LOCUS       NM_001197296            2553 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens extracellular matrix protein 2 (ECM2), transcript
            variant 3, mRNA.
ACCESSION   NM_001197296
VERSION     NM_001197296.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Nishiu,J., Tanaka,T. and Nakamura,Y.
  TITLE     Identification of a novel gene (ECM2) encoding a putative
            extracellular matrix protein expressed predominantly in adipose and
            female-specific tissues and its chromosomal localization to 9q22.3
  JOURNAL   Genomics 52 (3), 378-381 (1998)
   PUBMED   9790758
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Oritani,K., Kanakura,Y., Aoyama,K., Yokota,T., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Tomiyama,Y., Matsuzawa,Y. and
            Kincade,P.W.
  TITLE     Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis
  JOURNAL   Blood 90 (9), 3404-3413 (1997)
   PUBMED   9345023
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC300418.1, AB011792.1 and
            BX537976.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001197296.1.
            
            Summary: ECM2 encodes extracellular matrix protein 2, so named
            because it shares extensive similarity with known extracelluar
            matrix proteins. Three transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2010].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction at the 5' end of an exon and differs in the 3' UTR
            and coding sequence compared to variant 1. The resulting isoform
            (3) lacks an internal segment and has a shorter and distinct
            C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX537976.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DC300418.1         103-122
            21-252              AB011792.1         9-240
            253-2553            BX537976.1         318-2618
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..2553
                     /gene="ECM2"
                     /note="extracellular matrix protein 2"
                     /db_xref="GeneID:1842"
                     /db_xref="HGNC:HGNC:3154"
                     /db_xref="MIM:603479"
     exon            1..58
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            59..377
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..566
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1073
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1189
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1325
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1483
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1623
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1950
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2553
                     /gene="ECM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2444..2449
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ECM2"
                     /note="hexamer: AATATA"
     polyA_site      2464
                     /gene="ECM2"
                     /note="major polyA site"
ORIGIN      
        1 attttcagct ggagacttaa atgacaccaa gcaaagccta cttagtttag atctccagaa
       61 attggctggt ggaaaaaaat caaacatgaa gattgcagtt ttgttttgtt tttttctgct
      121 tatcattttt caaactgact ttggaaaaaa tgaagaaatt cctaggaagc aaaggaggaa
      181 gatctaccac agaaggttga ggaaaagttc aacctcacac aagcacagat caaacagaca
      241 gcttggaatt cagcaaacaa cagtttttac accagtagca agacttccta ttgttaactt
      301 tgattatagc atggaggaaa agtttgaatc cttttcaagt tttcctggag tagaatcaag
      361 ttataatgtg ttaccaggaa agaagggaca ctgtttggta aagggcataa ccatgtacaa
      421 caaagctgtg tggtcgcctg agccctgcac tacctgcctc tgctcagatg gaagagttct
      481 ttgtgatgaa accatgtgcc atccccagag gtgcccccaa acagttatac ctgaagggga
      541 atgctgcccg gtctgctccg ctactgaaca aagagaacct accaatttac ttcataagca
      601 actgccacct cctcaggtgg gaatggaccg aatagtaaga aaagaagcac ttcaatctga
      661 ggaggatgaa gaagtgaaag aagaagatac agagcaaaag agagagaccc ctgaatctag
      721 aaatcagggg caactttaca gtgaggggga cagcagagga ggagacagaa agcagaggcc
      781 tggagaggag aggaggctgg cacaccagca acaacgccaa ggaagggagg aggaggagga
      841 tgaggaggag gagggtgagg agggtgagga ggatgaggag gacgaggagg acccggtaag
      901 aggagatatg ttccgaatgc cctctcgatc cccgcttcct gctcctccca gaggcacact
      961 gcgcctgcca agcgggtgct ctctgtccta caggaccatc agctgcatca acgccatgct
     1021 tacccagata ccaccgctga cagcaccaca gataacaagt ctggagctca ctggcaattc
     1081 catcgcctcc atcccagatg aagcatttaa tggattacca aatttggaaa ggcttgatct
     1141 gagtaaaaat aatatcactt cttcaggcat aggtccaaaa gcattcaagc ttctgaagaa
     1201 gttaatgcgt ttgaatatgg atggaaataa tttgatacag attccttcac aattgccatc
     1261 tacattagaa gaacttaaag tcaatgagaa caatcttcag gctatcgatg aagaaagttt
     1321 atcagactta aatcagttgg tcaccttaga attggaagga aacaatctca gtgaagccaa
     1381 tgtcaatcct ttagctttca aacctttgaa gagcctagcc tacttgcgtc tgggaaaaaa
     1441 taaatttaga attataccgc agggtcttcc tggttctatt gaggaattat acctagaaaa
     1501 taaccaaatt gaagaaataa ctgaaatttg tttcaatcat accagaaaga tcaatgtcat
     1561 tgtactacgt tataacaaaa ttgaagaaaa taggattgct cctttagcct ggataaatca
     1621 agaaaatcta gaatccattg atctctccta caacaagctc tatcacgtcc cgtcctatct
     1681 acccaagtcc ttgctgcacc tagtactcct tgggaaccag attgaacgga tccctggcta
     1741 tgtgtttggc cacatggaac caggcctgga atacttgtac ctgtcattta acaaacttgc
     1801 tgatgatggc atggaccgtg tctccttcta tggggcatat cattctctga gagaattatt
     1861 tctggatcac aatgacttaa aatctatacc acctgggata caagaaatga aagcactaca
     1921 ttttctgagg ctgaacaaca acaagatacg ctgtgtttca gatgctgttc tagagacagt
     1981 gacaaacaga tcagatgtgg cctttcctct ctggtagagg caataagcag gaaatcaaac
     2041 agacaagtaa gcaggcaagt gctgtgcagt cagaaaaatg ggtgacaatg cgacgagcac
     2101 actggggcct gagggccgcc aggagactac ggccaccctc aacggcctgg attaacagca
     2161 gatccagacc ggtgcctgtg gagcagacgc actgtgggct tgctgtgtat gtcgcttctc
     2221 aactctgctc tggctgcaga atcccaagaa aaaaatgaaa atcagaatga ctgattgaag
     2281 cttttttctt aagtggaagt tgtacttatt tctactgatt ttataatttt taaaatatgg
     2341 ctagcatgga acttgttcag ccctgaaatt tcatgatgtt ctagatggga agttttaatt
     2401 ccataaaaaa gtgataaatg tccttatagc aaacactctt cacaatataa tgtactaaaa
     2461 aacagatgtt ctgtttggct tcaaaaatta cactataatt actaacacac atatacacta
     2521 aagaagtcct ggtctagcca tgatctaaaa ata
//
