LOCUS       NM_001375380            5106 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens EBF transcription factor 3 (EBF3), transcript variant
            1, mRNA.
ACCESSION   NM_001375380 XM_006717739
VERSION     NM_001375380.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5106)
  AUTHORS   Hu,W., Wang,M., Sun,G., Zhang,L. and Lu,H.
  TITLE     Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through
            directly regulating contactin-associated protein-like 4 (CNTNAP4)
            transcription: An experimental study
  JOURNAL   Cell Signal 118, 111139 (2024)
   PUBMED   38479556
  REMARK    GeneRIF: Early B Cell Factor 3 (EBF3) attenuates Parkinson's
            disease through directly regulating contactin-associated
            protein-like 4 (CNTNAP4) transcription: An experimental study.
REFERENCE   2  (bases 1 to 5106)
  AUTHORS   Deisseroth,C.A., Lerma,V.C., Magyar,C.L., Pfliger,J.M., Nayak,A.,
            Bliss,N.D., LeMaire,A.W., Narayanan,V., Balak,C., Zanni,G.,
            Valente,E.M., Bertini,E., Benke,P.J., Wangler,M.F. and Chao,H.T.
  TITLE     An Integrated Phenotypic and Genotypic Approach Reveals a High-Risk
            Subtype Association for EBF3 Missense Variants Affecting the Zinc
            Finger Domain
  JOURNAL   Ann Neurol 92 (1), 138-153 (2022)
   PUBMED   35340043
  REMARK    GeneRIF: An Integrated Phenotypic and Genotypic Approach Reveals a
            High-Risk Subtype Association for EBF3 Missense Variants Affecting
            the Zinc Finger Domain.
REFERENCE   3  (bases 1 to 5106)
  AUTHORS   Ignatius,E., Puosi,R., Palomaki,M., Forsbom,N., Pohjanpelto,M.,
            Alitalo,T., Anttonen,A.K., Avela,K., Haataja,L., Carroll,C.J.,
            Lonnqvist,T. and Isohanni,P.
  TITLE     Duplication/triplication mosaicism of EBF3 and expansion of the
            EBF3 neurodevelopmental disorder phenotype
  JOURNAL   Eur J Paediatr Neurol 37, 1-7 (2022)
   PUBMED   34999443
  REMARK    GeneRIF: Duplication/triplication mosaicism of EBF3 and expansion
            of the EBF3 neurodevelopmental disorder phenotype.
REFERENCE   4  (bases 1 to 5106)
  AUTHORS   Kim,J., Min,S.Y., Lee,H.E. and Kim,W.H.
  TITLE     Aberrant DNA methylation and tumor suppressive activity of the EBF3
            gene in gastric carcinoma
  JOURNAL   Int J Cancer 130 (4), 817-826 (2012)
   PUBMED   21387304
  REMARK    GeneRIF: EBF3 tumor suppressor is epigenetically silenced and that
            it serves as an independent prognostic marker in gastric carcinoma.
REFERENCE   5  (bases 1 to 5106)
  AUTHORS   Liao,D.
  TITLE     Emerging roles of the EBF family of transcription factors in tumor
            suppression
  JOURNAL   Mol Cancer Res 7 (12), 1893-1901 (2009)
   PUBMED   19996307
  REMARK    Review article
REFERENCE   6  (bases 1 to 5106)
  AUTHORS   Mao,L.P., Wang,H.M., Wang,Y.G. and Wang,X.Y.
  TITLE     [Construction of eukaryotic expression vector for EBF3 and EGFP
            fusion protein and its expression in HepG2 cells]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24 (10), 954-957 (2008)
   PUBMED   18845077
  REMARK    GeneRIF: Findings suggested that the transfection of EBF3 gene into
            HepG2 induced the cell proliferation from G1 phase to G2 phase by
            increasing the number of cells.
REFERENCE   7  (bases 1 to 5106)
  AUTHORS   Bennett,K.L., Karpenko,M., Lin,M.T., Claus,R., Arab,K.,
            Dyckhoff,G., Plinkert,P., Herpel,E., Smiraglia,D. and Plass,C.
  TITLE     Frequently methylated tumor suppressor genes in head and neck
            squamous cell carcinoma
  JOURNAL   Cancer Res 68 (12), 4494-4499 (2008)
   PUBMED   18559491
  REMARK    GeneRIF: Frequent methylation of EBF3 gene is associated with head
            and neck squamous cell carcinoma
REFERENCE   8  (bases 1 to 5106)
  AUTHORS   Zhao,L.Y., Niu,Y., Santiago,A., Liu,J., Albert,S.H., Robertson,K.D.
            and Liao,D.
  TITLE     An EBF3-mediated transcriptional program that induces cell cycle
            arrest and apoptosis
  JOURNAL   Cancer Res 66 (19), 9445-9452 (2006)
   PUBMED   17018599
  REMARK    GeneRIF: Expression of EBF3 resulted in cell cycle arrest and
            apoptosis. EBF3 regulates a transcriptional program underlying a
            putative tumor suppression pathway.
REFERENCE   9  (bases 1 to 5106)
  AUTHORS   Zardo,G., Tiirikainen,M.I., Hong,C., Misra,A., Feuerstein,B.G.,
            Volik,S., Collins,C.C., Lamborn,K.R., Bollen,A., Pinkel,D.,
            Albertson,D.G. and Costello,J.F.
  TITLE     Integrated genomic and epigenomic analyses pinpoint biallelic gene
            inactivation in tumors
  JOURNAL   Nat Genet 32 (3), 453-458 (2002)
   PUBMED   12355068
REFERENCE   10 (bases 1 to 5106)
  AUTHORS   Narayanan,D.L., Kutsche,K. and Girisha,K.M.
  TITLE     EBF3 Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   33956416
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354950.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 25, 2019 this sequence version replaced XM_006717739.3.
            
            Summary: This gene encodes a member of the early B-cell factor
            (EBF) family of DNA binding transcription factors. EBF proteins are
            involved in B-cell differentiation, bone development and
            neurogenesis, and may also function as tumor suppressors. The
            encoded protein inhibits cell survival through the regulation of
            genes involved in cell cycle arrest and apoptosis, and aberrant
            methylation or deletion of this gene may play a role in multiple
            malignancies including glioblastoma multiforme and gastric
            carcinoma. [provided by RefSeq, Sep 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000440978.2/ ENSP00000387543.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-640               AL354950.8         143710-144349       c
            641-797             AL354950.8         143442-143598       c
            798-861             AL354950.8         143017-143080       c
            862-917             AL354950.8         142246-142301       c
            918-991             AL354950.8         139009-139082       c
            992-1060            AL354950.8         137333-137401       c
            1061-1142           AL354950.8         57843-57924         c
            1143-1287           AL354950.8         53527-53671         c
            1288-1418           AL354950.8         47857-47987         c
            1419-1545           AL354950.8         47216-47342         c
            1546-1634           AL354950.8         28467-28555         c
            1635-1700           AL354950.8         23212-23277         c
            1701-1878           AL354950.8         22191-22368         c
            1879-2067           AL354950.8         20919-21107         c
            2068-2265           AL354950.8         20320-20517         c
            2266-2378           AL354950.8         19158-19270         c
            2379-5106           AL354950.8         15308-18035         c
FEATURES             Location/Qualifiers
     source          1..5106
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..5106
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /note="EBF transcription factor 3"
                     /db_xref="GeneID:253738"
                     /db_xref="HGNC:HGNC:19087"
                     /db_xref="MIM:607407"
     exon            1..640
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             507..2396
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor COE3; olf-1/EBF-like 2; early B cell
                     factor 3"
                     /codon_start=1
                     /product="transcription factor COE3 isoform 1"
                     /protein_id="NP_001362309.1"
                     /db_xref="CCDS:CCDS91377.1"
                     /db_xref="GeneID:253738"
                     /db_xref="HGNC:HGNC:19087"
                     /db_xref="MIM:607407"
                     /translation="MFGIQENIPRGGTTMKEEPLGSGMNPVRSWMHTAGVVDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVEKEKEPNNE
                     KTNNGIHYKLQLLYSNGVRTEQDLYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTAPSYLENATPCIKAISPSEGWTT
                     GGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQ
                     FCKGAPGRFVYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLVEALYG
                     MPHNNQEIILKRAADIAEALYSVPRNHNQIPTLGNNPAHTGMMGVNSFSSQLAVNVSE
                     TSQANDQVGYSRNTSSVSPRGYVPSSTPQQSNYNTVSTSMNGYGSGAMASLGVPGSPG
                     FLNGSSANSPYGIVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAVKQKSAFAPV
                     VRPQASPPPSCTSANGNGLQGSLLGAEDVAAEKTNWPFCEVGGIFHFDELMLKKGTGK
                     LCLGW"
     exon            641..797
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            798..861
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..917
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..991
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1060
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1142
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1287
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1418
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1545
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1634
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1700
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1878
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2067
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2265
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2378
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..5106
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4043..4048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /note="hexamer: AATAAA"
     polyA_site      4074
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /note="major polyA site"
     regulatory      5029..5034
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /note="hexamer: ATTAAA"
     polyA_site      5057
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /note="major polyA site"
     regulatory      5086..5091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
                     /note="hexamer: ATTAAA"
     polyA_site      5106
                     /gene="EBF3"
                     /gene_synonym="COE3; EBF-3; HADDS; O/E-2; OE-2"
ORIGIN      
        1 attcctcggg gagagagggc tgagttttgt gcgcctccgt ccgctgcgcg cgccgctcca
       61 ggccccgccg cgccccgcct gcgcccggga ctgcgccgca gcactcactg ccccgtttat
      121 ttgtctttgg agcaggcggg ccgcgccaga agcgggcgat cccgcagtgt cctgcagccg
      181 cggacgccgc ctggctagga tgacaccacg ttgagcgcgc ctgcaaacaa caacaacaac
      241 aagcgccgcc gcggccaccg cgtcctgctc cttcgaagcg ccgccgccgc cggtggagcc
      301 gcctccgcgc ccctggccgt ccggagcgcc cggccgctgg tgtatgtcgc gcctgcccgg
      361 gacgggctga agccggcggc ggggccggac cgcaggcgcc gagcagggcg agggcggcca
      421 gggcagccgc ctgccgccaa gccccgagcg ccgctgctcg aggaaacgct ttcggccggg
      481 agctgcggcc gccgccagca gttttcatgt ttgggattca ggagaatatt ccgcgcgggg
      541 ggacgaccat gaaggaggag ccgctgggca gcggcatgaa cccggtgcgc tcgtggatgc
      601 acacggcggg cgtggtggac gccaacacgg ccgcccagag cggcgtgggg ctggcgcggg
      661 cgcacttcga gaagcagccg ccttccaacc tccggaaatc caatttcttc cacttcgtgc
      721 tggcgctcta cgataggcag gggcagccgg tggagattga aaggaccgct tttgtggact
      781 ttgtggagaa agagaaagag ccaaacaacg agaaaaccaa caacggcatc cactataaac
      841 tccagttatt gtacagcaac ggagtcagaa cagagcaaga tctgtatgtt cgcctcatag
      901 attcaatgac caaacaggcc atcgtctacg agggccagga caagaacccg gagatgtgcc
      961 gtgtgctgct gacccacgag atcatgtgca gccggtgctg tgacaagaaa agttgtggca
     1021 atagaaacga aacgccctca gaccctgtaa tcattgacag attctttcta aagtttttcc
     1081 tcaagtgcaa tcagaactgt ttgaagaatg caggcaaccc tcgagatatg cggagattcc
     1141 aggttgttgt atcgacaaca gtcaacgtgg acggccacgt gctggccgtg tcagacaaca
     1201 tgtttgtgca caacaattcc aaacacggga ggcgggcccg ccgcctagac ccgtcagaag
     1261 gtacggcccc ttcttatctg gaaaatgcca ctccgtgcat caaggccatc agtcccagtg
     1321 aaggctggac cacggggggt gccaccgtca tcataattgg cgacaacttc tttgacgggc
     1381 tgcaagttgt attcggaact atgttggtgt ggagcgagct gataactccc catgccatcc
     1441 gagtccagac cccgccgagg cacattcctg gcgtcgtcga agtgaccctc tcctacaaat
     1501 ccaagcagtt ctgcaaaggt gctcctgggc gctttgtcta caccgccctt aatgaaccaa
     1561 ccatagatta cggctttcag aggttgcaga aagtgatccc aagacatccg ggtgatcccg
     1621 aaaggttacc caaggaggtg ttactgaagc gggcggcgga cctggtggaa gccttatacg
     1681 gaatgcctca caacaaccag gagatcatct tgaagcgagc ggcggacatc gccgaggcgc
     1741 tgtacagcgt tccccgcaat cacaaccaga tccccaccct gggcaacaac cctgcacaca
     1801 cgggcatgat gggcgtcaac tccttcagca gccagctagc cgtcaacgtg tcagagacgt
     1861 cacaagccaa cgaccaagtc ggctacagtc gcaatacaag cagcgtgtcc ccgcgaggct
     1921 acgtccccag cagtactccc cagcagtcca attacaacac agtcagcact agcatgaatg
     1981 gatatggaag tggcgccatg gccagtctag gggtccctgg ctcgcctgga tttcttaatg
     2041 gctcctccgc taactctccc tacggcatag tgccgtccag ccccaccatg gcagcctctt
     2101 cggtcaccct cccttcaaac tgtagcagca cacacggcat tttctcattc tcacctgcca
     2161 atgtcatctc cgcagtgaaa cagaagagcg ccttcgcgcc cgtggtccgg ccccaagcct
     2221 ctcctcctcc ttcctgcacc agcgccaacg ggaatggact gcaaggctct ctgctgggtg
     2281 ctgaggacgt agccgcggag aagacaaact ggcccttttg tgaagtcggt ggcatatttc
     2341 actttgatga actaatgctc aaaaaaggaa ctggaaagct atgtctgggc tggtagtccc
     2401 gccaatgtga gggacttctg tttaccttcc gcagcaccca gcatcaaagg acggacttca
     2461 ggggacacgt ttagtatatt aagacatgct gatggaaaca gtatcttcaa aaaaatcagc
     2521 agcaattgaa atgctacaaa agactttgtt taaagatttt atttaaacta ttaagaatca
     2581 acatgcaaac agcctacttc ttcatgaaca attccatttt attgactgaa cttttctcat
     2641 attttcacat ttctcagtcc tgaagaataa ggaaaacaaa gcgacgccta ttttgtataa
     2701 agtttccgac tccgtcttgg ccatgtctag taattgctat gtgttgggag aaactttgtg
     2761 aatgcaccat tttgatgatc atgaaacgct gatgaaaaat gcctccaaac atttttctgt
     2821 actcatactt agattcacaa tggttgtgta tctctataat gtgaaatatt tttttgtggt
     2881 gataaaaaga gggccaagga ggtatgagcc atcagactgg aaaaaaggat gactatatga
     2941 tgaggagaaa ctggggtggc agggagggag ggagggttta tcactgctta acttcatctt
     3001 catgaaatga aactttgtaa cttattgtag ttagaaattg taactttgat attgaattct
     3061 cttgccttca acaagcacac tgacagagaa aaaatgctac tgtctgttgg ttccaatatt
     3121 ctcccactgc tagagcttcc tgttaagcaa gtgtgatctg caacattttt tcaacttttg
     3181 ctagcactgt atactattgc attcttaggc tactgtgagg tctatgtttc ttgtaccaga
     3241 aattgtcctt ttgacttcta gatccttctt ccctaatgtg ttttgtatgt ggttataaaa
     3301 ttgtagactt ttgtgatttt gccaaagttg tagctaaata tttatacact tgtcttgaat
     3361 ttttttcaga tccacttaaa atatttagaa aaacaagttt tattccttat gtgtcttata
     3421 aggaataaaa tggtcttcat ttgacactta ctttcccatg aacacttgca gttgctaagg
     3481 gactttattt tgtaacatat caattataaa tattgtattt atctttgaaa ttttgtacat
     3541 tgcttttccc accttttcct ttttcttctt tcttgtctgt attggttttt gatcacggcc
     3601 tggtgttgtg atactgggaa gagcattagc caagaacttg tctctttgat ctgtttcgtt
     3661 aagctgaacc agtgtcttta catttcattt gtacttcaaa aaatatgcta ttgtttagac
     3721 tttccatcct tttttttttt attttgagga aaagtcaaat tcattgttta tttttatatt
     3781 atttttaagt tatctgaaca aatacttttg aaaaaaaagt ttgttgtata gtcaaaacaa
     3841 atcggtgcca cccggccgtg acaaatccta gtagattctg tgcatgtgga gcggccgcga
     3901 agaggtgaca ccgtttgggg ctgtgtcctt attttatttt atttttttgt agaatgtaaa
     3961 aagtcatttt agatgccacc cattgacttt gccacatagc tgaactgtgt ttactggaaa
     4021 aattcagagg cctaaagttt aaaataaaat ttacttctga tgttttaatt aaaatgtttg
     4081 ccacattaac ttttctgatg ccttaaaagt gaacttcttt aaagaacctt tgtgctattt
     4141 tatcacaggc ttacactaca attgttaata aatacttcat ttggagatgt atggtgtaaa
     4201 acacacaaac acacacaaaa aagcacaagc ccgctgcatg acccgtctct cctttctggg
     4261 actatttctg ctgcgtcctg caccctcctg ggcccacctc cgattcacag aggtttcagg
     4321 gggacccaaa tcactgctgg ttttcaattt ttttttaaca atacattttt gtggtcagtt
     4381 ccaacagcac tgtccgtact tttaaaactg gaatgacctc cttcagatat cgtgcctctt
     4441 agtgccaaac ccacagtgag accaaaagtg tcaggtgttt tttttttttt ctttctcctt
     4501 tgcactaagt gctttgcaga cacggcacag caaacatttt gcaaactgca gcagaaatcg
     4561 aatttaaaac aaaaaggagg gactttaaaa taccttcttg acaaaaatca acaatgcaca
     4621 acttacaaag tgttcattct agggacaaaa ttaaataaac agaatgtccc caggagtcag
     4681 caggtcacag tctggctttg tgatggttga caaggtctag ctacatggga aagcctgaga
     4741 agtcactttg gaactaaatt gcctccattt tattttgtac gagtaagggt ttgatctaca
     4801 aaagagctca catggacgca ctgagaacgc ctgccagctt ccccatgccc tcacttggtt
     4861 tgtgttttag gttaagtagt caatgcccac atcacttcac tgtctcaaga ctgagcactt
     4921 cactaaatgg tagattttac tgttaaagac cctacaataa gattgtttta tctgtacatt
     4981 ttttcagata tttaactgta taaaaatgtt cattttacac aatatttaat taaagtattt
     5041 cttgtctgtg aatttcactt ttggtaattt tctctgtttt tgattattaa aatgactaaa
     5101 cactaa
//
