagg acctggccac gaaaatcaat gagaagccac
      361 aggtgatcgc ggactatgag agcggacggg ccatacccaa taaccaggtg cttggcaaaa
      421 tcgagcgggc cattggcctc aagctccggg gaaaggacat tggaaagccc atcgagaagg
      481 ggcctagggc gaaatgaaca caaagcctcg aaatcagtgc gctccagctg atctcgttcc
      541 gccggttccc cttggccgcc agttccgttc tcctcacggg ccgaacggaa caaggggtcc
      601 agcttgcggg ggaccctccc cagcccattc ctgctgtcaa acaaacaaaa ccttgcaaag
      661 cg
//
