LOCUS       NM_014329               4767 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens enhancer of mRNA decapping 4 (EDC4), transcript
            variant 2, mRNA.
ACCESSION   NM_014329
VERSION     NM_014329.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4767)
  AUTHORS   Bloch,D.B., Sinow,C.O., Sauer,A.J. and Corman,B.H.P.
  TITLE     Assembly and regulation of the mammalian mRNA processing body
  JOURNAL   PLoS One 18 (3), e0282496 (2023)
   PUBMED   36877681
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4767)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4767)
  AUTHORS   Qin,Y., Huttlin,E.L., Winsnes,C.F., Gosztyla,M.L., Wacheul,L.,
            Kelly,M.R., Blue,S.M., Zheng,F., Chen,M., Schaffer,L.V., Licon,K.,
            Backstrom,A., Vaites,L.P., Lee,J.J., Ouyang,W., Liu,S.N., Zhang,T.,
            Silva,E., Park,J., Pitea,A., Kreisberg,J.F., Gygi,S.P., Ma,J.,
            Harper,J.W., Yeo,G.W., Lafontaine,D.L.J., Lundberg,E. and Ideker,T.
  TITLE     A multi-scale map of cell structure fusing protein images and
            interactions
  JOURNAL   Nature 600 (7889), 536-542 (2021)
   PUBMED   34819669
REFERENCE   4  (bases 1 to 4767)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4767)
  AUTHORS   Wu,X., Zhong,Y., Chen,Q., Zhang,X. and Zhang,H.
  TITLE     Enhancer of mRNA Decapping protein 4 (EDC4) interacts with
            replication protein a (RPA) and contributes to Cisplatin resistance
            in cervical Cancer by alleviating DNA damage
  JOURNAL   Hereditas 157 (1), 41 (2020)
   PUBMED   33054858
  REMARK    GeneRIF: Enhancer of mRNA Decapping protein 4 (EDC4) interacts with
            replication protein a (RPA) and contributes to Cisplatin resistance
            in cervical Cancer by alleviating DNA damage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4767)
  AUTHORS   Bloch,D.B., Gulick,T., Bloch,K.D. and Yang,W.H.
  TITLE     Processing body autoantibodies reconsidered
  JOURNAL   RNA 12 (5), 707-709 (2006)
   PUBMED   16641511
REFERENCE   7  (bases 1 to 4767)
  AUTHORS   Fenger-Gron,M., Fillman,C., Norrild,B. and Lykke-Andersen,J.
  TITLE     Multiple processing body factors and the ARE binding protein TTP
            activate mRNA decapping
  JOURNAL   Mol Cell 20 (6), 905-915 (2005)
   PUBMED   16364915
REFERENCE   8  (bases 1 to 4767)
  AUTHORS   Yu,J.H., Yang,W.H., Gulick,T., Bloch,K.D. and Bloch,D.B.
  TITLE     Ge-1 is a central component of the mammalian cytoplasmic mRNA
            processing body
  JOURNAL   RNA 11 (12), 1795-1802 (2005)
   PUBMED   16314453
REFERENCE   9  (bases 1 to 4767)
  AUTHORS   Garcia-Lozano,J.R., Gonzalez-Escribano,M.F., Wichmann,I. and
            Nunez-Roldan,A.
  TITLE     Cytoplasmic detection of a novel protein containing a nuclear
            localization sequence by human autoantibodies
  JOURNAL   Clin Exp Immunol 107 (3), 501-506 (1997)
   PUBMED   9067524
REFERENCE   10 (bases 1 to 4767)
  AUTHORS   Bloch,D.B., Rabkina,D., Quertermous,T. and Bloch,K.D.
  TITLE     The immunoreactive region in a novel autoantigen contains a nuclear
            localization sequence
  JOURNAL   Clin Immunol Immunopathol 72 (3), 380-389 (1994)
   PUBMED   7520377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC403765.1 and BC064567.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014329.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043616.1, SRR1803615.133095.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358933.10/ ENSP00000351811.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                DC403765.1         31-104
            75-4767             BC064567.1         1-4693
FEATURES             Location/Qualifiers
     source          1..4767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..4767
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /note="enhancer of mRNA decapping 4"
                     /db_xref="GeneID:23644"
                     /db_xref="HGNC:HGNC:17157"
                     /db_xref="MIM:606030"
     exon            1..292
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..4416
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /note="isoform 2 is encoded by transcript variant 2;
                     enhancer of mRNA-decapping protein 4; autoantigen Ge-1;
                     autoantigen RCD-8; human enhancer of decapping large
                     subunit"
                     /codon_start=1
                     /product="enhancer of mRNA-decapping protein 4 isoform 2"
                     /protein_id="NP_055144.3"
                     /db_xref="CCDS:CCDS10849.1"
                     /db_xref="GeneID:23644"
                     /db_xref="HGNC:HGNC:17157"
                     /db_xref="MIM:606030"
                     /translation="MASCASIDIEDATQHLRDILKLDRPAGGPSAESPRPSSAYNGDL
                     NGLLVPDPLCSGDSTSANKTGLRTMPPINLQEKQVICLSGDDSSTCIGILAKEVEIVA
                     SSDSSISSKARGSNKVKIQPVAKYDWEQKYYYGNLIAVSNSFLAYAIRAANNGSAMVR
                     VISVSTSERTLLKGFTGSVADLAFAHLNSPQLACLDEAGNLFVWRLALVNGKIQEEIL
                     VHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEESSPTVALLHEDRAEVWDLDMLRSSH
                     STWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGYVKFWQIYIEGQDEP
                     RCLHEWKPHDGRPLSCLLFCDNHKKQDPDVPFWRFLITGADQNRELKMWCTVSWTCLQ
                     TIRFSPDIFSSVSVPPSLKVCLDLSAEYLILSDVQRKVLYVMELLQNQEEGHACFSSI
                     SEFLLTHPVLSFGIQVVSRCRLRHTEVLPAEEENDSLGADGTHGAGAMESAAGVLIKL
                     FCVHTKALQDVQIRFQPQLNPDVVAPLPTHTAHEDFTFGESRPELGSEGLGSAAHGSQ
                     PDLRRIVELPAPADFLSLSSETKPKLMTPDAFMTPSASLQQITASPSSSSSGSSSSSS
                     SSSSSLTAVSAMSSTSAVDPSLTRPPEELTLSPKLQLDGSLTMSSSGSLQASPRGLLP
                     GLLPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLPQASPSRTRSPDVISSASTAL
                     SQDIPEIASEALSRGFGSSAPEGLEPDSMASAASALHLLSPRPRPGPELGPQLGLDGG
                     PGDGDRHNTPSLLEAALTQEASTPDSQVWPTAPDITRETCSTLAESPRNGLQEKHKSL
                     AFHRPPYHLLQQRDSQDASAEQSDHDDEVASLASASGGFGTKVPAPRLPAKDWKTKGS
                     PRTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRELAELRHSQEELL
                     QRLCTQLEGLQSTVTGHVERALETRHEQEQRRLERALAEGQQRGGQLQEQLTQQLSQA
                     LSSAVAGRLERSIRDEIKKTVPPCVSRSLEPMAGQLSNSVATKLTAVEGSMKENISKL
                     LKSKNLTDAIARAAADTLQGPMQAAYREAFQSVVLPAFEKSCQAMFQQINDSFRLGTQ
                     EYLQQLESHMKSRKAREQEAREPVLAQLRGLVSTLQSATEQMAATVAGSVRAEVQHQL
                     HVAVGSLQESILAQVQRIVKGEVSVALKEQQAAVTSSIMQAMRSAAGTPVPSAHLDCQ
                     AQQAHILQLLQQGHLNQAFQQALTAADLNLVLYVCETVDPAQVFGQPPCPLSQPVLLS
                     LIQQLASDLGTRTDLKLSYLEEAVMHLDHSDPITRDHMGSVMAQVRQKLFQFLQAEPH
                     NSLGKAARRLSLMLHGLVTPSLP"
     exon            293..449
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            450..561
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            562..661
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            662..851
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            852..999
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1104
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1214
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1298
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1394
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1497
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1678
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1751
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1843
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2031
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2153
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2307
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2741
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2742..2846
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2999
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3036
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3214
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3370
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3371..3486
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3487..3652
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3839
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..4059
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4223
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4767
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4761..4766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /note="hexamer: AATAAA"
     polyA_site      4767
                     /gene="EDC4"
                     /gene_synonym="Ge-1; GE1; HEDL5; HEDLS; RCD-8; RCD8"
                     /note="major polyA site"
ORIGIN      
        1 agcctcggct cgtgggtgcc ggaagtggag gcggttggtg gggttggcgg ggctcagcga
       61 cgctgcgcgg gtggcggttt gcgaactgcg ggtggactgt gtagtgaccg gcgtcccgct
      121 gtctcgcccc gtggcgggtg agcgagggtg cgtggtgcgc ggcggcggcg gaacgaacgc
      181 ggtgcgggcg gggcgcccgc cgcagggccc atggcctcct gcgcgagcat cgacatcgag
      241 gacgccacgc agcacctgcg ggacatcctc aagctggacc ggcccgcggg cggccccagt
      301 gcagagagcc cacggccatc cagtgcctac aatggggacc tcaatggact tctggtccca
      361 gacccgctct gctcaggtga tagtacctca gcaaacaaga ctggtcttcg gaccatgcca
      421 cccattaacc tgcaagagaa gcaggtcatc tgtctctcag gagatgatag ctccacctgc
      481 attgggattt tggccaagga ggtggagatt gtggctagca gtgactctag catttcaagc
      541 aaggcccggg gaagcaacaa ggtgaaaatt cagcctgtcg ccaagtatga ctgggaacag
      601 aagtactact atggcaacct gattgctgtg tctaactcct tcttggccta tgccattcgg
      661 gctgccaaca atggctctgc catggtgcgg gtgatcagcg tcagcacttc ggagcggacc
      721 ttgctcaagg gcttcacagg cagtgtggct gatctggctt tcgcgcacct caactctcca
      781 cagctggcct gcctggatga ggcaggcaac ctgttcgtgt ggcgcttggc tctggttaat
      841 ggcaaaattc aagaagagat cttggtccat attcggcagc cagagggcac gccactgaac
      901 cactttcgca ggatcatctg gtgccccttc atccctgagg agagcgaaga ctgctgtgag
      961 gagagcagcc caacagtggc cctgctgcat gaagaccggg ctgaggtgtg ggacctggac
     1021 atgctccgct ccagccacag tacctggcct gtggatgtta gccagatcaa gcagggcttc
     1081 attgtggtaa aaggtcatag cacgtgcctc agtgaaggag ccctctctcc tgatgggact
     1141 gtgctggcta ctgcgagcca cgatggctat gtcaagttct ggcagatcta cattgagggg
     1201 caagatgagc caaggtgtct gcacgagtgg aaacctcatg atgggcggcc cctctcctgc
     1261 ctcctgttct gtgacaacca taagaaacaa gaccctgatg tccctttctg gaggttcctt
     1321 attactggtg ctgaccagaa ccgagagtta aagatgtggt gtacagtatc ctggacctgc
     1381 ctgcagacta ttcgcttctc cccagatatc ttcagctcag tgagtgtgcc ccctagcctc
     1441 aaggtttgct tggacctctc agcagaatac ctgattctca gcgatgtgca acggaaggtc
     1501 ctctatgtga tggagctgct gcaaaaccag gaggagggcc acgcctgctt cagctccatc
     1561 tcggagttcc tgctcaccca ccctgtgctg agctttggta tccaggttgt gagtcgctgc
     1621 cggctacggc acactgaggt gctgcctgcc gaagaggaaa atgacagcct gggtgctgat
     1681 ggtacccatg gagccggtgc catggagtct gcggccggtg tgctcatcaa gctcttttgt
     1741 gtgcatacta aggcactgca agatgtgcag atccgcttcc agccacagct gaaccctgat
     1801 gtggtggccc cactgcccac ccacactgcc cacgaggact tcacatttgg agagtctcgg
     1861 cccgaactgg gctctgaggg cctggggtca gccgctcacg gctcccagcc tgacctccga
     1921 cgaatcgtgg agctgcctgc acctgccgac ttcctcagtc tgagcagtga gaccaagccc
     1981 aagttgatga cacctgacgc cttcatgaca cctagcgcct ccttgcagca gatcactgcc
     2041 tctcccagca gcagcagcag cggtagcagc agcagcagca gcagtagcag cagctccctt
     2101 acagctgtgt ctgccatgag cagcacctca gctgtggacc cctccttgac caggccacct
     2161 gaggagctga ccttgagccc caagctgcag ctggatggca gcctgacaat gagcagcagt
     2221 ggcagccttc aggcaagccc gcgtggcctc ctgcctggcc tgctcccagc cccagctgac
     2281 aaactgactc ccaaggggcc gggccaggtg cctactgcca cctctgcact gtccctggag
     2341 ctgcaggaag tggagcccct ggggctaccc caagcctccc ctagccgcac tcgttcccct
     2401 gatgtcatct cctcagcttc cactgccctg tcccaggaca tccctgagat tgcatctgag
     2461 gccctgtccc gtggttttgg ctcctctgca ccagagggcc ttgagccaga cagtatggct
     2521 tcagccgcct cggcactgca cctgctgtcc ccacggcccc ggccagggcc cgagctcggc
     2581 ccccagctcg ggcttgatgg aggccctggg gatggagatc ggcataatac cccctccctc
     2641 ctggaggcag ccttgaccca ggaggcctcg actcctgaca gtcaggtttg gcccacagca
     2701 cctgacatta ctcgtgagac ctgcagcacc ctggcagaaa gccccaggaa tggccttcag
     2761 gaaaagcaca agagcctggc cttccaccga ccaccatatc acctgctgca gcaacgtgac
     2821 agccaggatg ccagtgctga gcaaagtgac catgatgatg aggtggccag ccttgcctct
     2881 gcttcaggag gctttggcac caaagttcct gctccacggc tgcctgccaa ggactggaag
     2941 accaagggat cccctcgaac ctcacccaag ctcaagagga aaagcaagaa ggatgatggg
     3001 gatgcagcca tgggatcccg gctcacagag caccaggtgg cagagccccc tgaggactgg
     3061 ccagcactaa tttggcaaca gcagagagag ctggcagagc tgcggcacag ccaggaagag
     3121 ctgctgcagc gtctgtgtac ccaactcgaa ggcctgcaga gcacagtcac aggccacgta
     3181 gaacgtgccc ttgagactcg gcacgagcag gaacagcggc ggctggagcg agcactggct
     3241 gaggggcagc agcggggagg gcagctgcag gagcagctga cacaacagtt gtcccaagca
     3301 ctgtcgtcag ctgtagctgg gcggctagag cgcagcatac gggatgagat caagaagaca
     3361 gtccctccat gtgtctcaag gagtctggag cctatggcag gccaactgag caactcagtg
     3421 gctaccaagc tcacagctgt ggagggcagc atgaaagaga acatctccaa gctgctcaag
     3481 tccaagaact tgactgatgc catcgcccga gcagctgcag acacattaca agggccgatg
     3541 caggctgcct accgggaagc cttccagagt gtggtgctgc cggcctttga gaagagctgc
     3601 caggccatgt tccagcaaat caatgatagc ttccggctgg ggacacagga atacttgcag
     3661 cagctagaaa gccacatgaa gagccggaag gcacgggaac aggaggccag ggagcctgtg
     3721 ctagcccagc tgcggggcct ggtcagcaca ctgcagagtg ccactgagca gatggcagcc
     3781 accgtggccg gcagtgttcg tgctgaggtg cagcaccagc tgcatgtggc tgtgggcagc
     3841 ctgcaggagt ccattttagc acaggtacag cgcatcgtta agggtgaggt gagtgtggcg
     3901 ctcaaggagc agcaggccgc cgtcacctcc agcatcatgc aggccatgcg ctcagctgct
     3961 ggcacacctg tcccctctgc ccaccttgac tgccaggccc agcaagccca tatcctgcag
     4021 ctgctgcagc agggccacct caatcaggcc ttccagcagg cgctgacagc tgctgacctg
     4081 aacctggtgc tgtatgtgtg tgaaactgtg gacccagccc aggtttttgg gcagccaccc
     4141 tgcccgctct cccagcctgt gctcctttcc ctcatccagc agctggcatc tgaccttggc
     4201 actcgaactg acctcaagct cagctacctg gaagaggccg tgatgcacct ggaccacagt
     4261 gaccccatca ctcgggacca catgggctcc gttatggccc aggtgcgcca aaagcttttt
     4321 cagttcctgc aggctgagcc acacaactca cttggcaaag cagctcggcg tctcagcctc
     4381 atgctgcatg gcctcgtgac ccccagcctc ccttagctgc taagcctgcc ttgcccaggg
     4441 gtgggatggc actgaaggcc agcagacagg cctaggctgg ggcagggtca cggctggcct
     4501 ttacctgctc aggcccccat ctctggggtg tttgggggtc agggagcagg gagcactggc
     4561 cgtggtctac agcgtgtggt agtcagaagg tttagctggg cccagggcag gtattgcgcc
     4621 tgcttgggtt ctgccatgcc tggagcatga ccctgagatc gtgacaccac ttgagtggaa
     4681 ttttccatgt tcctttttac ctctaatttg gatctttttg tttttgaaaa acattgagaa
     4741 attcaattaa atgcttttgg aataaaa
//
