LOCUS       NM_024007               5405 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens EBF transcription factor 1 (EBF1), transcript variant
            2, mRNA.
ACCESSION   NM_024007
VERSION     NM_024007.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5405)
  AUTHORS   Mladenic,T., Wagner,J., Kadivnik,M., Pereza,N., Ostojic,S.,
            Peterlin,B. and Devic Pavlic,S.
  TITLE     Protective Effect of EBF Transcription Factor 1 (EBF1) Polymorphism
            in Sporadic and Familial Spontaneous Preterm Birth: Insights from a
            Case-Control Study
  JOURNAL   Int J Mol Sci 25 (20), 11192 (2024)
   PUBMED   39456973
  REMARK    GeneRIF: Protective Effect of EBF Transcription Factor 1 (EBF1)
            Polymorphism in Sporadic and Familial Spontaneous Preterm Birth:
            Insights from a Case-Control Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5405)
  AUTHORS   Wu,Y., Chen,S., Huang,G., Zhang,L., Zhong,L., Feng,Y., Wen,P. and
            Liu,J.
  TITLE     Transcriptome analysis reveals EBF1 ablation-induced injuries in
            cardiac system
  JOURNAL   Theranostics 14 (12), 4894-4915 (2024)
   PUBMED   39239522
  REMARK    GeneRIF: Transcriptome analysis reveals EBF1 ablation-induced
            injuries in cardiac system.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5405)
  AUTHORS   Li,L., Zhang,D. and Cao,X.
  TITLE     EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms
  JOURNAL   Front Immunol 15, 1320689 (2024)
   PUBMED   38318177
  REMARK    GeneRIF: EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5405)
  AUTHORS   Liu,Y., Fan,M., Xian,S., Hu,P., Zhang,M., Zhang,X., Zhang,H.,
            Zhang,J., Dai,L., Lin,M., Mei,W., Huang,D., Huang,R., Zhang,J. and
            Huang,Z.
  TITLE     RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte Meiosis
            Pathway in Bone Metastases of Bladder Urothelial Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 189 (2023)
   PUBMED   37664915
  REMARK    GeneRIF: RBP7 Regulated by EBF1 Affects Th2 Cells and the Oocyte
            Meiosis Pathway in Bone Metastases of Bladder Urothelial Carcinoma.
REFERENCE   5  (bases 1 to 5405)
  AUTHORS   Al Madhoun,A., Haddad,D., Nizam,R., Miranda,L., Kochumon,S.,
            Thomas,R., Thanaraj,T.A., Ahmad,R., Bitar,M.S. and Al-Mulla,F.
  TITLE     Caveolin-1 rs1997623 Single Nucleotide Polymorphism Creates a New
            Binding Site for the Early B-Cell Factor 1 That Instigates Adipose
            Tissue CAV1 Protein Overexpression
  JOURNAL   Cells 11 (23), 3937 (2022)
   PUBMED   36497195
  REMARK    GeneRIF: Caveolin-1 rs1997623 Single Nucleotide Polymorphism
            Creates a New Binding Site for the Early B-Cell Factor 1 That
            Instigates Adipose Tissue CAV1 Protein Overexpression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5405)
  AUTHORS   Tsai,R.Y. and Reed,R.R.
  TITLE     Cloning and functional characterization of Roaz, a zinc finger
            protein that interacts with O/E-1 to regulate gene expression:
            implications for olfactory neuronal development
  JOURNAL   J Neurosci 17 (11), 4159-4169 (1997)
   PUBMED   9151733
REFERENCE   7  (bases 1 to 5405)
  AUTHORS   Hagman,J., Gutch,M.J., Lin,H. and Grosschedl,R.
  TITLE     EBF contains a novel zinc coordination motif and multiple
            dimerization and transcriptional activation domains
  JOURNAL   EMBO J 14 (12), 2907-2916 (1995)
   PUBMED   7796816
REFERENCE   8  (bases 1 to 5405)
  AUTHORS   Milatovich,A., Qiu,R.G., Grosschedl,R. and Francke,U.
  TITLE     Gene for a tissue-specific transcriptional activator (EBF or
            Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory
            neurons, is located on human chromosome 5, band q34, and proximal
            mouse chromosome 11
  JOURNAL   Mamm Genome 5 (4), 211-215 (1994)
   PUBMED   8012110
REFERENCE   9  (bases 1 to 5405)
  AUTHORS   Travis,A., Hagman,J., Hwang,L. and Grosschedl,R.
  TITLE     Purification of early-B-cell factor and characterization of its
            DNA-binding specificity
  JOURNAL   Mol Cell Biol 13 (6), 3392-3400 (1993)
   PUBMED   8497258
REFERENCE   10 (bases 1 to 5405)
  AUTHORS   Hagman,J., Belanger,C., Travis,A., Turck,C.W. and Grosschedl,R.
  TITLE     Cloning and functional characterization of early B-cell factor, a
            regulator of lymphocyte-specific gene expression
  JOURNAL   Genes Dev 7 (5), 760-773 (1993)
   PUBMED   8491377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134043.1, DA485473.1, BC038805.1, AC008442.6 and BM802733.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024007.4.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is one aa
            shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.169524.1, BC038805.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313708.11/ ENSP00000322898.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC134043.1         132523-132676
            155-390             DA485473.1         1-236
            391-2644            BC038805.1         248-2501
            2645-4646           AC008442.6         100087-102088
            4647-5405           BM802733.1         1-759
FEATURES             Location/Qualifiers
     source          1..5405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..5405
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="EBF transcription factor 1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
     exon            1..572
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..2214
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     olfactory neuronal transcription factor 1; early B cell
                     factor 1; Collier, Olf and EBF transcription factor 1;
                     transcription factor COE1"
                     /codon_start=1
                     /product="transcription factor COE1 isoform 2"
                     /protein_id="NP_076870.1"
                     /db_xref="CCDS:CCDS4343.1"
                     /db_xref="GeneID:1879"
                     /db_xref="HGNC:HGNC:3126"
                     /db_xref="MIM:164343"
                     /translation="MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQ
                     SGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSE
                     KTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIM
                     CSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTT
                     VNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTG
                     GATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQF
                     CKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGM
                     PHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEA
                     SQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNG
                     SAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQT
                     SPPPTCTSTNGNSLQAISGMIVPPM"
     exon            573..729
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..793
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..849
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..923
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..992
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1074
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1216
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1347
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1474
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1563
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1629
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1807
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1808..1987
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2182
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..5405
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5382..5387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="hexamer: ATTAAA"
     polyA_site      5405
                     /gene="EBF1"
                     /gene_synonym="COE1; EBF; O/E-1; OLF1"
                     /note="major polyA site"
ORIGIN      
        1 cctgcttctt caagtgaagg gtacctctac aaaaggaaac tccagcccct cctgtcctcc
       61 accggcctgt gatcattaca aaaaaaaaaa aaaaaaagca aaaaaaaaaa aaaagcaccc
      121 aaaccaaaaa tcaaccaacc aaacaacccc caacagccaa gcatacatct ctaattttat
      181 tattttggtc ttttcgttgg attttccctt tcttcttttt ttcgggttat cgctcagttt
      241 tgagcagagg tttacatttt ttaaaaattt gctttccagc ccgccttgat cttctaagtg
      301 cgagttcatc gtctgagaaa aaaaaaaatc tctggttggc gtttttgttt cttttctttt
      361 ctttcttttc tttccttttt tttttttttt aatttttttc aagggggagg agattttcca
      421 caagaaaagg ttgttttcat gtttgggatt caggaaagca tccaacggag tggaagcagc
      481 atgaaggaag agccgctggg cagcggcatg aacgcggtgc ggacgtggat gcagggcgcc
      541 ggggtgctgg acgccaacac ggcggcgcag agcggggtgg gtctggcccg ggctcacttt
      601 gagaagcagc cgccttccaa tctgcggaaa tccaacttct tccacttcgt cctggccctc
      661 tacgacagac agggccagcc cgtggagatc gagaggacag cgtttgtggg gttcgtggag
      721 aaggaaaaag aagccaacag cgaaaagacc aataacggaa ttcactaccg gcttcagctt
      781 ctctacagca atgggataag gacggagcag gatttctacg tgcgcctcat tgactccatg
      841 acaaaacaag ccatagtgta tgaaggccaa gacaagaacc cagaaatgtg ccgagtcttg
      901 ctcacacatg agatcatgtg cagccgctgt tgtgacaaga aaagctgtgg caaccgaaat
      961 gagactccct cagatccagt gataattgac aggttcttct tgaaattttt cctcaaatgt
     1021 aaccaaaatt gcctaaagaa tgcgggaaac ccacgtgaca tgcggagatt ccaggtcgtg
     1081 gtgtctacga cagtcaatgt ggatggccat gtcctggcag tctctgataa catgtttgtc
     1141 cataataatt ccaagcatgg gcggagggct cggaggcttg acccctcgga aggtacgccc
     1201 tcttatctgg aacatgctac tccctgtatc aaagccatca gcccgagtga aggatggacg
     1261 acgggaggtg cgactgtgat catcataggg gacaatttct ttgatgggtt acaggtcata
     1321 ttcggtacca tgctggtctg gagtgagttg atcactcctc atgccatccg tgtgcagacc
     1381 cctcctcggc acatccctgg tgttgtggaa gtcacactgt cctacaaatc taagcagttc
     1441 tgcaaaggaa caccaggcag attcatttat acagcgctca acgaacccac catcgattat
     1501 ggtttccaga ggttacagaa ggtcattcct cggcaccctg gtgaccctga gcgtttgcca
     1561 aaggaagtaa tactcaaaag ggctgcggat ctggtagaag cactgtatgg gatgccacac
     1621 aacaaccagg aaatcattct gaagagagcg gccgacattg ccgaggccct gtacagtgtt
     1681 ccccgcaacc acaaccaact cccggccctt gctaacacct cggtccacgc agggatgatg
     1741 ggcgtgaatt cgttcagtgg acaactggcc gtgaatgtct ccgaggcatc acaagccacc
     1801 aatcagggtt tcacccgcaa ctcaagcagc gtatcaccac acgggtacgt gccgagcacc
     1861 actccccagc agaccaacta taactccgtc accacgagca tgaacggata cggctctgcc
     1921 gcaatgtcca atttgggcgg ctcccccacc ttcctcaacg gctcagctgc caactccccc
     1981 tatgccatag tgccatccag ccccaccatg gcctcctcca caagcctccc ctccaactgc
     2041 agcagctcct cgggcatctt ctccttctca ccagccaaca tggtctcagc cgtgaaacag
     2101 aagagtgctt tcgcaccagt cgtcagaccc cagacctccc cacctcccac ctgcaccagc
     2161 accaacggga acagcctgca agcgatatct ggcatgattg ttcctcctat gtgaaagaat
     2221 tgccttgaag aattgtatta atgaagaggt tggattctgc tacagagagt aatctgatac
     2281 aagtcccaga gtggaacttt taactcaggc ctttttaaga ggaatcacaa taactgcaga
     2341 tttttaaaca aacaaaatca ccgaccttgc aaatactgaa attggaagag ggatctgcaa
     2401 gtgcagggtg ttggttaaag ttgtacctcc caagtatttg ggggatatat ttattctgta
     2461 ttgacaaaag caaatccact ttttcttttt cttttttttt tttaagctta attctgcaat
     2521 catttgtctt ttataaaccg taaagctcta tacaagggac actataaata agactccatg
     2581 ttttaattta tgatgttttt aaagctgtgt aaaggaagaa tgaagtggtg atatttacaa
     2641 aaaagtaaaa aaaaaaaaaa agaaaaaaag gaaaaaaaaa aaagcttgta tgggacagaa
     2701 taggaatgcc agttagattt tttagaaaaa ctaagggtcg gcttttgcgc cttaaagcat
     2761 atcaaatggt agttagctca gacagtgcat tttcaatatc taacttaaca tgccacccct
     2821 tagcagtgca agcttattta tctcttttgt attgttgtct taagcaactg tgtaaataaa
     2881 tgcagcctgg aaagttaaaa cgcgatgtaa gtgatcacat ttttccctct actcgaaaat
     2941 ccagtgcctc tagacagatt gttaaaactg catatttaaa tctgatctca ttctctcctt
     3001 ttacttaagt cagtttcttc tgaagccgat ggcctctcga gagcttggtg gcacacatac
     3061 tgtgtgagaa tctcctttga gacttcatgg aacagggtcc aggcacagaa ttccacactc
     3121 tgccctccag ttaacaagcc aaaacctcac gtacgctccc ccatttgcaa gtttaaagtt
     3181 tactcgtcct aaatgcagac ttcataccta tcttccaaaa gttgataaaa gcaacgtggc
     3241 aggtattttc gattttccca ttccagatac tgcctctatc agtcgaccct taccatttgt
     3301 aacataatag attgaaacaa caggttaagt gctttggaat taagagttaa agggaaccgg
     3361 gggtggagaa aggaaaagaa ggttgagacc tccaaaacat agttttctgt tctatgggaa
     3421 tttttgctct cattatctgg gaagtgttct taaaaataag aattaatagc aaagatgcag
     3481 caaagctctg aggatgcatt tgcctgatat ttttttcttt gctcttgtgt ttttgtatgt
     3541 agttataaat actgtagatt ttttttttgt gattttttgc caaagttgtt gttctattta
     3601 tacattttaa tgtcttaaga cattttttca atatcacaaa aagattttac tgcgtatttt
     3661 gcaaagaaaa aaagctcact acctttagct tgcacatact tgcaaagtta attaaaaggc
     3721 tttttgtttt aaaggggatt ttgtaaaata tccatataaa taatgtattt atctttcgaa
     3781 tttgtacatt gcttttccct tcttcctctt ccttccaccc ccaatttatt ttattgtgta
     3841 tgtttgctac gtgaaaagtg cgtatttgtt tggtcaccta cacttgtatt agctgtttca
     3901 atgtgatttt taaacatttc atttatagtt atttttagta ttgttataaa ccatgcttca
     3961 gtttttttaa tttccaccca aaagtcattg tctatttttg tattatttgt aagttaagaa
     4021 gttttttcca atatatggca aaaaaaaaaa aatagtagca tattattctt gtagtattta
     4081 gttcagtaga tttaaaaaaa aatgtatcct ttgctttgga agcttacaaa acaaccctaa
     4141 tgctgtttta ctctattaat atgcatggaa tctctccctt tggagtgacg cattttgtgc
     4201 attaaattct agggagaaac ttcatagaaa tcaatgaaca tactttcttt cttaagtctg
     4261 cttgtatatt tcctctgtct ttcacataaa tataaaccag cagattggat gccttaacaa
     4321 tgcaaatcat attcatttca cttgtacatt gtaactgtgc accagaactg tcagtcatca
     4381 ctaacattct aagaaaaaag aaaaagaaaa aaagaaaaaa aaaaaaacaa agaaatcgaa
     4441 aagcacaaaa gaactgtttt gttaccttaa gacaatgtaa ctttttctag tagagcaaga
     4501 aatcatttac aacaatgctg caactgtgca tgcccccata tggattttgc aatggttttc
     4561 actaggctgt caagagtgcg atttttatgg gttggggtgg gtgggggagg ggagttgtgg
     4621 gagggtaggg gagggaggaa agctgttttt catggtgaga aataataatg atgactaata
     4681 ataataaaaa aaactggaaa atgtaagcaa ggtggacgca ttgcttctcg gtactcagaa
     4741 aggttatctg aatttgcgtg gtaagcgctg gcctgaagat gtacacaagt taaagccata
     4801 ttttatctgg tgagcccctt aactgtttct gaaggaatga acggtcagcc gggaaggtgt
     4861 ccggcttaga ccttgacaac agacactacc catctgtcag ccatgtgcag tggttagaac
     4921 tcttcttgaa agtccaaaga gcctttaaaa tgtgtataat ttgtgttttg ttgcttctat
     4981 ttctattgat tagatgaaaa gacattctgg ccctctgatc ctctttcttc tccacaaaag
     5041 ttttacaaat aaaagatgtt cccctaaata cagaatatgg ctttaagaag aaaatgaaat
     5101 gaagaattaa attaagattt cagtgttggg ggaaaaaata cagcttctgg atgactggat
     5161 tgcataacat tgccctggcc tcacattgta ctaggatgca gcttaaatga agtcatctct
     5221 aaatctacta acctttcacc ttcttatcaa aactttttga atagacacac actgtacagt
     5281 tcaattgtta gagaacctaa ctactgtaga gattgttaaa tttttttttt ttttttgcaa
     5341 aaattcaagc tgtaaaaact tttcaacttt cacaatattt aattaaagtt acttcctgtc
     5401 tgtga
//
