LOCUS       NM_025083               3744 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens enhancer of mRNA decapping 3 (EDC3), transcript
            variant 3, mRNA.
ACCESSION   NM_025083
VERSION     NM_025083.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3744)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3744)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 3744)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3744)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3744)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3744)
  AUTHORS   Rudolph,C., Sigruener,A., Hartmann,A., Orso,E., Bals-Pratsch,M.,
            Gronwald,W., Seifert,B., Kalbitzer,H.R., Verdorfer,I.,
            Luetjens,C.M., Ortmann,O., Bornstein,S.R. and Schmitz,G.
  TITLE     ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and
            hYjeF_N3 comprise the YjeF_N domain protein family in humans with a
            role in spermiogenesis and oogenesis
  JOURNAL   Horm Metab Res 39 (5), 322-335 (2007)
   PUBMED   17533573
REFERENCE   7  (bases 1 to 3744)
  AUTHORS   Fenger-Gron,M., Fillman,C., Norrild,B. and Lykke-Andersen,J.
  TITLE     Multiple processing body factors and the ARE binding protein TTP
            activate mRNA decapping
  JOURNAL   Mol Cell 20 (6), 905-915 (2005)
   PUBMED   16364915
REFERENCE   8  (bases 1 to 3744)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   9  (bases 1 to 3744)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   10 (bases 1 to 3744)
  AUTHORS   Albrecht,M. and Lengauer,T.
  TITLE     Novel Sm-like proteins with long C-terminal tails and associated
            methyltransferases
  JOURNAL   FEBS Lett 569 (1-3), 18-26 (2004)
   PUBMED   15225602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC091230.23 and BC011534.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_025083.4.
            
            Summary: This gene encodes a protein that is important in mRNA
            degradation. The encoded protein is a component of a decapping
            complex that promotes efficient removal of the monomethylguanosine
            (m7G) cap from mRNAs, as part of the 5' to 3' mRNA decay pathway.
            Mutations in this gene have been identified in human patients with
            an autosomal recessive form of intellectual disability. [provided
            by RefSeq, May 2017].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-4 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011534.1, SRR1803614.246983.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315127.9/ ENSP00000320503.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC091230.23        177943-177947
            6-3744              BC011534.1         1-3739
FEATURES             Location/Qualifiers
     source          1..3744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..3744
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /note="enhancer of mRNA decapping 3"
                     /db_xref="GeneID:80153"
                     /db_xref="HGNC:HGNC:26114"
                     /db_xref="MIM:609842"
     exon            1..145
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            146..327
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1690
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /note="isoform 1 is encoded by transcript variant 3; LSM16
                     homolog (EDC3, S. cerevisiae); enhancer of mRNA-decapping
                     protein 3; yjeF domain-containing protein 1; yjeF
                     N-terminal domain-containing protein 2; yjeF domain
                     containing; enhancer of mRNA decapping 3 homolog"
                     /codon_start=1
                     /product="enhancer of mRNA-decapping protein 3 isoform 1"
                     /protein_id="NP_079359.2"
                     /db_xref="CCDS:CCDS10267.1"
                     /db_xref="GeneID:80153"
                     /db_xref="HGNC:HGNC:26114"
                     /db_xref="MIM:609842"
                     /translation="MATDWLGSIVSINCGDSLGVYQGRVSAVDQVSQTISLTRPFHNG
                     VKCLVPEVTFRAGDITELKILEIPGPGDNQHFGDLHQTELGPSGAGCQVGINQNGTGK
                     FVKKPASSSSAPQNIPKRTDVKSQDVAVSPQQQQCSKSYVDRHMESLSQSKSFRRRHN
                     SWSSSSRHPNQATPKKSGLKNGQMKNKDDECFGDDIEEIPDTDFDFEGNLALFDKAAV
                     FEEIDTYERRSGTRSRGIPNERPTRYRHDENILESEPIVYRRIIVPHNVSKEFCTDSG
                     LVVPSISYELHKKLLSVAEKHGLTLERRLEMTGVCASQMALTLLGGPNRLNPKNVHQR
                     PTVALLCGPHVKGAQGISCGRHLANHDVQVILFLPNFVKMLESITNELSLFSKTQGQQ
                     VSSLKDLPTSPVDLVINCLDCPENVFLRDQPWYKAAVAWANQNRAPVLSIDPPVHEVE
                     QGIDAKWSLALGLPLPLGEHAGRIYLCDIGIPQQVFQEVGINYHSPFGCKFVIPLHSA
                     "
     exon            328..647
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..983
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1137
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1355
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..3744
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3722..3727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /note="hexamer: AATAAA"
     polyA_site      3744
                     /gene="EDC3"
                     /gene_synonym="hYjeF_N2-15q23; LSM16; MRT50; YJDC; YJEFN2"
                     /note="major polyA site"
ORIGIN      
        1 gtgggggcgc ttccggcagc ggcggcggtg gtgaaggccg atgctgtggg ggtgggcgtg
       61 gagagaattc ttctgtgggt cctctggtgt tgagtggtcg gcttggtgtg gtgtgcggag
      121 gagctccagg cccgtcggcg cggagtggtc tcacgtgtga aacatggcta cagattggct
      181 gggaagtatt gtgtccatca attgtggaga tagcttgggt gtctatcagg gaagagtgtc
      241 agctgtggat caggtcagcc agaccatttc tctcacccgg cctttccata atggagtgaa
      301 gtgtcttgtt ccagaagtca ccttcagggc aggtgacatt acggagttaa aaattctgga
      361 gataccagga cctggagaca accaacattt tggagacctt catcaaacag aattaggccc
      421 ctctggtgct ggctgccaag tgggcatcaa tcagaatggc acaggcaagt ttgtcaagaa
      481 gccagcctct tccagcagtg cccctcagaa tatccctaag aggacagatg tgaagagcca
      541 ggatgttgcc gtttccccgc agcagcaaca gtgctcaaag agctatgtcg acaggcacat
      601 ggaatccttg agtcagtcca aaagtttccg tcgtcggcac aactcctggt catctagtag
      661 caggcaccca aatcaggcaa ctcccaagaa aagtggttta aagaatggcc agatgaagaa
      721 taaagatgac gagtgcttcg gggatgatat tgaggagatc ccagacacag attttgattt
      781 tgaagggaac ctggctcttt ttgacaaggc agctgtgttt gaggagattg atacctatga
      841 aaggagaagt ggtacccgtt cccggggcat cccaaatgaa aggcccactc ggtaccgcca
      901 tgatgagaac atcttggagt ccgagcccat tgtctatcga cggatcatag tgccccacaa
      961 cgtgagcaag gagttctgca cggactctgg cctggttgtc ccaagtattt cctatgagct
     1021 gcataaaaag ctgttgtccg tggctgagaa gcatgggctg acccttgagc ggagactgga
     1081 gatgacaggt gtgtgtgcca gtcagatggc actgaccctc ctcggaggac ctaacaggtt
     1141 gaatcccaaa aatgttcacc agaggcctac agtggctcta ctgtgtggac ctcatgtgaa
     1201 gggggctcag ggtatcagct gtggaaggca cctagccaac catgatgtcc aggtcatcct
     1261 tttcctgccc aattttgtca agatgttgga atctatcacc aatgagctgt cgctcttcag
     1321 caagacccaa ggccaacaag tgtctagcct caaagatctg cccactagcc ctgtggacct
     1381 ggtcatcaac tgcctggatt gccctgagaa cgtcttcctg cgcgatcaac cctggtacaa
     1441 ggcagctgtg gcctgggcca accagaaccg ggcaccagta ctcagcatag accctcctgt
     1501 gcatgaagtc gaacagggca ttgatgccaa atggtcactg gcactgggcc tgcctctgcc
     1561 actgggggag cacgcaggcc gtatctattt gtgcgacatt ggcattcccc agcaggtctt
     1621 ccaggaggtg ggcatcaact accactcgcc ctttggctgc aagtttgtta tcccactgca
     1681 ctctgcttag agggttcctg cgcaggcagg actctgctgt cccctgctgc tcctgataac
     1741 aaacgcctta aggatatgaa gcttcatgga ccttgttaaa gttttttctc ttttgggttt
     1801 gtttcttctg tgagagaaca gaacttactt aaaactgacc tgtcacttgc tcttagccag
     1861 ggaagtcttt cccactgggt tccgggctgg gtggcaggct gagcgtgcag caactccagg
     1921 catctctacc ctcagccccc tgcacggcca ggtgggcctt tgtttacagc cgtaggcagc
     1981 tctcaagact gtgtttcagg tttacagcca ctgggcctgg gcacacacat tgaagagtgg
     2041 gccaggtcct gtctgggggc ctgtacctgc tctatttcag agcttgtggc tttgtgtctc
     2101 ccctgctttc cccacgcaga cagcccttcc tctgtagaac cagctgcacg gcagctgtcc
     2161 accagagggc agacctgcac tctccattca tgtccagggc tgtgacagac caggccttcc
     2221 cctagcccca caagttgatt tggggggttt tgacccttac tcctgagctg atccaagttt
     2281 tatgctgatt tttccaagga tctctccctc cttttccctc catcactcag aggtagggaa
     2341 gggggcggca ttaggatggt gttactgtat tgggatttta tgttgttctg tcgtcttcag
     2401 cacaggtagt ataaggttat attactgtag aaccacagtg cccatcttgc cagcagtgcc
     2461 cgcccccacc ctcaaagctg agcaggttga gcctttgcct agtctggggc cagacccctc
     2521 agatggggat atccctgggg gagcctggtg ctgaaccaga agaggcttcc tggtgcttct
     2581 gtcctaggcc accactcctc cagccctttg cccgcacata catgccccac ctactctttc
     2641 atcccctctg cccttcccct gaaacggtcc tttgcagctg tcatcccaga gcaggcagat
     2701 gggctcccgt gcttgagctc caccccagct cttacatcat ctgggctttg aaccttttac
     2761 atttgtccag tctagatgag taggcttggg gccagcaccc tgtctcaaag atggcaaaat
     2821 gaggctagtt ctggatgagc tagctggtgt gggttccaac cataggaaca cactgatgct
     2881 caaatcctaa ggtgccaagc tctaggccct ggaggctggt agaacaggat ctatgcctgg
     2941 aatcctggca gggattcctg tcaaggactt gtgtttaagc ctgcttcagg gcttcaggct
     3001 gcttctgctc tgtgtctgcc caggctggct gagcgggtgg atgggtggac agaagggctc
     3061 accaaggatt gtggacatag ggtaggccct ggtaccacgg gtttcaggct gttatcactt
     3121 cccttgtagg aacatagcca gaagcagatg agccagggta gagggctggc ccctcctctc
     3181 atcttccctt cagtcttaaa ttgtctccag cgatgggaag aggccaggga ctgtaaccct
     3241 tgtgctgtgt attctctgag cctctgctca ctctcagggc caagcagctc ccaagccggg
     3301 gccctctctt ggccaaaatc tgaggagcag tctaggttac aggctttttg gtaggtaggt
     3361 tctggctgcc tgttaatgca gttaggcccc ctgattaggt acagtgagaa acaagctaga
     3421 acaaccctgg cccagaagac tgtccactcc agcaagatcc agggatgata gccttgcagg
     3481 gccactggga gtttgtgccc aagcttctcc ctcttctctc cccagggggc actgggactg
     3541 gtccctgccc tcatccttag cctgggcctt ccccagaggt attaaagaga agtatgattc
     3601 ctctgtcttc agttcttttc aggggcatcc tgcccatagt acccagttcc caaggggccc
     3661 ccagtcacgt ggtgaagcct agcactcatg cagctcttag ggaaccaaaa accagcactg
     3721 aaataaagct gaatgactga ctga
//
