LOCUS       NM_001395167            3521 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens EBF family member 4 (EBF4), transcript variant 3,
            mRNA.
ACCESSION   NM_001395167
VERSION     NM_001395167.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3521)
  AUTHORS   Kubo,S., Kataria,R., Yao,Y., Gabrielski,J.Q., Zheng,L.,
            Markowitz,T.E., Chan,W., Song,J., Boddapati,A.K., Saeki,K.,
            Haupl,B., Park,A.Y., Cheng,Y.H., Cui,J., Oellerich,T. and
            Lenardo,M.J.
  TITLE     Early B cell factor 4 modulates FAS-mediated apoptosis and promotes
            cytotoxic function in human immune cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2208522119 (2022)
   PUBMED   35939714
  REMARK    GeneRIF: Early B cell factor 4 modulates FAS-mediated apoptosis and
            promotes cytotoxic function in human immune cells.
REFERENCE   2  (bases 1 to 3521)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 3521)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035460.15.
            
            Summary: EBF4 belongs to the conserved Olf/EBF family of
            helix-loop-helix transcription factors, members of which play
            important roles in neural development and B-cell maturation (Wang
            et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3505557.1,
                                           SRR14038195.2224239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000609451.6/ ENSP00000477023.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1003              AL035460.15        8376-9378
            1004-1160           AL035460.15        21173-21329
            1161-1224           AL035460.15        21570-21633
            1225-1280           AL035460.15        21805-21860
            1281-1354           AL035460.15        23543-23616
            1355-1423           AL035460.15        25170-25238
            1424-1505           AL035460.15        64145-64226
            1506-1623           AL035460.15        64997-65114
            1624-1757           AL035460.15        65216-65349
            1758-1884           AL035460.15        65443-65569
            1885-1973           AL035460.15        67296-67384
            1974-2039           AL035460.15        67518-67583
            2040-2217           AL035460.15        67682-67859
            2218-2406           AL035460.15        67953-68141
            2407-2604           AL035460.15        71223-71420
            2605-2680           AL035460.15        74505-74580
            2681-3521           AL035460.15        74864-75704
FEATURES             Location/Qualifiers
     source          1..3521
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3521
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="EBF family member 4"
                     /db_xref="GeneID:57593"
                     /db_xref="HGNC:HGNC:29278"
                     /db_xref="MIM:609935"
     exon            1..1003
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             867..2675
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="isoform 2 is encoded by transcript variant 3;
                     transcription factor COE4; olf-1/EBF-like 4; early B cell
                     factor 4"
                     /codon_start=1
                     /product="transcription factor COE4 isoform 2"
                     /protein_id="NP_001382096.1"
                     /db_xref="CCDS:CCDS93003.1"
                     /db_xref="GeneID:57593"
                     /db_xref="HGNC:HGNC:29278"
                     /db_xref="MIM:609935"
                     /translation="MFPAQDALPRSGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAA
                     QSGVGLARAHFEKQPPSNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGA
                     EKTNNGIHYRLRLVYNNGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEI
                     MCSRCCDRKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVST
                     TVSVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIV
                     IGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPG
                     RFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPGSNQE
                     LLLKRAADVAEALYSTPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEP
                     GYARSCSSASPRGFAPSPGSQQSGYGGGLGAGLGGYGAPGVAGLGVPGSPSFLNGSTA
                     TSPFAIMPSSPPLAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPVLRPPSSP
                     PQACPRAHGEGLPDQSFEDSDKFHSPARGLQGLAYS"
     exon            1004..1160
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1224
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1280
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1354
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1423
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1505
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1623
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1757
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1884
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1973
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2039
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2217
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2406
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2604
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2680
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..3521
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3466..3471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="hexamer: AATAAA"
     polyA_site      3521
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="major polyA site"
ORIGIN      
        1 cccttcggct accgctcccc cgggagcggc ggcggcggcg gcggcggcgg cgggatggcc
       61 cgggcccgag gccaggcccc ggggagcggc gggcggcggc ggccgcggcg gggcggcgcg
      121 ggaaccgggc cccgggggga gtcggccggg ctgctgctgc tgctgctcca ggtgctgccg
      181 cccggggcta cggcagggcc gggacgccgg ggcacgcggg gcgctggcgc tggcggcggc
      241 ggcgtctgct ggcccggcgc ggccccagcc tttccccggg acgcgcggct gctgctgctc
      301 ctgccgccgc tgccgccact gtcgccgccg ccgccgagct ccgcgcccgc agcctccgcc
      361 tcccggatgg taatcagcgc cccgcgctgg cgccgcgggc gggcgggcgg gcgggaggtg
      421 ggggcggcga gggggaaagg gcgggcggcc ccgcgccccc gccttgcccg aggcagctcc
      481 cggggcgctc gggccccccc tccgacgacc gcggccccgg gcagccgcca gagcgcgcct
      541 ctggggcgcc tccgcgcgga ccgggtgcgg gctccgctcc ccgccctccc cgccccgctc
      601 gcagtccgcc cgccagcgct caggccgcgg gggaatccct ccatctcccc gcccagcgcc
      661 ccaggagggg aggggacagc gccggcgccc gcggacccgc tttctccgag ggagcgccca
      721 agaggcgagc gcgcactgag ccacccggac tcggcgctgc gctgctggag gcgcctggtg
      781 ccgtcgggtc gggctgagct agacgcccgc agcctcagcg ggaccggatc cggggcggcg
      841 ggggcgctca ctcaccgcgc gccctcatgt tccctgcgca ggacgctctg ccccgcagcg
      901 ggctgaacct gaaggaggag ccgctgctgc ccgccggcct gggctcagtg cgctcctgga
      961 tgcagggcgc gggcatcctg gacgccagca ccgcggcgca gagtggcgtg ggtctggcac
     1021 gagcacattt tgagaagcag cctccctcca acctcaggaa atccaacttc ttccacttcg
     1081 tgctggccat gtacgaccgg caggggcagc ccgtggaggt ggagcgcaca gccttcatcg
     1141 acttcgtgga aaaggaccga gagcccgggg cggaaaagac taacaatggg atccattacc
     1201 gcctccggct ggtgtataac aatggactgc ggacagagca agacctctac gtgcgtctca
     1261 tcgactccat gtccaaacag gccatcatct atgaggggca ggacaagaac cccgaaatgt
     1321 gccgagtgct gctcacccat gagatcatgt gcagccggtg ctgtgaccgg aagagctgtg
     1381 gcaaccggaa tgagacgccc tcagaccccg tcatcattga caggttcttc ctcaagttct
     1441 tcctcaaatg caaccagaac tgcctgaaga atgcggggaa tcccagagac atgcgccgct
     1501 tccaggtggt ggtgtccacg acggtgagcg tggacggaca cgtgctggcc gtgtccgaca
     1561 acatgtttgt gcacaacaac tccaagcatg gccgcagggc gcgccgcctg gacccctccg
     1621 aagctgccac cccctgcatc aaggccatca gccccgggga gggctggacc acgggcggcg
     1681 ccaccgtcat tgtcatcggc gacaacttct tcgacgggtt gcaggtcgtg ttcggaaacg
     1741 tgctcgtgtg gagcgagctc atcacgcccc acgccatccg ggtgcagacg cccccgcggc
     1801 acatccccgg ggtggtggag gtgaccctct cctacaagtc caagcagttt tgcaagggat
     1861 gccccggccg ctttgtctac acagctctga acgagcccac cattgactac ggattccaga
     1921 ggctacagaa agtcattccc agacaccccg gagaccccga gaggctgccc aaggaagtgc
     1981 tgctgaagcg ggcggccgac ttggcagaag ccctgtacgg agtgcccggc agtaaccagg
     2041 agctgctcct gaagcgcgcg gcggacgtgg ccgaggctct gtacagcacc ccccgcgcac
     2101 ccgggccgct cgcacccctg gccccgagcc acccacaccc cgccgtcgtg ggcatcaacg
     2161 ccttcagcag cccgctggcc atcgccgtcg gggacgccac cccggggccc gagccgggct
     2221 acgcgcgcag ctgcagcagc gcgtcccccc gcgggttcgc gcccagcccc ggctcgcagc
     2281 agagcggcta cggcggcggc ctcggagctg gcctgggcgg ctacggcgcg ccgggcgtgg
     2341 ccggcctcgg cgtgcctggg tcccccagct tcctcaatgg ctccaccgcc acctcgccct
     2401 tcgccatcat gccctctagc cccccgctgg cggctgcctc ctccatgtcc ctcccggccg
     2461 ctgcccccac caccagcgtg ttctccttct cgcctgtcaa catgatctcc gccgtcaaac
     2521 agaggagcgc cttcgccccc gtgctgcgcc ccccaagctc cccaccccag gcctgcccca
     2581 gagcccacgg agaggggctt ccagaccagt cttttgagga ttctgacaag tttcactctc
     2641 cagcccgggg gcttcagggc ctggcatact cctaattacg gtctgcagct gttcccatgg
     2701 agcccggact ggaggtccct ctgggattca cagccacacc ccggatggtg gcacagacag
     2761 atgcagggcc agggccatgg gcggacctca acccgtgagc tgaacgggga gaggccttca
     2821 ccccatgctc aagcctcccc gctagcagcc ccacaggctt ctctcgcctc cctgtcttgg
     2881 ggtagtcaga agccccagca ctgtgcagat gctcttggca ggacagcatc gcagggaggt
     2941 gctgggattc tgggcctcac tgtctgggtc ttggttcctc tgaaagagat ggatcttgtg
     3001 cagaccaggg ttgttgagtg aggggagcgt gggatgggga ccgtgggaaa gaggacagct
     3061 cagggagaag tgacctggaa aggtcctgtt tgcatctgac ccatctcaac tggcccagca
     3121 tcccaacttc tctgcagcga aagggtggcg ccccgcagcc tcgggaggcc tgcccaggct
     3181 cccgtggagc ttccaacagc tgcttggccc cgcagctgcc cccacttcct ttgagacctg
     3241 cactctcatg cttgccgcat catgcctccc tgtgggggct ttgggcatgg aggaggcaga
     3301 agagggggtg ccaggcctcc tgtatttggg gtcttccccc agtggatgtc tcatggactc
     3361 tggccccaca cactcacaat gactctggct ggccccacgc agcgggccca gccgcccccc
     3421 aggtggcctc acattctgct ctgctaagtt tggagaaaac agaacaataa accagatgca
     3481 ggtggtgccc gcccggcctc tcacctgcct ccttggtgtg a
//
