LOCUS       NM_001394757            1777 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens endogenous Bornavirus like nucleoprotein 1 (EBLN1),
            transcript variant 2, mRNA.
ACCESSION   NM_001394757
VERSION     NM_001394757.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1777)
  AUTHORS   Myers,K.N., Barone,G., Ganesh,A., Staples,C.J., Howard,A.E.,
            Beveridge,R.D., Maslen,S., Skehel,J.M. and Collis,S.J.
  TITLE     The bornavirus-derived human protein EBLN1 promotes efficient cell
            cycle transit, microtubule organisation and genome stability
  JOURNAL   Sci Rep 6, 35548 (2016)
   PUBMED   27739501
  REMARK    GeneRIF: human EBLN1 possesses important cellular functions within
            human cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1777)
  AUTHORS   Sung,Y.J., Perusse,L., Sarzynski,M.A., Fornage,M., Sidney,S.,
            Sternfeld,B., Rice,T., Terry,J.G., Jacobs,D.R. Jr., Katzmarzyk,P.,
            Curran,J.E., Jeffrey Carr,J., Blangero,J., Ghosh,S., Despres,J.P.,
            Rankinen,T., Rao,D.C. and Bouchard,C.
  TITLE     Genome-wide association studies suggest sex-specific loci
            associated with abdominal and visceral fat
  JOURNAL   Int J Obes (Lond) 40 (4), 662-674 (2016)
   PUBMED   26480920
  REMARK    GeneRIF: Our results provide evidence for new loci influencing
            abdominal visceral (BBS9, ADCY8, KCNK9) and subcutaneous
            (MLLT10/DNAJC1/EBLN1) fat, and confirmed a locus (THNSL2)
            previously reported to be associated with abdominal fat in women.
REFERENCE   3  (bases 1 to 1777)
  AUTHORS   He,P., Sun,L., Zhu,D., Zhang,H., Zhang,L., Guo,Y., Liu,S., Zhou,J.,
            Xu,X. and Xie,P.
  TITLE     Knock-Down of Endogenous Bornavirus-Like Nucleoprotein 1 Inhibits
            Cell Growth and Induces Apoptosis in Human Oligodendroglia Cells
  JOURNAL   Int J Mol Sci 17 (4), 435 (2016)
   PUBMED   27023521
  REMARK    GeneRIF: Numerous genes were dysregulated by Endogenous
            bornavirus-like nucleoprotein 1 silencing, some of which may be key
            target genes of Rho family GTPase 3, oncostatin M receptor, and
            cAMP responsive element binding protein 3-like 2 protein.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1777)
  AUTHORS   Horie,M., Kobayashi,Y., Suzuki,Y. and Tomonaga,K.
  TITLE     Comprehensive analysis of endogenous bornavirus-like elements in
            eukaryote genomes
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 368 (1626), 20120499 (2013)
   PUBMED   23938751
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1777)
  AUTHORS   Kobayashi,Y., Horie,M., Tomonaga,K. and Suzuki,Y.
  TITLE     No evidence for natural selection on endogenous borna-like
            nucleoprotein elements after the divergence of Old World and New
            World monkeys
  JOURNAL   PLoS One 6 (9), e24403 (2011)
   PUBMED   21912690
REFERENCE   6  (bases 1 to 1777)
  AUTHORS   Belyi,V.A., Levine,A.J. and Skalka,A.M.
  TITLE     Unexpected inheritance: multiple integrations of ancient bornavirus
            and ebolavirus/marburgvirus sequences in vertebrate genomes
  JOURNAL   PLoS Pathog 6 (7), e1001030 (2010)
   PUBMED   20686665
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1777)
  AUTHORS   Horie,M., Honda,T., Suzuki,Y., Kobayashi,Y., Daito,T., Oshida,T.,
            Ikuta,K., Jern,P., Gojobori,T., Coffin,J.M. and Tomonaga,K.
  TITLE     Endogenous non-retroviral RNA virus elements in mammalian genomes
  JOURNAL   Nature 463 (7277), 84-87 (2010)
   PUBMED   20054395
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157831.29.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1968968, SAMEA2148093
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422359.3/ ENSP00000473842.1
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AL157831.29        147500-147599       c
            101-224             AL157831.29        142426-142549       c
            225-1777            AL157831.29        138059-139611       c
FEATURES             Location/Qualifiers
     source          1..1777
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.31"
     gene            1..1777
                     /gene="EBLN1"
                     /gene_synonym="EBLN-1"
                     /note="endogenous Bornavirus like nucleoprotein 1"
                     /db_xref="GeneID:340900"
                     /db_xref="HGNC:HGNC:39430"
                     /db_xref="MIM:613249"
     exon            1..100
                     /gene="EBLN1"
                     /gene_synonym="EBLN-1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..224
                     /gene="EBLN1"
                     /gene_synonym="EBLN-1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..1777
                     /gene="EBLN1"
                     /gene_synonym="EBLN-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1369
                     /gene="EBLN1"
                     /gene_synonym="EBLN-1"
                     /note="endogenous Borna-like N element-containing protein
                     1; endogenous Borna-like N element-1"
                     /codon_start=1
                     /product="endogenous Bornavirus-like nucleoprotein 1"
                     /protein_id="NP_001381686.1"
                     /db_xref="CCDS:CCDS60498.1"
                     /db_xref="GeneID:340900"
                     /db_xref="HGNC:HGNC:39430"
                     /db_xref="MIM:613249"
                     /translation="MSRPRNNPQTSSPQDSTKDGSSFHYFQGRFELSGKSRQYPADAL
                     EPQPGIGDVKVIEKATKSMLDPAQRSHFYLVTPSLVFLCFIFDGLHKALLSVGVSKRS
                     NIVIGNENKETGTLYASKFEDVLPTFTALEMSSILRHCCDLIGIAAGSSDPICTNSLQ
                     VQRQFKAMMISIGRPLHSESADLLISYNAGPAIDWINSRPWVGGLMFTFLFGEFESPA
                     CELLDQVKVVASKAQMMTYYTVRMFLDQCVDGSTALPAVVLEIPVFEQKKPLAKKVLG
                     DFFEFGGVLRHPVIGVLSPQMFPNLATAANYWAKRRNSTFSGFEALDIIPGSTITFPV
                     LQMASAQKISRGSDMDPYTLNILRGYGISGFE"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBLN1"
                     /gene_synonym="EBLN-1"
                     /note="hexamer: AATAAA"
     polyA_site      1777
                     /gene="EBLN1"
                     /gene_synonym="EBLN-1"
                     /note="major polyA site"
ORIGIN      
        1 gctctttctc taggtcctgc tgccctgtga ggaaggtgct tgcttctcct ccttcagcca
       61 tgcttgtagt ttcctgaggc cttcccagcc atgcagaact agacaggatc tcactctgtt
      121 ggccaggctg gagtgcagtg gtatgatcat agctcactgc acctctgagc tcctggagtc
      181 aagcaatcct cctacctcag cctccaaagt agctaggact gcagtacagt acaaaattgt
      241 gtgaaaatca cagaaacaat cacccacaat gtcccgccca agaaacaacc cacagaccag
      301 cagcccacaa gacagtacaa aggatgggag cagcttccat tactttcaag ggagatttga
      361 gctctctggg aagagcagac agtatccagc agatgcattg gagccccaac ctggtattgg
      421 agatgttaag gtcattgaaa aagcaactaa gtctatgcta gacccagcac agagatctca
      481 tttttacctt gtaaccccaa gcttagtatt tttgtgtttt atattcgatg gattacacaa
      541 ggcactactc agtgtcggtg tgagcaaaag gtctaatatt gtgattggga atgagaacaa
      601 ggaaacaggt actctctatg ctagcaaatt tgaagatgtt ttgcctacct tcactgccct
      661 tgagatgtca tcaattctgc gtcactgctg tgatctgata ggcattgctg ccggatcgag
      721 tgacccgata tgcaccaaca gcctccaagt acagagacaa ttcaaggcaa tgatgatatc
      781 cattggaaga cctttgcata gtgaaagtgc tgatttatta attagctata atgcagggcc
      841 agctatagat tggatcaact caagaccatg ggttggagga ttaatgttca catttctatt
      901 tggagaattt gaatcccctg cgtgcgagct acttgatcaa gttaaagtag ttgccagcaa
      961 agcacagatg atgacctact acactgtgag aatgttcctg gatcagtgtg tggatggttc
     1021 cactgcttta cccgctgttg tgttggagat tccagttttt gagcagaaga aaccactggc
     1081 taaaaaggta cttggagatt tctttgaatt tgggggtgta cttcgccacc ctgttattgg
     1141 ggtgctatca ccacaaatgt tcccaaacct agcaacagca gcaaactact gggccaaaag
     1201 aaggaattcc acattttctg gatttgaagc ccttgacatt ataccaggat caactattac
     1261 attccctgta cttcaaatgg catctgctca gaaaatctcc agaggaagtg acatggatcc
     1321 atatacactt aacatccttc gcggttatgg gatttcggga tttgaataac aaatacgtga
     1381 actaatcctt atatatacat ataaaaagaa attatgtgaa aatcacattc taaaatagta
     1441 tctgagtgtt gcctattgtt ttcaatcttg gtctgtctct gacatctatc gcaacttctc
     1501 tataatcttt tattctttaa aagagtccat ccaatattct ctggccactg aaagatgtga
     1561 tctccaaagt ctttttaagt actggaggcc aaaaatatgc tttgacatgt agaattttga
     1621 aataattgaa atgttttctg tagtcacgtg gggagttttt attttattct tcatagataa
     1681 ggcccagatc atttttaagg ttattgtatt tcttctctaa tttgtcttga ttatttttta
     1741 taattatgtt gaaataaatc tgatgcatta tcactta
//
