LOCUS       NM_032565                977 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens EBP like (EBPL), transcript variant 1, mRNA.
ACCESSION   NM_032565
VERSION     NM_032565.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 977)
  AUTHORS   Ma,J., Dempsey,A.A., Stamatiou,D., Marshall,K.W. and Liew,C.C.
  TITLE     Identifying leukocyte gene expression patterns associated with
            plasma lipid levels in human subjects
  JOURNAL   Atherosclerosis 191 (1), 63-72 (2007)
   PUBMED   16806233
REFERENCE   2  (bases 1 to 977)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   3  (bases 1 to 977)
  AUTHORS   Moebius,F.F., Fitzky,B.U., Wietzorrek,G., Haidekker,A., Eder,A. and
            Glossmann,H.
  TITLE     Cloning of an emopamil-binding protein (EBP)-like protein that
            lacks sterol delta8-delta7 isomerase activity
  JOURNAL   Biochem J 374 (Pt 1), 229-237 (2003)
   PUBMED   12760743
  REMARK    GeneRIF: encoded by four exons on human chromosome 13q14.2 covering
            30.7 kb, and a partially processed EBPL pseudogene was found on
            16q21; expressed ubiquitously and most abundant in liver, lung and
            kidney
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135901.23 and AF243433.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032565.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC092471.1, SRR1163658.570485.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000242827.11/ ENSP00000242827.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL135901.23        94801-94811         c
            12-925              AF243433.1         2-915
            926-977             AL135901.23        63999-64050         c
FEATURES             Location/Qualifiers
     source          1..977
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..977
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /note="EBP like"
                     /db_xref="GeneID:84650"
                     /db_xref="HGNC:HGNC:18061"
                     /db_xref="MIM:617335"
     exon            1..233
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..683
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     emopamil binding related protein, delta8-delta7 sterol
                     isomerase related protein; emopamil-binding-related
                     protein; emopamil binding protein like"
                     /codon_start=1
                     /product="emopamil-binding protein-like isoform 1"
                     /protein_id="NP_115954.1"
                     /db_xref="CCDS:CCDS9420.1"
                     /db_xref="GeneID:84650"
                     /db_xref="HGNC:HGNC:18061"
                     /db_xref="MIM:617335"
                     /translation="MGAEWELGAEAGGSLLLCAALLAAGCALGLRLGRGQGAADRGAL
                     IWLCYDALVHFALEGPFVYLSLVGNVANSDGLIASLWKEYGKADARWVYFDPTIVSVE
                     ILTVALDGSLALFLIYAIVKEKYYRHFLQITLCVCELYGCWMTFLPEWLTRSPNLNTS
                     NWLYCWLYLFFFNGVWVLIPGLLLWQSWLELKKMHQKETSSVKKFQ"
     exon            234..303
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /inference="alignment:Splign:2.1.0"
     exon            304..442
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /inference="alignment:Splign:2.1.0"
     exon            443..977
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      905..910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /note="hexamer: AATAAA"
     polyA_site      923
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /note="major polyA site"
     regulatory      956..961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBPL"
                     /gene_synonym="EBRP"
                     /note="hexamer: AGTAAA"
     polyA_site      977
                     /gene="EBPL"
                     /gene_synonym="EBRP"
ORIGIN      
        1 gtttctctcc ctgctttcct ctgccgcatg gtcctgggcc gttggcgtcg gaagcctgaa
       61 gcatgggcgc tgagtgggag ctgggggccg aggctggcgg ttcgctgctg ctgtgcgccg
      121 cgctgctggc ggcgggctgc gccctgggcc tgcgcctggg ccgcgggcag ggggcggcgg
      181 accgcggggc gctcatctgg ctctgctacg acgcgctggt gcacttcgcg ctggaaggcc
      241 cttttgtcta cttgtcttta gtaggaaacg ttgcaaattc cgatggcttg attgcttctt
      301 tatggaaaga atatggcaaa gctgatgcaa gatgggttta ttttgatcca accattgtgt
      361 ctgtggaaat tctgaccgtc gccctggatg ggtctctggc attgttcctc atttatgcca
      421 tagtcaaaga aaaatattac cggcatttcc tgcagatcac cctgtgcgtg tgcgagctgt
      481 atggctgctg gatgaccttc ctcccagagt ggctcaccag aagccccaac ctcaacacca
      541 gcaactggct gtactgttgg ctttacctgt ttttttttaa cggtgtgtgg gttctgatcc
      601 caggactgct actgtggcag tcatggctag aactcaagaa aatgcatcag aaagaaacca
      661 gttcagtgaa gaagtttcag tgaactttca aaaccataaa caccattatc taacttcatg
      721 aaccagaatg aatcaaatct ttttgtttgg ccaaaatgta atacattcca gtctacactt
      781 tgtttttgta ttgttgctcc tgaacaacct gtttcaaatt ggttttaagg cgaccagttt
      841 tcgttgtatt gttgttcaat taaatggtga tatagggaaa agagaacaaa tttgaatttg
      901 taataataaa atgtttaatt atacatttta tggctggcat taattgttcc acattagtaa
      961 aaccaattat cttagaa
//
