LOCUS       NM_022659               5166 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens EBF transcription factor 2 (EBF2), mRNA.
ACCESSION   NM_022659 XM_927203 XM_931923 XM_939691
VERSION     NM_022659.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5166)
  AUTHORS   Yao,B., Xing,M., Meng,S., Li,S., Zhou,J., Zhang,M., Yang,C., Qu,S.,
            Jin,Y., Yuan,H., Zen,K. and Ma,C.
  TITLE     EBF2 Links KMT2D-Mediated H3K4me1 to Suppress Pancreatic Cancer
            Progression via Upregulating KLLN
  JOURNAL   Adv Sci (Weinh) 11 (2), e2302037 (2024)
   PUBMED   38015024
  REMARK    GeneRIF: EBF2 Links KMT2D-Mediated H3K4me1 to Suppress Pancreatic
            Cancer Progression via Upregulating KLLN.
REFERENCE   2  (bases 1 to 5166)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5166)
  AUTHORS   Chen,G., Yu,W., Li,Z., Wang,Q., Yang,Q., Du,Z., Zhang,G. and
            Song,Y.
  TITLE     Potential Regulatory Effects of miR-182-3p in Osteosarcoma via
            Targeting EBF2
  JOURNAL   Biomed Res Int 2019, 4897905 (2019)
   PUBMED   30993113
  REMARK    GeneRIF: research indicated that downexpression of miR-182-3p in
            Osteosarcoma (OS) cells results in overexpression of EBF2 and
            promotes the progression of OS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5166)
  AUTHORS   Li,M., Shen,Y., Wang,Q. and Zhou,X.
  TITLE     MiR-204-5p promotes apoptosis and inhibits migration of
            osteosarcoma via targeting EBF2
  JOURNAL   Biochimie 158, 224-232 (2019)
   PUBMED   30529043
  REMARK    GeneRIF: data indicated that miR-204-5p is an anti-oncogenic miRNA
            in osteosarcoma which functions through inhibiting oncogenic
            transcription factor EBF2. These results provided new therapeutic
            targets for metastatic osteosarcoma and insights into molecular
            regulation of EBF2.
REFERENCE   5  (bases 1 to 5166)
  AUTHORS   Bae,Y., Shin,D., Nam,J., Lee,H.R., Kim,J.S., Kim,K.Y., Kim,D.S. and
            Chung,Y.J.
  TITLE     Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a
            Korean Population
  JOURNAL   Yonsei Med J 59 (4), 519-523 (2018)
   PUBMED   29749135
  REMARK    GeneRIF: EBF2 gene variants can contribute to KD [ Kawasaki
            disease]in the Korean population.
REFERENCE   6  (bases 1 to 5166)
  AUTHORS   Patino-Garcia,A., Zalacain,M., Folio,C., Zandueta,C.,
            Sierrasesumaga,L., San Julian,M., Toledo,G., De Las Rivas,J. and
            Lecanda,F.
  TITLE     Profiling of chemonaive osteosarcoma and paired-normal cells
            identifies EBF2 as a mediator of osteoprotegerin inhibition to
            tumor necrosis factor-related apoptosis-inducing ligand-induced
            apoptosis
  JOURNAL   Clin Cancer Res 15 (16), 5082-5091 (2009)
   PUBMED   19671856
  REMARK    GeneRIF: EBF2 as a mediator of osteoprotegerin inhibition to tumor
            necrosis factor-related apoptosis-inducing ligand-induced
            apoptosis.
REFERENCE   7  (bases 1 to 5166)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   8  (bases 1 to 5166)
  AUTHORS   Nusbaum,C., Mikkelsen,T.S., Zody,M.C., Asakawa,S., Taudien,S.,
            Garber,M., Kodira,C.D., Schueler,M.G., Shimizu,A., Whittaker,C.A.,
            Chang,J.L., Cuomo,C.A., Dewar,K., FitzGerald,M.G., Yang,X.,
            Allen,N.R., Anderson,S., Asakawa,T., Blechschmidt,K., Bloom,T.,
            Borowsky,M.L., Butler,J., Cook,A., Corum,B., DeArellano,K.,
            DeCaprio,D., Dooley,K.T., Dorris,L. 3rd, Engels,R., Glockner,G.,
            Hafez,N., Hagopian,D.S., Hall,J.L., Ishikawa,S.K., Jaffe,D.B.,
            Kamat,A., Kudoh,J., Lehmann,R., Lokitsang,T., Macdonald,P.,
            Major,J.E., Matthews,C.D., Mauceli,E., Menzel,U., Mihalev,A.H.,
            Minoshima,S., Murayama,Y., Naylor,J.W., Nicol,R., Nguyen,C.,
            O'Leary,S.B., O'Neill,K., Parker,S.C., Polley,A., Raymond,C.K.,
            Reichwald,K., Rodriguez,J., Sasaki,T., Schilhabel,M., Siddiqui,R.,
            Smith,C.L., Sneddon,T.P., Talamas,J.A., Tenzin,P., Topham,K.,
            Venkataraman,V., Wen,G., Yamazaki,S., Young,S.K., Zeng,Q.,
            Zimmer,A.R., Rosenthal,A., Birren,B.W., Platzer,M., Shimizu,N. and
            Lander,E.S.
  TITLE     DNA sequence and analysis of human chromosome 8
  JOURNAL   Nature 439 (7074), 331-335 (2006)
   PUBMED   16421571
REFERENCE   9  (bases 1 to 5166)
  AUTHORS   Wang,S.S., Betz,A.G. and Reed,R.R.
  TITLE     Cloning of a novel Olf-1/EBF-like gene, O/E-4, by degenerate
            oligo-based direct selection
  JOURNAL   Mol Cell Neurosci 20 (3), 404-414 (2002)
   PUBMED   12139918
REFERENCE   10 (bases 1 to 5166)
  AUTHORS   Wang,S.S., Tsai,R.Y. and Reed,R.R.
  TITLE     The characterization of the Olf-1/EBF-like HLH transcription factor
            family: implications in olfactory gene regulation and neuronal
            development
  JOURNAL   J Neurosci 17 (11), 4149-4158 (1997)
   PUBMED   9151732
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023566.11, BC137106.1,
            AK304372.1, AK021562.1, BY798905.2, BQ878633.1, AK093878.1,
            AI457889.1 and AC090103.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022659.3.
            
            Summary: The protein encoded by this gene belongs to the COE
            (Collier/Olf/EBF) family of non-basic, helix-loop-helix
            transcription factors that have a well conserved DNA binding
            domain. The COE family proteins play an important role in variety
            of developmental processes. Studies in mouse suggest that this gene
            may be involved in the differentiation of osteoblasts. [provided by
            RefSeq, Oct 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.21673.1,
                                           DRR138518.374363.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000520164.6/ ENSP00000430241.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC023566.11        51770-52058
            290-1105            BC137106.1         1-816
            1106-2092           AK304372.1         465-1451
            2093-2834           AK021562.1         843-1584
            2835-3235           BY798905.2         25-425
            3236-3881           BQ878633.1         99-744
            3882-4793           AK093878.1         918-1829
            4794-5152           AI457889.1         1-359               c
            5153-5161           AK093878.1         2189-2197
            5162-5166           AC090103.4         127600-127604
FEATURES             Location/Qualifiers
     source          1..5166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..5166
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /note="EBF transcription factor 2"
                     /db_xref="GeneID:64641"
                     /db_xref="HGNC:HGNC:19090"
                     /db_xref="MIM:609934"
     exon            1..685
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             555..2282
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /note="Collier, Olf and EBF 2; OLF-1/EBF-LIKE 3; Collier,
                     Olf and EBF transcription factor 2; early B cell factor 2;
                     metencephalon-mesencephalnon-olfactory transcription
                     factor 1"
                     /codon_start=1
                     /product="transcription factor COE2"
                     /protein_id="NP_073150.2"
                     /db_xref="CCDS:CCDS43726.1"
                     /db_xref="GeneID:64641"
                     /db_xref="HGNC:HGNC:19090"
                     /db_xref="MIM:609934"
                     /translation="MFGIQDTLGRGPTLKEKSLGAEMDSVRSWVRNVGVVDANVAAQS
                     GVALSRAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEK
                     TNNGTHYKLQLLYSNGVRTEQDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMC
                     SRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTV
                     NVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGD
                     NFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFI
                     YTALNEPTIDYGFQRLQKVIPRHPGDPERLAKEMLLKRAADLVEALYGTPHNNQDIIL
                     KRAADIAEALYSVPRNPSQLPALSSSPAHSGMMGINSYGSQLGVSISESTQGNNQGYI
                     RNTSSISPRGYSSSSTPQQSNYSTSSNSMNGYSNVPMANLGVPGSPGFLNGSPTGSPY
                     GIMSSSPTVGSSSTSSILPFSSSVFPAVKQKSAFAPVIRPQGSPSPACSSGNGNGFRA
                     MTGLVVPPM"
     exon            686..842
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..906
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..962
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1036
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1105
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1187
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1305
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1436
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1563
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1652
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1718
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1896
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2082
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2250
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..5166
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5143..5148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /note="hexamer: AATAAA"
     polyA_site      5166
                     /gene="EBF2"
                     /gene_synonym="COE2; EBF-2; O/E-3; OE-3"
                     /note="major polyA site"
ORIGIN      
        1 agggccgtag taacccattc atggggcccg cgcgcggctg cagccgggct ccgtggcgct
       61 cgcagccacc gcctcctctc ggctccaggt cttccccttc tttttacaac tgatcctgtt
      121 ggggattttt tttttttcta aattggaacg gtggggagga gcagggaggg gggacctgga
      181 ggaaggggag agattaggca gccatcaatt tcctccagtt tctcccagaa caggtgatgc
      241 ttctaaattg tgatcacttt caggaggcag cactgcagct ggaaggatgc gagcgaccta
      301 gggtggagtg gctgaggcgg cagatctgaa cttgcggagg ataagaaccc aaactttgac
      361 tacatcagtc cgcacctcgc cagtgaagca aaggacgggt tatctttttt ttttttctaa
      421 gactcaaact tgggcacttg atcccttttc ttggattgct ttggaggaga cgatttgctg
      481 gcaacgttgg gaacagtcag gactgtgttg taactcttac ttttaaagcg acagtagagg
      541 atcagacttt ttaaatgttt ggaattcaag atactttagg aagaggacca actctgaaag
      601 agaaatcgct gggcgcggag atggattcgg tcaggtcctg ggtccggaat gtcggagtgg
      661 tggacgctaa tgtcgccgcg cagagcgggg tcgccctgtc ccgggcccac tttgagaaac
      721 agcctccttc caacttgagg aaatccaact tctttcactt cgtcctggcg ctctatgaca
      781 ggcagggcca gccggtggag atcgagcgga cggccttcgt ggactttgtg gagaatgaca
      841 aagaacaagg caacgagaag accaacaacg gcactcacta caagttacag ctcctctaca
      901 gcaacggtgt ccgcacggaa caggacctct atgtcaggct catcgactcg gtcaccaagc
      961 agcccatcgc ttacgaggga cagaataaga atccggaaat gtgccgagtt ctcctgacgc
     1021 acgaagtgat gtgtagtcga tgctgcgaaa agaaaagctg tggaaaccga aatgagactc
     1081 catcggaccc agtcataatt gacagattct ttttaaaatt tttcctcaag tgcaatcaga
     1141 attgtttgaa aacagcagga aacccaaggg acatgagacg gtttcaggtt gtgttgtcaa
     1201 caacggtgaa tgtggatgga cacgtcctgg ctgtttctga caacatgttt gttcataaca
     1261 actccaagca tggacggaga gcaagaagac tcgatccatc ggaagctacc ccctgcatca
     1321 aagccattag cccgagtgaa ggctggacca caggaggagc catggtcatc atcatcgggg
     1381 acaacttctt tgatggtctc caagtggtgt ttgggactat gcttgtatgg agcgagctaa
     1441 taacccctca tgccatcaga gtacagactc ctccccggca catcccaggc gtggtagagg
     1501 tgacattatc ttataaatct aaacagttct gcaaaggagc cccaggaagg ttcatttaca
     1561 cagcattaaa tgaacccacc atagactatg gcttccagag actgcagaag gtcatcccta
     1621 ggcatcctgg agatcctgag agattagcta aggagatgct gttgaaaaga gctgcagatc
     1681 tagtggaagc tctttatggc acaccacaca ataaccagga catcattttg aagcgagccg
     1741 cagacattgc tgaagctctc tacagcgtcc ccaggaatcc cagccagctt ccagccctct
     1801 ctagctcccc agcgcacagt ggcatgatgg gaatcaactc ctatggcagc cagcttgggg
     1861 tcagcatctc agagtcaaca caaggaaata atcaagggta catccgcaac acaagcagca
     1921 tctctccgcg gggatactct tccagctcca cgcctcaaca gtctaattac agtacctcca
     1981 gcaacagtat gaatggctac agcaatgtcc ccatggccaa cttgggtgtt ccaggttcac
     2041 caggatttct aaatggctca cccaccggct ctccttatgg aatcatgtca tcaagtccca
     2101 ccgttgggtc ttccagcaca tcctccatcc tcccattttc ctcttcagtt tttcctgctg
     2161 tcaaacagaa gagtgccttt gcccctgtca tcaggcccca aggctcccct tcacctgcct
     2221 gctccagcgg caatggaaat ggattcagag ccatgaccgg acttgttgta cccccgatgt
     2281 aaagaagaac tgctttctta tagcacaaaa ctacttactc tgatggacca ataatgaaga
     2341 aagcactagg agctcttttg ggggtgtagt ggtgccccca catgaacatg atggacaccc
     2401 ttgggtctgc aaggagccag catcttactt ggtcccacgt cctcctatag ctctgatggt
     2461 ggctacacaa actgaccctc ttgggacaag gacaaaagat gtcattgacg tagtcagtgc
     2521 taagagcaga aatgcaattc tttgttatga acattatgaa aaccaccttc ctatgtttgt
     2581 aaaatattta agaaaaaatt ggcaaacaat taatgcttaa tattttggat actatttgtt
     2641 tttctttgta ggaaaaaaaa gttgaaagtt tctattttct atgaagcctt tcagatacca
     2701 atttagttta tgcagaaaaa aattgaacaa aacagggtac cagcacggaa gactttctta
     2761 aaacgcaacc tgaattgaat gatgaaatgt tgtatgtgtg tttgcttata gcttaatctc
     2821 tttaaaaaat gaacaaaaaa agggaaaaat tttaaaatgt tttacaatta tttaaataaa
     2881 taaatgtgta acttattgta agtagaggta gaaattaaga cctttttttg gaagagagag
     2941 ggatttctct tcctgatgta aaatgaaaat gatgcaaaca tgtagtaaca agttttaaag
     3001 gtgtgtgatt attactgcag ttacttacta gattcttatc ccctgtcctg caccccctcc
     3061 ttttccatca ctttattgac ccaagggcaa gaacatgtag attcccacag aacaccctaa
     3121 tgcagaaaca gacactctag cacatgcaca aatactccaa cccatcaatt cattcccagc
     3181 tccgtctgat ttctaaatag tccacactct tgtgaatact ttttaaaatt cctattatta
     3241 gctttcaacg ttctcccctg agcagtccag agaattccca tgtttgagtc tgtctcaggc
     3301 tttcagcatc ccaaggaaag aagcacctca ccttctagca gagccaaaac cacagacttt
     3361 cttaaccaag ggaccccttg ggaattcctc ctcaccagaa ccccaccact ccctccgctt
     3421 tgggtgcctg gttcagtaca gaggtacaca gccccataga acttcagcaa cacggtttgg
     3481 agaagataac tctgtttgat ggactcttta gagtcagtct tagaacatcc aagtcctttc
     3541 ctctccctgt caatttcccc ttttatggca ttaaactctc ttgaaaaaca tagctatgcc
     3601 actcgacagt ttctagtcaa gaatgagacg gaatgtggga gagggatatt aaaagcccta
     3661 atcccctctt ctgatgttcg aagaaaggca agaccagatt cttgggagat ccagagatta
     3721 ggggcatctg cgttctatgc agcacagtta cccagccctt tgatgggctc ttcatcgttt
     3781 tgtgactagc tcttagaggg gaagaacctt gccttagctg ctaacagtgg ttgattcttg
     3841 aaagcttatg taatcctaga gacatatcca ggcatattgg gattgccaat aaagatgtca
     3901 cttgtttcca cgttggggtt ctccttattg actcatgagc accacaatag agtctataca
     3961 cagacttagt ttggggttct tggttgggat ttcagcatta gaaatagatg cagcactcat
     4021 ggaaaaacat catgagtgca tctgagccaa ttttagatga tttcattaat tctgcatacc
     4081 ttctctttga cccattgatg caggcccaca tctatccagc cccaactgtc ttatttgcct
     4141 ttaacccatt ctggaattac ccagtatgac ttatattatt tctatgcaca tgagaatcca
     4201 aggttttaga aacctggcat gcttataact actgctgaca gtccctcata gtcagggctt
     4261 aaagcgccaa aatacacgga aacataagag aaaaagtccc ccagtgagaa acctgattga
     4321 tggaagggga agaatgtgtg gaatatgaat gttaccttcc aaaagtgaag gcagagcaaa
     4381 attaagcatg tttagccctg gatttgagcc aatccaacat aaggaaattt tgtttttttt
     4441 aagtagcatt gcttttagaa cctgtgaatt ttccttttgc atgaagatga gtgcagtact
     4501 gtcttcaaaa tgattgtaga atttcttggt agctttacac cgaaaaatgc gtgtaactaa
     4561 ataccagaca tcttgaccat tcagctagaa ccctggcagc aacagagcta tttaattgta
     4621 caaatgtgtg taaggattat ttttagtgta ctaataaatt aaaaacaaag ctaccctgtc
     4681 ctcgttagtc attgctattc aatcattcca gtcccaagtt atttttgtgc cacttggaat
     4741 atgagtattt ctattggtaa ctacaaactc tatcctgtgt ttgtaagagg agctgtgtaa
     4801 gatttttttc atttaaaggg acaatttact tcattattta tctttctttt gttatagcgt
     4861 tgtaattctt ctcagttttt ctttgcacat ttcaatatgc atggtttaaa aaccattaac
     4921 ttctctacct tttgtacagt aaggtttcat tttcacactg tatagtttca ttttattgtt
     4981 ttgctttgtc agttatatac agtataaagt tgctatgcac agagcttttt gtaaagacag
     5041 cttttttgtt tactgttttt aatggtctta cttaaagaat atcttgtttg taaaatgaat
     5101 atgtctactt cagttttaaa ctttaaatta tcctaacaaa aaaataaaat ttttgtactg
     5161 taaaaa
//
