LOCUS       NM_005755               1158 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens Epstein-Barr virus induced 3 (EBI3), mRNA.
ACCESSION   NM_005755
VERSION     NM_005755.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1158)
  AUTHORS   Luo,Y.H., Zhang,Y.Y., Li,M.Q., Zhang,X.Y. and Zheng,Z.M.
  TITLE     Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy
            Complications
  JOURNAL   Am J Reprod Immunol 92 (4), e13942 (2024)
   PUBMED   39422056
  REMARK    GeneRIF: Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy
            Complications.
            Review article
REFERENCE   2  (bases 1 to 1158)
  AUTHORS   Sun,H., Ge,Y., Liu,J., Li,Z., Li,H., Zhao,T., Wang,X., Feng,Y.,
            Wang,H., Gao,S., Shi,L., Yang,S., Sun,P., Chang,A., Hao,J. and
            Huang,C.
  TITLE     Tumor-derived interleukin 35 mediates the dissemination of
            gemcitabine resistance in pancreatic adenocarcinoma
  JOURNAL   Oncogene 43 (11), 776-788 (2024)
   PUBMED   38243080
  REMARK    GeneRIF: Tumor-derived interleukin 35 mediates the dissemination of
            gemcitabine resistance in pancreatic adenocarcinoma.
REFERENCE   3  (bases 1 to 1158)
  AUTHORS   Hildenbrand,K., Bohnacker,S., Menon,P.R., Kerle,A.,
            Prodjinotho,U.F., Hartung,F., Strasser,P.C., Catici,D.A.M.,
            Ruhrnossl,F., Haslbeck,M., Schumann,K., Muller,S.I., da Costa,C.P.,
            Esser-von Bieren,J. and Feige,M.J.
  TITLE     Human interleukin-12alpha and EBI3 are cytokines with
            anti-inflammatory functions
  JOURNAL   Sci Adv 9 (43), eadg6874 (2023)
   PUBMED   37878703
  REMARK    GeneRIF: Human interleukin-12alpha and EBI3 are cytokines with
            anti-inflammatory functions.
REFERENCE   4  (bases 1 to 1158)
  AUTHORS   Zhang,T., Yamagata,K., Iwata,S., Sonomoto,K., Trimova,G.,
            Nguyen,A.P., Hao,H., Shan,Y., Nguyen,M.P., Nakayamada,S. and
            Tanaka,Y.
  TITLE     Epstein-Barr virus-induced gene 3 commits human mesenchymal stem
            cells to differentiate into chondrocytes via endoplasmic reticulum
            stress sensor
  JOURNAL   PLoS One 17 (12), e0279584 (2022)
   PUBMED   36548354
  REMARK    GeneRIF: Epstein-Barr virus-induced gene 3 commits human
            mesenchymal stem cells to differentiate into chondrocytes via
            endoplasmic reticulum stress sensor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1158)
  AUTHORS   Yang,P.X., Wang,P., Fang,L. and Wang,Q.
  TITLE     [Expression of Tregs and IL-35 in Peripheral Blood of Patients with
            Newly Diagnosed Acute Myeloid Leukemia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (6), 1688-1692 (2022)
   PUBMED   36476890
  REMARK    GeneRIF: [Expression of Tregs and IL-35 in Peripheral Blood of
            Patients with Newly Diagnosed Acute Myeloid Leukemia].
REFERENCE   6  (bases 1 to 1158)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   7  (bases 1 to 1158)
  AUTHORS   Larousserie,F., Pflanz,S., Coulomb-L'Hermine,A., Brousse,N.,
            Kastelein,R. and Devergne,O.
  TITLE     Expression of IL-27 in human Th1-associated granulomatous diseases
  JOURNAL   J Pathol 202 (2), 164-171 (2004)
   PUBMED   14743498
REFERENCE   8  (bases 1 to 1158)
  AUTHORS   Devergne,O., Birkenbach,M. and Kieff,E.
  TITLE     Epstein-Barr virus-induced gene 3 and the p35 subunit of
            interleukin 12 form a novel heterodimeric hematopoietin
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 12041-12046 (1997)
   PUBMED   9342359
REFERENCE   9  (bases 1 to 1158)
  AUTHORS   Devergne,O., Hummel,M., Koeppen,H., Le Beau,M.M., Nathanson,E.C.,
            Kieff,E. and Birkenbach,M.
  TITLE     A novel interleukin-12 p40-related protein induced by latent
            Epstein-Barr virus infection in B lymphocytes
  JOURNAL   J Virol 70 (2), 1143-1153 (1996)
   PUBMED   8551575
  REMARK    Erratum:[J Virol 1996 Apr;70(4):2678]
REFERENCE   10 (bases 1 to 1158)
  AUTHORS   Small,R.D.
  TITLE     Letter: Statistical analysis of respiratory sensitivity to CO2
  JOURNAL   N Engl J Med 295 (7), 397 (1976)
   PUBMED   934235
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005578.1.
            
            On Nov 26, 2018 this sequence version replaced NM_005755.2.
            
            Summary: This gene was identified by its induced expression in B
            lymphocytes in response Epstein-Barr virus infection. It encodes a
            secreted glycoprotein belonging to the hematopoietin receptor
            family, and heterodimerizes with a 28 kDa protein to form
            interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory
            responses, in part by activating the Jak/STAT pathway of CD4+ T
            cells. [provided by RefSeq, Sep 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015364.1, SRR1163657.205051.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221847.6/ ENSP00000221847.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC005578.1         22199-22293
            96-228              AC005578.1         23867-23999
            229-407             AC005578.1         25805-25983
            408-565             AC005578.1         27343-27500
            566-1158            AC005578.1         29612-30204
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1158
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /note="Epstein-Barr virus induced 3"
                     /db_xref="GeneID:10148"
                     /db_xref="HGNC:HGNC:3129"
                     /db_xref="MIM:605816"
     exon            1..95
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..718
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /note="Epstein-Barr virus induced gene 3; IL27 subunit;
                     IL35 subunit; cytokine receptor; interleukin-27 subunit
                     beta; IL-27 subunit beta; EBV-induced gene 3 protein;
                     epstein-Barr virus-induced gene 3 protein"
                     /codon_start=1
                     /product="interleukin-27 subunit beta precursor"
                     /protein_id="NP_005746.2"
                     /db_xref="CCDS:CCDS12123.1"
                     /db_xref="GeneID:10148"
                     /db_xref="HGNC:HGNC:3129"
                     /db_xref="MIM:605816"
                     /translation="MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAV
                     DCSWTLPPAPNSTSPVSFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPY
                     VLNVTAVHPWGSSSSFVPFITEHIIKPDPPEGVRLSPLAERQLQVQWEPPGSWPFPEI
                     FSLKYWIRYKRQGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTDYGELSDWS
                     LPATATMSLGK"
     exon            96..228
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /inference="alignment:Splign:2.1.0"
     exon            229..407
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /inference="alignment:Splign:2.1.0"
     exon            408..565
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /inference="alignment:Splign:2.1.0"
     exon            566..1158
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1153..1158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /note="hexamer: AATAAA"
     polyA_site      1158
                     /gene="EBI3"
                     /gene_synonym="IL-27B; IL27B; IL35B"
                     /note="major polyA site"
ORIGIN      
        1 actcctgaga gcagagctgg ccgcagccat gaccccgcag cttctcctgg cccttgtcct
       61 ctgggccagc tgcccgccct gcagtggaag gaaagggccc ccagcagctc tgacactgcc
      121 ccgggtgcaa tgccgagcct ctcggtaccc gatcgccgtg gattgctcct ggaccctgcc
      181 gcctgctcca aactccacca gccccgtgtc cttcattgcc acgtacaggc tcggcatggc
      241 tgcccggggc cacagctggc cctgcctgca gcagacgcca acgtccacca gctgcaccat
      301 cacggatgtc cagctgttct ccatggctcc ctacgtgctc aatgtcaccg ccgtccaccc
      361 ctggggctcc agcagcagct tcgtgccttt cataacagag cacatcatca agcccgaccc
      421 tccagaaggc gtgcgcctaa gccccctcgc tgagcgccag ctacaggtgc agtgggagcc
      481 tcccgggtcc tggcccttcc cagagatctt ctcactgaag tactggatcc gttacaagcg
      541 tcagggagct gcgcgcttcc accgggtggg gcccattgaa gccacgtcct tcatcctcag
      601 ggctgtgcgg ccccgagcca ggtactacgt ccaagtggcg gctcaggacc tcacagacta
      661 cggggaactg agtgactgga gtctccccgc cactgccaca atgagcctgg gcaagtagca
      721 agggcttccc gctgcctcca gacagcacct gggtcctcgc caccctaagc cccgggacac
      781 ctgttggagg gcggatggga tctgcctagc ctgggctgga gtccttgctt tgctgctgct
      841 gagctgccgg gcaacctcag atgaccgact tttccctttg agcctcagtt tctctagctg
      901 agaaatggag atgtactact ctctccttta cctttacctt taccacagtg cagggctgac
      961 tgaactgtca ctgtgagata ttttttattg tttaattaga aaagaattgt tgttgggctg
     1021 ggcgcagtgg atcgcacctg taatcccagt cactgggaag ccgacgtggg agggtagctt
     1081 gaggccagga gctcgaaacc agtccgggcc acacagcaag accccatctc taaaaaatta
     1141 atataaatat aaaataaa
//
