LOCUS       NM_001077706            4507 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens epithelial cell transforming 2 like (ECT2L),
            transcript variant 1, mRNA.
ACCESSION   NM_001077706 XM_294019 XM_941136
VERSION     NM_001077706.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4507)
  AUTHORS   Rose,J.E., Behm,F.M., Drgon,T., Johnson,C. and Uhl,G.R.
  TITLE     Personalized smoking cessation: interactions between nicotine dose,
            dependence and quit-success genotype score
  JOURNAL   Mol Med 16 (7-8), 247-253 (2010)
   PUBMED   20379614
  REMARK    GeneRIF: Clinical trial of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
            Erratum:[Mol Med. 2012;18(1):729]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121834.20.
            
            On Aug 7, 2020 this sequence version replaced NM_001077706.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ904331.1, BC146884.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2144333, SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000541398.7/ ENSP00000442307.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AL121834.20        23946-24051
            107-246             AL121834.20        40697-40836
            247-415             AL121834.20        41031-41199
            416-528             AL121834.20        42350-42462
            529-691             AL121834.20        66211-66373
            692-944             AL121834.20        70838-71090
            945-1113            AL121834.20        72271-72439
            1114-1252           AL121834.20        74398-74536
            1253-1418           AL121834.20        77128-77293
            1419-1547           AL121834.20        81885-82013
            1548-1640           AL121834.20        90486-90578
            1641-1823           AL121834.20        92855-93037
            1824-1927           AL121834.20        95962-96065
            1928-2014           AL121834.20        104331-104417
            2015-2229           AL121834.20        108816-109030
            2230-2377           AL121834.20        110583-110730
            2378-2451           AL121834.20        113365-113438
            2452-2608           AL121834.20        113533-113689
            2609-2674           AL121834.20        114716-114781
            2675-2763           AL121834.20        116802-116890
            2764-2936           AL121834.20        128807-128979
            2937-4507           AL121834.20        130359-131929
FEATURES             Location/Qualifiers
     source          1..4507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1"
     gene            1..4507
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /note="epithelial cell transforming 2 like"
                     /db_xref="GeneID:345930"
                     /db_xref="HGNC:HGNC:21118"
     exon            1..106
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            107..246
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            247..415
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..3064
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /note="ECT2-like; lung specific F-box and DH domain
                     containing protein; putative guanine nucleotide exchange
                     factor LFDH; F-box protein 49"
                     /codon_start=1
                     /product="epithelial cell-transforming sequence 2
                     oncogene-like"
                     /protein_id="NP_001071174.1"
                     /db_xref="CCDS:CCDS43508.1"
                     /db_xref="GeneID:345930"
                     /db_xref="HGNC:HGNC:21118"
                     /translation="MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQ
                     EFLFAIFLRCTKSQLRFVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAA
                     QVSWPWKFLTEQDCLWMPKCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREA
                     AATYGTLNEPKTEDEELLERQREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVL
                     KPRCQPRLSQTVRERVGLHEALEKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVH
                     KNDDRSSYALRPHFMLISSRIPAYEMVMESVKAGVVSVVYEHSVTLESLLYLIEKALD
                     GQKAQSIGIFSDGDSREINLLQGYKIGVKNLLRPEVRDFWEKLGSYVATEEEGGHVDF
                     FVPLGASEAGIEVLSQLSQLTGTFFTAPTGIATGSYQHILSDWLGSQWGKAPSSIYFC
                     ESKLQTWSSFTDFLEETLKTVRKQLYPFFKELQKSISGRMIGQFMFDTMGMTNILNNQ
                     DTAQALADGLMELSKEDSERNVVEDNSWDTKSRLSKNDLNFEALINLERILQKDSAEK
                     RARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILS
                     LNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIP
                     AFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLLYAVRLHTPAEHVDRGDLTTA
                     IDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEVNRYLIRVQDVAQLHCCDE
                     EISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKTTYQFIASVALHRLLIE
                     NIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKSSMEK"
     exon            416..528
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            529..691
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            692..944
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1113
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1252
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1418
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1547
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1640
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1823
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1927
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2014
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2229
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2377
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2451
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2452..2608
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2674
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2675..2763
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2936
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..4507
                     /gene="ECT2L"
                     /gene_synonym="ARHGEF32; C6orf91; dJ509I19.2; dJ509I19.3;
                     dJ509I19.5; FBXO49; LFDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccctctcc ggagctgcgg cccgagttgg cgcactcgat tttcactgcg cggttccaag
       61 aggagacagc cgccactgta ccgggcctca tagccacttc ctagaggtaa agaaaaagtc
      121 aacctccttg gctgatgaat cacggcagtt tctaagtagc atttcctgga acgttcttaa
      181 tgcttcccat tttcccagca aagtaaaaaa caacttttgt ttaaattcag atttgggtga
      241 aagcaggtga tcttaattgc acacctattg aaataaacct gtagtttcta gaagtggaag
      301 aaaatttgct gagacgtcag ctggggattc ttcctggaga actccagaaa tggagagctt
      361 ccacaccaga tttagtgcct ggacaccttt tagcaacaag tcattaaata gacagctctt
      421 tcaggaaaga gtggctctta taagtcattg gtttgacctc tggactaaca agcaacgtca
      481 agaattctta ttcgcaattt ttttaagatg cactaaatca caattaaggt ttgtccaaga
      541 ctggttttca gaaaggatgc aagtggccaa agtggacttc tctacagtgt taccacgctt
      601 catttctcta tatatctttt cctttttgag tccgaaagat ttgtgtgccg ctgcccaagt
      661 cagctggccc tggaagtttt taactgaaca ggattgctta tggatgccca aatgcgttaa
      721 gttcggatgg tttctgccct atactccaac agataatgag tatggtgctt ggaagcgcca
      781 ttacattgct tgtgtgtccc acttagactg gctgacacct agggaggctg ctgctactta
      841 tgggacgctg aatgaaccca aaacagaaga tgaggaacta ctggagagac aaagagaaaa
      901 gtgcctgagg aaaagaattt gggagaaaat tgcactacgt aagaaggagt tattcaaagt
      961 tcgaccccct tgggtgagtg gaacttgctg ctctagcgtg ctaaagccca gatgccaacc
     1021 acgcctctcc cagactgtaa gggagcgagt gggattacat gaagctttgg agaaacagct
     1081 tgttttgaca tcgttagaaa ccttgcccaa gcgaagcaat atttctggaa gccattccta
     1141 ccctttatta tcaaagaaaa attggcatgg agttcataaa aatgatgaca gatcttcata
     1201 tgctctccgg ccacacttca tgttaatatc atcccggatt cctgcgtatg agatggtgat
     1261 ggagagtgtg aaggctggtg ttgtttctgt ggtatatgaa cacagcgtaa ccttggaaag
     1321 ccttctgtat cttatagaaa aagctctgga tgggcagaag gcacagagca tcggaatatt
     1381 tagcgatgga gacagcagag aaatcaattt actccaaggc tataaaattg gtgttaaaaa
     1441 tttactgagg cctgaagtga gagatttctg ggagaaatta ggaagctatg tggccactga
     1501 agaagaaggg ggtcacgtgg acttcttcgt gccccttgga gcatcagagg caggaattga
     1561 agttctttcc cagctgtctc aactaactgg cacgttcttt acggccccca ctgggattgc
     1621 aactggctct taccagcaca ttcttagtga ttggctggga tcccaatggg gaaaggcccc
     1681 ctcttccatc tacttctgcg aatcgaagct acagacgtgg tccagcttca cagacttcct
     1741 agaagaaacc ttgaaaacag taaggaagca gctgtatcct ttcttcaagg aactgcagaa
     1801 gagcatcagt ggcaggatga tagggcagtt tatgtttgac accatgggta tgaccaacat
     1861 tctaaacaac caagatactg cgcaagctct ggcagatgga ttgatggagt tgtcaaaaga
     1921 agattctgaa agaaatgttg tagaagacaa ttcttgggac acaaagtcca ggctcagcaa
     1981 aaatgattta aattttgaag cactgattaa tctggagaga atactccaga aggactcagc
     2041 agaaaagcga gctagagttg tcagagaact cttacagagt gagagaaaat acgtgcagat
     2101 actggaaatt gtgagagatg tttatgtcgc accactgaaa gcagcattgt catcaaacag
     2161 agcgattctg agtgctgcca atatccagat cattttctgt gacattctac agattttaag
     2221 tctcaacagg cagtttctag ataacctgag agacagactg caggaatggg gcccagctca
     2281 ctgtgtggga gaaatagtca cgaagtttgg aagccagtta aacacatata ccaatttctt
     2341 caacaattac cctgtcattc tgaaaactat tgagaagtgc agagaaatga taccagcatt
     2401 ccgaactttc ctgaagaggc atgataagac cattgttacc aaaatgctga gcctgccaga
     2461 gctgctgctg tacccatccc gaagatttga agaatacctt aatcttctct acgctgtcag
     2521 gcttcatacc cctgcagagc atgttgaccg tggggacttg accactgcaa ttgaccaaat
     2581 caaaaaatat aaaggttata tagatcagat gaagcaaaac atcactatga aggatcatct
     2641 gtcagatata cagagaatca tctggggatg ccctactcta tcagaagtaa acagatatct
     2701 gattagggta caagatgtag cccaacttca ttgctgtgat gaagaaataa gtttctcttt
     2761 aaggctctat gaacacatcc atgatctcag ccttttcctc ttcaatgatg ccctgctcgt
     2821 ttctagtcgg ggcacatctc acactccatt tgagaggact tcaaaaacaa cctaccagtt
     2881 cattgcatca gtggcccttc atcggttact catagaaaat attccagatt ccaagtatgt
     2941 caagaatgca tttattcttc agggtccaaa atataaatgg atttgtgcta cagaaataga
     3001 ggatgataag ttcctatggc tgtcagtact tcgaaatgca atcaaaagca gtatggagaa
     3061 gtgagaccga acttgaaaac ttcaggggtg ccaattctcc ccagcaaaga cagacaacat
     3121 gtattttctg ttccaaaata tccagtaaga aacagaataa ctgtcatgga tgatgagata
     3181 aactaagatg acccatagga tctttccaac ttttaaactt tatcacttgt gctcacttat
     3241 gtagaatgta taagtacatt ttgagtccaa aattttgaac tacttctttt ggtagctgta
     3301 tttcatggat aatattattt agagtaattt gatgtgatga aacctaagac agagcaagca
     3361 cattgtgtaa agctttgttt tatgatctaa tgaaaaaagc agaatgaaag tgtttcttaa
     3421 gtgatcagtc tagaaagata ttttaatttg ttggtgattt accattttta acattttcat
     3481 gaaacaatta ttgatttaaa atatggataa gagggctggg catgatgact cacgcctgta
     3541 atcccagcac tttgggaggc tgaggtggca gattacctga ggtcaggagt ttgagaccag
     3601 cctcaccaac atggagaaac cccgtctcta ctaaaaatac aaaattagcc aggcatggtg
     3661 gcacacgcct gtagtccctg ctacttgcga cgctgaggca ggagaagaat cacttgtacc
     3721 cgggagtcgg aggttgtagt aagctgagat ggctccattg cacttcagcc tgggtgacaa
     3781 gagcgaacct ctgtctcaaa aaaaaaagaa aaaaaaaagg acaagaaata caaatggcaa
     3841 tttactcaaa aacttgtcac acttatcctt agtatgaatg tactcctcta gagagcatta
     3901 aagatatacc actacaaagt actaaaaagt tttctataat ttttaagtgt tatttattgg
     3961 aaggctaaat tctaagaagc tttaacaaat atttttgaca ttgttaaatt agaaggctat
     4021 ttttaaaaag catattttaa aaaacaaaac taaatggaaa cagcaaaact tgcttgtaat
     4081 gaaatacagc tgagtaaaaa tgtttctttg aaaacaaaga cactcagaaa aacaggtgtt
     4141 gagtagtttc ctgggccttt aatgctttaa atttattatt taacaactaa agccatactg
     4201 aaagccactt ggaaacttca gctgatgtat atttttacct agatattgtc aggtaaaaat
     4261 tgtattaatc ttggaagctt gaggttgtca gtttcccttg ttcttcaaat tcttgtttac
     4321 agtaacaaag tctatcggtg cagtttagga ctgtgaatct atagtattta aacatttttt
     4381 ctttcagaaa tgaaaataca aaatcttcta tttcttaaaa ctttaaatct tgttaaaaag
     4441 atgaacaaaa gttaaaatat tatgctgttt tattggtgta aaaccacact tctgattctg
     4501 ccaagat
//
