LOCUS       NM_001077693            1031 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens endothelial cell surface expressed chemotaxis and
            apoptosis regulator (ECSCR), transcript variant 1, mRNA.
ACCESSION   NM_001077693 XM_930608 XM_944077
VERSION     NM_001077693.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Pircher,A., Johrer,K., Kocher,F., Steiner,N., Graziadei,I.,
            Heidegger,I., Pichler,R., Leonhartsberger,N., Kremser,C., Kern,J.,
            Untergasser,G., Gunsilius,E. and Hilbe,W.
  TITLE     Biomarkers of evasive resistance predict disease progression in
            cancer patients treated with antiangiogenic therapies
  JOURNAL   Oncotarget 7 (15), 20109-20123 (2016)
   PUBMED   26956051
  REMARK    GeneRIF: Low expression level of ECSCR is associated with evasive
            resistance and disease progression in cancer.
REFERENCE   2  (bases 1 to 1031)
  AUTHORS   Chen,L., Ma,C., He,J., He,Y., Wang,J., Gou,L. and Yang,J.
  TITLE     Preparation of anti-hECSM2 mouse monoclonal antibodies and their
            application in the analysis of hECSM2 expression
  JOURNAL   Monoclon Antib Immunodiagn Immunother 32 (4), 301-308 (2013)
   PUBMED   23909426
REFERENCE   3  (bases 1 to 1031)
  AUTHORS   Pircher,A., Fiegl,M., Untergasser,G., Heidegger,I., Medinger,M.,
            Kern,J. and Hilbe,W.
  TITLE     Favorable prognosis of operable non-small cell lung cancer (NSCLC)
            patients harboring an increased expression of tumor endothelial
            markers (TEMs)
  JOURNAL   Lung Cancer 81 (2), 252-258 (2013)
   PUBMED   23664449
REFERENCE   4  (bases 1 to 1031)
  AUTHORS   Kilari,S., Remadevi,I., Zhao,B., Pan,J., Miao,R., Ramchandran,R.,
            North,P.E., You,M., Rahimi,N. and Wilkinson,G.A.
  TITLE     Endothelial cell-specific chemotaxis receptor (ECSCR) enhances
            vascular endothelial growth factor (VEGF) receptor-2/kinase insert
            domain receptor (KDR) activation and promotes proteolysis of
            internalized KDR
  JOURNAL   J Biol Chem 288 (15), 10265-10274 (2013)
   PUBMED   23393131
  REMARK    GeneRIF: Endothelial cell-specific chemotaxis receptor (ECSCR)
            enhances vascular endothelial growth factor (VEGF)
            receptor-2/kinase insert domain receptor (KDR) activation and
            promotes proteolysis of internalized KDR.
REFERENCE   5  (bases 1 to 1031)
  AUTHORS   Lu,J., Li,C., Shi,C., Balducci,J., Huang,H., Ji,H.L., Chang,Y. and
            Huang,Y.
  TITLE     Identification of novel splice variants and exons of human
            endothelial cell-specific chemotaxic regulator (ECSCR) by
            bioinformatics analysis
  JOURNAL   Comput Biol Chem 41, 41-50 (2012)
   PUBMED   23147565
  REMARK    GeneRIF: identification of three novel full-length splice variants
            potentially encoding different protein isoforms
REFERENCE   6  (bases 1 to 1031)
  AUTHORS   Ikeda,K., Nakano,R., Uraoka,M., Nakagawa,Y., Koide,M., Katsume,A.,
            Minamino,K., Yamada,E., Yamada,H., Quertermous,T. and Matsubara,H.
  TITLE     Identification of ARIA regulating endothelial apoptosis and
            angiogenesis by modulating proteasomal degradation of cIAP-1 and
            cIAP-2
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8227-8232 (2009)
   PUBMED   19416853
  REMARK    GeneRIF: Knockdown of ARIA in HUVECs significantly reduced
            endothelial apoptosis without affecting either cell migration or
            proliferation. ARIA knockdown significantly increased inhibitor of
            apoptosis cIAP-1 and cIAP-2 protein expression
REFERENCE   7  (bases 1 to 1031)
  AUTHORS   Ma,F., Zhang,D., Yang,H., Sun,H., Wu,W., Gan,Y., Balducci,J.,
            Wei,Y.Q., Zhao,X. and Huang,Y.
  TITLE     Endothelial cell-specific molecule 2 (ECSM2) modulates actin
            remodeling and epidermal growth factor receptor signaling
  JOURNAL   Genes Cells 14 (3), 281-293 (2009)
   PUBMED   19267780
  REMARK    GeneRIF: ECSM2 is involved in cell-shape changes and actin
            cytoskeletal rearrangement, suppresses tyrosine phosphorylation
            signaling and ECSM2 can cross-talk with EGFR to attenuate the
            EGF-induced cell migration.
REFERENCE   8  (bases 1 to 1031)
  AUTHORS   Graubert,T.A., Payton,M.A., Shao,J., Walgren,R.A., Monahan,R.S.,
            Frater,J.L., Walshauser,M.A., Martin,M.G., Kasai,Y. and Walter,M.J.
  TITLE     Integrated genomic analysis implicates haploinsufficiency of
            multiple chromosome 5q31.2 genes in de novo myelodysplastic
            syndromes pathogenesis
  JOURNAL   PLoS One 4 (2), e4583 (2009)
   PUBMED   19240791
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1031)
  AUTHORS   Armstrong,L.J., Heath,V.L., Sanderson,S., Kaur,S., Beesley,J.F.,
            Herbert,J.M., Legg,J.A., Poulsom,R. and Bicknell,R.
  TITLE     ECSM2, an endothelial specific filamin a binding protein that
            mediates chemotaxis
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (9), 1640-1646 (2008)
   PUBMED   18556573
  REMARK    GeneRIF: Characterize a novel cell surface protein ECSM2 that
            regulates endothelial chemotaxis and tube formation, and interacts
            with filamin A.
REFERENCE   10 (bases 1 to 1031)
  AUTHORS   Permana,P.A., Nair,S., Lee,Y.H., Luczy-Bachman,G., Vozarova De
            Courten,B. and Tataranni,P.A.
  TITLE     Subcutaneous abdominal preadipocyte differentiation in vitro
            inversely correlates with central obesity
  JOURNAL   Am J Physiol Endocrinol Metab 286 (6), E958-E962 (2004)
   PUBMED   14970008
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EU025066.1 and AI699314.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001077693.3.
            
            Summary: The protein encoded by this gene is primarily found in
            endothelial cells and blood vessels, where it is involved in cell
            shape changes and EGF-induced cell migration. It can enhance the
            activation of vascular endothelial growth factor receptor-2/kinase
            insert domain receptor and also promote the proteolysis of
            internalized kinase insert domain receptor. This gene may play a
            role in angiogenesis-related diseases. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jun 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU025066.1, DQ462572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000618155.3/ ENSP00000479243.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-964               EU025066.1         1-964
            965-1031            AI699314.1         21-87               c
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..1031
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /note="endothelial cell surface expressed chemotaxis and
                     apoptosis regulator"
                     /db_xref="GeneID:641700"
                     /db_xref="HGNC:HGNC:35454"
                     /db_xref="MIM:615736"
     exon            1..134
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..691
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; endothelial cell-specific molecule 2; apoptosis
                     regulator through modulating IAP expression; endothelial
                     cell-specific chemotaxis regulator"
                     /codon_start=1
                     /product="endothelial cell-specific chemotaxis regulator
                     isoform 1 precursor"
                     /protein_id="NP_001071161.1"
                     /db_xref="CCDS:CCDS75317.1"
                     /db_xref="GeneID:641700"
                     /db_xref="HGNC:HGNC:35454"
                     /db_xref="MIM:615736"
                     /translation="MGTAGAMQLCWVILGFLLFRGHNSQPTMTQTSSSQGGLGGLSLT
                     TEPVSSNPGYIPSSEANRPSHLSSTGTPGAGVPSSGRDGGTSRDTFQTVPPNSTTMSL
                     SMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDP
                     QKPGSSGLSESCSTANGEKDSITLISMKNINMNNGKQSLSAEKVL"
     exon            135..179
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            180..230
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            231..290
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            291..335
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..449
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            450..548
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            549..585
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..682
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     exon            683..1031
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1008..1013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /note="hexamer: ATTAAA"
     polyA_site      1031
                     /gene="ECSCR"
                     /gene_synonym="ARIA; ECSM2"
                     /note="major polyA site"
ORIGIN      
        1 actccctctc tcttctccac tatggacaga gcctccactg agctgctgcc tgcccgccac
       61 atacccagct gacatgggca ccgcaggagc catgcagctg tgctgggtga tcctgggctt
      121 cctcctgttc cgaggccaca actcccagcc cacaatgacc cagacctcta gctctcaggg
      181 aggccttggc ggtctaagtc tgaccacaga gccagtttct tccaacccag gatacatccc
      241 ttcctcagag gctaacaggc caagccatct gtccagcact ggtaccccag gcgcaggtgt
      301 ccccagcagt ggaagagacg gaggcacaag cagagacaca tttcaaactg ttccccccaa
      361 ttcaaccacc atgagcctga gcatgaggga agatgcgacc atcctgccca gccccacgtc
      421 agagactgtg ctcactgtgg ctgcatttgg tgttatcagc ttcattgtca tcctggtggt
      481 tgtggtgatc atcctagttg gtgtggtcag cctgaggttc aagtgtcgga agagcaagga
      541 gtctgaagat ccccagaaac ctgggagttc agggctgtct gaaagctgct ccacagccaa
      601 tggagagaaa gacagcatca cccttatctc catgaagaac atcaacatga ataatggcaa
      661 acaaagtctc tcagcagaga aggttcttta aaagcaactt tgggtcccca tgagtccaag
      721 gatgatgcag ctgccctgtg actacaagga ggaagagatg gaattagtag aggcaatgaa
      781 ccacatgtaa attattttat tgtttcatgt ctgcttctag atctaaagga cactagcatt
      841 gccccagatc tgggagcaag ctaccaacag gggagactct ttcctgtatg gacagctgct
      901 gtggaaatac tgcctgcttc tcccacctcc tcagagccac aggaaagagg aggtgacaga
      961 gagagagcaa ggaaagtgat gaggtggatt gatactttct actttgcatt aaaattattt
     1021 tctagcctgc a
//
