LOCUS       NM_006824               1352 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens EBNA1 binding protein 2 (EBNA1BP2), transcript variant
            2, mRNA.
ACCESSION   NM_006824
VERSION     NM_006824.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Uchihara,Y., Tago,K., Tamura,H. and Funakoshi-Tago,M.
  TITLE     EBP2, a novel NPM-ALK-interacting protein in the nucleolus,
            contributes to the proliferation of ALCL cells by regulating tumor
            suppressor p53
  JOURNAL   Mol Oncol 15 (1), 167-194 (2021)
   PUBMED   33040459
  REMARK    GeneRIF: EBP2, a novel NPM-ALK-interacting protein in the
            nucleolus, contributes to the proliferation of ALCL cells by
            regulating tumor suppressor p53.
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1352)
  AUTHORS   Li,B.B., Qian,C., Gameiro,P.A., Liu,C.C., Jiang,T., Roberts,T.M.,
            Struhl,K. and Zhao,J.J.
  TITLE     Targeted profiling of RNA translation reveals
            mTOR-4EBP1/2-independent translation regulation of mRNAs encoding
            ribosomal proteins
  JOURNAL   Proc Natl Acad Sci U S A 115 (40), E9325-E9332 (2018)
   PUBMED   30224479
  REMARK    GeneRIF: Targeted profiling of RNA translation reveals
            mTOR-4EBP1/2-independent translation regulation of mRNAs encoding
            ribosomal proteins.
REFERENCE   6  (bases 1 to 1352)
  AUTHORS   Huber,M.D., Dworet,J.H., Shire,K., Frappier,L. and McAlear,M.A.
  TITLE     The budding yeast homolog of the human EBNA1-binding protein 2
            (Ebp2p) is an essential nucleolar protein required for pre-rRNA
            processing
  JOURNAL   J Biol Chem 275 (37), 28764-28773 (2000)
   PUBMED   10849420
REFERENCE   7  (bases 1 to 1352)
  AUTHORS   Shire,K., Ceccarelli,D.F., Avolio-Hunter,T.M. and Frappier,L.
  TITLE     EBP2, a human protein that interacts with sequences of the
            Epstein-Barr virus nuclear antigen 1 important for plasmid
            maintenance
  JOURNAL   J Virol 73 (4), 2587-2595 (1999)
   PUBMED   10074103
REFERENCE   8  (bases 1 to 1352)
  AUTHORS   Sherrington,R., Rogaev,E.I., Liang,Y., Rogaeva,E.A., Levesque,G.,
            Ikeda,M., Chi,H., Lin,C., Li,G., Holman,K., Tsuda,T., Mar,L.,
            Foncin,J.F., Bruni,A.C., Montesi,M.P., Sorbi,S., Rainero,I.,
            Pinessi,L., Nee,L., Chumakov,I., Pollen,D., Brookes,A., Sanseau,P.,
            Polinsky,R.J., Wasco,W., Da Silva,H.A., Haines,J.L.,
            Perkicak-Vance,M.A., Tanzi,R.E., Roses,A.D., Fraser,P.E.,
            Rommens,J.M. and St George-Hyslop,P.H.
  TITLE     Cloning of a gene bearing missense mutations in early-onset
            familial Alzheimer's disease
  JOURNAL   Nature 375 (6534), 754-760 (1995)
   PUBMED   7596406
REFERENCE   9  (bases 1 to 1352)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
REFERENCE   10 (bases 1 to 1352)
  AUTHORS   Chatterjee,A., Freeman,J.W. and Busch,H.
  TITLE     Identification and partial characterization of a Mr 40,000
            nucleolar antigen associated with cell proliferation
  JOURNAL   Cancer Res 47 (4), 1123-1129 (1987)
   PUBMED   2879624
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM791254.1, BC009175.2 and U86602.1.
            
            On Feb 27, 2020 this sequence version replaced NM_006824.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U86602.1, BC009175.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000236051.3/ ENSP00000236051.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BM791254.1         27-60
            35-1227             BC009175.2         1-1193
            1228-1352           U86602.1           1198-1322
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1352
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /note="EBNA1 binding protein 2"
                     /db_xref="GeneID:10969"
                     /db_xref="HGNC:HGNC:15531"
                     /db_xref="MIM:614443"
     exon            1..238
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1093
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /note="isoform 2 is encoded by transcript variant 2;
                     nucleolar protein p40; homolog of yeast EBNA1-binding
                     protein; nuclear FGF3 binding protein; probable
                     rRNA-processing protein EBP2"
                     /codon_start=1
                     /product="probable rRNA-processing protein EBP2 isoform 2"
                     /protein_id="NP_006815.2"
                     /db_xref="CCDS:CCDS478.1"
                     /db_xref="GeneID:10969"
                     /db_xref="HGNC:HGNC:15531"
                     /db_xref="MIM:614443"
                     /translation="MDTPPLSDSESESDESLVTDRELQDAFSRGLLKPGLNVVLEGPK
                     KAVNDVNGLKQCLAEFKRDLEWVERLDVTLGPVPEIGGSEAPAPQNKDQKAVDPEDDF
                     QREMSFYRQAQAAVLAVLPRLHQLKVPTKRPTDYFAEMAKSDLQMQKIRQKLQTKQAA
                     MERSEKAKQLRALRKYGKKVQTEVLQKRQQEKAHMMNAIKKYQKGFSDKLDFLEGDQK
                     PLAQRKKAGAKGQQMRKGPSAKRRYKNQKFGFGGKKKGSKWNTRESYDDVSSFRAKTA
                     HGRGLKRPGKKGSNKRPGKRTREKMKNRTH"
     exon            239..322
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            323..495
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            496..619
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            620..709
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            710..785
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            786..879
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1042
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1352
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1199..1204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /note="hexamer: AATAAA"
     regulatory      1218..1223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /note="hexamer: ATTAAA"
     polyA_site      1218
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /note="major polyA site"
     polyA_site      1227
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /note="major polyA site"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
                     /note="hexamer: AATAAT"
     polyA_site      1352
                     /gene="EBNA1BP2"
                     /gene_synonym="EBP2; NOBP; P40"
ORIGIN      
        1 gagcagtagc tgtgagttgc tggcgctgga gcgattcggt ggcacgtgga gccacggcgt
       61 gggagtaggg ggctgaaggc aggcagcagc ggccagggcc gccctctgct agccgcttgg
      121 gtctcgggat accccgtttc ttcctgtagg tgtgggacgt gcgtgcggcg agatggacac
      181 tcccccgctc tcggattcgg agtcggaatc cgatgaatcc cttgtcacag acagagagtt
      241 gcaggatgcg ttttcccgag ggcttctgaa gccaggcctc aatgtcgtgc tagaggggcc
      301 gaagaaggcc gtgaacgacg tgaatggcct gaagcaatgt ttggcagaat tcaagcggga
      361 tctggaatgg gttgaaaggc tcgatgtgac actgggtccg gtaccggaga tcggtggatc
      421 tgaggcgcca gcacctcaga acaaggacca gaaagctgtt gatccagaag acgacttcca
      481 gcgagagatg agtttctatc gccaagccca ggccgcagtg cttgcagtct taccccgcct
      541 ccatcagctc aaagtcccta cgaagcgacc cactgattat tttgcggaaa tggccaaatc
      601 tgatctgcag atgcagaaga ttcgacagaa gctgcagact aaacaggctg ccatggagag
      661 gtctgaaaaa gctaagcaac tgcgagcact taggaaatac gggaagaagg tgcaaacgga
      721 ggttcttcag aagaggcagc aggagaaagc ccatatgatg aatgctatta agaaatatca
      781 gaaaggcttc tctgataaac tggatttcct tgagggagat cagaaacctc tggcacagcg
      841 caagaaggca ggagccaaag gccagcagat gaggaagggg cccagtgcta aacgacggta
      901 taaaaaccag aagtttggtt ttggtggaaa gaagaaaggc tcaaagtgga acactcggga
      961 gagctatgat gatgtatcta gcttccgggc caagacagct catggcagag gcctcaagag
     1021 gcctggcaag aaagggtcaa ataagagacc tggaaaacga acaagagaga agatgaagaa
     1081 cagaacacac taaatagcat ctttgaatac aaagaaccaa gaaaaaggaa tgaagactcg
     1141 caatttcacg acacactttg atcccttctg ttggtgtcat gttgtaaaca tttctttcaa
     1201 taaactaaag aaaaattatt aaaggaacac atacctttgg ttaaatagtc tagactaaaa
     1261 gattgagaag ttactttcca ttgctatcta ttgataattt agacattgag ttcaaattgc
     1321 cttcatttta tgataaataa tgatttaact ga
//
