LOCUS       NM_007265               3006 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ecdysoneless cell cycle regulator (ECD), transcript
            variant 1, mRNA.
ACCESSION   NM_007265 XM_939187
VERSION     NM_007265.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3006)
  AUTHORS   Lee,K.T., Pranoto,I.K.A., Kim,S.Y., Choi,H.J., To,N.B., Chae,H.,
            Lee,J.Y., Kim,J.E., Kwon,Y.V. and Nam,J.W.
  TITLE     Comparative interactome analysis of alpha-arrestin families in
            human and Drosophila
  JOURNAL   Elife 12, 88328 (2024)
   PUBMED   38270169
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3006)
  AUTHORS   Mohapatra,B.C., Mirza,S., Bele,A., Gurumurthy,C.B., Raza,M.,
            Saleem,I., Storck,M.D., Sarkar,A., Kollala,S.S., Shukla,S.K.,
            Southekal,S., Wagner,K.U., Qiu,F., Lele,S.M., Alsaleem,M.A.,
            Rakha,E.A., Guda,C., Singh,P.K., Cardiff,R.D., Band,H. and Band,V.
  TITLE     Ecdysoneless Overexpression Drives Mammary Tumorigenesis through
            Upregulation of C-MYC and Glucose Metabolism
  JOURNAL   Mol Cancer Res 20 (9), 1391-1404 (2022)
   PUBMED   35675041
  REMARK    GeneRIF: Ecdysoneless Overexpression Drives Mammary Tumorigenesis
            through Upregulation of C-MYC and Glucose Metabolism.
REFERENCE   3  (bases 1 to 3006)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3006)
  AUTHORS   Klimesova,K., Vojackova,J., Radivojevic,N., Vandermoere,F.,
            Bertrand,E., Verheggen,C. and Stanek,D.
  TITLE     TSSC4 is a component of U5 snRNP that promotes tri-snRNP formation
  JOURNAL   Nat Commun 12 (1), 3646 (2021)
   PUBMED   34131137
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3006)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3006)
  AUTHORS   Zhang,M., Boter,M., Li,K., Kadota,Y., Panaretou,B., Prodromou,C.,
            Shirasu,K. and Pearl,L.H.
  TITLE     Structural and functional coupling of Hsp90- and Sgt1-centred
            multi-protein complexes
  JOURNAL   EMBO J 27 (20), 2789-2798 (2008)
   PUBMED   18818696
REFERENCE   7  (bases 1 to 3006)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 3006)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 3006)
  AUTHORS   Gaziova,I., Bonnette,P.C., Henrich,V.C. and Jindra,M.
  TITLE     Cell-autonomous roles of the ecdysoneless gene in Drosophila
            development and oogenesis
  JOURNAL   Development 131 (11), 2715-2725 (2004)
   PUBMED   15128659
REFERENCE   10 (bases 1 to 3006)
  AUTHORS   Sato,T., Jigami,Y., Suzuki,T. and Uemura,H.
  TITLE     A human gene, hSGT1, can substitute for GCR2, which encodes a
            general regulatory factor of glycolytic gene expression in
            Saccharomyces cerevisiae
  JOURNAL   Mol Gen Genet 260 (6), 535-540 (1999)
   PUBMED   9928932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D88208.1, BC103720.1 and AC016394.13.
            
            On May 17, 2019 this sequence version replaced NM_007265.2.
            
            Transcript Variant: This variant (1) represents a more abundant
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1338526.1,
                                           SRR1660803.56480.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372979.9/ ENSP00000362070.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2141              D88208.1           52-2192
            2142-2150           BC103720.1         1671-1679
            2151-3006           AC016394.13        15958-16813         c
FEATURES             Location/Qualifiers
     source          1..3006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..3006
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /note="ecdysoneless cell cycle regulator"
                     /db_xref="GeneID:11319"
                     /db_xref="HGNC:HGNC:17029"
                     /db_xref="MIM:616464"
     exon            1..143
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..361
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2091
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     suppressor of S. cerevisiae gcr2; ecdysoneless homolog;
                     protein SGT1; human suppressor of GCR two; suppressor of
                     GCR2; protein ecdysoneless homolog"
                     /codon_start=1
                     /product="protein ecdysoneless homolog isoform 1"
                     /protein_id="NP_009196.1"
                     /db_xref="CCDS:CCDS7321.1"
                     /db_xref="GeneID:11319"
                     /db_xref="HGNC:HGNC:17029"
                     /db_xref="MIM:616464"
                     /translation="MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIIT
                     RFAPMLVPYIWQNQPFNLKYKPGKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEF
                     PELVARIEDNDGEFLLIEAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWL
                     PTTPPTIPQALNIITAHSEKILASESIRAAVNRRIRGYPEKIQASLHRAHCFLPAGIV
                     AVLKQRPRLVAAAVQAFYLRDPIDLRACRVFKTFLPETRIMTSVTFTKCLYAQLVQQR
                     FVPDRRSGYRLPPPSDPQYRAHELGMKLAHGFEILCSKCSPHFSDCKKSLVTASPLWA
                     SFLESLKKNDYFKGLIEGSAQYRERLEMAENYFQLSVDWPESSLAMSPGEEILTLLQT
                     IPFDIEDLKKEAANLPPEDDDQWLDLSPDQLDQLLQEAVGKKESESVSKEEKEQNYDL
                     TEVSESMKAFISKVSTHKGAELPREPSEAPITFDADSFLNYFDKILGPRPNESDSDDL
                     DDEDFECLDSDDDLDFETHEPGEEASLKGTLDNLKSYMAQMDQELAHTCISKSFTTRN
                     QVEPVSQTTDNNSDEEDSGTGESVMAPVDVDLNLVSNILESYSSQAGLAGPASNLLQS
                     MGVQLPDNTDHRPTSKPTKN"
     exon            362..479
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            480..567
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..746
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..939
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1068
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1197
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1283
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1390
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1577
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1645
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1860
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..3006
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2124..2129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /note="hexamer: AATAAA"
     polyA_site      2150
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /note="major polyA site"
     regulatory      2881..2886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /note="hexamer: AATATA"
     polyA_site      2908
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
     regulatory      2951..2956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
                     /note="hexamer: AATAAA"
     polyA_site      2972
                     /gene="ECD"
                     /gene_synonym="GCR2; HSGT1; SGT1"
ORIGIN      
        1 ggcttcaggt tccggtcagg cgtcgggaca gagcctgatc caggcttcgg cggccggtgg
       61 cagctctcga tcagctctcg cagtcggaga ggcggctaag gaaaggtgcc acagcagaga
      121 cgcgaaggag aggccctaga accttttcaa agaagaatgg aagaaaccat gaagcttgct
      181 acgatggaag acacagtgga gtactgcctg ttcctgatac cagatgagtc aagggactca
      241 gataaacata aagagattct tcagaagtac attgagagaa taatcactcg gtttgcacct
      301 atgctggtcc cctacatctg gcagaatcag cctttcaatc ttaaatataa acctgggaaa
      361 ggaggtgttc ctgctcatat gtttggcgtg acaaagtttg gggataacat tgaggatgaa
      421 tggtttattg tttatgtaat aaagcagatc acaaaggaat ttccagagtt agtagcaagg
      481 attgaagaca atgatggtga attcttgtta atagaagctg ctgactttct ccctaaatgg
      541 ctggatcctg aaaatagcac caatagggta tttttctgcc atggggaatt gtgtattatc
      601 cctgcaccaa gaaaatctgg agcagaatct tggttaccca ccacaccccc aacaattcca
      661 caagcattga atataatcac agcacattca gaaaaaatac ttgcttcaga atctatacga
      721 gctgctgtga ataggcgcat cagagggtac ccagaaaaaa ttcaggcctc acttcatcga
      781 gcacactgct tccttccagc tggcattgtg gcagtgctaa agcagcgccc cagattggtg
      841 gctgcagcag tccaggcatt ttacctacga gaccctattg acctgcgagc ttgtcgtgtt
      901 ttcaagacat tcttgcctga aacacgaata atgacatcgg tcacattcac taaatgtcta
      961 tatgcacaat tggtgcaaca aaggtttgtg ccagaccggc ggagtggata caggctgcct
     1021 cctccatctg atccccagta ccgagcccat gaattgggca tgaaattggc tcatggattt
     1081 gagatcttat gctccaaatg tagcccacat ttttctgact gcaagaaatc ccttgtgact
     1141 gcctcaccac tctgggccag tttccttgaa agtctgaaaa agaatgatta ctttaaggga
     1201 ctgatagaag gttctgctca gtaccgggaa aggctagaaa tggcagagaa ttacttccag
     1261 ctctcagtag actggccaga aagttctctt gctatgagcc ctggtgaaga aatcttaacc
     1321 ttattacaga caataccatt tgatatagaa gaccttaaga aagaagcagc taatcttccc
     1381 ccagaggatg atgaccagtg gttagatctc tcaccagatc agctggacca gctgctgcag
     1441 gaagctgttg gcaaaaaaga atccgagtct gtttccaagg aggagaagga gcagaactat
     1501 gacttaactg aagtctcaga gagcatgaaa gctttcatat ccaaagtctc aacccacaag
     1561 ggagcagagc tgcctcgaga accttctgag gctccaatca cttttgatgc agattctttt
     1621 cttaattatt ttgataagat tttagggcca aggcctaatg agtcagattc tgatgatctg
     1681 gatgatgaag actttgaatg tttagatagt gatgatgact tggactttga aacacacgaa
     1741 cctggcgaag aggcttccct gaaaggaaca cttgataatc tcaagtcata catggcccag
     1801 atggaccagg aactagcaca cacctgcatc agcaaaagtt tcaccactag gaaccaagtg
     1861 gaacctgtat cccagactac cgataacaat tcagatgagg aagattctgg tacgggagaa
     1921 tctgttatgg caccagtaga tgtagacctg aacctggttt caaatatatt ggaatcctat
     1981 agctcccaag ctggactggc aggacctgct tccaatcttt tacaaagcat gggagtgcag
     2041 ctgcctgaca acaccgatca cagaccaaca agtaagccaa caaaaaatta accagcacat
     2101 ttagcttctc ttttttcttt ttaaataaat attgaatatg attctgttca tttctagttt
     2161 agattactca tttagtaaaa atgtttcttc attacaagtt ttacagattg acttctccat
     2221 gagccccaaa tgtggccctc ttggcacaag tctttgtgat ctcagctgtg ggttatacac
     2281 aggttttgaa ctcggcaggg tagaatctag cccctagaca accttgagat gaaattcaca
     2341 cacttcatgc taaagacata ccctaccaca atataccctt ggagtaattc taaatattta
     2401 aatttctccc ttactgctat tcatcctcag atcaaaattt caagttgaca aatttggatt
     2461 tgaaaactca ttcacttttt caattttttt aatgaggcat aacatgcata tggttaagtg
     2521 cacaaatctt aagtgtacag tcagtgaatt tttgcatgta tgtatgtacc tgaagcaaga
     2581 tatagaactt atttacttgt aaataacagc tatattgata tgtcacatac caaaaaattt
     2641 accctttaaa ttatacaatt cagtggtttt tagtatattt acaaaattgt gcaaccatcc
     2701 ctaccatcta attctagaat attagaaacc ccatactcac taatagtctc tcattccctt
     2761 ctactcccag cccctagaaa ccactagtct actttctgtc tctatggatt tgcctatttt
     2821 ggatatttca tacctgatac tgtacttaat tgttttaatt aattaattgg tttgatattt
     2881 aatataactg atatatcttt tgctaagatg aaatgtttat ttcttaaaat gatgctcata
     2941 ttcctcctaa aataaatcaa gtattatcta tatatcataa aattcaccat taaaagcaaa
     3001 aaaaaa
//
