LOCUS       NM_001393               3185 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens extracellular matrix protein 2 (ECM2), transcript
            variant 1, mRNA.
ACCESSION   NM_001393
VERSION     NM_001393.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3185)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   2  (bases 1 to 3185)
  AUTHORS   Nishiu,J., Tanaka,T. and Nakamura,Y.
  TITLE     Identification of a novel gene (ECM2) encoding a putative
            extracellular matrix protein expressed predominantly in adipose and
            female-specific tissues and its chromosomal localization to 9q22.3
  JOURNAL   Genomics 52 (3), 378-381 (1998)
   PUBMED   9790758
REFERENCE   3  (bases 1 to 3185)
  AUTHORS   Oritani,K., Kanakura,Y., Aoyama,K., Yokota,T., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Tomiyama,Y., Matsuzawa,Y. and
            Kincade,P.W.
  TITLE     Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis
  JOURNAL   Blood 90 (9), 3404-3413 (1997)
   PUBMED   9345023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300418.1, AB011792.1 and
            BM972177.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001393.3.
            
            Summary: ECM2 encodes extracellular matrix protein 2, so named
            because it shares extensive similarity with known extracelluar
            matrix proteins. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312820.1, AB011792.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344604.10/ ENSP00000344758.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DC300418.1         103-122
            21-3183             AB011792.1         9-3171
            3184-3185           BM972177.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..3185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..3185
                     /gene="ECM2"
                     /note="extracellular matrix protein 2"
                     /db_xref="GeneID:1842"
                     /db_xref="HGNC:HGNC:3154"
                     /db_xref="MIM:603479"
     exon            1..58
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            59..377
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..566
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1139
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1255
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1391
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1549
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1689
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..2016
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..3185
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3166..3171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ECM2"
                     /note="hexamer: ATTAAA"
     polyA_site      3185
                     /gene="ECM2"
                     /note="major polyA site"
ORIGIN      
        1 attttcagct ggagacttaa atgacaccaa gcaaagccta cttagtttag atctccagaa
       61 attggctggt ggaaaaaaat caaacatgaa gattgcagtt ttgttttgtt tttttctgct
      121 tatcattttt caaactgact ttggaaaaaa tgaagaaatt cctaggaagc aaaggaggaa
      181 gatctaccac agaaggttga ggaaaagttc aacctcacac aagcacagat caaacagaca
      241 gcttggaatt cagcaaacaa cagtttttac accagtagca agacttccta ttgttaactt
      301 tgattatagc atggaggaaa agtttgaatc cttttcaagt tttcctggag tagaatcaag
      361 ttataatgtg ttaccaggaa agaagggaca ctgtttggta aagggcataa ccatgtacaa
      421 caaagctgtg tggtcgcctg agccctgcac tacctgcctc tgctcagatg gaagagttct
      481 ttgtgatgaa accatgtgcc atccccagag gtgcccccaa acagttatac ctgaagggga
      541 atgctgcccg gtctgctccg ctactgtctc ctattctcta ctcagtggta tagcattaaa
      601 tgatagaaat gaattttctg gtgattcttc agaacaaaga gaacctacca atttacttca
      661 taagcaactg ccacctcctc aggtgggaat ggaccgaata gtaagaaaag aagcacttca
      721 atctgaggag gatgaagaag tgaaagaaga agatacagag caaaagagag agacccctga
      781 atctagaaat caggggcaac tttacagtga gggggacagc agaggaggag acagaaagca
      841 gaggcctgga gaggagagga ggctggcaca ccagcaacaa cgccaaggaa gggaggagga
      901 ggaggatgag gaggaggagg gtgaggaggg tgaggaggat gaggaggacg aggaggaccc
      961 ggtaagagga gatatgttcc gaatgccctc tcgatccccg cttcctgctc ctcccagagg
     1021 cacactgcgc ctgccaagcg ggtgctctct gtcctacagg accatcagct gcatcaacgc
     1081 catgcttacc cagataccac cgctgacagc accacagata acaagtctgg agctcactgg
     1141 caattccatc gcctccatcc cagatgaagc atttaatgga ttaccaaatt tggaaaggct
     1201 tgatctgagt aaaaataata tcacttcttc aggcataggt ccaaaagcat tcaagcttct
     1261 gaagaagtta atgcgtttga atatggatgg aaataatttg atacagattc cttcacaatt
     1321 gccatctaca ttagaagaac ttaaagtcaa tgagaacaat cttcaggcta tcgatgaaga
     1381 aagtttatca gacttaaatc agttggtcac cttagaattg gaaggaaaca atctcagtga
     1441 agccaatgtc aatcctttag ctttcaaacc tttgaagagc ctagcctact tgcgtctggg
     1501 aaaaaataaa tttagaatta taccgcaggg tcttcctggt tctattgagg aattatacct
     1561 agaaaataac caaattgaag aaataactga aatttgtttc aatcatacca gaaagatcaa
     1621 tgtcattgta ctacgttata acaaaattga agaaaatagg attgctcctt tagcctggat
     1681 aaatcaagaa aatctagaat ccattgatct ctcctacaac aagctctatc acgtcccgtc
     1741 ctatctaccc aagtccttgc tgcacctagt actccttggg aaccagattg aacggatccc
     1801 tggctatgtg tttggccaca tggaaccagg cctggaatac ttgtacctgt catttaacaa
     1861 acttgctgat gatggcatgg accgtgtctc cttctatggg gcatatcatt ctctgagaga
     1921 attatttctg gatcacaatg acttaaaatc tataccacct gggatacaag aaatgaaagc
     1981 actacatttt ctgaggctga acaacaacaa gatacggaac attcttccag aagaaatttg
     2041 caatgctgaa gaggatgatg actcaaatct ggaacatctt catcttgaaa acaattatat
     2101 taaaattaga gaaataccat cttacacatt ttcatgcata agatcatact caagtatcgt
     2161 tcttaaacca caaaacatca agtaattcca agttttcctt tgctgtttat aaactttact
     2221 catgtatttg tagtagctgc atttgtcatt aataagagag acataatcct cctgttatac
     2281 tcagtatcat tatatgctag tcaacctgat tcactaacac acagatgaac aaccaaaata
     2341 tacctaaaag gtatagtctc taggagtttt attaatagta aaggtaaaat ctctcagttt
     2401 cctacctcta gaaagaggcc atctcactag aataggatat tatgcatact gagctagacc
     2461 agaagagtct ggaacaaaat aaacacagcc tttataatca acttgaatac tggtgttagc
     2521 tgagaactct gtaagtccct ttaaaaatta tgtatctttt ggttcaagat taagaagcat
     2581 aatgacaaca aaaaaagcag gcagaattta tgaataagtg ttgtttatta ttaaaacaat
     2641 aatttgttaa tttcttataa ggtcctgtgc tataattact ggtataaata taactgaata
     2701 ttggggtagc tttcatttct tccattaatt acatgtgtaa aattaaaaca ctactgtaat
     2761 gttaatttcc tggttttgaa aatcatatta tggttatgta cattgttaac attaaggaaa
     2821 gctggcagaa gggtgtgcat aaattctata ctctttttga aacttttcta taattctaaa
     2881 attatttttt aaagttaaac agtatattaa gattaccttc actattcctc actcaagatt
     2941 aagacatttt ttgaaaagca gtagagtttg cttaaaatac aaattaatta ttcttgacta
     3001 taaccttgta aaggtaaatc taatgtataa atttttgaaa aattttgcac cactggtcat
     3061 agcatctatc tcctttgcct taatttactg aaatacatca ttttattcgg ttcaattgaa
     3121 ataaagctat gtctttacta tgtattggcc ctaccaaaat catatattaa aattttctaa
     3181 cataa
//
