LOCUS       NM_014674               6113 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ER degradation enhancing alpha-mannosidase like
            protein 1 (EDEM1), mRNA.
ACCESSION   NM_014674 XM_376201
VERSION     NM_014674.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6113)
  AUTHORS   Nowakowska-Golacka,J., Czapiewska,J., Sominka,H.,
            Sowa-Rogozinska,N. and Slominska-Wojewodzka,M.
  TITLE     EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism and
            Amyloid-beta Production
  JOURNAL   Int J Mol Sci 23 (1), 117 (2021)
   PUBMED   35008544
  REMARK    GeneRIF: EDEM1 Regulates Amyloid Precursor Protein (APP) Metabolism
            and Amyloid-beta Production.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6113)
  AUTHORS   George,G., Ninagawa,S., Yagi,H., Furukawa,J.I., Hashii,N.,
            Ishii-Watabe,A., Deng,Y., Matsushita,K., Ishikawa,T., Mamahit,Y.P.,
            Maki,Y., Kajihara,Y., Kato,K., Okada,T. and Mori,K.
  TITLE     Purified EDEM3 or EDEM1 alone produces determinant oligosaccharide
            structures from M8B in mammalian glycoprotein ERAD
  JOURNAL   Elife 10, e70357 (2021)
   PUBMED   34698634
  REMARK    GeneRIF: Purified EDEM3 or EDEM1 alone produces determinant
            oligosaccharide structures from M8B in mammalian glycoprotein ERAD.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6113)
  AUTHORS   Zhang,H.M., Qiu,Y., Zhao,G., Wang,H., Chen,Y.T., Aghakeshmiri,S.,
            Hanson,P. and Yang,D.
  TITLE     Cleavage and degradation of EDEM1 promotes coxsackievirus B3
            replication via ATF6a-mediated unfolded protein response signalling
  JOURNAL   Cell Microbiol 22 (7), e13198 (2020)
   PUBMED   32083795
  REMARK    GeneRIF: Cleavage and degradation of EDEM1 promotes coxsackievirus
            B3 replication via ATF6a-mediated unfolded protein response
            signalling.
REFERENCE   4  (bases 1 to 6113)
  AUTHORS   Chiritoiu,M., Chiritoiu,G.N., Munteanu,C.V.A., Pastrama,F.,
            Ivessa,N.E. and Petrescu,S.M.
  TITLE     EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits
            ER-Phagy as Back-Up Mechanism When ERAD Is Impaired
  JOURNAL   Int J Mol Sci 21 (10), 3468 (2020)
   PUBMED   32423001
  REMARK    GeneRIF: EDEM1 Drives Misfolded Protein Degradation via ERAD and
            Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6113)
  AUTHORS   Papaioannou,A., Higa,A., Jegou,G., Jouan,F., Pineau,R., Saas,L.,
            Avril,T., Pluquet,O. and Chevet,E.
  TITLE     Alterations of EDEM1 functions enhance ATF6 pro-survival signaling
  JOURNAL   FEBS J 285 (22), 4146-4164 (2018)
   PUBMED   30281916
  REMARK    GeneRIF: A somatic variant of EDEM1 (N198I) alters ATF6 signaling
            and provides a selective advantage to the transforming cells and
            results in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 6113)
  AUTHORS   Oda,Y., Okada,T., Yoshida,H., Kaufman,R.J., Nagata,K. and Mori,K.
  TITLE     Derlin-2 and Derlin-3 are regulated by the mammalian unfolded
            protein response and are required for ER-associated degradation
  JOURNAL   J Cell Biol 172 (3), 383-393 (2006)
   PUBMED   16449189
REFERENCE   7  (bases 1 to 6113)
  AUTHORS   Olivari,S., Galli,C., Alanen,H., Ruddock,L. and Molinari,M.
  TITLE     A novel stress-induced EDEM variant regulating endoplasmic
            reticulum-associated glycoprotein degradation
  JOURNAL   J Biol Chem 280 (4), 2424-2428 (2005)
   PUBMED   15579471
  REMARK    GeneRIF: EDEM1 is a soluble protein of the ER lumen in HEK293 cells
REFERENCE   8  (bases 1 to 6113)
  AUTHORS   Molinari,M., Calanca,V., Galli,C., Lucca,P. and Paganetti,P.
  TITLE     Role of EDEM in the release of misfolded glycoproteins from the
            calnexin cycle
  JOURNAL   Science 299 (5611), 1397-1400 (2003)
   PUBMED   12610306
  REMARK    GeneRIF: EDEM was shown to extract misfolded glycoproteins, but not
            glycoproteins undergoing productive folding, from the calnexin
            cycle [EDEM]
REFERENCE   9  (bases 1 to 6113)
  AUTHORS   Oda,Y., Hosokawa,N., Wada,I. and Nagata,K.
  TITLE     EDEM as an acceptor of terminally misfolded glycoproteins released
            from calnexin
  JOURNAL   Science 299 (5611), 1394-1397 (2003)
   PUBMED   12610305
REFERENCE   10 (bases 1 to 6113)
  AUTHORS   Hosokawa,N., Wada,I., Hasegawa,K., Yorihuzi,T., Tremblay,L.O.,
            Herscovics,A. and Nagata,K.
  TITLE     A novel ER alpha-mannosidase-like protein accelerates ER-associated
            degradation
  JOURNAL   EMBO Rep 2 (5), 415-422 (2001)
   PUBMED   11375934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC019088.1, AK292643.1, AC026202.7 and CN364698.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014674.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86967.1, SRR1803612.130328.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256497.9/ ENSP00000256497.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-713               BC019088.1         41-753
            714-1670            AK292643.1         615-1571
            1671-2281           BC019088.1         1711-2321
            2282-5707           AC026202.7         111897-115322       c
            5708-6113           CN364698.1         1-406
FEATURES             Location/Qualifiers
     source          1..6113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.1"
     gene            1..6113
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /note="ER degradation enhancing alpha-mannosidase like
                     protein 1"
                     /db_xref="GeneID:9695"
                     /db_xref="HGNC:HGNC:18967"
                     /db_xref="MIM:607673"
     exon            1..608
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2073
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /note="ER degradation-enhancing alpha-mannosidase-like 1;
                     ER degradation enhancer, mannosidase alpha-like 1"
                     /codon_start=1
                     /product="ER degradation-enhancing alpha-mannosidase-like
                     protein 1"
                     /protein_id="NP_055489.1"
                     /db_xref="CCDS:CCDS33686.1"
                     /db_xref="GeneID:9695"
                     /db_xref="HGNC:HGNC:18967"
                     /db_xref="MIM:607673"
                     /translation="MQWRALVLGLVLLRLGLHGVLWLVFGLGPSMGFYQRFPLSFGFQ
                     RLRSPDGPASPTSGPVGRPGGVSGPSWLQPPGTGAAQSPRKAPRRPGPGMCGPANWGY
                     VLGGRGRGPDEYEKRYSGAFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHC
                     RGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKD
                     STVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFE
                     NTKTGIPYPRVNLKTGVPPDTNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVK
                     ALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMF
                     NAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIG
                     DVEDAICLHAFYYAIWKRYGALPERYNWQLQAPDVLFYPLRPELVESTYLLYQATKNP
                     FYLHVGMDILQSLEKYTKVKCGYATLHHVIDKSTEDRMESFFLSETCKYLYLLFDEDN
                     PVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFSEEGGQDQGGKSVHRPKPHELKVIN
                     SSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI"
     exon            609..681
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            682..785
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            786..957
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1141
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1316
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1437
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1608
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1682
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1779
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1983
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..6113
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6092..6097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /note="hexamer: ATTAAA"
     polyA_site      6113
                     /gene="EDEM1"
                     /gene_synonym="EDEM"
                     /note="major polyA site"
ORIGIN      
        1 aaaggggaag cgagccgggc tacggggcga gcgcggggtg cggtggtcgg cggggaggcc
       61 cccgcgcttt aaaataatgc ccgcggcgcc cgcgcgacca tgcaatggcg agcgctcgtc
      121 ctggggctgg tgctcctccg gcttggcctc catggagtat tgtggctcgt cttcgggctg
      181 gggcccagca tgggcttcta ccagcgcttt ccgctcagct tcggcttcca gcgtctgagg
      241 agccccgacg gccccgcgtc gcccacctcg gggcccgtgg gccggcctgg gggggtatcc
      301 gggccgtcgt ggctgcagcc gccggggacc ggggcagcgc agagcccgcg caaggctccg
      361 cggcgtcctg ggccggggat gtgcggccca gccaactggg gctacgtgct gggcggccgg
      421 ggccgcggcc cggacgagta cgagaagcgc tacagcggcg ccttccctcc gcagctgcgt
      481 gcccagatgc gcgacctggc acggggcatg ttcgtctttg gctacgacaa ctacatggct
      541 cacgccttcc cccaggacga gctcaacccc atccactgcc gcggccgtgg gcccgaccgc
      601 ggggaccctt caaatctgaa catcaatgat gtactaggga actactcatt gactcttgtt
      661 gatgcattgg atacacttgc aataatggga aattcatccg agttccagaa agccgtcaag
      721 ttagtgatca acacagtttc atttgacaaa gattccaccg tccaagtctt tgaggccacg
      781 ataagggtcc tgggaagcct cctttctgct cacagaataa taactgactc caagcagccc
      841 tttggtgaca tgacaattaa ggactatgat aatgagttgt tatacatggc ccatgacctg
      901 gcggtgcggc tcctccctgc ttttgaaaac accaagacag ggattccata tcctcgggtg
      961 aatctaaaga caggagttcc tcctgacacc aataatgaga catgcacagc gggagccggt
     1021 tccctcctgg tggaatttgg gattctgagt cgactcctgg gggactccac atttgagtgg
     1081 gtggccagac gagcagtgaa agccctttgg aacctccgga gcaatgatac aggattacta
     1141 ggcaatgtcg tgaacattca gacgggccac tgggttggaa agcagagtgg cctgggtgcc
     1201 gggctggact ccttctatga atacctcttg aaatcttaca ttctctttgg agaaaaagaa
     1261 gacctagaaa tgtttaatgc tgcatatcag agtattcaga actacttaag aagagggcgg
     1321 gaagcctgca atgaaggaga aggagaccct ccactctatg tcaacgtgaa catgttcagt
     1381 gggcagctga tgaacacctg gattgactct ctgcaggcct ttttccctgg actgcaggtg
     1441 ctgataggag atgtggaaga tgccatctgc cttcatgcct tctactatgc catatggaaa
     1501 cgatatggtg ccctccctga gagatataac tggcagctgc aggcccctga cgttctcttc
     1561 tacccactga gaccagagtt agtggaatcc acatatctcc tctaccaggc aaccaagaat
     1621 cccttctacc tccatgtagg aatggatatt ctgcagagtc tggaaaagta cacaaaagtc
     1681 aagtgtgggt acgccacgct gcatcacgtc attgacaagt ccacagaaga ccggatggag
     1741 agcttctttc tcagtgagac ctgtaaatat ttgtatctgc tgtttgatga agacaatcca
     1801 gtacacaagt ctggaaccag atacatgttc acaacagagg gacacattgt atctgtggat
     1861 gagcatcttc gggaattgcc atggaaggaa ttcttctctg aagagggagg gcaggaccaa
     1921 gggggaaagt ctgtgcacag gccgaaacct catgagttaa aagtcatcaa ctccagctcc
     1981 aactgcaatc gtgtacctga tgagaggagg tactccctgc ccttaaagag catctacatg
     2041 cgacagattg accagatggt tggtttgatt tgatctgctc tctgtgaggc ctcatcttga
     2101 accagacctt aacgaccaaa cccagaccat gccaaagtcc agtctgaaat gaaaggggac
     2161 agaagtcttg ctgtccatgg tggtgtagga atttctgtgc aacacctcac cacgtctggt
     2221 taatccttgc acacttcagt gtttctctcc tgttcaataa aatgccctgt taaggatata
     2281 atttgaagtg agaagataca tggaaattgc cctcttatga catgttgatg ttataagcac
     2341 aatagatggg gcatctttgg attgatgttc acagctttat acttcagaac ctaagtctct
     2401 tcactttgct ggcacctgct atactggagt attgctatgt ctttaaaaaa ttttttttat
     2461 tatattttat ttttttgaga cagggtcttg atattttttt gggacagggt tacctgggct
     2521 caagtgatcc ttctgcctca gcctcccgag tagctgggat tacaggtgag caccactgta
     2581 cctggctagc tacttctttg ttagaggatt gagaatgaaa tttctgcaaa agggcccatg
     2641 gttcatttgg tatccctatt taattgcatt gaaaatgtca tcctttctgt tgttagataa
     2701 ttggggtctt cccctgatat ccaaccgtga ttttggatca catgggagaa aaagtcatcc
     2761 agtttttcat gtttgcctca agtaatcttt acagtgttac aaattatttg cttaagaaga
     2821 atggtcttaa ccagaattct taacagatag tctcttaggt tattatgtta tggtctaaga
     2881 ggttaactga catcttttgg gtggtatttt gcattttgaa tatgaactta cctgaggaac
     2941 tcccatagtt ccagaatcag gtgcctttta gggagagaac aatacctaag attgtctgag
     3001 cttccatctt tctcatattt cctaagcaag gattctcact tctgaccata tttgggttag
     3061 agttctgttt tgtttctgtt ttctgtgtct agtgccaatt agctaaatca gggagaaaga
     3121 aatgatcaca tgacttttag catccttgag ccatttctct gtgtaataca ggctttagat
     3181 tagtgcctta tattggtttt ggtttggggc actggatgtc gcagctactg ctatggtttc
     3241 aggaggcctg tttagccaca tggtgagacc gtggtgaaag ggggatggaa attgcttggc
     3301 cagtctttgc ctttcatcct gtaaaagtaa gcatgtagaa ggaggaagtt gtgctaaaat
     3361 gcctttgttt ttttgttatt attttcttag ccagaacatc tctctttgaa ctcacactga
     3421 tacacacctg ctactcttac acagtgcagc agggttgact cttagtctgg cttccatgaa
     3481 gcgtcatggg tggaaacgca ttctagtaaa aaaggtagga aatccctaaa acttccagcc
     3541 tcacatagca cggttctcac ctgtcactgt tttcccacct ctaaggattt catgtacatc
     3601 ttttcaaagc tagaaataag cactgtctaa gtttatgttg catttttagt caaaagggag
     3661 aaatcttatt ccttcttgaa aattttaagt gttatggttt tatatagttc agttctttga
     3721 gatttttgaa aagagtattt tcagtaataa acgtgccatc tctatctctt aaacatttat
     3781 tacaacaatt gttttaaaat agaaaaaata aaatgcttct attttacctt ttttcatttc
     3841 agaagcatta ttctgtttat taacagtgtc ccatctactg aatagaaaac tttgagaata
     3901 atatatatat atattttaaa tgttttcact gactcattga aaatgttaat tacacacaca
     3961 tgcatgcatg cacacacgag catacttgta cctttgtctc tgggcaaaca ggtgggactg
     4021 ttagtgaccc atttgggaaa atagagcatc tcagagaagg aggtgagttc ttcctgcctg
     4081 tgatttctct tggcgctccc ctcctctccc gctctggctt ctgtggcggc agtggtgggt
     4141 aagcactcca gtgttctctt aatgaggcac tttgcctgtc actcgagcaa gcctgggtgt
     4201 tccttcctcc tcatgctcct ggaataggga atagggatct catgcttgca aactacacaa
     4261 tgctgcaggt gcttcccagg ggccacaggc tgtcaggaaa cgtgttttat gttaagtcac
     4321 aaacccactt gacttctggg tactggaatt aataccagtg ggtgagactg agggtgagtg
     4381 agttagtaca tattaatcct ggttgttgag cttccagact accccgtcca aagtttgatg
     4441 ctatgtagtc agtggtttgt ggggctggat gccagaaggt tctttgagcc agtttcaaag
     4501 gttacttgtt tttttttttt ttttttaaag tcagaatgtt aacagctgtg atatatcctg
     4561 cagggctttt gcagtttctt ctgttctgtg ttctgaaata ctgggtagag aatggctgag
     4621 gaggagatta ccagagaagt tgctttgctc agtgctttgc cccaggattg cctcaaatct
     4681 gagtggactt catcctttgc ggcggctctg agcctggccc atcttcctat tcccacgtgt
     4741 agctagtgtc tagtgtcagc tttgctcagt gtggtggaaa cattttgcag aactgttgta
     4801 gaaagctgcc ttatagttgg cttgacaaag cataattctc tcataacaaa ctttcaaatc
     4861 attacagtag cttagctact ttagttgatg tgaccgagga atcccttcta gaatcatagg
     4921 tggcaaggga gggtttgcta gctctccatt tgcactggcc attgtgaaaa accagcttct
     4981 gtattcaaat ctttccttca tttttttaaa tttttttttt ggcagcgctt gtgctggaac
     5041 ttactcattg taactgaatc ctcagggctt ttcttgtttt agatcatgga ctgtgcacgt
     5101 gacacttaaa taattttcta tgtatttaaa gaaaaatgca ccaggatggt gtctgtgcac
     5161 gtgactatta gaggagcgtc tgtagaagta cctggtttgg tcagtgcagt tgtgcaatct
     5221 gagggccttg tttcctcctc ccctttcccc ttctccccac caaaggaaaa tatccctctt
     5281 aatgatttcg tagttcagtt tactgaatga ttaccacctg taattcctct ttggattgtg
     5341 tagactcaac atgagacatt cctttctgct ttctggaggg caccaggggc ctttctcttt
     5401 gataaatttt ttttgtctgt tgacaaaaac aaaaatcttt tttcaaatgt agtgctggtg
     5461 aaaaggtagg gctgagtgat taccttagcc acagggtggc tgagcaggaa ctttagaaga
     5521 aaatcctgag ctttcctgtc cattcccagc atccagctcc tattctagtg cctcttccct
     5581 gcagggcagg gaccccttgg gaaatcgagg aggtgggacg ggctgggccc tgtgtcccag
     5641 gtttcacagg gctcagggtt atgctcccgc ttgaatctgg acgtgaatct ggtaaaaata
     5701 tcaagtacct gtggaactcc ctgattctat accctcttcc ttctttctgc aaggcagagg
     5761 aataatattt ttaaaggtta ttttgtttta gttttaaata gcaaaacaca agctgcattt
     5821 ttatttattt tgcataagaa aggtaaatct ttttacaaaa aaaagtatag agttggaaac
     5881 tctgggaaaa cttacggaaa tacacaaatg cttctctgta atgtgcaata tgctttgcaa
     5941 ctgtagatga tattttatgt ttaatctgta aataagaaat gtatttaaat taaaagggat
     6001 ctttttgtaa aaggaccaaa tgttctttta taaatgtaat aaggaatatc ttgctcttta
     6061 aaatttatta ggatttttat gagtaatttt tattaaaaga tttctttttt tga
//
