LOCUS       NM_001110514            3009 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens EBF family member 4 (EBF4), transcript variant 1,
            mRNA.
ACCESSION   NM_001110514 XM_044921 XM_938882
VERSION     NM_001110514.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Kubo,S., Kataria,R., Yao,Y., Gabrielski,J.Q., Zheng,L.,
            Markowitz,T.E., Chan,W., Song,J., Boddapati,A.K., Saeki,K.,
            Haupl,B., Park,A.Y., Cheng,Y.H., Cui,J., Oellerich,T. and
            Lenardo,M.J.
  TITLE     Early B cell factor 4 modulates FAS-mediated apoptosis and promotes
            cytotoxic function in human immune cells
  JOURNAL   Proc Natl Acad Sci U S A 119 (33), e2208522119 (2022)
   PUBMED   35939714
  REMARK    GeneRIF: Early B cell factor 4 modulates FAS-mediated apoptosis and
            promotes cytotoxic function in human immune cells.
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035460.15.
            
            On Jan 4, 2023 this sequence version replaced NM_001110514.1.
            
            Summary: EBF4 belongs to the conserved Olf/EBF family of
            helix-loop-helix transcription factors, members of which play
            important roles in neural development and B-cell maturation (Wang
            et al., 2002 [PubMed 12139918]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.873894.1,
                                           SRR14038195.2245523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145774
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AL035460.15        8376-8744
            370-491             AL035460.15        9257-9378
            492-648             AL035460.15        21173-21329
            649-712             AL035460.15        21570-21633
            713-768             AL035460.15        21805-21860
            769-842             AL035460.15        23543-23616
            843-911             AL035460.15        25170-25238
            912-993             AL035460.15        64145-64226
            994-1111            AL035460.15        64997-65114
            1112-1245           AL035460.15        65216-65349
            1246-1372           AL035460.15        65443-65569
            1373-1461           AL035460.15        67296-67384
            1462-1527           AL035460.15        67518-67583
            1528-1705           AL035460.15        67682-67859
            1706-1894           AL035460.15        67953-68141
            1895-2092           AL035460.15        71223-71420
            2093-2168           AL035460.15        74505-74580
            2169-3009           AL035460.15        74864-75704
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..3009
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="EBF family member 4"
                     /db_xref="GeneID:57593"
                     /db_xref="HGNC:HGNC:29278"
                     /db_xref="MIM:609935"
     exon            1..369
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2163
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transcription factor COE4; olf-1/EBF-like 4;
                     early B cell factor 4"
                     /codon_start=1
                     /product="transcription factor COE4 isoform 1 precursor"
                     /protein_id="NP_001103984.2"
                     /db_xref="CCDS:CCDS46573.1"
                     /db_xref="GeneID:57593"
                     /db_xref="HGNC:HGNC:29278"
                     /db_xref="MIM:609935"
                     /translation="MARARGQAPGSGGRRRPRRGGAGTGPRGESAGLLLLLLQVLPPG
                     ATAGPGRRGTRGAGAGGGGVCWPGAAPAFPRDARLLLLLPPLPPLSPPPPSSAPAASA
                     SRMDALPRSGLNLKEEPLLPAGLGSVRSWMQGAGILDASTAAQSGVGLARAHFEKQPP
                     SNLRKSNFFHFVLAMYDRQGQPVEVERTAFIDFVEKDREPGAEKTNNGIHYRLRLVYN
                     NGLRTEQDLYVRLIDSMSKQAIIYEGQDKNPEMCRVLLTHEIMCSRCCDRKSCGNRNE
                     TPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVSVDGHVLAVSDNMF
                     VHNNSKHGRRARRLDPSEAATPCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNV
                     LVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGRFVYTALNEPTIDYGF
                     QRLQKVIPRHPGDPERLPKEVLLKRAADLAEALYGVPGSNQELLLKRAADVAEALYST
                     PRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAP
                     SPGSQQSGYGGGLGAGLGGYGAPGVAGLGVPGSPSFLNGSTATSPFAIMPSSPPLAAA
                     SSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPVLRPPSSPPQACPRAHGEGLPDQS
                     FEDSDKFHSPARGLQGLAYS"
     exon            370..491
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            492..648
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            649..712
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            713..768
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            769..842
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            843..911
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            912..993
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1111
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1245
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1372
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1461
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1527
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1705
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1894
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2092
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2168
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..3009
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="hexamer: AATAAA"
     polyA_site      3009
                     /gene="EBF4"
                     /gene_synonym="COE4; O/E-4; OE-4"
                     /note="major polyA site"
ORIGIN      
        1 cccttcggct accgctcccc cgggagcggc ggcggcggcg gcggcggcgg cgggatggcc
       61 cgggcccgag gccaggcccc ggggagcggc gggcggcggc ggccgcggcg gggcggcgcg
      121 ggaaccgggc cccgggggga gtcggccggg ctgctgctgc tgctgctcca ggtgctgccg
      181 cccggggcta cggcagggcc gggacgccgg ggcacgcggg gcgctggcgc tggcggcggc
      241 ggcgtctgct ggcccggcgc ggccccagcc tttccccggg acgcgcggct gctgctgctc
      301 ctgccgccgc tgccgccact gtcgccgccg ccgccgagct ccgcgcccgc agcctccgcc
      361 tcccggatgg acgctctgcc ccgcagcggg ctgaacctga aggaggagcc gctgctgccc
      421 gccggcctgg gctcagtgcg ctcctggatg cagggcgcgg gcatcctgga cgccagcacc
      481 gcggcgcaga gtggcgtggg tctggcacga gcacattttg agaagcagcc tccctccaac
      541 ctcaggaaat ccaacttctt ccacttcgtg ctggccatgt acgaccggca ggggcagccc
      601 gtggaggtgg agcgcacagc cttcatcgac ttcgtggaaa aggaccgaga gcccggggcg
      661 gaaaagacta acaatgggat ccattaccgc ctccggctgg tgtataacaa tggactgcgg
      721 acagagcaag acctctacgt gcgtctcatc gactccatgt ccaaacaggc catcatctat
      781 gaggggcagg acaagaaccc cgaaatgtgc cgagtgctgc tcacccatga gatcatgtgc
      841 agccggtgct gtgaccggaa gagctgtggc aaccggaatg agacgccctc agaccccgtc
      901 atcattgaca ggttcttcct caagttcttc ctcaaatgca accagaactg cctgaagaat
      961 gcggggaatc ccagagacat gcgccgcttc caggtggtgg tgtccacgac ggtgagcgtg
     1021 gacggacacg tgctggccgt gtccgacaac atgtttgtgc acaacaactc caagcatggc
     1081 cgcagggcgc gccgcctgga cccctccgaa gctgccaccc cctgcatcaa ggccatcagc
     1141 cccggggagg gctggaccac gggcggcgcc accgtcattg tcatcggcga caacttcttc
     1201 gacgggttgc aggtcgtgtt cggaaacgtg ctcgtgtgga gcgagctcat cacgccccac
     1261 gccatccggg tgcagacgcc cccgcggcac atccccgggg tggtggaggt gaccctctcc
     1321 tacaagtcca agcagttttg caagggatgc cccggccgct ttgtctacac agctctgaac
     1381 gagcccacca ttgactacgg attccagagg ctacagaaag tcattcccag acaccccgga
     1441 gaccccgaga ggctgcccaa ggaagtgctg ctgaagcggg cggccgactt ggcagaagcc
     1501 ctgtacggag tgcccggcag taaccaggag ctgctcctga agcgcgcggc ggacgtggcc
     1561 gaggctctgt acagcacccc ccgcgcaccc gggccgctcg cacccctggc cccgagccac
     1621 ccacaccccg ccgtcgtggg catcaacgcc ttcagcagcc cgctggccat cgccgtcggg
     1681 gacgccaccc cggggcccga gccgggctac gcgcgcagct gcagcagcgc gtccccccgc
     1741 gggttcgcgc ccagccccgg ctcgcagcag agcggctacg gcggcggcct cggagctggc
     1801 ctgggcggct acggcgcgcc gggcgtggcc ggcctcggcg tgcctgggtc ccccagcttc
     1861 ctcaatggct ccaccgccac ctcgcccttc gccatcatgc cctctagccc cccgctggcg
     1921 gctgcctcct ccatgtccct cccggccgct gcccccacca ccagcgtgtt ctccttctcg
     1981 cctgtcaaca tgatctccgc cgtcaaacag aggagcgcct tcgcccccgt gctgcgcccc
     2041 ccaagctccc caccccaggc ctgccccaga gcccacggag aggggcttcc agaccagtct
     2101 tttgaggatt ctgacaagtt tcactctcca gcccgggggc ttcagggcct ggcatactcc
     2161 taattacggt ctgcagctgt tcccatggag cccggactgg aggtccctct gggattcaca
     2221 gccacacccc ggatggtggc acagacagat gcagggccag ggccatgggc ggacctcaac
     2281 ccgtgagctg aacggggaga ggccttcacc ccatgctcaa gcctccccgc tagcagcccc
     2341 acaggcttct ctcgcctccc tgtcttgggg tagtcagaag ccccagcact gtgcagatgc
     2401 tcttggcagg acagcatcgc agggaggtgc tgggattctg ggcctcactg tctgggtctt
     2461 ggttcctctg aaagagatgg atcttgtgca gaccagggtt gttgagtgag gggagcgtgg
     2521 gatggggacc gtgggaaaga ggacagctca gggagaagtg acctggaaag gtcctgtttg
     2581 catctgaccc atctcaactg gcccagcatc ccaacttctc tgcagcgaaa gggtggcgcc
     2641 ccgcagcctc gggaggcctg cccaggctcc cgtggagctt ccaacagctg cttggccccg
     2701 cagctgcccc cacttccttt gagacctgca ctctcatgct tgccgcatca tgcctccctg
     2761 tgggggcttt gggcatggag gaggcagaag agggggtgcc aggcctcctg tatttggggt
     2821 cttcccccag tggatgtctc atggactctg gccccacaca ctcacaatga ctctggctgg
     2881 ccccacgcag cgggcccagc cgccccccag gtggcctcac attctgctct gctaagtttg
     2941 gagaaaacag aacaataaac cagatgcagg tggtgcccgc ccggcctctc acctgcctcc
     3001 ttggtgtga
//
